SciELO - Scientific Electronic Library Online

vol.18 issue2Endocrine disrupting chemicals: harmful substances and how to test themEndocrine disruptors and dental materials: health implications associated with their use in Brazil author indexsubject indexarticles search
Home Page  

Services on Demand




Related links


Cadernos de Saúde Pública

On-line version ISSN 1678-4464Print version ISSN 0102-311X


SILBERGELD, Ellen K.; FLAWS, Jodi A.  and  BROWN, Ken M.. Organizational and activational effects of estrogenic endocrine disrupting chemicals. Cad. Saúde Pública [online]. 2002, vol.18, n.2, pp.495-504. ISSN 1678-4464.

Endocrine disruption is a hypothesis of common mode of action that may define a set of structurally varied chemicals, both natural and synthetic. Their common mode of action may suggest that they produce or contribute to similar toxic effects, although this has been difficult to demonstrate. Insights from developmental biology suggest that development of hormone sensitive systems, such as the brain and the genitourinary tract, may be particularly sensitive to EDCs. Because these systems are both organized and later activated by hormones, the brain and vagina may be valuable model systems to study the toxicity of EDCs in females and to elucidate mechanisms whereby early exposures appear to affect long term function.

Keywords : Chemical Compound Exposure; Brain; Vagina; Endocrine Disruptors.

        · abstract in Portuguese     · text in English     · English ( pdf )