Revista Brasileira de Epidemiologia
Print version ISSN 1415-790X
LESSA, Ines. Serum creatinine levels: hypercreatinemia in a segment of the adult population of Salvador, Brazil. Rev. bras. epidemiol. [online]. 2004, vol.7, n.2, pp. 176-186. ISSN 1415-790X. http://dx.doi.org/10.1590/S1415-790X2004000200007.
The prevalence of chronic kidney disease (CKD) has been increasing, its social impact is great and creatinine is one of its markers. OBJECTIVE: To estimate the prevalence of hypercreatinemia in a segment of the adult population of Salvador in order to investigate its association with cardiovascular risk factors, and to identify the groups at greatest risk of developing CKD. METHODS: A home interview was carried out in a sample of 2,298 individuals 20 years of age and over and a segment of 1,439 was tested for elevated serum creatinine. Blood pressure and anthropometric measurements were taken. Serum creatinine levels =1.3mg/dl were considered abnormal for either sex. Exploratory analysis included bivariate analysis and multiple logistic regression. RESULTS: The total prevalence of hypercreatinemia was 3.1% (5.2% in men and 1.6% in women). In patients 60 years of age and older, prevalence was 12.9%, 95% CI (4.3; 20.3) in men and 7.9%, 95% CI (3.0; 12.8) in women. Adjusted OR were found to be significant for the elderly, Afro-Brazilians, hypertensive patients and those with a past history of stroke. Non-significant associations were found for diabetes and family history of CKD. Isolated hypercreatininemia occurred in 2.6% of men, 95% CI (1.9; 3.1). CONCLUSION: At the present time, population surveys of hypercreatininemia are unnecessary, although serum creatinine screening should be strongly recommended within routine medical practice for individuals at higher risk for developing CKD.
Keywords : Hypercreatininemia; Chronic Kidney Disease; Prevalence; Risk Factors.