Revista de Saúde Pública
On-line version ISSN 1518-8787
GUSMAO, Hermelino Herbster and SOUZA, José Antonio Gomes de. Cicatrization of lesions of cutaneous leishmaniasis with a single dose of cicloguanil pamoate. Rev. Saúde Pública [online]. 1973, vol.7, n.4, pp. 335-341. ISSN 1518-8787. http://dx.doi.org/10.1590/S0034-89101973000400003.
The treatment of Cutaneous Leishmaniasis with Cicloguanil Pamoate ("Comolar" Park-Davis), in Amapa Territory, North of the Amazon River, Brazil, is reported. Complete cicatrization of lesions was observed in 33 patients of which 28 received a single dose and 5 were treated with a second injection of the drug. Diagnosis was made by direct microscopic examination and the finding of Leishmaniae. Age of the lesions varied from 8 days to 12 month, 82% being from 8 to 30 days. The average time necessary for cicatrization was 104 days, varying from 60 to 170 days for patients receiving a single dose. Complete cicatrization among patients that received a second dose occurred in an average time of 163 days after the first treatment and 85 days after the second dose. After cicatrization the patients were kept under observation for an average period of 8.4 months, varying from 3 to 19 months. It was shown that the cure of the lesions requires a rather long period after the first dose, with recrudescence in several cases and requiring in some patients a second dose to accelerate the cure.
Keywords : Leishmaniasis, cutaneous; Chemotherapy; Cycloguanil pamoate.