Print version ISSN 0042-9686
Bull World Health Organ vol.82 n.12 Genebra Dec. 2004
Estimation de l'incidence mondiale de la pneumopathie clinique chez les enfants de moins de cinq ans
Estimación mundial de la incidencia de neumonía clínica entre los menores de 5 años
Igor RudanI; Lana TomaskovicII; Cynthia Boschi-PintoIII; Harry CampbellIV, 1 on behalf of WHO Child Health Epidemiology Reference Group
IAssistant Professor, Department of Medical Statistics, Epidemiology and Medical Informatics, School of Public Health "Andrija Štampar", Zagreb, Croatia
IITechnical Officer, Child and Adolescent Health and Development, World Health Organization, Geneva, Switzerland
IIIMedical Officer, Child and Adolescent Health and Development, World Health Organization, Geneva, Switzerland
IVProfessor, Public Health Sciences, University of Edinburgh Medical School, Teviot Place, Edinburgh EH8 9AG, Scotland (email: email@example.com)
OBJECTIVE: Clinical pneumonia (defined as respiratory infections associated with clinical signs of pneumonia, principally pneumonia and bronchiolitis) in children under five years of age is still the leading cause of childhood mortality in the world. In this paper we aim to estimate the worldwide incidence of clinical pneumonia in young children.
METHODS: Our estimate for the developing world is based on an analysis of published data on the incidence of clinical pneumonia from community based longitudinal studies. Among more than 2000 studies published since 1961, we identified 46 studies that reported the incidence of clinical pneumonia, and 28 of these met pre-defined quality criteria.
FINDINGS: The estimate of the median incidence from those studies was 0.28 episodes per child-year (e/cy). The 2575% interquartile range was 0.210.71. We assessed the plausibility of this estimate using estimates of global mortality from acute respiratory infections and reported case fatality rates for all episodes of clinical pneumonia reported in community-based studies or the case-fatality rate reported only for severe cases and estimates of the proportion of severe cases occurring in a defined population or community.
CONCLUSION: The overlap between the ranges of the estimates implies that a plausible incidence estimate of clinical pneumonia for developing countries is 0.29 e/cy. This equates to an annual incidence of 150.7 million new cases, 1120 million (713%) of which are severe enough to require hospital admission. In the developed world no comparable data are available. However, large population-based studies report that the incidence of community-acquired pneumonia among children less than five years old is approximately 0.026 e/cy, suggesting that more than 95% of all episodes of clinical pneumonia in young children worldwide occur in developing countries.
Keywords: Pneumonia/epidemiology/mortality; Bronchiolitis/epidemiology/mortality; Child, Preschool; Incidence; Longitudinal studies; Meta-analysis; Developing countries (source: MeSH, NLM).
OBJECTIF: La pneumopathie clinique (définie comme l'ensemble des infections respiratoires associées à des signes cliniques de pneumopathie, principalement la pneumonie et la bronchiolite) chez l'enfant de moins de cinq ans reste la cause majeure de mortalité infantile dans le monde. Le but de cet article est d'estimer l'incidence mondiale de la pneumopathie clinique chez les jeunes enfants.
MÉTHODES: L'estimation pour les pays en développement repose sur l'analyse des données publiées au sujet de l'incidence de la pneumopathie clinique et tirées d'études longitudinales en communauté. Les auteurs ont établi que, parmi les plus de 2000 études publiées depuis 1961, 46 rapportent l'incidence de la pneumopathie clinique et 28 répondent aux critères de qualité prédéfinis.
RÉSULTATS: D'après ces études, l'incidence médiane est estimée à 0,28 épisode par enfant - année (ép./e.a). L'intervalle interquartile 25-75 % correspond à 0,21-0,71 ép./e.a. Les auteurs ont évalué la plausibilité de cette estimation à partir d'estimations de la mortalité mondiale par infections respiratoires aiguës et des taux de létalité indiqués pour l'ensemble des épisodes de pneumopathie clinique rapportés dans les études en communauté ou du taux de létalité indiqué uniquement pour les cas graves et des estimations de la proportion de cas graves survenant dans une population ou une communauté définie.
CONCLUSION: D'après le recouvrement entre les intervalles de fiabilité des estimations, on peut conclure que 0,29 ép/e.a constitue une estimation plausible de l'incidence de la pneumopathie clinique dans les pays en développement. Ce chiffre équivaut à une incidence annuelle de 150,7 millions de nouveaux cas, dont 11 à 20 millions (7 à 13 %) sont des cas suffisamment graves pour imposer une hospitalisation. On ne dispose pas de données comparables pour le monde développé. Cependant, des études en populations de grande ampleur indiquent que l'incidence des pneumopathies contractées dans la communauté chez les enfants de moins de cinq ans est d'approximativement 0,026 ép/e.a, ce qui laisse à penser que plus de 95 % de l'ensemble des épisodes de pneumopathie clinique chez les jeunes enfants dans le monde surviennent dans les pays en développement.
Mots clés: Pneumonie/épidémiologie/mortalité; Bronchiolite/épidémiologie/mortalité; Enfant âge pré-scolaire; Incidence; Etude longitudinale; Méta-analyse; Pays en développement (source: MeSH, INSERM).
OBJETIVO: La neumonía clínica (definida como las infecciones respiratorias asociadas a signos clínicos de neumonía, principalmente neumonía y bronquiolitis) entre los menores de 5 años es todavía la principal causa de mortalidad en la niñez en el mundo. En este artículo hacemos una estimación de la incidencia mundial de neumonía clínica en los niños pequeños.
MÉTODOS: Nuestras estimaciones para los países en desarrollo se han basado en un análisis de los datos publicados en estudios longitudinales comunitarios sobre la incidencia de neumonía clínica. Entre los más de 2000 estudios publicados desde 1961, identificamos 46 en los que se notificaba la incidencia de neumonía clínica, 28 de los cuales reunían los criterios de calidad preestablecidos.
RESULTADOS: La incidencia mediana estimada obtenida a partir de esos estudios fue de 0,28 episodios por niño y año (e/na). El intervalo intercuartílico 25%-75% fue de 0,210,71. Evaluamos la verosimilitud de esos valores empleando estimaciones de la mortalidad mundial por infecciones respiratorias agudas y las tasas de letalidad registradas para todos los episodios de neumonía clínica notificados en estudios comunitarios, o bien la tasa de letalidad notificada sólo para los casos graves y las estimaciones de la proporción de casos graves que ocurrían en una determinada población o comunidad.
CONCLUSIÓN: Considerando el solapamiento de los márgenes de las estimaciones, una estimación verosímil de la incidencia de neumonía clínica en los países en desarrollo es la cifra de 0,29 e/na. Esto equivale a una incidencia anual de 150,7 millones de casos nuevos, de los cuales unos 11-20 millones (7%13%) son suficientemente graves para requerir hospitalización. En el mundo desarrollado no se dispone de datos comparables. Sin embargo, diversos estudios poblacionales muestran que la incidencia de neumonía adquirida en la comunidad entre los niños menores de cinco años es aproximadamente de 0,026 e/na, lo que lleva a pensar que más del 95% de todos los episodios de neumonía clínica que sufren los niños pequeños en todo el mundo se dan en los países en desarrollo.
Palabras clave: Neumonía/epidemiología/mortalidad; Bronquiolitis/epidemiología/mortalidad; Preescolar; Incidencia; Estudios longitudinales; Meta-análisis; Países en desarrollo (fuente: DeCS, BIREME).
Acute respiratory infections (ARI) in children less than five years old are the leading cause of childhood mortality in the world. Most of these deaths are caused by pneumonia and bronchiolitis. WHO estimated that the annual number of ARI-related deaths in this age group (excluding those caused by measles and pertussis and neonatal deaths) was 2.1 million (1), accounting for about 20% of all childhood deaths. This was based largely on estimates of mortality published by Williams et al. (2). The primary aim of this paper is to estimate the incidence of pneumonia and bronchiolitis in the developing world. This can be considered a close approximation of the global incidence of these conditions because nearly 90% of children less than five years old live in developing countries (2), and the incidence of these diseases is substantially greater among children in developing countries (3, 4). This work was commissioned and directed by the Child Health Epidemiology Reference Group (CHERG) which is coordinated by the Department of Child and Adolescent Health (CAH) of WHO, and the estimates obtained were subject to critical review by this group.
Acute lower respiratory infections (ALRI) are defined in the International statistical classification of diseases and related health problems, tenth revision, as those infections that affect the airways below the epiglottis. These include acute manifestations of laryngitis, tracheitis, bronchitis, bronchiolitis, lung infections, any combination of these, or any of these along with upper respiratory infections, including influenza. The focus of the global burden of disease programme has been on conditions accounting for a substantial loss of disability-adjusted life years. Within CHERG, a decision was made to concentrate on pneumonia and bronchiolitis because these are considered to be the major components of ALRI that account for the global burden of disease from acute respiratory infections among young children. This approach is consistent with the WHO approach to the case management of ARI, which was introduced first by the programme for the control of ARI in order to standardize and facilitate clinical decision-making in places with limited resources and which has now been incorporated into the global Integrated Management of Childhood Illness, or IMCI, programmes. IMCI programmes train health workers to identify fast breathing, lower chest wall indrawing or selected danger signs in children with respiratory symptoms (such as cyanosis or an inability to drink). For the programme's purposes, these are labelled "pneumonia", although it is recognized that children identified in this way include those with pneumonia, bronchiolitis and a proportion of those with reactive airways disease associated with a respiratory infection. The studies reviewed in this paper have adopted this approach and we have called the conditions identified "clinical pneumonia". The review thus reports episodes of pneumonia, bronchiolitis and, in some studies, reactive airways disease associated with respiratory infections; it does not report episodes of acute laryngitis, bronchitis or tracheitis.
Our estimate is based on an analysis of published data on the incidence of clinical pneumonia from community-based longitudinal studies that met pre-defined quality criteria (532). We assessed the plausibility of our estimate (and the internal consistency of incidence, mortality and case-fatality data) in two ways. The first approach was based on the reported total number of childhood deaths due to ARI (1) and our best approximation of the case-fatality rate from all cases of clinical pneumonia in a community (21, 22, 33, 34). The second approach was based on the reported total number of childhood deaths due to ARI (1), reported case-fatality rates only for severe episodes of clinical pneumonia (those that require hospital admission) (26, 3545), and estimates of the proportion of severe cases in a defined population or community (1, 5, 8, 20, 23, 46, 47).
Box 1 details the research plan. The initial literature review was performed by searching Medline, Science Citation Index and Current Contents for data from the period 19612000. Search terms included acute (lower) respiratory infections, bronchiolitis, croup, pneumonia, tracheobronchitis, children, under five years, developing countries, incidence, mortality, epidemiology, and combinations of these terms. Free text searches were performed in the title and abstract fields in PubMed and Ovid. The WHO library database (WHOLIS) was searched for journals, documents, publications and reports not indexed on Medline. Additional electronic databases searched included the WHO Statistical Information System (WHOSIS), UNICEF, the UN Population Division, and the US Centers for Disease Control and Prevention's National Center for Health Statistics database; this last resource also pointed us towards significant reports from unpublished "grey" literature including national reports and unpublished studies (A Marx, unpublished data, 2000).
After reviewing more than 2000 studies, we selected the most informative studies. These studies estimated the incidence of clinical pneumonia among children less than five years old in a developing country or provided information that helped us to understand the determinants of clinical pneumonia occurrence, aetiology, clinical features, management, case-fatality rate or outcome in developing countries. A pre-defined set of key data was extracted systematically from each study and recorded in an electronic database. (This information is available from http://www.who.int/child-adolescent-health/New_Publications/Overview/ari_db.htm.)
The review then focused on studies that met the minimum quality criteria (Box 1). The minimum criteria were that:
community-based surveillance of a defined population of children had to have been carried out for a minimum period of one year (and in multiples of 12 months) because clinical pneumonia has such a markedly seasonal nature;
the study had to use a strategy of active case detection. The surveillance interval had to be 2 weeks or shorter to minimize recall bias;
case definitions had to be clearly defined and consistently applied.
Applying these criteria yielded 28 studies that formed the basis of this review. Their geographical distribution and reported incidence rates are shown in Fig. 1, and their characteristics are summarized in Table 1, web version only, available at: http://www.who.int/bulletin.
An attempt was made to ensure that the reported incidence rates across a full age range of 04 years were comparable between the studies. When different incidence rates were provided for several cohorts within the same study (e.g., separately by village or sex), a weighted mean was calculated. In cases where intervention studies were undertaken, only the incidence rate in the control ("no intervention") arm of the trial was used in the analysis. When studies reported incidence only for restricted age ranges of children (e.g., 0.53 years), an adjustment to the full age range was performed. This was based on the mean age-specific incidence ratios obtained from five studies that reported incidence separately for each of the 1-year age groups (5, 14, 26, 27, 32). Relative to an incidence of 1.0 in the first year of life, the mean ratios across the five studies for the other four years were 0.58 (year 2), 0.48 (year 3), 0.31 (year 4) and 0.19 (year 5). These ratios were used to adjust reported incidences to the full 04 year age range when necessary.
Controlling for differences in study design
We needed to ensure that all of the longitudinal studies were measuring the same entity using comparable study designs or to introduce appropriate corrections if this was not the case. Our main concern was that differences in case definitions might produce estimates that were not comparable. A simple classification of ARI into three categories according to severity was proposed by WHO in 1985 to define a classification system that would be useful in community-based studies in developing countries (48). The WHO ARI classification system defines episodes of ARI as:
(1) severe if there is cough and chest indrawing, cough and not being able to drink, or stridor at rest (requiring hospital referral);
(2) moderate if there is cough and fast breathing but no chest indrawing (requiring home treatment with antimicrobials and supportive measures); or
(3) mild if there is cough without fast breathing (< 50 breaths per minute) and no chest indrawing, with sore throat, ear discharge for more than 2 weeks and blocked or runny nose (requiring home treatment with supportive measures only).
In each of the 28 studies, we were primarily interested in determining whether clinical pneumonia was diagnosed by a non-physician (i.e., a trained field worker or lay reporter) or a physician or paediatrician. In these studies, trained field workers or lay reporters based their diagnosis of clinical pneumonia on whether a child had a respiratory rate at or above the threshold of 50, or lower chest wall indrawing (which is included in the moderate or severe category of the WHO ARI classification), or both (49, 50). The physicians based their diagnosis on experience and supported it with chest auscultation to identify signs consistent with pneumonia or bronchiolitis.
We aimed to investigate whether non-physicians were likely to overdiagnose cases regardless of how strict the criteria were that they used. Therefore, using their definition of a case, we divided all 28 studies into either category I (diagnosis established by non-physicians) or category II (diagnosis established by physicians). Our hypothesis was that studies in category II would generally report lower estimates of incidence. Table 1 (web version only, available at: http://www.who.int/bulletin) shows whether diagnosis was done by a physician or non-physician for the majority of cases of clinical pneumonia in the community by study.
To further explore the possible effects of differences in case definition on incidence, we studied the diagnostic criteria used within the group of studies in which non-physicians had the principal role in diagnosis (that is, category I studies). Among those we identified studies in which the diagnostic criteria were based on WHO definition only (called category I-A) or also included 13 additional criteria, such as cyanosis or shock (called category I-B), or four or more such criteria (category I-C). We presumed that the more additional criteria there were, the lower the estimates should be. Also, in some studies within category I, case definitions also allowed for wheeze (classified as W+), which could bias the estimates upwards, or required crepitations to be heard on auscultation (designated as C+/R+), which might lower the estimates. Appendix 1 (web version only, available at: http://www.who.int/bulletin) gives further details on how we developed four case definition variables to explore the possible effects of these differences.
Understanding determinants of variation in incidence of clinical pneumonia
We treated all 28 studies as random data points from their specific setting within the developing world, each of which was needed to produce a global estimate. Thus, their results needed adjustment only for differences in study design and not for differences in settings. However, an additional attempt was made to improve our understanding of the determinants of variations in incidence by investigating the effects of 15 variables related to the design or setting of each study. Most of these variables were quantitative (altitude, annual rainfall, average annual temperature, median year of study, mean cohort size, duration of study and duration of surveillance intervals). These are shown in detail in Table 1 (web version only, available at: http://www.who.int/bulletin). Qualitative variables (information on population, who diagnosed clinical pneumonia, place of diagnosis, risk of malaria and ALRI case definition) were specifically categorized (Table 2 (web version only, available at: http://www.who.int/bulletin)).
To investigate the effect of case definition on the estimated incidence, four different case definition variables (CDV1CDV4) were developed (Appendix 1, (web version only, available at: http://www.who.int/bulletin)). A number of other factors known to be related to the incidence of clinical pneumonia (such as prevalence of malnutrition, low birth weight, whether the child had been breastfed, incomplete vaccination status, or overcrowding at home) were not reported consistently enough to be included in the regression model (although their national prevalence was used in a subsequent study to produce estimates for WHO regions). The correlation between the 15 variables and the estimates of the incidence of clinical pneumonia was first investigated through univariate regression analysis. Because the number of studies included was relatively small, only the six variables that had the most significant correlation with incidence were entered into the multiple regression analysis. The other variables were omitted to ensure that the number of studies is approximately five times greater than the number of selected variables, to improve the statistical power of this analysis. Statistical analysis was done using Systat 7.0 for Windows software and the Poisson regression model.
Estimation of incidence and ranges
Because the incidence reported in the individual studies reflect only their specific settings, their results should not necessarily be viewed as representative of the country or region where the study took place. However, each study represents a valid incidence estimate from the surveillance of a number of populations in developing countries that are widely scattered across the world (Fig. 1). Our estimate of the incidence in developing countries is thus based on the median incidence from 28 community-based studies. The burden of clinical pneumonia among the minority of children less than five years old who live in developed countries (about 13% of children less than five years old worldwide (1)) was inferred from the population estimate for the year 2000 by the United Nations Population Division and population-based studies of the incidence of clinical pneumonia in the United States of America and the United Kingdom (3, 4).
We assessed the plausibility (and internal consistency with other related data) of the estimate for the developing world using two approaches. In the first approach, global ARI mortality was divided by the median, 25th and 75th percentile values of case-fatality rates for all clinical pneumonia reported in the literature. In the second approach, global ARI mortality was divided by the median, 25th and 75th percentile values of reported case-fatality rates only for severe cases of pneumonia, and also by the median, 25th and 75th percentile values of the proportions of all clinical pneumonia cases reported as severe (requiring admission to hospital).
Table 1 (web version only, available at: http://www.who.int/bulletin) summarizes the data on study design and incidence from the 28 studies that satisfied the inclusion criteria (532). They are listed in chronological order and classified according to WHO region. Most of the studies were performed in the following regions: the South-East Asia Region (11 studies; eight in subregion D and three in subregion B), the Western Pacific Region (six studies; all in subregion B), the African Region (four studies; all in subregion D), and the Region of the Americas (four studies; all in subregion B). Only two studies were available from subregion D of the Region of the Americas and only one study from subregion E of the African Region; none were available from the Eastern Mediterranean Region. (See http://www.who.int/about/contactregional/en/ for details of WHO regions.)
The majority of studies (19; 68%) were performed in the late 1980s. Fourteen studies were performed in rural populations, seven in suburban areas, six in urban areas, and one study covered several different populations. Seven studies were carried out near sea level, while seven others investigated populations living at an altitude higher than 1500 m. The average annual rainfall at the study sites ranged from almost none in Peru to 2500 mm in Costa Rica. The mean annual temperatures ranged from 15 ºC in China to 29 ºC in Thailand. The period of follow-up was 1 year in 12 studies, 2 years in nine studies, and 3 years in seven studies. The size of the cohort was fewer than 300 children in six studies, 3001000 in 12 studies, and more than 1000 in 10 studies. The surveillance intervals were weekly or more frequently in 18 studies (64%). In eight studies physicians or paediatricians established the diagnosis; in 11 diagnosis was performed solely by lay reporters or trained field workers; and in nine studies trained field workers were principally involved in establishing the diagnosis, but subsets of children under surveillance were checked or field workers were assisted by physicians. In 20 studies (71%) the incidence was reported across the full age range (04 years), while in eight it was adjusted as described earlier.
Two studies (from the Gambia and Peru) reported on both clinical pneumonia as defined by clinical criteria and radiologically confirmed pneumonia. These studies reported that the percentage of radiologically confirmed pneumonia was only 2436% of the estimates of the incidence as measured by community surveillance.
Reports of the percentage of episodes considered severe from four studies ranged from 612%. The generalizability of these four studies is not known. (The mean incidence from these studies is higher than from all 28 studies.) The estimated incidence was less than 0.1 episode per child-year (e/cy) in four studies, 0.10.5 e/cy in 14 studies, 0.61.0 e/cy in four studies, and more than 1.0 e/cy in six studies. The variation in estimates of incidence seemed large and had a bimodal distribution (Fig. 1). However, this is perhaps not surprising given the wide variety of risk factors underlying the incidence of clinical pneumonia in developing countries. We considered these risk factors further in our subsequent study on incidence in different WHO regions. For the purpose of this study it was important to ensure that elements of study design (the case definition of clinical pneumonia in particular) were not responsible for systematic deviations in incidence. To account for this, a multiple regression analysis was performed to determine the effects of 15 study characteristics on incidence.
The multiple regression analysis of variables that could influence reported incidence was limited to those variables that were provided in the majority of published reports. The main purpose was to determine whether any further adjustment needed to be made to the incidence because the four case definitions significantly affected the estimates. In the initial univariate analysis, only the most basic difference in case definition (WHO criteria compared with physician's assessment) showed any correlation with reported incidence, but it was a rather weak correlation. In studies that allowed episodes of wheezing to be scored as clinical pneumonia or which extended the definition to also include findings on chest auscultation or additional rarer features of clinical pneumonia (such as cyanosis and heart failure), we were unable to demonstrate any significantly increased estimates of incidence under any model (Table 2, web version only, available at: http://www.who.int/bulletin).
In order to increase the statistical power of the analysis, given the small number of data points and the large number of variables, the six most significant predictors from the initial analysis were entered into the multiple regression analysis. This showed that only annual rainfall and the place where the child was diagnosed were statistically significantly correlated with incidence. Since both of these factors reflect the setting of the study rather than the design of the study, we concluded that there was no need for further adjustment.
The effect of annual rainfall on overall incidence has not been reported previously. We investigated whether this effect might be due to the misclassification of malaria episodes (presenting as fast breathing) by categorizing studies by level of intensity of transmission of falciparum malaria. There was no evidence to support the idea of misclassification. Some of the alternative hypotheses to be explored further are the relationship of the amount of time children spend crowded together indoors, higher risks of transmission of respiratory infections in rainy climates and the greater bacterial superinfection of viral ARI episodes in humid conditions.
Table 3 presents the annual estimates of clinical pneumonia for the year 2000 for developing countries (where the total population of children aged 04 years is estimated to be 523.3 million) using the approaches described in the Methods section. The median estimate of incidence was 0.28 episodes per child-year. The 2575% interquartile range of the estimate was 0.21-0.71 e/cy.
To check the plausibility of the main estimate we used two approaches. The first approach was based on global ARI mortality and reported case-fatality rates for all clinical pneumonia. This was less robust than the above estimate since we could only identify four community-based studies that gave a valid estimate of the case-fatality rate. These estimates varied quite widely: 0.2%, 1.3%, 2.6% and 3.2% (21, 22, 33, 34). This yielded a median incidence of 0.20 e/cy (2575% interquartile range 0.150.31).
The second approach was based on the proportion of cases of severe clinical pneumonia acquired in the community and the reported case-fatality rate for severe cases. Estimates of the case-fatality rate were available from 12 studies (26, 3545) and ranged from 6.614.1%. Similarly, the proportion of severe community-acquired episodes was available from six community-based studies (5, 8, 20, 23, 46, 47) and ranged from 5.916.8%. This produced a median incidence of 0.44 e/cy with a range of 0.280.76 e/cy (based on the 2575% interquartile ranges of case-fatality rates and of reported proportions of severe clinical pneumonia).
The ranges obtained by the main approach and the two ancillary approaches overlap between the values of 146 million and 159 million new episodes of clinical pneumonia per year. Giving the most weight to the estimate obtained through the main approach, but also taking into account the results of the other two approaches, the analyses suggest that the most plausible point of overlap is close to 0.29 e/cy. This equates to 150.7 million new cases of clinical pneumonia, 1120 million (713%) of which are severe enough to require hospital admission.
We were unable to identify any population-based studies from developed countries that used active surveillance and similar case definitions. In Table 3 we show the median estimate of incidence in young children reported in four large population-based studies in the United States and Europe. This median estimate of 0.026 e/cy (3, 4, 51, 52) is approximately 10% of the estimate of clinical pneumonia in developing countries, but these results are not directly comparable because the studies used different methods of case ascertainment and different definitions. However, this estimate represents 2.1 million cases of pneumonia occurring in a population of 81.6 million children less than five years old in developed countries (1).
The number of studies from developing countries that we judged to meet a limited number of essential quality criteria was small. Summarizing the findings of these studies is complicated by differences in their design and settings. Some of the communities being studied could have had particularly high mortality from ARI, thus further limiting the generalizability of the findings. None of the studies reported the incidence of clinical pneumonia in areas where there is a high prevalence of HIV. It is clear, therefore, that despite our efforts to identify valid estimates and to control for confounding and modifying factors, estimates of ALRI incidence in children in developing countries continue to be uncertain. In particular there is a need for studies to define current incidence in settings where HIV is a significant public health problem. The results of this review should therefore be interpreted with caution.
This review highlights the magnitude of the burden of clinical pneumonia in developing countries where often only mortality is considered. This study's definition of clinical pneumonia encompassed the clinical conditions of pneumonia, bronchiolitis and reactive airways disease associated with respiratory infections (although the proportion of the episodes due to the latter was low in the populations discussed). These episodes result in acute suffering and short-term complications and have a detrimental effect on a child's nutritional status and may also influence the risk of other childhood diseases. In addition, a number of studies have suggested that clinical pneumonia in early childhood may have long-term consequences for respiratory function and health. This review demonstrates the substantial variation in annual incidence among young children in different settings. This points to the potential to intervene against risk factors to prevent clinical pneumonia and significantly reduce the large burden of disease in childhood resulting from clinical pneumonia.
The authors would like to acknowledge the help and guidance of members of the Child Health Epidemiology Reference Group (CHERG) during meetings in Geneva and London at which this work was presented. (List of CHERG members is available on the web version only: http://www.who.int/bulletin)
Funding: This work was supported by the Department of Child and Adolescent Health and Development of WHO and the Bill and Melinda Gates Foundation.
Conflicts of interest: none declared.
1. Murray CJL, Lopez AD, Mathers CD, Stein C. The global burden of disease 2000 project: aims, methods and data sources. Geneva: World Health Organization; 2001. (Global Programme on Evidence for Health Policy, Discussion Paper No. 36, available at http://www3.who.int/whois/burden/papers/discussion%20paper%2036%20revised.doc) [ Links ]
2. Williams BG, Gouws E, Boschi-Pinto C, Bryce J, Dye C. Estimates of world-wide distribution of child deaths from acute respiratory infections. Lancet Infectious Diseases 2002;2:25-32. [ Links ]
3. Jokinen C, Heiskanen L, Juvonen H, Kallinen S, Karkola K, Korppi M, et al. Incidence of community-acquired pneumonia in the population of four municipalities in Eastern Finland. American Journal of Epidemiology 1993;137:977-88. [ Links ]
4. Weigl JA, Bader HM, Everding A, Schmitt HJ. Population-based burden of pneumonia before school entry in Schleswig-Holstein, Germany. European Journal of Pediatrics 2003;162:309-16. [ Links ]
5. Campbell H, Byass P, Lamont AC, Forgie IM, O'Neill KP, Lloyd-Evans N, et al . Assessment of clinical criteria for identification of severe acute lower respiratory tract infections in children. Lancet 1989;1:297-9. [ Links ]
6. Oyejide CO, Osinusi K. Acute respiratory tract infection in children in Idikan Community, Ibadan, Nigeria: severity, risk factors and severity of occurence. Reviews of Infectious Diseases 1990;12 Suppl 8:S1042-6. [ Links ]
7. Afari EA, Sakatoku H, Nakano T, Binka F, Assoku A. Acute respiratory infections in children under five in two rural communities in southern Ghana. Japanese Journal of Tropical Medicine and Hygiene 1991;19:275-80. [ Links ]
8. Fagbule D, Parakoyi DB, Spiegel R. Acute respiratory infections in Nigerian children: prospective cohort study of incidence and case management. Journal of Tropical Pediatrics 1994;40:279-84. [ Links ]
9. Wafula EM, Onyango FE, Mirza WM, Macharia WM, Wamola I, Ndinya- Achola JO, et al . Epidemiology of acute respiratory tract infections among young children in Kenya. Reviews of Infectious Diseases 1990;12 Suppl 8:S1035-8. [ Links ]
10. James JW. Longitudinal study of the morbidity of diarrheal and respiratory infections in malnourished children. American Journal of Clinical Nutrition 1972;25:690-4. [ Links ]
11. Borrero I, Fajardo L, Bedoya A, Zea A, Carmona F, de Borrero MF. Acute respiratory infections among a birth cohort of children from Cali, Colombia, who were studied through 17 months of age. Reviews of Infectious Diseases 1990;12 Suppl 8:S950-6. [ Links ]
12. Hortal M, Benitez A, Contera M, Etorena P, Montano A, Meny M. A community-based study of acute respiratory tract infections in children in Uruguay. Reviews of Infectious Diseases 1990;12 Suppl 8: S966-72. [ Links ]
13. Barreto ML, Santos LM, Assis AM, Araujo MP, Farenzena GG, Santos PA, et al. Effect of vitamin A supplementation on diarrhoea and acute lower respiratory tract infections in young children in Brazil. Lancet 1994;344:228-31. [ Links ]
14. Cruz JR, Pareja G, de Fernandez A, Peralta F, Caceres P, Cano F. Epidemiology of acute respiratory infections among Guatemalan ambulatory pre-school children. Reviews of Infectious Diseases 1990;12 Suppl 8: S1029-34. [ Links ]
15. Lanata CF: Incidence and evolution of pneumonia at the community level. In: Benguigui Y, Antunano FL, Schmunis G, Yunes J, editors. In: Respiratory infections in children: Integrated Management of Childhood Illness. Washington (DC); Pan American Health Organization, World Health Organization; 1999. p. 59-82. (Series HCT/AIEPI-1.I.) [ Links ]
16. Vathanophas K, Sangchai R, Raktham S, Pariyanonda A, Thangsuvan J, Bunyaratabhandu P, et al. A community-based study of acute respiratory tract infection in Thai children. Reviews of Infectious Diseases 1990;12 Suppl 8: S957-65. [ Links ]
17. Kartasasmita CB, Rosmayudi O, Deville W, Demedts M. Plasma retinol level, vitamin A supplementation and acute respiratory infections in children of 1-5 years old in a developing country. Tuberculosis and Lung Diseases 1995;76:563-9. [ Links ]
18. Dibley MJ, Sadjimin T, Kjolhede CL, Moulton LH. Vitamin A supplementation fails to reduce incidence of acute respiratory illness and diarrhea in preschool-age Indonesian children. Journal of Nutrition 1996;126:434-42. [ Links ]
19. Kamath KR, Feldman RA, Rao PS, Webb JK. Infection and disease in a group of South Indian families. American Journal of Epidemiology 1969;8:375-83. [ Links ]
20. Black RE, Brown K, Becker S. Longitudinal studies of infectious diseases and physical growth of children in rural Bangladesh. American Journal of Epidemiology 1982;115:305-14. [ Links ]
21. Datta N, Kumar V, Kumar L, Singhi S. Application of case management to the control of acute respiratory infections in low-birth-weight infants: A feasibility study. Bulletin of the World Health Organization 1987;65:77-82. [ Links ]
22. Reddaiah VP, Kapoor SK. Acute respiratory infections in rural underfives. Indian Journal of Pediatrics 1988;55:424-6. [ Links ]
23. Pandey MR, Sharma PR, Gubhaju BB, Shakya GM, Neupane RP, Gautam A, et al. Impact of a pilot acute respiratory infection (ARI) control programme in a rural community of the hill region of Nepal. Annals of Tropical Pediatrics 1989;9:212-20. [ Links ]
24. Pandey MR, Daulaire NM, Starbuck ES, Houston RM, McPherson K. Reduction in total under-five mortality in western Nepal through community-based antimicrobial treatment of pneumonia. Lancet 1991;338:993-7. [ Links ]
25. Singh MP, Nayar S. Magnitude of acute respiratory infections in under five children. Journal of Communicable Diseases 1996;28:273-8. [ Links ]
26. Zaman K, Baqui AH, Yunus M, Sack RB, Bateman OM, Chowdhury HR, et al. Acute respiratory infections in children: a community-based longitudinal study in rural Bangladesh. Journal of Tropical Pediatrics 1997;43:133-7. [ Links ]
27. Riley I, Carad E, Gratten H. The status of research in acute respiratory infections in children in Papua New Guinea. Pediatric Research 1983;17:1041-3. [ Links ]
28. Zhang ZJ, Gao LM, Wang ZL, Cao YP, Wu GC, Zhu ZH. Acute respiratory infections in Beijing children: epidemiological studies at Dongguan Brigade. Chinese Medical Journal 1986;99:561-8. [ Links ]
29. Zeng DL, Zhang ZJ, Wang ZL, Zhang JN, Yang ML. Surveillance of acute respiratory infections in three kindergartens in Beijing. Chinese Medical Journal 1988;101:787-92. [ Links ]
30. Tupasi TE, de Leon LE, Lupisan S, Torres CU, Leonor ZA, Sunico ES, et al. Patterns of acute respiratory tract infection in children: a longitudinal study in a depressed community in Metro Manila. Reviews of Infectious Diseases 1990;12 Suppl 8:S940-9. [ Links ]
31. Lehmann D. Mortality and morbidity from acute lower respiratory tract infections in Tari, Southern Highland Province 1977-1983. Papua New Guinea Medical Journal 1991;34 Suppl 1:S174-84. [ Links ]
32. Lehmann D. Epidemiology of acute respiratory tract infections, especially those due to Haemophilus influenzae, in Papua New Guinean children. Journal of Infectious Diseases 1992;165 Suppl 1:S20-5. [ Links ]
33. Hortal M, Contera M, Mogdasy C, Russi JC. Acute respiratory infections in children from a deprived urban population from Uruguay. Revista do Instituto de Medicina Tropical de Sao Paulo 1994;36:51-7. [ Links ]
34. Gordon JE, Ascoli W, Mata LJ, Guzman MA, Scrimshaw NS. Nutrition and infection field study in Guatemalan villages, 1959-1964. VI. Acute diarrheal disease and nutritional disorders in general disease incidence. Archives of Environmental Health 1968;16:424-37. [ Links ]
35. Phillips PA, Lehmann D, Spooner V, Barker J, Tulloch S, Sungu M, et al. Viruses associated with acute lower respiratory tract infections in children from the eastern highlands of Papua New Guinea (1983-1985). Southeast Asian Journal of Tropical Medicine and Public Health 1990;21:373-82. [ Links ]
36. Qazi SA, Rehman GN, Khan MA. Standard management of acute respiratory infections in a children's hospital in Pakistan: impact on antibiotic use and case fatality. Bulletin of the World Health Organization 1996;74:501-7. [ Links ]
37. Johnson AW, Osinusi K, Aderele WI, Adeyemi-Doro FA. Bacterial aetiology of acute lower respiratory infections in pre-school Nigerian children and comparative predictive features of bacteraemic and non-bacteraemic illnesses. Journal of Tropical Pediatrics 1993;39:97-106. [ Links ]
38. Nathoo KJ, Nkrumah FK, Ndlovu D, Nhembe M, Pirie DJ, Kowo H. Acute lower respiratory tract infection in hospitalized children in Zimbabwe. Annals of Tropical Paediatrics 1993;13:253-61. [ Links ]
39. Banajeh SM, al-Sunbali NN, al-Sanahani SH. Clinical characteristics and outcome of children aged under 5 years hospitalized with severe pneumonia in Yemen. Annals of Tropical Paediatrics 1997;17:321-6. [ Links ]
40. Fagbule D, Adedoyin MA, Nzeh DA. Childhood pneumonia in the University of Ilorin teaching hospital. Nigerian Journal of Paediatrics 1987;14:73-8. [ Links ]
41. Ruutu P, Halonen P, Meurman O, Torres C, Paladin F, Yamaoka K, et al. Viral lower respiratory tract infections in Filipino children. Journal of Infectious Diseases 1990;161:175-9. [ Links ]
42. Shann F, Gratten M, Germer S, Linnemann V, Hazlett D, Payne R. Aetiology of pneumonia in children in Goroka Hospital, Papua New Guinea. Lancet 1984;2:537-41. [ Links ]
43. Bahl R, Mishra S, Sharma D, Singhal A, Kumari S. A bacteriological study in hospitalized children with pneumonia. Annals of Tropical Paediatrics 1995;15:173-7. [ Links ]
44. Roy P, Sen PK, Das KB, Chakraborty AK. Acute respiratory infections in children admitted in a hospital of Calcutta. Indian Journal of Public Health 1991;35:67-70. [ Links ]
45. Tupasi TE, Lucero MG, Magdangal DM, Mangubat NV, Sunico ME, Torres CU, et al. Etiology of acute lower respiratory tract infection in children from Alabang, Metro Manila. Rewiews of Infectious Diseases 1990;12 Suppl 8:S929-39. [ Links ]
46. Bashour HN, Webber RH, Marshall TF. A community-based study of acute respiratory infections among preschool children in Syria. Journal of Tropical Pediatrics 1994;40:207-13. [ Links ]
47. Chhabra P, Garg S, Mittal SK, Satyanarayan L, Mehra M, Sharma N. Magnitude of acute respiratory infections in under five. Indian Pediatrics 1993;30:1315-9. [ Links ]
48. World Health Organization. Case management of acute respiratory infections in children in developing countries. Report of a working group meeting. Geneva: World Health Organization; 1984. WHO document WHO/ RSD/85.15, Rev.2. [ Links ]
49. Mulholland EK, Simoes EA, Costales MO, McGrath EJ, Manalac EM, Gove S. Standardized diagnosis of pneumonia in developing countries. Pediatric Infectious Disease Journal 1992;11:77-81. [ Links ]
50. Lanata CF, Quintanilla N, Verastegui HA. Validity of a respiratory questionnaire to identify pneumonia in children in Lima, Peru. International Journal of Epidemiology 1994;23:827-34. [ Links ]
51. McConnochie KM, Hall CS, Barher WH. Lower respiratory tract illness in the fi rst two years of life: epidemiological patterns and costs in a suburban pediatric practice. American Journal of Public Health 1988;78:34-9. [ Links ]
52. Foy HM, Cooney MK, Allan I, Kenny GE. Rates of pneumonia during infl uenza epidemics in Seattle, 19641975. JAMA 1979;139:681-7. [ Links ]
(Submitted: 8 July 2003 Final revised version received: 5 February 2004 Accepted: 10 February 2004)
1 Correspondence should be sent to this author.
List of CHERG members
Robert Black, Johns Hopkins University, USA, Chair; Harry Campbell and Igor Rudan, University of Edinburgh, Scotland, technical experts, ARI; Claudio Lanata and Walter Mendoza, Instituto de Investigación Nutricional, Peru, technical experts, diarrhoea; Alex Rowe and Rick Steketee, US Centers for Disease Control and Prevention, USA, technical experts, malaria; Joanna Schellenberg and Ilona Carneiro, and Arantxa Roca-Feltrer, London School of Hygiene and Tropical Medicine, UK, technical experts, malaria; Joy Lawn, Institute of Child Health, UK, and Zulfiqar Bhutta, Aga Khan University Medical Centre, Pakistan, technical experts, neonatal; Saul Morris and Simon Cousens, London School of Hygiene and Tropical Medicine,UK, technical experts, methods and modelling; Kim Mulholland, Royal Children's Hospital, Australia, technical expert; methods and modelling; Edilberto Loaiza, UNICEF; Jennifer Bryce, Cynthia Boschi-Pinto, Lana Tomaskovic, WHO members of the CHERG Secretariat CAH/FCH; Olivier Fontaine, Shamim Qazi, Martin Weber and José Martines, CAH/FCH/WHO; Colin Mathers and Claudia Stein GPE/EIP/WHO; David Alnwick, Bernard Nahlen and Eline Kohrenromp, RBM/CDS/WHO.