Revista Panamericana de Salud Pública
On-line version ISSN 1680-5348Print version ISSN 1020-4989
Guidelines for the use of antiretroviral agents to treat HIV infection in pediatric patients. Rev Panam Salud Publica [online]. 2001, vol.10, n.6, pp.426-435. ISSN 1680-5348. http://dx.doi.org/10.1590/S1020-49892001001200014.
This document presents the most recent recommendations issued by the Task Force on the Antiretroviral and Medical Treatment of Children with HIV Infection on the management of HIV-infected children and adolescents with antiretroviral drugs. Topics discussed include the diagnosis of the infection in newborns, surveillance of pediatric HIV infection (immunologic and viral criteria), specific problems surrounding treatment with antiretroviral agents and compliance in children and adolescents, therapeutic recommendations in symptomatic and asymptomatic patients, and the use of tests for detecting resistance to antiretorviral drugs. In general, the Task Force recommends at least three antiretroviral agents combining two reverse transcriptase nucleoside inhibitors (RTNI) plus one protease inhibitor (PI) or combining efavirenz (a reverse transcriptase non-nucleoside inhibitor) plus one or two RTNI and one PI. Finally, recommendations are made on when to change an antiretroviral treatment due to lack of efficacy or toxicity or to the development of more effective treatments.
Keywords : antirretrovíricos; SIDA; VIH; infección pediátrica.