Abstract

MIRANZI, Sybelle de Souza Castro; MORAES, Suzana Alves de  and  FREITAS, Isabel Cristina Martins de. Impact of the Haemophilus influenzae type b vaccination program on HIB meningitis in Brazil. Cad. Saúde Pública [online]. 2007, vol.23, n.7, pp. 1689-1695. ISSN 0102-311X.  http://dx.doi.org/10.1590/S0102-311X2007000700021.

This study aimed to evaluate the impact of vaccination against Haemophilus influenzae type b (HIB) in Brazil on the morbidity, mortality, and case fatality of HIB meningitis, using the Ministry of Health database and population data from the Brazilian Institute of Geography and Statistics (Instituto Brasileiro de Geografia e Estatística - IBGE). Impact was evaluated through a time series analysis (1983-2002), using regression forecasting (RF) by dividing the time series into two periods: (a) historical (1983-1998) and (b) validation (1999-2002). Impact of the vaccination was positive, although more significant for incidence and mortality than for case fatality rates.

Keywords : Haemophilus influenzae; Bacterial Meningitis; Vaccination; Time Series Studies.