Cadernos de Saúde Pública
Print version ISSN 0102-311X
NOGUEIRA, Rita Maria Ribeiro; MIAGOSTOVICH, Marize Pereira and SCHATZMAYR, Hermann Gonçalves. Molecular epidemiology of dengue viruses in Brazil. Cad. Saúde Pública [online]. 2000, vol.16, n.1, pp. 205-211. ISSN 0102-311X. http://dx.doi.org/10.1590/S0102-311X2000000100021.
Dengue viruses (DEN) are found as four antigenically distinct serotypes designated DEN-1, 2, 3, and 4. Laboratory evidence that strain-intratypical variation occurs among DEN viruses has been demonstrated since the 1970s, although only with the advances in molecular technologies has it been possible to determine the genetic variability of each serotype. Genotypical identification has proven to be a useful tool for determining the origin and spread of epidemics and to correlate virulence of strains. In this report we present the results of molecular epidemiological studies with the DEN-1 and DEN-2 viruses that caused dengue epidemics in Brazil during the last decade.
Keywords : Dengue Viruses; Dengue; Molecular Epidemiology.