Annali dell'Istituto Superiore di Sanità
Print version ISSN 0021-2571
BOZZUTO, Giuseppina; RUGGIERI, Paola and MOLINARI, Agnese. Molecular aspects of tumor cell migration and invasion. Ann. Ist. Super. Sanità [online]. 2010, vol.46, n.1, pp. 66-80. ISSN 0021-2571. http://dx.doi.org/10.4415/ANN_10_01_09.
Cell migration and invasion are crucial steps in many physiological events. However, they are also implicated in the physiopathology of many diseases, such as cancer. To spread through the tissues, tumor cells use mechanisms that involve several molecular actors: adhesion receptor families, receptor tyrosine kinases, cytoskeleton proteins, adapter and signalling proteins interplay in a complex scenario. The balance of cellular signals for proliferation and survival responses also regulates migratory behaviours of tumor cells. To complicate the scene of crime drug resistance players can interfere thus worsening this delicate situation. The complete understanding of this molecular jungle is an impossible mission: some molecular aspects are reviewed in this paper.
Keywords : neoplasms; neoplasm invasion; molecular markers.