Revista de Saúde Pública
On-line version ISSN 1518-8787
Print version ISSN 0034-8910
AMATO NETO, Vicente et al. Experimental assay of the possible use of gentian violet in the prevention of post-transfusion malaria. Rev. Saúde Pública [online]. 1987, vol.21, n.6, pp.497-500. ISSN 1518-8787. http://dx.doi.org/10.1590/S0034-89101987000600005.
Considering that gentian violet is effective in the prevention of transfusion-acquired Chagas' disease and possibly toxoplasmosis, it is decided to carry out an experimental assay on the acitvity of this dye in the prevention of post-transfusion malaria. Mice infected with Plasmodium berghei were studied with regard to parasitemia, mortality and histopathologic changes. Gentian violet added to blood in 1/1.000 and 1/4.000 concentrations turned out to be effective in abolishing infectivity after storage for 24 hours at 4°C. Thus is opened up a new prospect in the prophylaxis of post-transfusion malaria.
Keywords : Malaria [prevention and control]; Gentian violet [pharmacodynamics]; Plasmodium berghei [drug effects]; Mice [parasitology]; Blood transfusion [adverse effects].