Abstract

BASTOS, Othon de Carvalho; RANGEL, Humberto de Araújo; MAGALHAES, Luiz Augusto  and  PIEDRABUENA, Aquiles Eugênico. The evolution of immunoglobulins involved in the immune response to mice infected with Schistosoma mansoni. Rev. Saúde Pública [online]. 1984, vol.18, n.2, pp. 138-154. ISSN 0034-8910.  http://dx.doi.org/10.1590/S0034-89101984000200006.

The evolution of immunoglobulins involved in the immune response of mice infected with Schistosoma mansoni was studied by using plurispecific sera and the bi-dimensional immunoelectrophoresis technique. Determinations of the level of different immunoglobulins in infected animals and control groups which were mantained under similar conditions detected significant variations in both groups over the 8 weeks of observation. The study of the relationship (I/C) between the level of immunoglobulins of the infected animals (I) and that of corresponding control (C) showed that the infected animals presented a primary response (1-2 weeks after infection date) and a secondary response that was initiated in the 6th week of infection, with levels of IgA, IgG and IgM that were respectively 4.5, 3 and 2 times higher than those of corresponding control.

Keywords : Schistosoma mansoni; Immunoglobulins; Schistosomiasis.