SciELO - Scientific Electronic Library Online

 
vol.47 número4Performance of V3-based HIV-1 sero subtyping in HIV endemic areasOverview of literature and information on "khat-related" mortality: a call for recognition of the issue and further research índice de autoresíndice de assuntospesquisa de artigos
Home Page  

Serviços Personalizados

Artigo

Indicadores

Links relacionados

  • Não possue artigos similaresSimilares em SciELO

Compartilhar


Annali dell'Istituto Superiore di Sanità

versão impressa ISSN 0021-2571

Resumo

LORENZETTI, Stefano et al. Innovative non-animal testing strategies for reproductive toxicology: the contribution of Italian partners within the EU project ReProTect. Ann. Ist. Super. Sanità [online]. 2011, vol.47, n.4, pp. 429-444. ISSN 0021-2571.  http://dx.doi.org/10.4415/ANN_11_04_16.

Reproductive toxicity, with its many targets and mechanisms, is a complex area of toxicology; thus, the screening and identification of reproductive toxicants is a main scientific challenge for the safety assessment of chemicals, including the European Regulation on Chemicals (REACH). Regulatory agencies recommend the implementation of the 3Rs principle (refinement, reduction, replacement) as well as of intelligent testing strategies, through the development of in vitro methods and the use of mechanistic information in the hazard identification and characterization steps of the risk assessment process. The EU Integrated Project ReProTect (6th Framework Programme) implemented an array of in vitro tests to study different building blocks of the mammalian reproductive cycle: methodological developments and results on male and female germ cells, prostate and placenta are presented.

Palavras-chave : alternative methods; male and female germ cells; prostate; placenta; REACH.

        · resumo em Italiano     · texto em Inglês     · pdf em Inglês