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Salud Pública de México

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LOPEZ-MORENO, Héctor Samuel. Tisular cestodiasis: The role of T helper cell subsets 1 and 2. Salud pública Méx [online]. 2002, vol.44, n.2, pp.145-152. ISSN 0036-3634.

Cysticercosis and hydatidosis are parasitic diseases caused by larvae of Taenia solium and Echinococcus sp., respectively. Parasitic diseases are useful models for in vivo studies of effector functions of T helper cell subsets 1 and 2, (called Th1 and Th2 on the basis of the pattern of cytokines they produce). The polarization to Th1 or Th2 is related to protective or permissive immune responses in these diseases. The role of Th1 and Th2 lymphocytes in tissue cestodiasis (cysticercosis and hydatidosis) has been studied in experimentally infected mice and in human patients; study results suggest that in individuals with cysticercosis or hydatidosis, the cellular immune response is polarized to Th2, while individuals in whom parasites are killed or their growth is limited, have an immune cellular response that is polarized towards Th1.

Keywords : cysticercosis; echinococcosis; T-lymphocytes; helper-inducer subset 1 (Th1); T-lymphocytes, helper-inducer subset 2 (Th2).

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