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Revista de Saúde Pública

On-line version ISSN 1518-8787

Abstract

AMATO NETO, Vicente et al. Experimental assay of the possible use of gentian violet in the prevention of post-transfusion malaria. Rev. Saúde Pública [online]. 1987, vol.21, n.6, pp. 497-500. ISSN 1518-8787.  http://dx.doi.org/10.1590/S0034-89101987000600005.

Considering that gentian violet is effective in the prevention of transfusion-acquired Chagas' disease and possibly toxoplasmosis, it is decided to carry out an experimental assay on the acitvity of this dye in the prevention of post-transfusion malaria. Mice infected with Plasmodium berghei were studied with regard to parasitemia, mortality and histopathologic changes. Gentian violet added to blood in 1/1.000 and 1/4.000 concentrations turned out to be effective in abolishing infectivity after storage for 24 hours at 4°C. Thus is opened up a new prospect in the prophylaxis of post-transfusion malaria.

Keywords : Malaria [prevention and control]; Gentian violet [pharmacodynamics]; Plasmodium berghei [drug effects]; Mice [parasitology]; Blood transfusion [adverse effects].

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