Abstract

BLAIR, Silvia; LACHARME, Leidy L.; FONSECA, Jaime Carmona  and  TOBON, Alberto. Resistance of Plasmodium falciparum to three antimalarials in Turbo (Antioquia, Colombia), 1998. Rev Panam Salud Publica [online]. 2001, vol.9, n.1, pp. 23-29. ISSN 1020-4989.  http://dx.doi.org/10.1590/S1020-49892001000100006.

In 1998 we determined in vivo and in vitro the frequency and the degree of resistance of Plasmodium falciparum to the three antimalarials (chloroquine, amodiaquine, and sulfadoxine/pyrimethamine) most utilized in the municipality of Turbo (in the area of Urabá, Antioquia, Colombia), in a sample representative of the population with malaria. We carried out clinical and parasitological analyses over a 14-day period using the standard test recommended by the World Health Organization. In vivo, P. falciparum showed resistance to chloroquine, amodiaquine, and sulfadoxine/ pyrimethamine, with a frequency of 97%, 7%, and 13%, respectively. In vitro, the corresponding figures were 21%, 23%, and 9%, respectively. For chloroquine the level of agreement between the in vivo and in vitro results was 23%.

Keywords : Antimaláricos; Colombia; farmacorresistencia; malaria [paludismo]; Plasmodium falciparum.