Revista Española de Salud Pública
Print version ISSN 1135-5727
SAINZ DE ROZAS APARICIO, Carlos; RUIZ CLAVIJO DIEZ, María Teresa and DIAZ MADERO, Alfonso. Evolution of the Utilization of Antidepressant Drugs in the Rioja and Zamora Health Districts Throughout the 1997-2001 Period. Rev. Esp. Salud Publica [online]. 2004, vol.78, n.5, pp. 631-645. ISSN 1135-5727. http://dx.doi.org/10.1590/S1135-57272004000500008.
Background: Due to the high increase in the utilization of antidepressant drugs and the change in the prescription profile within this group, this study is aimed at discovering the evolution of the utilization of antidepressant drugs (NO6A subgroup) outside of the hospital setting in the Rioja and Zamora health districts throughout the 1997-2001 period and to evaluate the impact of the new drugs. Methods: A study was made of the utilization of drugs included in the NO6A treatment subgroup under the Anatomical Therapeutic Chemical (ATC) classification. The data on the utilization of each specialty was taken from the pharmacy management (SIFAR) software applications and has been stated for each active ingredient in Daily Dose per Inhabitant (DDI). Results: In the period under study, there was an increase in the total utilization of antidepressants in the two areas (Zamora 55% and Rioja 93%) due mainly to the increase in selective serotinin reuptake inhibitors (SSRI) (Zamora 80% and Rioja 143%) and in the new heterocyclic antidepressants (Zamora 82% and Rioja 78%). Conclusions: There has been an increase in the utilization of antidepressants, all of which has taken place in conjunction with a change in the prescription profile. There is a clear shift toward the utilization of the SSRI's and some heterocyclic antidepressants (venlafaxine, trazodone, reboxetine), the utilization of tricyclic antidepressants and IMAO's having decreased.
Keywords : Antidepressive Agents; Depression; Pharmacoepidemiology; Drug utilization.