Revista de Saúde Pública
Print version ISSN 0034-8910
GUIDOLIN, Rosalvo et al. Sterilization of sera and vaccines by cobalt gamma radiation. Rev. Saúde Pública [online]. 1988, vol.22, n.2, pp. 113-117. ISSN 0034-8910. http://dx.doi.org/10.1590/S0034-89101988000200007.
Diphteria, tetanus, anti-snake venom sera and Diphteria-Pertussis-Tetanus vaccine were submited to different intensities of gamma radiation, in order to: verify the resistance of their specific activities to the action of gamma rays; evaluate the possibility of using this type of energy to sterilize some heterogenous hyperimmune sera and vaccines commonly utilized in Public Health. The results, according to the range employed, show the possibility of sterilizing the products tested, without any alteration to specific biological and chemical properties.
Keywords : Sterilization [methods]; Gamma rays; Tetanus toxoid [radiation effects]; Diphteria toxoid [radiation effects]; Pertussis vaccine [radiation effects]; Tetanus antitoxin [radiation effects]; Diphteria antitoxin [radiation effects]; Antivenin [radiation effects].