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Salud Pública de México

Print version ISSN 0036-3634

Abstract

RODRIGUEZ-MORAN, MARTHA  and  GUERRERO-ROMERO, FERNANDO. Serum cholesterol levels and ischemic heart disease in non insulin dependent diabetes mellitus patients. Salud pública Méx [online]. 1997, vol.39, n.5, pp. 420-426. ISSN 0036-3634.  http://dx.doi.org/10.1590/S0036-36341997000500004.

Objective. Determine the frequency and relationship between ischemic heart disease (IHD) and serum cholesterol levels (SCL) in non insulin dependent diabetes mellitus (NIDDM) of the primary medical care level. Material and methods. A total of 411 patients from the first medical care level were studied. The sociodemographic profile, SCL and glycemia were determined and conventional ECG was taken. The ST unevenness, ischemic T or pathological Q waves in two or more tappings was considered as IHD. Patients with history of IHD were not included. Results. The male: female ratio was 1.5:1. Mean SCL was 225 mg/dl (in females 240.8±56 mg/dl and 220.7±50.7 in males). In 90 patients we identified IHD (22%), with male predominance (0.85:1, F:M). In the stratified statistical analysis the SCL ³ 200 mg/dl and IHD were significantly associated. The frequency of IHD by SCL levels of 200-239 mg/dl was 24.6% (OR 2.04; CI 95% 1.03-4.07, p= 0.04) and 24.2% (OR 1.99; CI 95% 1.02-3.96, p= 0.04) for SCL of 240-300 mg/dl; in patients with SCL >300 mg/dl, an increase of IHD to 38.7% was observed (OR 3.95; CI 95% 1.52-10.30, p= 0.002). Conclusions. The hypercholesterolemia was one of the most important cardiovascular risk factors in NIDDM, in which SCL ³ 200 mg/dl must be considered strongly associated to IHD.

Keywords : myocardial ischemia; diabetes mellitus [non-insulin-dependent]; cholesterol; Mexico.

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