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Revista Peruana de Medicina Experimental y Salud Pública

On-line version ISSN 1726-4642Print version ISSN 1726-4634


HARO-GARCIA, Luis et al. Blood disorders among workers exposed to a mixture of benzene-toluene-xylene (BTX) in a paint factory. Rev Peru Med Exp Salud Publica [online]. 2012, vol.29, n.2, pp.181-187. ISSN 1726-4642.

Objectives. Evaluate the three blood cell series and identify the presence of hypochromia, macrocytosis, leucopenia, lymphopenia, and thrombocytopenia in a group of workers exposed to the mixture of benzene-toluene-xylene (BTX). Materials and methods. A cross-sectional study which included 97 workers from a paint factory in Mexico. The participants underwent conventional blood count and tests for potential cumulative daily dose of BTX fumes, to estimate exposure. Results. From the total of workers, 19.6% showed macrocytosis, 18.6%, lymphopenia, hypochromia 10.3%, 7.2% and 5.2% thrombocytopenia leukopenia. The crude association of macrocytosis with exposure to high doses of BTX mixture was the only with statistical significance (OR: 3.6, 95% CI 1.08 to 13.9, P = 0.02), and the base for a logistic regression model (OR: 6.7, 95% CI 1.33 to 13.55, P = 0.02) adjusted for age, alcohol consumption, and smoking. Conclusions. All blood cytological components analyzed demonstrated mild changes, potentially associated with exposure to the mixture of BTX. Macrocytosis could constitute an early manifestation worthy for surveillance.

Keywords : Hematologic diseases; Workers; Occupational health; Benzene derivatives.

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