SciELO - Scientific Electronic Library Online

vol.29 número2Blastomicosis oral, papilomatosis laríngea y tuberculosis esofágicaTuberculosis y salud pública: ¿derechos individuales o derechos colectivos? índice de autoresíndice de materiabúsqueda de artículos
Home Page  

Servicios Personalizados




Links relacionados

  • No hay articulos similaresSimilares en SciELO


Revista Peruana de Medicina Experimental y Salud Pública

versión On-line ISSN 1726-4642versión impresa ISSN 1726-4634


PINTO, Miguel E.; BANDA, Claudia  y  SEAS, Carlos. Pulmonary aspergillosis due to methimazole-induced neutropenia: a case report. Rev Peru Med Exp Salud Publica [online]. 2012, vol.29, n.2, pp.255-258. ISSN 1726-4642.

A 48-year old woman with a recent diagnosis of Graves’ disease arrived at the emergency room with fever, palpitations, and a sore throat. Her regular treatment included methimazole. On admission, laboratory results showed suppressed TSH, elevated free thyroxine, and neutropenia. She was admitted and started on antibiotics and granulocyte-macrophage colony stimulating factor (gm-csf). After ten days, the patient developed leukocytosis, fever, and hemoptysis. Chest CT scan showed a lung cavity with multiple nodules in the upper right lobe. Cultures from a lung biopsy were positive for Aspergillus Fumigatus and Aspergillus Flavus. Amphotericin B was started but then switched to voriconazole, with both treatments failing to result in clinical improvement. The patient died of multi-organ failure.

Palabras clave : Aspergillus; Pulmonary aspergillosis; Neutropenia; Methimazole; Antithyroid agents.

        · resumen en Español     · texto en Español     · Español ( pdf )