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Revista Panamericana de Salud Pública

Print version ISSN 1020-4989

Abstract

OLVERA, Adib; SIGNORINI, Marcelo  and  TARABLA, Héctor. Verotoxin-producing Escherichia coli: quantitative model of exposure and risk scenarios in cattle carcasses in Argentina. Rev Panam Salud Publica [online]. 2010, vol.27, n.6, pp. 403-413. ISSN 1020-4989.  http://dx.doi.org/10.1590/S1020-49892010000600001.

OBJECTIVES: Quantify contamination by verotoxin-producing Escherichia coli associated with hemolytic uremic syndrome (VTEC-HUS) in cattle carcasses and generate estimates of exposure in three likely scenarios. METHODS: A model was constructed of the frequency and magnitude of VTEC-HUS contamination from primary production to the removal of the carcasses from cold storage, based on the published scientific information, epidemiological data, and information from local experts. The probability distributions that best described each step in the process and scenarios were input to the @Risk® program with multiple simulations using Monte Carlo analysis. Pearson´s correlation test was used for the sensitivity analysis. RESULTS: The estimated frequency of carcasses with VTEC-HUS was 0.37 (95% CI: 0.26 to 0.58) and the final load of VTEC-HUS was 0.47 log CFU/carcass (95% CI: -2.46 to 3.62). The most closely related variables were the fattening system (r = -0.681) and the theoretical concentration of VTEC-HUS on the cattle's skin (r = 0.702). Vaccinating the animals reduced the frequency of VTEC-HUS in the carcasses by 54.1%, although there were no significant changes in the final VTEC-HUS load. Washing the carcasses reduced the final load by 0.42 log CFU/carcass compared with the baseline model, without any change in the frequency. A 50%-60% increase in the percentage of animals fattened in pens would increase the frequency of carcasses contaminated with VTEC-HUS by 15%-23%. CONCLUSIONS: Vaccinating the animals was the most effective scenario for reducing introduction of the bacteria in the beef production chain. Intensifying livestock production will increase the public health risk due to greater exposure to VTEC-HUS.

Keywords : Shiga-toxigenic Escherichia coli; hemolytic-uremic syndrome; meat industry; risk assessment; Argentina.

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