Access and adherence to medication among people with diabetes in Brazil: evidences from PNAUM

Micheline Marie Milward de Azevedo Meiners Noemia Urruth Leão Tavares Luciano Santos Pinto Guimarães Andréa Dâmaso Bertoldi Tatiane da Silva Dal Pizzol Vera Lucia Luiza Sotero Serrate Mengue Edgar Merchan-Hamann About the authors

ABSTRACT:

Objective:

To describe people with diabetes in Brazil and to compare their sociodemographic characteristics, access and self-reported adherence to diabetes prescribed drugs.

Methods:

Data analysis from the National Survey on Access, Use and Promotion of the Rational Use of Medicines, a household survey, with sampling by clusters, according to sex and age domains and national and macro-regional representativeness. Adults (≥ 20 years old) who reported having diabetes constituted the sample. The weighted frequencies of the variables in the sample were analyzed and the Pearson χ2 test was applied to evaluate the statistical significance of the differences between the strata for the data of access, form of financing and adherence to the drugs, considering the level of significance of 5%.

Results:

We found a higher proportion of women, people over 60 years and economy class C. Most participants reported having two or more comorbidities, in addition to diabetes, and taking five or more drugs. Regarding access, 97.8% say they have access to prescription drugs for diabetes and 70.7% say they get them totally free of charge. There was low adherence to anti-diabetic treatment, with significant macro-regional differences (p = 0,001), and greater vulnerability in the South and Northeast regions.

Conclusion:

Better access to diabetes medicines in the country has been demonstrated. However, to improve the efficiency of health public spending, it is necessary to achieve higher rates of adherence to treatment.

Keywords:
Diabetes mellitus; Health services accessibility; Prescription drugs; Medication adherence; Public policies

INTRODUCTION

Noncommunicable chronic diseases (NCDs), including diabetes mellitus (DM), are the leading cause of mortality and premature disability in most developing countries, including Brazil. This problem affects socioeconomic issues, increasing inequities and compromising the quality of life of millions of people11. Daar AS, Singer PA, Persad DL, Pramming SK, Matthews DR, Beaglehole R, et al. Grand challenges in chronic non-communicable diseases. Nature. 2007;450(7169):494-6.,22. World Health Organization. Global report on diabetes. Geneva: WHO; 2016. [cited on 2016 May 20]. Available from: http://apps.who.int/iris/bitstream/10665/204871/1/9789241565257_eng.pdf
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. The predictions regarding the evolution of its global prevalence are alarming. An international review of 751 studies on the worldwide trends in diabetes in the period 1980-2014 estimated an increase in cases of the disease from 4.3 to 9.0% and from 5.0 to 7.8% among adult men and women, respectively, when standardized by age33. NCD Risk Factor Collaboration. Worldwide trends in diabetes since 1980: a pooled analysis of 751 population-based studies with 4.4 million participants. Lancet. 2016;387:1513-30.. National data on the prevalence of DM in Brazil come from surveys that use self-reported morbidity44. Brasil. Ministério do Planejamento, Orçamento e Gestão e Ministério da Saúde. Pesquisa Nacional de Saúde 2013. Rio de Janeiro: IBGE; 2014. 181p.,55. Brasil. Ministério da Saúde. Vigitel Brasil 2014: vigilância de fatores de risco e proteção para doenças crônicas por inquérito telefônico. Brasília: MS/SVS/DVDANTPS; 2015. 152p. and estimate a prevalence between 6.2 and 8.0%.

Morbidity data indicate that the disease contributes to the development of other neurological and macro and microvascular conditions, which may cause physical limitations and premature death66. Inzucchi SE, Bergenstal RM, Buse JB, Diamant M, Ferrannini E, Nauck M, et al. Management of Hyperglycemia in Type2 Diabetes: A Patient-Centered Approach Position Statement of the American Diabetes Association (ADA) and the European Association for the Study of Diabetes (EASD). Diabetes Care. 2012;35:1364-79.. The hospitalization rate for DM in Brazil has been estimated at around 77/100,000 population77. Santos MAS, Oliveira MMD, Andrade SSCDA, Nunes ML, Malta DC, Moura LD. Non-communicable hospital morbidity trends in Brazil, 2002-2012. Epidemiol Serv Saúde. 2015;24(3):389-98.. DM appears as the basic cause of death in about 55,000 deaths reported in Brazil, representing a mortality rate of 28.8/100,000 population in 201088. Brasil. Ministério da Saúde. Rede Interagencial de Informação para a Saúde (RIPSA). Indicadores e Dados Básicos (IDB). [Internet]. 2011 [cited on 2016 Mar 10]. Available from: http://tabnet.datasus.gov.br/cgi/idb2011/matriz.htm
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, of which 2.45/100,000 were due to acute complications99. Klafke A, Duncan BB, Rosa RDS, Moura LD, Malta DC, Schmidt MI. Mortalidade por complicações agudas do diabetes melito no Brasil, 2006-2010. Epidemiol Serv Saúde. 2014;23(3):455-62..

Brazil has prioritized DM in public health policies since 2001, with the implementation of the Plan for the Reorganization of Care to Hypertension and Diabetes Mellitus, of the National Program of Pharmaceutical Assistance for Hypertension and Diabetes and the Health Information System (SIS-Hiperdia)1010. Chazan AC, Perez EA. Avaliação da implementação do sistema informatizado de cadastramento e acompanhamento de hipertensos e diabéticos (hiperdia) nos municípios do Estado do Rio de Janeiro. Rev APS. 2008;11(1):10-6.. Since 2006, Federal Law No. 11,347 guarantees access to medication and self-monitoring supplies to people with DM1111. Brasil. Governo Federal. Lei nº 11.347 de 27 de setembro de 2006: Distribuição gratuita de medicamentos e materiais necessários à sua aplicação e à monitoração da glicemia capilar aos portadores de diabetes. Brasília: Diário Oficial da União; 2006. Seção 1, p. 1.. Currently, the Brazilian Strategic Action Plan to Combat Chronic Non-communicable Diseases, (2011 - 20221212. Brasil. Ministério da Saúde. Plano de Ações Estratégicas para o Enfrentamento das Doenças Crônicas Não Transmissíveis (DCNT) no Brasil 2011-2022. Brasília: MS/SVS/DASIS; 2011.), and the organization of the National Public Health System (SUS) on networks to offer a comprehensive delivery system design for chronic conditions, promote integrated treatment of people with DM, with the coordination of actions from primary health care (PHC)1313. Brasil. Ministério da Saúde. Gabinete do Ministro. Portaria nº 2.488, de 21 de fevereiro de 2011: Aprova a Política Nacional de Atenção Básica. Brasília: Diário Oficial da União; 2011. Seção 1, p. 48..

Therapeutic goals for people with DM include controlling metabolic changes, preventing complications and promoting quality of life. Thus, the most effective treatment associates non-pharmacological measures (physical activity and diet) with pharmacological measures (hypoglycemic agents)1414. Sociedade Brasileira de Diabetes. Diretrizes da Sociedade Brasileira de Diabetes: 2014-2015. São Paulo: SBD/AC Farmacêutica; 2015. 390p.,1515. American Diabetes Association. Standards of medical care in diabetes - 2013. Diabetes Care. 2013;36(Suppl. 1):S11-66.. Therefore, access and adherence to medication are important factors in achieving these goals.

By 2014, access to medication in Brazil was only studied indirectly1616. Instituto de Pesquisa Econômica Aplicada. Dimensões do acesso a medicamentos no Brasil: perfil e desigualdades dos gastos das famílias, segundo as pesquisas de orçamentos familiares 2002-2003 e 2008-2009. Brasília/Rio de Janeiro: Ipea; 2013. 56p.,1717. Szwarcwald CL, Viacava F, Vasconcellos MLD, Leal MDC, Azevedo LOD, Queiroz RSBD et al. Pesquisa mundial de saúde 2003: o Brasil em números. RADIS. 2004;23:14-33.,1818. Viana KP, Brito ADS, Rodrigues CS, Luiz RR. Access to continued-use medication among older adults, Brazil. Rev Saúde Pública. 2015;49:1-10. or in local1919. Bersusa AAS, Pascalicchio AE, Pessoto UC, Escuder MML. Acesso a serviços de saúde na Baixada Santista de pessoas portadoras de hipertensão arterial e ou diabetes. Rev Bras Epidemiol. 2010;13(3):513-22.,2020. Karnikowski MGO, Nóbrega ODT, Naves JDOS, Silver LD. Access to essential drugs in 11 Brazilian cities: a community-based evaluation and action method. J Public Health Policy. 2004;25(3-4):288-98.,2121. Boing AC, Bertoldi AD, Peres KG. Acesso a medicamentos no setor público: análise de usuários do Sistema Único de Saúde no Brasil. Cad Saúde Pública. 2013;29(4):691-701.,2222. Monteiro CN, Gianini RJ, Barros MBA, Cesar CLG, Goldbaum M. Access to medication in the Public Health System and equity: populational health surveys in São Paulo, Brazil. Rev Bras Epidemiol. 2016;19(1):26-37. and regional studies2323. Paniz VMV, Fassa AG, Facchini LA, Bertoldi AD, Piccini RX, Tomasi E, et al. Acesso a medicamentos de uso contínuo em adultos e idosos nas regiões Sul e Nordeste do Brasil. Cad. Saúde Pública. 2008;24(2):267-80., with different approaches, analytical cuts, methodologies and with little possibility of expansion of results. Results from the Brazilian National Health Survey (NHS) provided information on the use of the Brazilian Popular Pharmacy Program (BPPP)2424. Helfer AP, Camargo AL, Tavares NUL, Kanavos P, Bertoldi AD. Capacidade aquisitiva e disponibilidade de medicamentos para doenças crônicas no setor público. Rev Panam Salud Publica. 2012;31(3):225-32., the prevalence of use of NCD medicines2525. Tavares NUL, Costa KS, Mengue SS, Vieira MLFP, Malta DC, Júnior S. Uso de medicamentos para tratamento de doenças crônicas não transmissíveis no Brasil: resultados da Pesquisa Nacional de Saúde, 2013. Epidemiol Serv Saúde. 2015;24(2):315-23., and the care of people with self-reported DM in Brazil, such as the use of medications (oral or insulin)2626. Malta DC, Iser BPM, Chueri PS, Stopa SR, Szwarcwald CL, Schmidt MI, et al. Cuidados em saúde entre portadores de diabetes mellitus autorreferido no Brasil, Pesquisa Nacional de Saúde, 2013. Rev Bras Epidemiol. 2015;18(Suppl. 2):17-32..

Adherence to treatment is defined as the degree to which a person’s behavior - taking a medication, following a diet and/or performing lifestyle changes - corresponds to the recommendations agreed upon with a health professional2727. World Health Organization. Adherence to long-term therapies: evidence for action. Geneva: WHO; 2003.. Non adhesion to treatment, especially of NCD such as DM, leads to serious health consequences such as the reduction of the quality of life of users and family members and the increase of direct and indirect health costs2727. World Health Organization. Adherence to long-term therapies: evidence for action. Geneva: WHO; 2003.,2828. Suhrcke M, Nugent RA, Stuckler D, Rocco L. Chronic Disease: An Economic Perspective. London: Oxford Health Alliance; 2006. 60p.,2929. Kocurek B. Promoting medication adherence in older adults... and the rest of us. Diabetes Spectrum. 2009;22(2):80-4.. We found no studies on adherence to treatment among people with DM with national coverage before 2014. We could only find local studies3030. Faria HTG, Rodrigues FFL, Zanetti ML, Araújo MFMD, Damasceno MMC. Fatores associados à adesão ao tratamento de pacientes com diabetes mellitus. Acta Paul Enferm. 2013;26(3):231-7.,3131. Carvalho ALLM, Leopoldino RWD, Silva JEGD, Cunha CDP. Adesão ao tratamento medicamentoso em usuários cadastrados no Programa Hiperdia no município de Teresina (PI). Ciênc Saúde Coletiva. 2012;17(7):1885-92.,3232. Araújo MFM, Freitas RWJFD, Fragoso LVC, Araújo TMD, Damasceno MMC, Zanetti ML. Cumprimento da terapia com antidiabéticos orais em usuários da atenção primária. Texto Contexto Enferm [Internet]. 2011 Mar [cited on 2016 Mar 18];20(1):135-43. Available from: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0104-07072011000100016&lng=en
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, which used different methods to measure adherence.

Thus, before the National Survey on Access, Utilization and Promotion of the Rational Use of Medicines in Brazil (PNAUM)3333. Brasil. Ministério da Saúde. Secretaria de Ciência, Tecnologia e Insumos Estratégicos. Componente populacional: introdução, método e instrumentos. Brasília: Ministério da Saúde; 2016. (Série PNAUM - Pesquisa Nacional sobre Acesso, Utilização e Promoção do Uso Racional de Medicamentos no Brasil; Caderno 1). 80p.,3434. Mengue SS, Bertoldi AD, Boing AC, Tavares NUL, Pizzol TSD, Oliveira MA, et al. Pesquisa Nacional sobre Acesso, Utilização e Promoção do Uso Racional de Medicamentos (PNAUM): métodos do inquérito domiciliar. Rev Saúde Pública [Internet]. 2016 Dec [cited on 2017 Jan 4];50(Suppl. 2):4s. Available from: https://dx.doi.org/10.1590/s1518-8787.2016050006156
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, we observe a gap of studies with greater generalization power and external validity that portray the access and way of obtaining medicines. PNAUM aimed to verify the advances of the National Medicines Policy (NMP) in Brazil, evaluating the expansion of its access and its use in different population groups and characterizing the morbidities for which these medicines are used3333. Brasil. Ministério da Saúde. Secretaria de Ciência, Tecnologia e Insumos Estratégicos. Componente populacional: introdução, método e instrumentos. Brasília: Ministério da Saúde; 2016. (Série PNAUM - Pesquisa Nacional sobre Acesso, Utilização e Promoção do Uso Racional de Medicamentos no Brasil; Caderno 1). 80p.,3434. Mengue SS, Bertoldi AD, Boing AC, Tavares NUL, Pizzol TSD, Oliveira MA, et al. Pesquisa Nacional sobre Acesso, Utilização e Promoção do Uso Racional de Medicamentos (PNAUM): métodos do inquérito domiciliar. Rev Saúde Pública [Internet]. 2016 Dec [cited on 2017 Jan 4];50(Suppl. 2):4s. Available from: https://dx.doi.org/10.1590/s1518-8787.2016050006156
https://dx.doi.org/10.1590/s1518-8787.20...
.

The present study approaches the PNAUM to describe and analyze the profile of people with DM in Brazil - socioeconomic and demographic characteristics, aspects related to health and use of health services - and especially to characterize access and adherence to non-insulin hypoglycemic drugs prescribed for the treatment of the disease.

METHODS

PNAUM is a population-based household survey with a cross-sectional design based on a probabilistic sample of the Brazilian population. Data collection took place from September 2013 to January 2014. The study population was composed of residents of private households in urban areas of the Brazilian territory, all ages included (n = 41,433). Sample size estimates considered 8 demographic domains (different sex and age ranges) for each macroregion in the country, resulting in 40 sample domains. In order to reach the expected proportion of each demographic group in the final sample, the sample was selected in three stages: municipality (primary unit); census area and domicile; and individuals within households. That is, it is a complex sample with national representativeness from the five macroregions of Brazil, stratified by sex and age groups3333. Brasil. Ministério da Saúde. Secretaria de Ciência, Tecnologia e Insumos Estratégicos. Componente populacional: introdução, método e instrumentos. Brasília: Ministério da Saúde; 2016. (Série PNAUM - Pesquisa Nacional sobre Acesso, Utilização e Promoção do Uso Racional de Medicamentos no Brasil; Caderno 1). 80p.,3434. Mengue SS, Bertoldi AD, Boing AC, Tavares NUL, Pizzol TSD, Oliveira MA, et al. Pesquisa Nacional sobre Acesso, Utilização e Promoção do Uso Racional de Medicamentos (PNAUM): métodos do inquérito domiciliar. Rev Saúde Pública [Internet]. 2016 Dec [cited on 2017 Jan 4];50(Suppl. 2):4s. Available from: https://dx.doi.org/10.1590/s1518-8787.2016050006156
https://dx.doi.org/10.1590/s1518-8787.20...
.

In order to carry out this study, we sectioned PNAUM database using as inclusion criteria subjects 20 years of age and older who answered affirmatively to the question: “Has a doctor ever told you that you have diabetes or high blood sugar?” (n = 2,624, N = 8,154,204) with yes and no as possible ansewers3333. Brasil. Ministério da Saúde. Secretaria de Ciência, Tecnologia e Insumos Estratégicos. Componente populacional: introdução, método e instrumentos. Brasília: Ministério da Saúde; 2016. (Série PNAUM - Pesquisa Nacional sobre Acesso, Utilização e Promoção do Uso Racional de Medicamentos no Brasil; Caderno 1). 80p.. The estimated prevalence of self-reported DM in the total sample was 6.8%3535. Brasil. Ministério da Saúde. Secretaria de Ciência, Tecnologia e Insumos Estratégicos. Componente populacional: resultados. Brasília; 2016. (Série PNAUM - Pesquisa Nacional sobre Acesso, Utilização e Promoção do Uso Racional de Medicamentos no Brasil; Caderno 3). 52p..

STUDY VARIABLES

The available data from PNAUM allowed the investigation of the following variables for the demographic and socioeconomic characterization of the people with DM: sex (male or female); age group (20 - 59 years and 60 years and older); race/skin color (according to the classification of the Brazilian Institute of Geography and Statistics, white, brown, black and others - for Asian and indigenous people); marital status (with or without partner); level of schooling (categorized from full years of study - never went to school, complete primary education, complete secondary education and higher education or more); economic classification (according to the Brazilian Classification of Economic Criteria - BCEC, developed by the Brazilian Research Company Association - ABEP, 20133636. Associação Brasileira de Empresas de Pesquisa. Critério de Classificação Econômica no Brasil: Edição 2013. São Paulo: ABEP; 2013. Available from: http://www.abep.org/criterio-brasil
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, under categories A/B, C and D/E); coverage by private health plan (yes or no); and region of the country (North, Northeast, Southeast, South and Midwest).

Regarding the characteristics of the disease, we analyzed the time of diagnosis of DM (categorized as follows from the declared diagnosis year in: up to 5 years, 5-10 years, 10-15 years and 15 or more); comorbidities (classified as: only DM, 1 more chronic condition and 2 or more chronic conditions); frequency of comorbidities or referred complications (hypertension, dyslipidemia, heart disease, depression); self-perception of health (arranged in a five-level scale ranging from very good to very bad); perception of limitations imposed by DM (arranged in a five-level scale ranging from not limited to very intensely limited); and frequency of hospital admission and use of emergency care, by any reason, in the last 12 months. In addition, we described the number of continuous- and/or eventual-use medications in the last 30 days.

We evaluated the access to medicines for DM treatment for the prescribed hypoglycemic agents (excluding insulins and their analogues) based on the theoretical model developed by Penchansky and Thomas (1981)3737. Penchansky R, Thomas JW. The concept of access: definition and relationship to consumer satisfaction. Med Care. 1981;19(2):127-40. and adapted by Luiza (2003)3838. Luiza VL. Acesso a medicamentos essenciais no Estado do Rio de Janeiro [Tese de Doutorado]. Rio de Janeiro: Escola Nacional de Saúde Pública; 2003. using two variables: access to medicines and purchasing methods.

Access was defined as the acquisition of medicines prescribed for DM and classified into three categories: total (when the respondent had access to all drugs prescribed for DM within 30 days prior to the interview); partial (if respondent lacked any medication in the period); or null (if no prescribed medication was obtained in the period, due to lack of user resources or lack of supply in the SUS unit)3232. Araújo MFM, Freitas RWJFD, Fragoso LVC, Araújo TMD, Damasceno MMC, Zanetti ML. Cumprimento da terapia com antidiabéticos orais em usuários da atenção primária. Texto Contexto Enferm [Internet]. 2011 Mar [cited on 2016 Mar 18];20(1):135-43. Available from: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0104-07072011000100016&lng=en
http://www.scielo.br/scielo.php?script=s...
,3333. Brasil. Ministério da Saúde. Secretaria de Ciência, Tecnologia e Insumos Estratégicos. Componente populacional: introdução, método e instrumentos. Brasília: Ministério da Saúde; 2016. (Série PNAUM - Pesquisa Nacional sobre Acesso, Utilização e Promoção do Uso Racional de Medicamentos no Brasil; Caderno 1). 80p..

The method of purchasing was also classified into three categories: free (when the respondent did not pay for any DM medication); mixed (at least one of the medicines was purchased out of the respondent’s own resources); or out of their own resources (when respondents paid for all medicines in use)3232. Araújo MFM, Freitas RWJFD, Fragoso LVC, Araújo TMD, Damasceno MMC, Zanetti ML. Cumprimento da terapia com antidiabéticos orais em usuários da atenção primária. Texto Contexto Enferm [Internet]. 2011 Mar [cited on 2016 Mar 18];20(1):135-43. Available from: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0104-07072011000100016&lng=en
http://www.scielo.br/scielo.php?script=s...
,3333. Brasil. Ministério da Saúde. Secretaria de Ciência, Tecnologia e Insumos Estratégicos. Componente populacional: introdução, método e instrumentos. Brasília: Ministério da Saúde; 2016. (Série PNAUM - Pesquisa Nacional sobre Acesso, Utilização e Promoção do Uso Racional de Medicamentos no Brasil; Caderno 1). 80p..

The analysis of adherence to treatment with hypoglycemic agents (excluding insulins and their analogs) among people with DM was done using a scale generated from the Brief Medication Questionnaire (BMQ)3939. Svarstad BL, Chewnin BA, Sleath BL, Claesson C. The brief medication questionnaire: a tool for screening patient adherence and barriers to adherence. Patient Educ Couns. 1999;37(2):113-24., which assesses adherence from three dimensions: regimen screen (five questions), belief screen (two questions) and recall screen (two questions). This questionnaire was tested for NCDs and validated for Brazilian Portuguese4040. Ben AJ, Neumann CR Mengue SS. Teste de Morisky-Green e Brief Medication Questionnaire para avaliar adesão a medicamentos. Rev Saúde Pública. 2012;46(2):279-89.. The calculated score allows the classification of adherence as: adherence (did not answer affirmatively to any questions); probable adherence (said yes to only one question); probable low adherence (answered yes to two questions); and low adherence (said yes to three or more questions).

DATA ANALYSIS

Data were analyzed from a database stored in the Satistical Package for the Social Sciences (SPSS) version 18.0® for Windows (SPSS Inc., Chicago, IL, USA). CSPLAN command set was used, suitable for the analysis of complex samples, guaranteeing the necessary sample weighting3333. Brasil. Ministério da Saúde. Secretaria de Ciência, Tecnologia e Insumos Estratégicos. Componente populacional: introdução, método e instrumentos. Brasília: Ministério da Saúde; 2016. (Série PNAUM - Pesquisa Nacional sobre Acesso, Utilização e Promoção do Uso Racional de Medicamentos no Brasil; Caderno 1). 80p.,3434. Mengue SS, Bertoldi AD, Boing AC, Tavares NUL, Pizzol TSD, Oliveira MA, et al. Pesquisa Nacional sobre Acesso, Utilização e Promoção do Uso Racional de Medicamentos (PNAUM): métodos do inquérito domiciliar. Rev Saúde Pública [Internet]. 2016 Dec [cited on 2017 Jan 4];50(Suppl. 2):4s. Available from: https://dx.doi.org/10.1590/s1518-8787.2016050006156
https://dx.doi.org/10.1590/s1518-8787.20...
. The variables were calculated in percentages, with respective 95% confidence intervals (95%CI) and Pearson’s chi-square tests were used to evaluate the statistical significance of the differences between the strata, considering a significance level of 5%. Results with coefficients of variation greater than 30% were pointed out due to the need for caution when interpreting the data.

ETHICAL ASPECTS

The source research was approved by the Brazilian National Commission for Research Ethics (CONEP) through Opinion no. 398,131, dated September 16, 2013. Interviews were all conducted after participants or their legal guardians read and signed the Informed Consent Form.

RESULTS

We observed the predominance of elderly women (60 years of age or older), people with complete primary education, members of socioeconomic class C and without private health insurance coverage (Table 1).

Table 1:
Socioeconomic and demographic characteristics of people aged 20 years or older who reported having diabetes (n = 2,624). PNAUM, Brasil, 2014.

The characteristics of the disease, its comorbidities and limitations, and self-perception of health among people with DM are presented in Table 2, which reveals a predominance of recent diagnoses (45.6% up to 5 years). Most subjects had a prescription of 4 or more medications of occasional or continuous use in the 30 days prior to the interview (41.7%; 95%CI 38.7 - 44.8), and used 0-19 different medicinal products, with a median of 4 medicines in use by the same person during the period.

Table 2:
Characteristics of the disease of persons aged 20 years or older who reported diagnosis of diabetes (n = 2,624). PNAUM, Brazil, 2014.

Most people with DM reported having two or more comorbidities. However, self-reported health and the reported limitation of daily activities yielded more positive results: almost 80% considered their health to be fair or good and approximately 66% considered that DM did not limit their activities. About 28% of people reported using emergency services and about 15% reported hospitalization in the 12 months prior to the interview.

Total access to the evaluated hypoglycemic drugs was broad (almost 98%) and without statistically significant differences (Table 3). The variables schooling and race/color - which are not included in the table - were analyzed and did not have significant differences either (p = 0.694 and 0.853, respectively).

Table 3:
Access to drugs prescribed for diabetes among 20 year olds and older who reported having diabetes according to demographic and socioeconomic characteristics. PNAUM, Brazil, 2014.

The results of the drug financing method (Table 4) showed statistically significant differences for the variables Region, BCEC and private health plan. The frequency of subjects who received free medication for DM treatment (with total public financing from SUS) was 70.7%. The variables schooling and race/color were evaluated and were not significant (p = 0.848 and 0.072, respectively).

Table 4:
Access to drugs prescribed for diabetes among 20 year olds and older who reported having diabetes according to demographic and socioeconomic characteristics. PNAUM, Brazil, 2014.

Regarding adherence to treatment with hypoglycemic agents, we observed a low percentage of adherence (2%; 95%CI 1.3 - 3.1), and most people with DM classified as probable adherence (71%; 95% IC: 67.2 - 74.5). However, an expressive part was classified as probable low adhesion (9.8%, 95% IC, 8 - 12) or low adhesion (17.2%, 95%CI 14.6 - 20.1). The difference in adherence to DM treatment was significant only for the variable Region (p = 0.001), with the midwest region having the highest adherence rates (6.2%; 95%CI 3.6 - 10.3) and the northeastern region, the lowest (1.5%, 95%CI 0.6 - 2.8). The southern region had the highest rates of low adhesion (23.0%; 95%CI 18.1 - 28.8), as it can be observed in Figure 1A. Results for other variables observed, such as sex (Figure 1B), showed no significant differences between adhesion and low adhesion.

Figure 1:
Adherence score to drug treatment for diabetes* among those over 20 years old who reported having the disease** according to the country’s Region (A) and sex (B). PNAUM, Brazil, 2014.

DISCUSSION

The higher proportion of women and elderly found in the sample studied corroborates the results presented in the NHS conducted in 2013: a higher prevalence of DM among women compared to men, in a ratio of 2:144. Brasil. Ministério do Planejamento, Orçamento e Gestão e Ministério da Saúde. Pesquisa Nacional de Saúde 2013. Rio de Janeiro: IBGE; 2014. 181p..

The percentage of people with DM who reported never having studied was high, in accordance with other national surveys that point to the higher health vulnerability of low education groups44. Brasil. Ministério do Planejamento, Orçamento e Gestão e Ministério da Saúde. Pesquisa Nacional de Saúde 2013. Rio de Janeiro: IBGE; 2014. 181p.,55. Brasil. Ministério da Saúde. Vigitel Brasil 2014: vigilância de fatores de risco e proteção para doenças crônicas por inquérito telefônico. Brasília: MS/SVS/DVDANTPS; 2015. 152p.. That is, chronic diseases seem to be more prevalent among the country’s most vulnerable populations, which increases inequity among countries and among populations within the same country22. World Health Organization. Global report on diabetes. Geneva: WHO; 2016. [cited on 2016 May 20]. Available from: http://apps.who.int/iris/bitstream/10665/204871/1/9789241565257_eng.pdf
http://apps.who.int/iris/bitstream/10665...
,4141. Barros MBA, Francisco PMSB, Zanchetta LM, César CLG. Tendências das desigualdades sociais e demográficas na prevalência de doenças crônicas no Brasil, PNAD: 2003- 2008. Ciênc Saúde Coletiva. 2011;16(9):3755-68..

The time of diagnosis, the age range of the population and the proportion of comorbidities and complications reported in the sample suggest late diagnosis, a fact reinforced by the complexity of the pharmacological treatment66. Inzucchi SE, Bergenstal RM, Buse JB, Diamant M, Ferrannini E, Nauck M, et al. Management of Hyperglycemia in Type2 Diabetes: A Patient-Centered Approach Position Statement of the American Diabetes Association (ADA) and the European Association for the Study of Diabetes (EASD). Diabetes Care. 2012;35:1364-79.,1313. Brasil. Ministério da Saúde. Gabinete do Ministro. Portaria nº 2.488, de 21 de fevereiro de 2011: Aprova a Política Nacional de Atenção Básica. Brasília: Diário Oficial da União; 2011. Seção 1, p. 48.,1414. Sociedade Brasileira de Diabetes. Diretrizes da Sociedade Brasileira de Diabetes: 2014-2015. São Paulo: SBD/AC Farmacêutica; 2015. 390p..

The impact of the disease on people’s quality of life - expressed in limitation of daily activities and self-perception of health - was small, which was considered a positive result of the study for people with DM. The prevalence of depression was lower than expected when compared to data from a systematic review of cross-sectional population-based studies conducted in the Brazilian adult population (13.7%)4242. Silva MT. Adultos com depressão: prevalência no Brasil e em estudo de base populacional no Distrito Federal [Tese de Doutorado]. Brasília: Universidade de Brasília; 2013 [cited on 2016 Out 20]. Available from: http://repositorio.unb.br/handle/10482/13745
http://repositorio.unb.br/handle/10482/1...
. An international systematic review on depression and diabetes identified a higher prevalence of depression among people with DM, up to twice the prevalence of those without diabetes (19.1% for type 2 DM). However, the prevalence varied considerably among the studies analyzed due to the different methods used4343. Roy T, Lloyd CE. Epidemiology of depression and diabetes: a systematic review. J Affect Disord. 2012;142:S8-21..

The proportion of people in the sample who reported hospitalization for any cause in the 12 months prior to the interview was considered high. In a review study, Almeida et al4444. Almeida MD, Barata RB, Montero CV, Silva ZD. Prevalência de doenças crônicas auto-referidas e utilização de serviços de saúde, PNAD/1998, Brasil. Ciênc Saúde Coletiva. 2002;7(4):743-56.. revealed a hospitalization rate of 10.26% among people who reported having a chronic disease. Francisco et al.4545. Francisco PMSB, Belon AP, de Azevedo Barros MB, Carandina L, Alves MCGP, Goldbaum M, et al. Diabetes auto-referido em idosos: prevalência, fatores associados e práticas de controle. Cad Saúde Pública. 2010;26(1):175-84., in turn, reported a hospitalization rate of 19.6% among the elderly with DM in municipalities in the state of São Paulo. Despite the different designs, the studies indicate that hospitalization rates among people with DM are higher than the estimates obtained from the Datasus Hospital Information System (HIS), as described by Santos et al.77. Santos MAS, Oliveira MMD, Andrade SSCDA, Nunes ML, Malta DC, Moura LD. Non-communicable hospital morbidity trends in Brazil, 2002-2012. Epidemiol Serv Saúde. 2015;24(3):389-98.. This could be justified by the fact that the HIS is a management system and the completion of diagnosis or reasons for hospitalization are likely to underestimate the data of people with DM.

We found very low prevalences for emergency care in national studies. In the USA, a national survey conducted in 1999 indicated a prevalence of 26.9%4646. Egede LE. Patterns and correlates of emergency department use by individuals with diabetes. Diabetes Care. 2004;27(7):1748-50.; in Australia, a longitudinal study among people with DM found a prevalence of 21.6%4747. Begum N, Donald M, Ozolins IZ, Dower J. Hospital admissions, emergency department utilisation and patient activation for self-management among people with diabetes. Diabetes Res Clin Pract. 2011;93(2):260-7., results close to those found in our study.

There are no comparative studies on drug access for DM treatment that use PNAUM findings. A study that uses data from the 2008 National Household Sample Survey (PNAD) estimated a rate of approximately 30% of free access to medications of continuous use among the elderly1818. Viana KP, Brito ADS, Rodrigues CS, Luiz RR. Access to continued-use medication among older adults, Brazil. Rev Saúde Pública. 2015;49:1-10.. Other analytical studies of the NHS estimated that 80.2% of people with DM who were 18 years of age or older used medicines (oral and/or insulin)2626. Malta DC, Iser BPM, Chueri PS, Stopa SR, Szwarcwald CL, Schmidt MI, et al. Cuidados em saúde entre portadores de diabetes mellitus autorreferido no Brasil, Pesquisa Nacional de Saúde, 2013. Rev Bras Epidemiol. 2015;18(Suppl. 2):17-32., of which 57.4% acquired at least one through the BPPP2525. Tavares NUL, Costa KS, Mengue SS, Vieira MLFP, Malta DC, Júnior S. Uso de medicamentos para tratamento de doenças crônicas não transmissíveis no Brasil: resultados da Pesquisa Nacional de Saúde, 2013. Epidemiol Serv Saúde. 2015;24(2):315-23..

Access to hypoglycemic drugs (except insulin and its analogues) was found to be quite high, with the vast majority of people getting all medicines free of charge, especially those with a lower economic level and without a private health plan coverage, totally dependent on SUS. This finding is in line with what was suggested in a study carried out in the city of São Paulo2222. Monteiro CN, Gianini RJ, Barros MBA, Cesar CLG, Goldbaum M. Access to medication in the Public Health System and equity: populational health surveys in São Paulo, Brazil. Rev Bras Epidemiol. 2016;19(1):26-37., that is, the financing of pharmaceutical assistance can contribute to equity of access to health. For other NCDs, free access was not as broad, as pointed out by Tavares et al. in another PNAUM study (48%).4848. Tavares NUL, Luiza VL, Oliveira MA, Costa KS, Mengue SS, Arrais PSD, et al. Acesso gratuito a medicamentos para tratamento de doenças crônicas no Brasil. Rev Saúde Pública [Internet]. 2016 [cited on 2017 Jan 24];50(Suppl. 2):7s. Available from: http://dx.doi.org/10.1590/s1518-8787.2016050006118
http://dx.doi.org/10.1590/s1518-8787.201...

However, the data show some regional weaknesses in access to medication in the country, with greater vulnerability in the Midwest and North regions. Thus, these gaps should be observed with new studies in an attempt to find solutions to reduce regional inequities.

In addition, it is essential to guarantee the efficient use of medicines through the improvement of adherence to treatment among beneficiaries. The literature emphasizes that, if, at the end of the whole care process, patients fail to adhere to treatment, the whole health system fails and expenditures can be considered inefficient2727. World Health Organization. Adherence to long-term therapies: evidence for action. Geneva: WHO; 2003.,2828. Suhrcke M, Nugent RA, Stuckler D, Rocco L. Chronic Disease: An Economic Perspective. London: Oxford Health Alliance; 2006. 60p.,2929. Kocurek B. Promoting medication adherence in older adults... and the rest of us. Diabetes Spectrum. 2009;22(2):80-4..

A recent systematic review of 27 studies on adherence among people with DM4949. Krass I, Schieback P, Dhippayom T. Adherence to diabetes medication: a systematic review. Diabetic Med. 2015;32(6):725-37. reports drug adherence rates ranging from 38.5-93.1%. Only 6 studies reported rates higher than 80%, which was considered acceptable by the authors.

Adhesion rates found in national studies also vary widely. Cross-sectional studies involving DM patients in PHC reported rates between 13.7 and 84.4%3030. Faria HTG, Rodrigues FFL, Zanetti ML, Araújo MFMD, Damasceno MMC. Fatores associados à adesão ao tratamento de pacientes com diabetes mellitus. Acta Paul Enferm. 2013;26(3):231-7.,3131. Carvalho ALLM, Leopoldino RWD, Silva JEGD, Cunha CDP. Adesão ao tratamento medicamentoso em usuários cadastrados no Programa Hiperdia no município de Teresina (PI). Ciênc Saúde Coletiva. 2012;17(7):1885-92.,3232. Araújo MFM, Freitas RWJFD, Fragoso LVC, Araújo TMD, Damasceno MMC, Zanetti ML. Cumprimento da terapia com antidiabéticos orais em usuários da atenção primária. Texto Contexto Enferm [Internet]. 2011 Mar [cited on 2016 Mar 18];20(1):135-43. Available from: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0104-07072011000100016&lng=en
http://www.scielo.br/scielo.php?script=s...
, depending on the method used to measure adherence. It is possible to observe the great variation between the rates found in the literature, probably due to the methods applied and interpretation of the results.

Adherence results for the present study were presented in four levels, based on BMQ scores. We verified that only 2% of people with DM were considered adherents, well below the values found in the literature. If the first two levels were grouped (adherence and probable adherence), the prevalence of adherence would be compatible with that described in the literature, but still below what would be considered acceptable4747. Begum N, Donald M, Ozolins IZ, Dower J. Hospital admissions, emergency department utilisation and patient activation for self-management among people with diabetes. Diabetes Res Clin Pract. 2011;93(2):260-7.. In addition, we found significant regional differences, which should be further studied.

Besides the informed prevalence bias that the surveys may present, the survival factor is considered a limitation of the present study, since the sample was not corrected for the early deaths due to DM and its comorbidities, cases that could have worse results in the health conditions5050. Viacava F. Informações em saúde: a importância dos inquéritos populacionais. Ciênc Saúde Coletiva. 2002;7(4):607-21.. Also, the use of self-reported morbidity and memory bias in the assessment of dependent variables, access and adherence to treatment, may bring error analysis. In addition, we used a subjective method (validated questionnaire) to access adherence, which, according to the literature, has some limitations5151. Garfield S, Clifford S, Eliasson L, Barber N, Willson A. Suitability of measures of self-reported medication adherence for routine clinical use: a systematic review. BMC Med Res Methodol [Internet]. 2011 [cited on 2016 Mar 18];11(1):149-58. Available from: http://www.biomedcentral.com/1471-2288/11/149
http://www.biomedcentral.com/1471-2288/1...
.

However, we consider that the originality of the data brings to light important results on health policies that should be widely debated. We believe that new studies could support the alignment of policies and new actions to improve the delivery system design and healthcare system based on the best scientific evidence.

CONCLUSION

The present study brings unprecedented data on access and adherence to treatment for people with diabetes, as well as the socioeconomic, demographic and health characteristics of this population. Our results suggest that the access and the way of getting hypoglycemic drugs among the Brazilian population, between 2013 and 2014, occurred in order to guarantee equity of access to health.

We verified the effectiveness of pharmaceutical assistance programs to guarantee the access to pharmacological treatment for people with DM, demonstrating that well-structured health policies and legislation can support the viability of the constitutional right to health.

However, low adherence deserves reflection. New studies should be conducted aiming at the formulation of effective interventions that have an impact on the reduction of health costs and on people’s quality of life. Consequently, we should observe a greater efficiency in the application of public resources.

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Publication Dates

  • Publication in this collection
    Jul-Sep 2017

History

  • Received
    10 Nov 2016
  • Accepted
    20 Feb 2017
Associação Brasileira de Pós -Graduação em Saúde Coletiva São Paulo - SP - Brazil
E-mail: revbrepi@usp.br