Services on Demand
Revista Panamericana de Salud Pública
On-line version ISSN 1680-5348Print version ISSN 1020-4989
SEKI, Matiko Okabe; MATSUO, Tiemi and SEKI, Mario. Non-HDL cholesterol levels in students aged 7 to 17 years in a Brazilian town. Rev Panam Salud Publica [online]. 2007, vol.21, n.5, pp.307-312. ISSN 1680-5348. http://dx.doi.org/10.1590/S1020-49892007000400006.
OBJECTIVE: To describe the levels of non-HDL cholesterol and correlated factors in a group of Brazilian male and female children and adolescents. METHODS: From March to October 2002 we evaluated 2 029 schoolchildren from 7 to 17 years old in the town of Maracaí, São Paulo, Brazil. The biochemical determinations of triglycerides, total cholesterol, and high-density lipoprotein (HDL) cholesterol were carried out using enzymatic reactions and the Vitros 750 analyzer. Low-density lipoprotein (LDL) cholesterol levels were calculated using the Friedewald formula: LDL cholesterol = total cholesterol - HDL cholesterol - (triglycerides/5). Non-HDL cholesterol was calculated by subtracting HDL cholesterol from total cholesterol. RESULTS: The correlation between non-HDL cholesterol levels and LDL cholesterol levels was 0.971 (P < 0.001). Non-HDL cholesterol had a stronger correlation than did LDL cholesterol with all the variables under study: total cholesterol, triglycerides, HDL cholesterol, very low-density lipoproteins, body mass index, and waist circumference. The non-HDL cutpoints identified as corresponding to the four cutpoints of LDL cholesterol (110, 130, 160, and 190 mg/dL) indicating the need to treat dyslipidemia in children and adolescents were, respectively: 127.8, 149.2, 181.2, and 213.2 mg/dL. CONCLUSIONS: Our findings contribute toward estimating non-HDL levels in Brazilian children and adolescents. The results also indicate that non-HDL cholesterol is a reliable and less costly method for researching the presence of dyslipidemias in this age group.
Keywords : Adolescent; child; cholesterol, HDL; cholesterol, LDL; dyslipidemias; Brazil.