Cadernos de Saúde Pública
On-line version ISSN 1678-4464
NATAL, Sonia; VALENTE, Joaquim Gonçalves; SANCHEZ, Alexandra Roma and PENNA, Maria Lúcia Fernandes. Isoniazid and rifampicin resistance and prior treatment for tuberculosis. Cad. Saúde Pública [online]. 2003, vol.19, n.5, pp. 1277-1281. ISSN 1678-4464. http://dx.doi.org/10.1590/S0102-311X2003000500006.
A case-control study in Rio de Janeiro in 1994 included 552 patients with a positive culture for Mycobacterium tuberculosis and reported a 1.8% resistance rate to rifampicin and isoniazid. Prior treatment for tuberculosis (the exposure factor) was associated with resistance. The binomial proportion was used to test the hypothesis of no dependence between the observed associations based on prior exposure to the drugs. This test showed a greater than expected dependence between resistances to rifampicin and isoniazid.
Keywords : Tuberculosis; Factors R; Microbial Drug Resistence.