Print version ISSN 0042-9686
Bull World Health Organ vol.82 n.11 Genebra Nov. 2004
POLICY AND PRACTICE
Le défaut de traitement en santé mentale
La brecha terapéutica en la atención de salud mental
Robert KohnI, 1; Shekhar SaxenaII; Itzhak LevavIII; Benedetto SaracenoII
IBrown University Department of Psychiatry and Human Behavior, Providence, RI, USA
IIWorld Health Organization, Department of Mental Health and Substance Dependence, Geneva, Switzerland
IIIMinistry of Health, Jerusalem, Israel
Mental disorders are highly prevalent and cause considerable suffering and disease burden. To compound this public health problem, many individuals with psychiatric disorders remain untreated although effective treatments exist. We examine the extent of this treatment gap. We reviewed community-based psychiatric epidemiology studies that used standardized diagnostic instruments and included data on the percentage of individuals receiving care for schizophrenia and other non-affective psychotic disorders, major depression, dysthymia, bipolar disorder, generalized anxiety disorder (GAD), panic disorder, obsessive–compulsive disorder (OCD), and alcohol abuse or dependence. The median rates of untreated cases of these disorders were calculated across the studies. Examples of the estimation of the treatment gap for WHO regions are also presented. Thirty-seven studies had information on service utilization. The median treatment gap for schizophrenia, including other non-affective psychosis, was 32.2%. For other disorders the gap was: depression, 56.3%; dysthymia, 56.0%; bipolar disorder, 50.2%; panic disorder, 55.9%; GAD, 57.5%; and OCD, 57.3%. Alcohol abuse and dependence had the widest treatment gap at 78.1%. The treatment gap for mental disorders is universally large, though it varies across regions. It is likely that the gap reported here is an underestimate due to the unavailability of community-based data from developing countries where services are scarcer. To address this major public health challenge, WHO has adopted in 2002 a global action programme that has been endorsed by the Member States.
Keywords: Mental health services/utilization; Health services accessibility; Schizophrenia/therapy; Anxiety disorders/therapy; Mood disorders/therapy; Compulsive personality disorder/therapy; Alcoholism/therapy; Epidemiologic studies; Cost of illness; Americas; Europe (source: MeSH, NLM).
Les troubles mentaux ont une prévalence élevée et représentent une charge considérable en termes de souffrance et de maladie. De plus, de nombreuses personnes atteintes de troubles psychiques restent sans traitement alors qu'il en existe d'efficaces. Dans le présent article, nous examinons l'étendue de ce défaut de traitement. Nous avons effectué une revue des études épidémiologiques psychiatriques en population utilisant des outils de diagnostic standard et comportant des données sur le pourcentage de sujets traités pour schizophrénie et autres troubles psychotiques non affectifs, dépression majeure, dysthymie, trouble bipolaire, anxiété généralisée, trouble panique, troubles obsessionnels-compulsifs (TOC) et abus d'alcool ou dépendance alcoolique. Les taux médians d'absence de traitement de ces affections ont été calculés pour l'ensemble de ces études. L'article présente également des exemples d'estimations du défaut de traitement dans les Régions OMS. Le taux médian de défaut de traitement pour la schizophrénie, y compris les autres psychoses non affectives, était de 32,2 %. Pour les autres affections il était de : dépression 56,3 %, dysthymie 56,0 %, trouble bipolaire 50,2 %, trouble panique 55,9 %, anxiété généralisée 57,5 % et TOC 57,3 %. Il était maximal pour l'abus d'alcool et la dépendance alcoolique avec 78,1 %. Le taux de défaut de traitement des troubles mentaux est élevé partout, même s'il varie d'une région à l'autre. Il est probable que les taux rapportés ici sont en-deçà de la réalité, du fait de l'absence de données concernant les pays en développement, où les services de santé mentale sont plus rares. Pour répondre à cet important problème de santé publique, l'OMS a adopté en 2002 un programme mondial d'action, qui a été approuvé par les Etats Membres.
Mots clés: Service santé mentale/utilisation; Accessibilité service santé; Schizophrénie/thérapeutique; Etat anxiété/thérapeutique; Troubles humeur/thérapeutique; Personnalité compulsive/thérapeutique; Alcoolisme/thérapeutique; Etude analytique (Epidémiologie); Coût maladie; Amérique; Europe (source: MeSH, INSERM).
Los trastornos mentales, cuya prevalencia es muy alta, son una causa destacada de sufrimiento y morbilidad. Este problema de salud pública se ve agravado por el hecho de que muchos individuos aquejados de trastornos psiquiátricos no reciben tratamiento alguno pese a que existen intervenciones eficaces. Hemos analizado la magnitud de esa brecha terapéutica, para lo cual se han examinado estudios comunitarios de epidemiología psiquiátrica que habían usado instrumentos diagnósticos normalizados e incluían datos sobre el porcentaje de individuos que recibían atención por padecer esquizofrenia y otros trastornos psicóticos no afectivos, depresión grave, distimia, trastorno bipolar, trastorno de ansiedad generalizado, trastorno de pánico, trastorno obsesivo–compulsivo (TOC) y abuso o dependencia del alcohol. Se calcularon las tasas medianas de casos sin tratar de esos trastornos en el conjunto de todos los estudios. Se presentan asimismo ejemplos de estimaciones de la brecha terapéutica para las Regiones de la OMS. En 37 estudios se facilitaba información sobre la utilización de los servicios. La brecha terapéutica mediana para la esquizofrenia, incluidas otras psicosis no afectivas, fue del 32,2%. Las brechas medidas para los otros trastornos fueron las siguientes: depresión, 56,3%; distimia, 56,0%; trastorno bipolar, 50,2%; trastorno de pánico, 55,9%; ansiedad generalizada, 57,5%, y TOC, 57,3%. La brecha más importante fue la correspondiente al abuso y la dependencia del alcohol, 78,1%. La brecha terapéutica de los trastornos mentales es muy amplia en general, aunque varía entre las regiones. Es probable que los valores aquí presentados subestimen la realidad, debido a la falta de datos comunitarios de los países en desarrollo donde más escasean los servicios. Para afrontar este importante reto de salud pública, la OMS ha adoptado en 2002 un programa mundial de acción que ha sido respaldado por los Estados Miembros.
Palabras clave: Servicios de salud mental/utilización; Accesibilidad a los servicios de salud; Esquizofrenia/terapia; Trastornos de ansiedad/terapia; Trastornos del humor/terapia; Trastorno de personalidad compulsiva/terapia; Alcoholismo/terapia; Estudios epidemiológicos; Costo de la enfermedad; Americas; Europa (fuente: DeCS, BIREME).
The care of people with mental and brain disorders is a growing public health concern. These disorders are highly prevalent and exact a high emotional toll on individuals, families, and society. Worldwide, community-based epidemiological studies have estimated rates of lifetime prevalence of mental disorders among adults ranging from 12.2% to 48.6% and 12-month prevalence rates ranging from 8.4% to 29.1% (1). These rates do not include neurological conditions affecting the brain (1). WHO (2) has estimated that approximately 450 million individuals worldwide suffer from neuropsychiatric disorders in their lifetime.
Mental disorders are not only highly prevalent medical conditions but they are also highly disabling. Measured by years lived with disability and by premature death in disability-adjusted life years (DALYs), psychiatric and neurological conditions accounted for over 13% of the global disease burden in the year 2001 (3). When compared with 1990, the contribution of neuropsychiatric disorders is expected to increase to almost 15% by the year 2020 (4). Among individuals age 15–44, unipolar depression is the second leading contributor of DALYs, with alcohol-related disorders, schizophrenia, and bipolar disorder among the top 10 disorders. Approximately 33% of all years lived with disability (YLD) are imputed to neuropsychiatric conditions. Of the 10 leading causes of YLD in the world among individuals of all ages, four are psychiatric conditions, with unipolar depression being the leading cause (2). Among individuals between the ages of 15 and 44, panic disorder, drug use disorders, and obsessive–compulsive disorder (OCD) were included in the top 20 disorders.
In part, the excess disability due to mental disorders is a result of their early age of onset (1). The magnitude of this burden also results from the fact that only a minority of individuals with these disorders ever receive treatment in the specialized mental health care system or in the general health care system (5); initial treatment is frequently delayed for many years (6). Numerous reasons have been imputed. These include: failing to seek help because the problem is not acknowledged, perceiving that treatment is not effective, believing that the problem will go away by itself, and desiring to deal with the problem without outside help (7, 8). In addition a lack of knowledge about mental disorders and stigma remain major barriers to care (9, 10). Factors that are direct barriers to care also preclude treatment, including financial considerations (11), issues of accessibility, as well as limited availability or lack of availability of services in many countries or for some populations (12).
If disability is to be reduced, a bridging of the "treatment gap" must occur. The treatment gap represents the absolute difference between the true prevalence of a disorder and the treated proportion of individuals affected by the disorder. Alternatively, the treatment gap may be expressed as the percentage of individuals who require care but do not receive treatment. Estimating the treatment gap in a population depends on the prevalence period of the disorder, the time frame of the examination of service utilization, and the demographic representativeness of the study sample with reference to the target population. The objective of this report is to examine the extent of the treatment gap for selected mental disorders.
To examine the worldwide extent of the treatment gap the following disorders were selected: schizophrenia and non-affective psychosis, major depressive disorder, dysthymia, bipolar disorder, OCD, panic disorder, generalized anxiety disorder (GAD), and alcohol abuse and dependence. The literature review was limited to community-based epidemiological surveys of adults age 15 and older that had been published since 1980 or provided by investigators or agencies. The literature search was conducted using the search engines of medical journals, Medline and LILACS (a database of Latin American and Caribbean literature), and using key words that included the terms "psychiatric epidemiology," "prevalence" and the name of a specific disorder, and the names of commonly used diagnostic instruments. The references of book chapters and review articles on psychiatric epidemiology or service utilization were examined. We also searched abstracts from proceedings of meetings of the World Psychiatric Association section on epidemiology and the annual meeting of the American Psychiatric Association.
The studies considered used standardized data collection instruments that generated a diagnosis linked to accepted classification systems. Surveys relying on diagnostic instruments designed specifically for use only in elderly populations were not included. Data on service utilization were obtained from community-based epidemiological studies of psychiatric disorders regardless of prevalence periods. Service utilization was defined as seeking assistance from any medical or professional service provider, specialized or not, public or private. By definition, traditional healers and non-professional providers were excluded. The category of service utilization included both somatic and psychotherapeutic treatment; however, most studies did not report utilization by treatment modality, thus limiting the analysis to overall utilization. The treatment gap from each of the available studies was determined for each specific disorder.
The median and average rates of service utilization across the studies were calculated for each disorder. Using the median rate prevents outliers from having an undue influence. Adequate data were not available for all WHO regions, but examples of regional treatment gap rates were calculated. Regional treatment gap (G) calculations take into account the service utilization rate (Sc), the prevalence rate (Rc), and the population size (Pc) of each of the countries:
We estimated the population in each country of individuals age 15 and older. The latest census data by age distribution were obtained from the United Nations demographic yearbook (13). Since the last census year varied from country to country, the estimates prepared by WHO for the year 1999 were used (14). These estimates provided data only on an individual Member country's total population. To estimate the proportion of individuals aged 15 and older, data from the last census was applied to the 1999 total population estimate to obtain an approximation of each country's population as well as of regional populations.
A description of the 37 studies with data on service utilization is included in Appendix 1. The references are available in Appendix 2 (Appendix 1 and Appendix 2, web version only, available at: http://www.who.int/bulletin). The treatment gap is shown as percentage and the median and average treatment gap for each disorder is shown in Table 1. Where available, the rates of use of specialized mental health services are presented.
The median untreated rate, or treatment gap, for schizophrenia including other non-affective psychoses was 32.2%. For other disorders the gap was: major depression, 56.3%; dysthymia, 56.0%; bipolar disorder, 50.2%; panic disorder, 55.9%; GAD, 57.5%; and OCD, 59.5%. Alcohol abuse and dependence had the largest treatment gap at 78.1%. The treatment gap varied widely between countries. As an illustration, for schizophrenia the gap among young adult Jews in Israel was only 5.9%, while the rate in New Zealand in a population of 21-year-olds was 61.5%. The treatment gap in Italy was 15.9% for major depression, while studies in the United Kingdom gave an estimate of 83.9%. The treatment gap for alcohol abuse and dependence was high across all studies: Jewish-Israeli young adults had the lowest gap (49.4%) but in Mexico City among the general adult population few were in treatment (96.0%).
Service-related information from psychiatric epidemiological studies for many regions of the world was not available, so regional estimates of the treatment gap were not possible. As a result, examples of the treatment gap for major depression are presented for the Americas and the European Regions of WHO, since there is a good representation of studies across the countries in these two regions. The 12-month prevalence, or if not available, the current prevalence, were applied. When more than one study was available for a country, the most representative ones were used (those that referred to the entire sample studied). For the United States, the Epidemiological Catchment Area (ECA) and National Comorbidity Survey (NCS) prevalence and service utilization rates were averaged, as were the rates for studies done by the United Kingdom Office for National Statistics (ONS) and the Office of Population Censuses and Surveys (OPCS). For Finland and the Netherlands, studies based on the Composite International Diagnostic Interview (CIDI) were used.
The treatment gap for major depression in the WHO European Region was 45.4%, and for the Americas it was 56.9%. The average 12-month prevalence for major depression, weighting for the proportion of the population over the age of 15 were: 4.7% for the WHO European Region and 6.2% for the Americas. This suggests that in these regions there are about 31 million people and 35 million people, respectively, with major depression during a 12-month period. Of those, about 14 million in the European Region are untreated and about 20 million in the Americas are untreated. Estimates for other disorders and WHO regions are presented in Table 2.
Admittedly, the sources of data that we present are limited. Yet they seem to indicate that the treatment gap across all the psychiatric disorders examined is wide. Even for the most severe mental disorder, schizophrenia, at least one-third of individuals remain untreated.
Clearly, the rates presented here are an underestimation. There are few studies of developing countries, where services are scarce, and the studies that are available are of highly selected regions. Thus, the treatment gap for the Americas would have been higher if all of the Latin American and Caribbean countries had been represented. As an illustration, in Belize a study of the prevalence of treatment that was based on a review of each record of all health-care providers who treated mental disorders found that about 63% of individuals with schizophrenia were untreated; 89% of those with affective disorders had not been treated; and 99% of those with an anxiety disorder also had not been treated (15). The scarcity of services in much of the world where epidemiological studies are not available is highlighted by the results of the Atlas study (12). Furthermore, common psychopharmacological agents used to treat psychosis, mania, depression and anxiety are not uniformly available (Table 3). Essential psychiatric medications at the primary care level are not available in 25% of countries (12). For 70% of the world's population there is access to less than one psychiatrist per 100 000 people (12).
This review did not examine the extent to which the skills of traditional healers and non-professional providers are utilized. Unfortunately, only a small number of studies have examined this issue. The Chilean epidemiological survey, however, suggested that contrary to popular belief, traditional healers were rarely utilized for mental health problems (16). Evidence-based data are needed on the efficacy of treatment by traditional healers and non-professional providers to help us understand their role in reducing the treatment gap.
There are few epidemiological studies that provide data on service utilization based on interviews with community respondents, and in general the method of elucidating service utilization is ill-defined and not uniform. The treatment gap for specific disorders also may be underestimated because comorbidity is not accounted for in studies of service utilization protocols that do not examine disorder-specific treatment. The treatment-gap estimates do not include childhood disorders or dementia and its effects on caregivers. In addition, some of the studies were regionally based and did not account for differences in socioeconomic status and its effects on service utilization, did not include members of indigenous populations, or did not account for regional inequities within a country. Moreover, reporting that services were sought does not imply that the treatment was adequately provided or provided at all. The studies reviewed did not measure the adequacy of treatment, and therefore, may greatly overestimate the number of people who received appropriate and adequate treatment. The primary care literature illustrates the inability of general physicians to accurately identify mental disorders and their failure to provide appropriate care (17). A study conducted in the United States among hospitalized individuals with schizophrenia revealed that over half had periods of 30 days or more off medication with an average time off medication of over seven months (18). Additionally, prevalence studies that reported on treatment utilization included individuals who are in treatment but have no current psychiatric diagnosis (19). These studies may refer to people with subclinical illness or to individuals who have benefited from treatment but no longer meet diagnostic criteria for one-year prevalence. Also, there are subclinical cases that merit treatment as they are evolving (20). If this were true, these service utilization studies might be underestimating the number of individuals with a specific diagnosis who have a past-year diagnosis and who receive treatment. Conversely, perhaps not everyone who meets diagnostic criteria needs treatment.
With regard to major depression there is some evidence that the advent of antidepressants that are better tolerated has played a part in reducing the treatment gap in countries that can afford their higher costs (21). It has also increased awareness of the disorder among primary care physicians (22). As noted in our analysis, the treatment gap was lower in the WHO European Region than in the Americas; in part this may be due to the wider availability of health coverage in western European countries. In the United States, treatment for depression increased between 1987 and 1997, despite a decline in the use of psychotherapy; this has been partially credited to expanded third-party payment for medication visits (22). This example from the United States may illustrate the role financial barriers have in contributing to the treatment gap. An alternative argument is that the increased rate of antidepressant use reflects the cohort effect of major depression and the increasing prevalence of the disorder among younger individuals (21).
Failing to reduce the treatment gap has implications beyond the impact on YLD and DALYs. An increased treatment gap has indirect economic costs. In the United States absenteeism and lost productivity at work as a result of affective disorders alone cost the nation US$ 23 billion annually and there is an additional cost of US$ 8 billion associated with premature death (23). Similarly, three-quarters of the cost of alcoholism in Germany is due to indirect factors (24). Improvements in antidepressant treatment and access to care has been credited with reducing suicide rates (25). Mental illness may result in an increased risk of living in poverty, having a lower socioeconomic status, and having lower educational attainment (26). Major depression, as well as other psychiatric disorders, has been shown to impair family function (27), increase the risk of teenage childbearing (28), and increase the risk of domestic violence (29). The impact of major depression on quality of life is as great or greater than the impact of chronic medical conditions (30). Individuals who do not seek treatment may be less clinically impaired, but there is little to suggest that treated and untreated individuals differ with regard to other psychosocial factors (31). The pervasive and chronic disability associated with major depression disappears when individuals become asymptomatic (32). Schizophrenia, major depression, and alcohol use disorders also result in an increased risk of early mortality other than suicide (33).
One factor that may diminish concern about addressing the treatment gap in health-care planning is that at least some of these disorders, such as major depression and alcohol abuse and dependence, may remit without treatment. Randomized controlled studies suggest that more than 20% of individuals with major depression who are untreated achieve remission within 20 weeks (34). However, longitudinal studies on the course of major depression, in which treatment of identified patients was not controlled, point to a more pessimistic outcome. A WHO cross-national study of 439 patients with major depression followed for 10 years found that 36% were readmitted to hospital; 11% committed suicide; and more than 18% had a poor clinical outcome (35). A 15-year follow-up study of 380 individuals who had recovered from major depression noted that 85% had a relapse (36).
The outcome is less clear for alcohol abuse and dependence. Sustained periods of abstinence without treatment are not uncommon (37). Individuals who need treatment are more likely to have significant social impairment and psychiatric comorbidity (38); therefore, accessibility and availability of care for a sizeable proportion of individuals with alcoholism is always necessary. Naturalistic studies of panic disorder have found low probabilities of remission and high rates of relapse among those who remit (39); a similar finding was noted for OCD (40). People with schizophrenia who remain untreated are often more symptomatic; stay ill longer; and are more disabled than those who receive treatment (41).
The long-term psychosocial complications of psychiatric disorders suggest not only that the treatment gap must be bridged but also that the treatment lag (the time from onset of a disorder to obtaining care) must be shortened. Of those individuals who seek help for affective disorder and anxiety disorder, 40% do so in the year of onset. In contrast, the remaining 60% have a median delay of eight years (42). Absenteeism and poor family functioning may be present, among other consequences, when a current disorder is untreated. It has been shown for individuals with panic disorder that the longer the duration of illness prior to treatment, the poorer the social outcome (43) and the more protracted the course (39). The duration of untreated psychosis (DUP) varies widely across studies: in an Australian study the average DUP was 6 months (44), while in Nigeria it was 2.1 years for women (45). Some investigators have suggested that the longer treatment lag in schizophrenia may have a neurotoxic affect on the brain (46), although more recent research has brought this finding into question (47).
To address the treatment gap, the 2001 World health report (2) has laid out 10 recommendations (Box 1). WHO has created various scenarios that begin to address these recommendations taking into account the fact that resources vary widely among nations. Following the report, WHO adopted the Mental Health Global Action Programme (mhGAP), which intends to modify the current world situation (48) with the endorsement of all Member States (49). Although the treatment gap remains wide for mental disorders, appropriate policies, programmes and service developments may allow this divide to be bridged for the benefit of those in need, their families and communities.
Funding: This paper was supported by WHO.
Conflicts of interest: none declared.
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Submitted: 22 June 2003 – Final revised version received: 20 November 2003 – Accepted: 21 November 2003
References for prevalence studies published since 1980 that provide data on service utilization
1. Andrews G, Hall W, Teesson M, Henderson S. The mental health of Australians. Australia: Mental Health Branch, Commonwealth Department of Health and Aged Care; 1999.
2. Henderson S, Andrews G, Hall W. Australia's mental health: an overview of the general population survey. Australian and New Zealand Journal of Psychiatry 2000;34:197-205.
3. Teesson M, Hall W, Lynskey M, Degenhardt L. Alcohol- and drug-use disorders in Australia: implications of the National Survey of Mental Health and Wellbeing. Australian and New Zealand Journal of Psychiatry 2000;34:206-13.
4. Andrade LH, Lolio CA, Gentil V, Laurenti R. Epidemiologia dos trastornos mentais em uma area definida de captação da cidade de São Paulo, Brasil. [Epidemiology of mental illness in a catchement area in São Paulo, Brasil.] Revista de Psiquiatria Clinica 1999;26. In Portuguese.
5. Bland RC, Orn H, Newman SC. Lifetime prevalence of psychiatric disorders in Edmonton. Acta Psychiatrica Scandinavica 1988;77 Suppl:338:24-32.
6. Bland RC, Newman SC, Orn H. Help-seeking for psychiatric disorders. Canadian Journal of Psychiatry 1997;42:935-42.
7. Offord DR, Boyle MH, Campbell D, Goering P, Lin E, Wong M, et al. One-year prevalence of psychiatric disorder in Ontarians 15 to 64 years of age. Canadian Journal of Psychiatry 1996;41:559-63.
8. Katz SJ, Kessler RC, Frank RG, Leaf P, Lin E, Edlund M. The use of outpatient mental health services in the United States and Ontario: the impact of mental morbidity and perceived need for care. American Journal of Public Health 1997;87:1136-43.
9. Parikh SV, Lin E, Lesage AD. Mental health treatment in Ontario: selected comparisons between the primary care and specialty sectors. Canadian Journal of Psychiatry 1997;42:929-34.
10. Vicente B, Rioseco P, Saldivia S, Kohn R, Torres S. Estudio Chileno de prevalencia de patología psiquiátrica (DSM-III-R/CIDI) (ECPP). [Prevalence of psychiatric disorder in Chile.] Revista Médica de Chile 2002;130:527-36. In Spanish.
11. Cooper JE, Sartorius N. Mental disorders in China: results of the National Epidemiological Survey in 12 Areas. London: Gaskell; 1996.
12. Ran M, Xiang M, Huang M, Shan Y. Natural course of schizophrenia: 2-year follow-up study in a rural Chinese community. British Journal of Psychiatry 2001;178:154-8.
13. Dzúrová D, Smolová E, Dragomirecká E. Mental health in the sociodemographic context: results of a sample survey in the Czech Republic. Prague, Czech Republic: Univerzita Karlova; 2000. In Czechoslovakian.
14. Dragomirecká E, Baudis P, Smolová E, Dzúrová D, Holub J. Psychiatric morbidity of the population in the Czech Republic. Ceska a Slovenska Psychiatrie 2002;98:72-80. In Czechoslovakian.
15. Lehtinen V, Joukamaa M, Lahtela K, Raitasalo R, Jyrkinen E, Maatela J, et al. Prevalence of mental disorders among adults in Finland: basic results from the Mini Finland Health Survey. Acta Psychiatrica Scandinavica 1990;81:418-25.
16. Lehtinen V, Joukamaa M, Jyrkinen E, Lahtela K, Raitasalo R, Maatela J, et al. Need for mental health services of the adult population in Finland: results from the Mini Finland Health Survey. Acta Psychiatrica Scandinavica 1990;81:426-31.
17. Lindeman S, Hämäläinen J, Isometsä E, Kaprio J, Poikolainen K, Heikkinen M, et al. The 12-month prevalence and risk factors for major depressive episode in Finland: representative sample of 5993 adults. Acta Psychiatrica Scandinavica 2000;102:178-84.
18. Laukkala T, Isomestä E, Hämäläinen J, Heikkinen M, Lindeman S, Aro H. Antidepresant treatment of depression in the Finnish general population. American Journal of Psychiatry 2001;158:2077-9.
19. Lepine JP, Lellouch J, Lovell A, Teherani M, Ha C, Verdier-Taillefer MH, et al. Anxiety and depressive disorders in a French population: methodology and preliminary results. Psychiatry and Psychobiology 1989;4:267-74.
20. Wittchen HU, Nelson CB, Lachner G. Prevalence of mental disorders and psychosocial impairments in adolescents and young adults. Psychological Medicine 1998;28:109-26.
21. Padmavathi R, Rajkumar S, Srinivasan N. Schizophrenia patients who were never treated – a study in an Indian urban community. Psychological Medicine 1998;28:1113-7.
22. Levav I, Kohn R, Dohrenwend BP, Shrout PE, Skodol AD, Schwartz S, et al. An epidemiological study of mental disorders in a 10-year cohort of young adults in Israel. Psychological Medicine 1993;23:691-707.
23. Faravelli C, Guerrini Degl'Innocenti B, Aiazzi L, Incerpi G, Pallanti S. Epidemiology of mood disorders: a community survey in Florence. Journal of Affective Disorders 1990;20:135-41.
24. Faravelli C, Guerrini Degl'Innocenti B, Giardinelli L. Epidemiology of anxiety disorders in Florence. Acta Psychiatrica Scandinavica 1989;79:308-12.
25. Karam EG. The nosological status of bereavement-related depressions. British Journal of Psychiatry 1994;165:48-52.
26. Caraveo-Anduaga JJ. Epidemiologia de la morbilidad psiquiátrica en la Ciudad de México. [Epidemiology of Psychiatric Morbidity in Mexico City.] Mexico City: Instituto Mexicano de Psiquiatria; 1995. In Spanish.
27. Carvaeo-Anduaga JJ, Martinez Vélez NA, Rivera Guevara BE, Dayan AP. Prevalencia en la vida de episodios depresivos y utilización de servicios especializados. [Lifetime prevalence of depressive episode and utilization of specialized services.] Salud Mental 1997;20 Suppl:15-23. In Spanish.
28. Caraveo-Anduaga JJ, Colmenares E, Saldivar GJ. Morbilidad psiquiátrica en la ciudad de México: prevalencia y comorbilidad a lo largo de la vida. [Psychiatric morbidity in Mexico City: lifetime prevalence and comorbidity.] Salud Mental 1999;22:62-7. In Spanish.
29. Salgado de Snyder VN, Diaz-Pérez M. Los trastornos afectivos en la población rural. [Depressive disorders in a rural population.] Salud Mental 1999;22:68-74. In Spanish.
30. Beekman ATF, Deeg DJH, Braam AW, Smit JH, van Tilburg W. Consequences of major and minor depression in later life: a study of disability, well-being and service utilization. Psychological Medicine 1997;27:1397-409.
31. Bijl RV, Ravelli A, van Zessen G. Prevalence of psychiatric disorder in the general population: results of the Netherlands Mental Health Survey and Incidence Study (NEMESIS). Social Psychiatry and Psychiatric Epidemiology 1998, 33:587-95.
32. Bijl RV, Ravelli A. Psychiatric morbidity, service use, and need for care in the general population: results of the Netherlands Mental Health Survey and Incidence Study. American Journal of Public Health 2000;90:602-7.
33. Well JE, Bushnell JA, Hornblow AR, Joyce PR, Oakley-Browne MA. Christchurch psychiatric epidemiology study, part I: methodology and lifetime prevalence for specific psychiatric disorders. Australian and New Zealand Journal of Psychiatry 1989;23:315-26.
34. Hornblow AR, Bushnell JA, Wells JE, Joyce PR, Oakley-Browne MA. Christchurch psychiatric epidemiology study: use of mental health services. New Zealand Medical Journal 1990;103:415-7.
35. Newman DL, Moffitt TE, Caspi A, Magdol L, Silva PA, Stanton WR. Psychiatric disorder in a birth cohort of young adults: prevalence, comorbidity, clinical significance, and new case incidence from ages 11 to 21. Journal of Consulting and Clinical Psychology 1996;64:552-62.
36. Sandanger I, Nygård JF, Ingebrigsten G, Sørensen T, Dalgard OS. Prevalence, incidence and age at onset of psychiatric disorders in Norway. Social Psychiatry and Psychiatric Epidemiology 1999;34:570-9.
37. Angst J. Epidemiology of depression. Psychopharmacology 1992;106 Suppl:71-4S.
38. Hwu HG, Yeh EK, Chang LY. Prevalence of psychiatric disorders in Taiwan defined by the Chinese Diagnostic Interview Schedule. Acta Psychiatrica Scandinavica 1989;79:136-47.
39. Hwu HG, Yeh EK, Yeh YL, Chang LY. Alcoholism by Chinese diagnostic interview schedule: a prevalence and validity study. Acta Psychiatrica Scandinavica 1988;77:7-13.
40. Kilç C. Mental health profile of Turkey: main report. Ankara, Turkey: Ministry of Health; 1998. In Turkish.
41. Singleton N, Bumpstead R, O'Brien M, Lee A, Meltzer H. Psychiatric morbidity among adults living in private households, 2000: the report of a survey carried out by Social Survey Division of the Office for National Statistics on behalf of the Department of Health, the Scottish Executive and the National Assembly for Wales. London: Stationery Office; 2001.
42. Meltzer H, Gill B, Petticrew M, Hinds K. OPCS surveys of psychiatric morbidity in Great Britain. Report 1: the prevalence of psychiatric morbidity among adults living in private households. London: HMSO; 1995.
43. Meltzer H, Gill B, Petticrew M, Hinds K. OPCS surveys of psychiatric morbidity in Great Britain. Report 2: physical complaints, service use and treatment of adults with psychiatric disorders. London: HMSO; 1995.
44. Ohayon MM, Priest RG, Guileminault C, Caulet M. The prevalence of depressive disorders in the United Kingdom. Biological Psychiatry 1999;45:300-7.
45. Robins LN, Regier DA, editors. Psychiatric disorders in America: the Epidemiologic Catchment Area Study. New York: Free Press; 1991.
46. Regier DA, Narrow WE, Rae DS, Manderscheid RW, Locke BZ, Goodwin FK. The de facto US mental and addictive disorders service system. Epidemiologic catchment area prospective 1-year prevalence rates of disorders and services. Archives of General Psychiatry 1993;50:85-94.
47. Vega WA, Kolody B, Aguilar-Gaxiola S, Alderete E, Catalano R, Caraveo-Anduaga J. Lifetime prevalence of DSM-III-R psychiatric disorders among urban and rural Mexican Americans in California. Archives of General Psychiatry 1998;55:771-8.
48. Vega WA, Kolody B, Aguilar-Gaxiola S, Catalano R. Gaps in service utilization by Mexican Americans with mental health problems. American Journal of Psychiatry 1999;156:928-34.
49. Kessler RC, McGonagle KA, Zhao S, Nelson CB, Highes M, Eshleman S, et al. Lifetime and 12-month prevalence of DSM-III-R psychiatric disorders in the United States. Archives of General Psychiatry 1994;51:8-19.
50. Kessler RC, Zhao S, Katz SJ, Kouzis AC, Frank RG, Edlund M, et al. Past-year use of outpatient services for psychiatric problems in the National Comorbidity Survey. American Journal of Psychiatry 1999;156:115-23.
51. Weissman MM, Myers JK, Harding PS. Psychiatric disorders in a U.S. urban community: 1975-1976. American Journal of Psychiatry 1978;135:459-62.
52. Weissman MM, Myers JK, Harding PS. Prevalence and psychiatric heterogeneity of alcoholism in a United States urban community. Journal of Studies on Alcohol 1980;41:672-81.
53. Grant BF, Harford TC. Comorbidity between DSM-IV alcohol use disorders and major depression: results of a national survey. Drug and Alcohol Dependence 1995;39:197-206.
54. Dawson DA. Correlates of past-year status among treated and untreated persons with former alcohol dependence: United States, 1992. Alcoholism: Clinical and Experimental Research 1996;20:771-9.
55. Alegria M, Kessler RC, Bijl R, Lin E, Heeringa SG, Takeuchi DT, et al. Comparing mental health service use data across countries. In: Andrews G, editor. Unmet need in mental health service delivery. Cambridge: Cambridge University Press; 2000. p. 97-118.
56. Canino GJ, Bird HR, Shrout PE, Rubio-Stipec M, Bravo M, Martinez R, et al. The prevalence of specific psychiatric disorders in Puerto Rico. Archives of General Psychiatry 1987;44:727-5.
57. Rubio-Stipec M, Stipec B, Canino G. Costs of schizophrenia in Puerto Rico. Journal of Mental Health Administration 1994;21:136-44.
58. Steffens DC, Skoog I, Norton MC, Hart AD, Tschanz JT, Plassman BL, et al. Prevalence of depression and its treatment in an elderly population: the Cache County study. Archives of General Psychiatry 2000;57:601-7.
59. Abas MA, Broadhead JC. Depression and anxiety among women in an urban setting in Zimbabwe. Psychological Medicine 1997;27:59-71.