SciELO - Scientific Electronic Library Online

vol.31 issue4Hearing findings in subjects after meningitisAflatoxins in foodstuffs: current concepts on mechanisms of toxicity and its involvement in the etiology of hepatocellular carcinoma author indexsubject indexarticles search
Home Page  

Services on Demand




Related links


Revista de Saúde Pública

On-line version ISSN 1518-8787Print version ISSN 0034-8910


REQUEJO, Henry I. Z.. Immunological behavior of the meningococcal vaccines. Rev. Saúde Pública [online]. 1997, vol.31, n.4, pp.402-416. ISSN 1518-8787.

Meningococcal disease continues to be a great health problem on all continents and the meningococcal vaccines have been proposed for their prevention and epidemic control. The polysaccharide A and C vaccines are relatively efficacious with distinct immunological behavior with regard to the different age groups, however, up to the present no highly efficacious vaccine for meningococcal B disease exists. The meningococcal B capsular polysaccharide is not immunogenic due to the structural mimicry of mammalian tissues and efforts to produce carrier proteins have been proposed in order to obtain an immunogenic vaccine for all age groups that would if possible, protect against all the meningococci. This review of the literature presents the study of the development of the immunological behavior of all the meningococcal vaccines undergoing development and reports on the efforts to obtain a safe and efficacious product for the control of meningococcal disease.

Keywords : Bacterial vaccines; Meningitis, meningococcal [immunology]; Immunity.

        · abstract in Portuguese     · text in Portuguese     · Portuguese ( pdf )