Bulletin of the World Health Organization
Print version ISSN 0042-9686
CHEN, R.T. and THE VACCINE SAFETY DATALINK TEAM et al. The Vaccine Safety Datalink: immunization research in health maintenance organizations in the USA. Bull World Health Organ [online]. 2000, vol.78, n.2, pp. 186-194. ISSN 0042-9686. http://dx.doi.org/10.1590/S0042-96862000000200006.
The Vaccine Safety Datalink is a collaborative project involving the National Immunization Program of the Centers for Disease Control and Prevention and several large health maintenance organizations in the USA. The project began in 1990 with the primary purpose of rigorously evaluating concerns about the safety of vaccines. Computerized data on vaccination, medical outcome (e.g. outpatient visits, emergency room visits, hospitalizations, and deaths) and covariates (e.g. birth certificates, census data) are prospectively collected and linked under joint protocol at multiple health maintenance organizations for analysis. Approximately 6 million persons (2% of the population of the USA) are now members of health maintenance organizations participating in the Vaccine Safety Datalink, which has proved to be a valuable resource providing important information on a number of vaccine safety issues. The databases and infrastructure created for the Vaccine Safety Datalink have also provided opportunities to address vaccination coverage, cost-effectiveness and other matters connected with immunization as well as matters outside this field.
Keywords : adverse drug reaction reporting systems; health maintenance organizations; vaccines, combined, adverse effects; viral vaccines, adverse effects; United States.