Salud Pública de México
Print version ISSN 0036-3634
FLORES-LUEVANO, Silvia et al. DDT/DDE concentrations and risk of hypospadias: a case-control pilot study. Salud pública Méx [online]. 2003, vol.45, n.6, pp. 431-438. ISSN 0036-3634. http://dx.doi.org/10.1590/S0036-36342003000600002.
OBJECTIVE: To evaluate the association between maternal serum DDT/DDE levels and risk of hypospadias. MATERIAL AND METHODS: A case-control study in Mexico City was conducted during 1997-1999 among 41 subjects with hypospadias and 28 controls. Blood samples were obtained from study subjects. Information was obtained using a standardized questionnaire. Data were analyzed using multivariate logistic regression models. RESULTS: Maternal DDT and DDE levels showed no association with hypospadias (OR 1.13; 95% CI 0.24-5.29 and OR=0.48; 95% CI 0.15-1.60, respectively). Associated factors were older age of mothers (OR 8.69; 95% CI 1.69-44.9), and working during pregnancy (OR 4.68; 95% CI 1.15-18.9). CONCLUSIONS: Information about the endocrine effects of different levels of DDT/DDE in human subjects is scarce; dosage may be a determinant factor of the type of effect.
Keywords : hypospadias; organochlorine pesticides; DDT; DDE; Mexico.