Cadernos de Saúde Pública
versão impressa ISSN 0102-311X
MATIDA, Luiza Harunari et al. Improving survival in children with AIDS in Brazil: results of the second national study, 1999-2002. Cad. Saúde Pública [online]. 2011, vol.27, suppl.1, pp. s93-s103. ISSN 0102-311X. http://dx.doi.org/10.1590/S0102-311X2011001300010.
The objective of this study is to characterize survival in children with AIDS diagnosed in Brazil between 1999-2002, compared with the first national study (1983-1998). This national retrospective cohort study examined a representative sample of Brazilian children exposed to HIV from mother-to-child transmission and followed through 2007. The survival probability after 60 months was analyzed by sex, year of birth and death, clinical classification, use of antiretroviral therapy (ART) and prophylaxis for opportunistic diseases. 920 children were included. The survival probability increased: comparing cases diagnosed before 1988 with those diagnosed from 2001-2002 it increased by 3.5-fold (from 25% to 86.3%). Use of ART, initial clinical classification, and final classification were significant (p < 0.001) predictors of survival. Issues regarding quality of records and care were identified. The results point to the success of the Brazilian policy of providing ART. The improvement of clinical status contributes to quality of life, while indicating challenges, particularly practices to improve long-term care.
Palavras-chave : Acquired Immunodeficiency Syndrome; Infections Disease Transmission; Survival Analysis; Highly Active Antiretroviral Therapy.