Annali dell'Istituto Superiore di Sanità
Print version ISSN 0021-2571
FIORI, Valentina; MAGNANI, Mauro and CIANFRIGLIA, Maurizio. The expression and modulation of CEACAM1 and tumor cell transformation. Ann. Ist. Super. Sanità [online]. 2012, vol.48, n.2, pp. 161-171. ISSN 0021-2571. http://dx.doi.org/10.4415/ANN_12_02_09.
BACKGROUND: In this review, we focus our discussion on one class of carcinoembryonic antigen-related cell adhesion molecules, Carcinoembryonic antigen-related cell adhesion molecules 1 (CEACAM1). This has been observed in several malignant transformations to be subjected to complex mechanisms of modulation and dysregulation. AIMS: Restoration of CEACAM1 expression in tumor cell lines often abolishes their oncogenicity in vivo, and therefore, this adhesion molecule has been regarded as a tumor suppressor. In contrast, de novo expression of CEACAM1 is found with the progression of malignancy and metastatic spread in a large array of cancer tissues which include melanoma, Non Small cell Lung carcinoma (NSCLC) as well as bladder, prostate, thyroid, breast, colon and gastric carcinomas. DISCUSSION: We report and discuss the most significant findings confirming at immunohistochemical and clinical level the correlation between poor prognosis and expression of CEACAM1 on the cell surface of tumors.
Keywords : CEACAM1; cancer; dysregulation; NSCLC; melanoma; poor prognosis.