Revista Panamericana de Salud Pública
On-line version ISSN 1680-5348Print version ISSN 1020-4989
NOGUEIRA, Rita Maria Ribeiro; ARAUJO, Josélio Maria Galvão de and SCHATZMAYR, Hermann Gonçalves. Dengue viruses in Brazil, 1986-2006. Rev Panam Salud Publica [online]. 2007, vol.22, n.5, pp.358-363. ISSN 1680-5348. http://dx.doi.org/10.1590/S1020-49892007001000009.
A total of 4 243 049 dengue cases have been reported in Brazil between 1981 and 2006, including 5 817 cases of dengue hemorrhagic fever/dengue shock syndrome (DHF/DSS) and a total of 338 fatal cases. Although all Brazilian regions have been affected, the Northeast and Southeast regions have registered the highest number of notifications. DENV-1 and DENV-4 were isolated for the first time in the Amazon region of Brazil in 1981 and 1982. The disease became a nationwide public health problem following outbreaks of DENV-1 and DENV-2 in the state of Rio de Janeiro in 1986 and 1990, respectively. The introduction of DENV-3 in 2000, also in the state of Rio de Janeiro, led to a severe epidemic with 288 245 reported dengue cases, including 91 deaths. Virus strains that were typed during the 2002 epidemic show that DENV-3 has displaced other dengue virus serotypes and entered new areas, a finding that warrants closer evaluation. Unusual clinical symptoms, including central nervous system involvement, have been observed in dengue patients in at least three regions of the country.
Keywords : Dengue; dengue [epidemiology]; dengue virus/classification; diagnosis; genome; Brazil.