Cadernos de Saúde Pública
On-line version ISSN 1678-4464
FRANCO, Sérgio Silveira; NARDOCCI, Adelaide Cássia and GUNTHER, Wanda Maria Risso. PAH biomarkers for human health risk assessment: a review of the state-of-the-art . Cad. Saúde Pública [online]. 2008, vol.24, suppl.4, pp. a569-s580. ISSN 1678-4464. http://dx.doi.org/10.1590/S0102-311X2008001600009.
Polycyclic aromatic hydrocarbons (PAH) are widely distributed in the environment, and some are carcinogenic to human beings. The study of biomarkers has helped clarify the nature and magnitude of the human health risks posed by such substances. This article provides a review of the state-of-the-art on PAH biomarkers for human health risk assessment and also discusses their applicability within the context of environmental management in Brazil. The article discusses the methodologies for determination of some biomarkers such as 1-hydroxypyrene and PAH-DNA adducts. Cytogenetic markers, frequency of chromosomal aberrations, and micronucleus induction were considered for the evaluation of cancer risk. The current stage of studies on validation of such biomarkers was also approached.
Keywords : Aromatic Polycyclic Hydrocarbons; Biological Markers; Risk Assessment.