SciELO - Scientific Electronic Library Online

vol.78 issue5Prevalence of Tuberculosis Infection among Immigrants in the Toledo Health District, SpainEvaluation of the SF-36 Health Index Applied to Methadone Maintenance Program Users: Reference Values for the Basque Autonomous Community, Spain author indexsubject indexarticles search
Home Page  

Services on Demand




Related links


Revista Española de Salud Pública

On-line version ISSN 2173-9110Print version ISSN 1135-5727


ANORO, Manel et al. Factors Related to Experiencing Respiratory Failure in Cases of Opiate Overdose for which Care Was Provided in an Open Setting. Barcelona, Spain. Rev. Esp. Salud Publica [online]. 2004, vol.78, n.5, pp.601-608. ISSN 2173-9110.

Background: To determine the factors associated with respiratory arrest in opiate overdoses (coma, pupillary miosis, respiratory depression, and response to naloxone) among injecting drug users in the Can Tunis quarter of Barcelona. Methods: We ran a transversal observational study where all overdoses assisted between March, 2001 and June, 2002. After overdose treatment, data were collected using a standard questionnaire, including: patients' sociodemographic data, opiate and other substances' use prior to overdose, clinical signs and symptoms presented, and medical intervention received, by ways of a standardised questionnaire. Logistic regression was used as a tool for analysis. Results: Of 222 opiate overdose cases, 60.8% showed respiratory arrest. Of all risk factors tested, only prior abstinence heroin abstinence for 2 weeks or longer days (OR= 1.893; p=0.04), and no previous consumption of benzodiazepines (OR:0,462; p=0,017), proved to have a statistically significant association with suffering a respiratory arrest. Concomitant use of alcohol, cocaine or methadone appeared not associated with suffering respiratory arrest in opiate overdose. Conclusions: The main risk factor for respiratory arrest in opiate overdoses was a prior abstinence period of more than 2 weeks. Benzodiazepines use was associated with absence of respiratory arrest in overdose cases. Alcohol or methadone use, as well as the use of larger quantities of heroin, was not associated with suffering respiratory arrest in opiate overdoses. A study of other factors, not included in this study, and that could interfere with our results, should be considered for their possible relationship to benzodiazepine use as well as to absence of respiratory arrest in overdose cases.

Keywords : Drug Addiction; Overdose; Heroin; Apnea; Risk factors; Prevention; Naloxone.

        · abstract in Spanish     · text in Spanish     · Spanish ( pdf )