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Revista Panamericana de Salud Pública

On-line version ISSN 1680-5348Print version ISSN 1020-4989


ROBERTSON, S. E. et al. Registro de ensayos con vacunas del Programa Mundial de Vacunas e Inmunización de la OMS. Rev Panam Salud Publica [online]. 1998, vol.4, n.4, pp.-. ISSN 1680-5348.

In 1995, the WHO Global Programme for Vaccines and Immunization established a vaccine trial registry. As of September 1996, this registry included 50 WHO supported vaccine trials, of which 25 (50%) were completed studies. The vaccines most frequently tested have been against measles (9 trials), poliovirus (8 trials), cholera (8 trials), enterotoxigenic Escherichia coli (4 trials), and pneumococcus (4 trials). Nearly 80% of these trials have been conducted in developing countries, with the largest number being in Africa. Among the 25 completed trials, outcomes measured were immune response (24 trials), adverse reactions (13 trials), morbidity (4 trials), and mortality (1 trial). WHO's contributions to these studies include direct funding, assistance with study design, site visits, data analysis, vaccine procurement, and vaccine potency testing.

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