Cadernos de Saúde Pública
On-line version ISSN 1678-4464
PINTO, Mônica Edelenyi and STRUCHINER, Claudio José. HIV-1 diversity: a tool for studying the pandemic. Cad. Saúde Pública [online]. 2006, vol.22, n.3, pp. 473-484. ISSN 1678-4464. http://dx.doi.org/10.1590/S0102-311X2006000300002.
HIV-1 is remarkable for the diversity of strains comprising the HIV/AIDS pandemic. In the last decade, classification of viral variants as groups, subtypes, and circulating recombinant forms (CRF) and the observation of specific mutational patterns have become powerful tools for studying viral molecular dynamics. Monitoring the worldwide distribution of HIV-1 diversity has been used in both epidemiological surveillance programs and in reconstructing the history of regional epidemics. Specific patterns of virus spatial distribution also suggest differences in pathogenicity and transmissibility among the various subtypes. Molecular analyses of viral sequences allow estimating the rate of divergence among variants and the dynamic forces shaping the phylogenetic trees.
Keywords : HIV-1; Acquired Immunodeficiency Syndrome; Molecular Epidemiology.