Services on Demand
Cadernos de Saúde Pública
On-line version ISSN 1678-4464Print version ISSN 0102-311X
LISOT, Cristina Lucia Alberti and SILLA, Lúcia Mariano da Rocha. Screening for hemoglobinopathies in blood donors from Caxias do Sul, Rio Grande do Sul, Brazil: prevalence in an Italian colony. Cad. Saúde Pública [online]. 2004, vol.20, n.6, pp.1595-1601. ISSN 1678-4464. http://dx.doi.org/10.1590/S0102-311X2004000600017.
The high prevalence of beta thalassemia among Italians and their participation in the ethnic formation of Caxias do Sul, Rio Grande do Sul State, Brazil, and neighboring cities prompted us to investigate hemoglobinopathies in 608 blood donors at the Caxias do Sul Regional Blood Center. Despite the ethnic influence, abnormal hemoglobin levels were found in only 1.81% of the donors (0.16% Hb AC, 0.99% Hb AS, and 0.66% Hb AH), similar to the levels observed in a study on qualitative disorders conducted in the rural area of Rio Grande do Sul. In our setting, the most commonly used screening tests for thalassemia, combined with DNA sequencing, were unable to detect quantitative hemoglobin synthesis disorders. This may be attributable to still-unknown genetic disorders, technical limitations, or simply to miscegenation.
Keywords : Hemoglobinopathies; Blood Donors; Electrophoresis.