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Revista Panamericana de Salud Pública

Print version ISSN 1020-4989

Abstract

VILLALOBOS RODRIGUEZ, Andrea Patricia et al. Trends of bacterial resistance phenotypes in high-complexity public and private hospitals in Colombia. Rev Panam Salud Publica [online]. 2011, vol.30, n.6, pp. 627-633. ISSN 1020-4989.  http://dx.doi.org/10.1590/S1020-49892011001200022.

OBJECTIVE: Describe and compare the frequency of bacterial resistance phenotypes of microorganisms obtained from patients in intensive care units (ICU) and other (non-ICU) high-complexity public and private hospital services in Colombia. METHODS: A retrospective observational, analytical, multicenter study was conducted. The records from January 2007 to December 2009 on bacterial isolates and bacterial resistance phenotypes of microorganisms obtained from ICU and non-ICU patients in 79 high-complexity public and private hospitals were consolidated. The information was analyzed with the WHONET® 5.5 (WHO) software, following the 2009 recommendations of the Clinical and Laboratory Standards Institute, and summarized on an Excel® spreadsheet. A descriptive analysis with the calculation of proportions was performed. The trends were analyzed with Spearman rank correlation. RESULTS: The 2007-2009 trends for bacterial resistance phenotypes show increased percentages of vancomycin-resistant Enterococcus faecium, imipenem-resistant Klebsiella pneumoniae, ciprofloxacin-resistant K. pneumoniae, ceftazidime-resistant Escherichia coli and cefotaxime-resistant Enterobacter cloacae (r = 1, P < 0.01), and reduced percentages of ciprofloxacin-resistant E. coli, ceftazidime-resistant K. pneumoniae, oxacillin-resistant Staphylococcus aureus, ceftazidime-resistant Pseudomonas aeruginosa, and ciprofloxacin-resistant P. aeruginosa (r = -1, P < 0.01). CONCLUSIONS: The trend analysis presented in this study is the baseline for establishing a national epidemiological surveillance subsystem. The trends observed reveal that bacterial resistance to antimicrobial drugs in hospitals in Colombia is a dynamic phenomenon, with evidence of the emergence of vancomycin-resistant E. faecium and imipenem-resistant K. pneumoniae phenotypes in the hospitals.

Keywords : Anti-bacterial agents; drug resistance, bacterial; epidemiologic surveillance; hospitals; Colombia.

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