Bulletin of the World Health Organization
Print version ISSN 0042-9686
HORROCKS, Paul et al. Entering the post-genomic era of malaria research. Bull World Health Organ [online]. 2000, vol.78, n.12, pp. 1424-1437. ISSN 0042-9686. http://dx.doi.org/10.1590/S0042-96862000001200009.
The sequencing of the genome of Plasmodium falciparum promises to revolutionize the way in which malaria research will be carried out. Beyond simple gene discovery, the genome sequence will facilitate the comprehensive determination of the parasites gene expression during its developmental phases, pathology, and in response to environmental variables, such as drug treatment and host genetic background. This article reviews the current status of the P. falciparum genome sequencing project and the unique insights it has generated. We also summarize the application of bioinformatics and analytical tools that have been developed for functional genomics. The aim of these activities is the rational, information-based identification of new therapeutic strategies and targets, based on a thorough insight into the biology of Plasmodium spp.
Keywords : Plasmodium falciparum [genetics]; genome, protozoan; base sequence; sequence analysis, DNA.