SciELO - Scientific Electronic Library Online

 
vol.43 issue6Hygiene and restraint of pigs is associated with absence of Taenia solium cysticercosis in a rural community of Mexico author indexsubject indexarticles search
Home Page  

Salud Pública de México

Print version ISSN 0036-3634

Abstract

BARRON-GONZALEZ, Arturo; ARIAS-MARTINEZ, Joel  and  CASTRO-ROMERO, Ivone. Antiestrogens: mechanism of action and clinical applications. Salud pública Méx [online]. 2001, vol.43, n.6, pp. 577-584. ISSN 0036-3634.  http://dx.doi.org/10.1590/S0036-36342001000600010.

Antiestrogens are compounds that inhibit estrogen action by competing for its receptors. Estrogens are involved in the proliferation and differentiation of target cells and are among the main risk factors for breast and uterine cancer. Some antiestrogens, such as Tamoxifen, are used as adjuvant therapy against breast cancer, and have been proposed to be included in prevention programs for women at high risk of cancer. Antiestrogens are classified according to their action mechanisms into Type I or partial (agonistic/antagonistic), and Type II or pure (pure antagonistic). Advancements in the development of new antiestrogens and their clinical importance are reviewed in this paper, as well as their mechanism of action and clinical applications. The English version of this paper is available at: http://www.insp.mx/salud/index.html

Keywords : estrogen antagonists; estrogens; selective estrogen receptor modulators; breast neoplasms.

        · abstract in Spanish     · text in Spanish     · pdf in Spanish