Cadernos de Saúde Pública
On-line version ISSN 1678-4464
SANTOS, Míria Conceição Lavinas et al. Association between stress and breast cancer in women: a meta-analysis. Cad. Saúde Pública [online]. 2009, vol.25, suppl.3, pp. S453-S463. ISSN 1678-4464. http://dx.doi.org/10.1590/S0102-311X2009001500010.
The objective of the current meta-analysis was to verify the association between stressful life events and primary breast cancer incidence in women. A total of 618 studies from 1982-2007 were found in the PubMed, LILACS, and Cochrane Library databases. Methodological quality was evaluated according to the Downs & Black criteria. Eight studies were selected (six case-controls and two cohorts). The studies were grouped in three analyses, two of which based on the categories widowhood and divorce and the other based on self-rated intensity and frequency of stressful events. Relative risks were: widowhood 1.04 (95%CI: 0.75-1.44; p = 0.800); divorce 1.03 (95%: 0.72-1.48; p = 0.850); and intensity/frequency of stress 1.73 (95%CI: 0.98-3.05; p = 0.059). We conclude that stressful life events as a whole are not associated with risk of breast cancer in women. However, it is not possible to rule out high-intensity stress as a risk factor for breast cancer.
Keywords : Life Change Events; Psychological Stress; Breast Neoplasms.