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Print version ISSN 0042-9686
Bull World Health Organ vol.83 n.11 Genebra Nov. 2005
Étude OMS sur la prévention des récidives d'infarctus du myocarde et d'accident vasculaire cérébral (WHO-PREMISE)
Estudio de la OMS sobre la prevención de las recidivas de infarto de miocardio y de accidente cerebrovascular (WHO-PREMISE)
Shanthi MendisI,1; Dele AbegundeI; Salim YusufII; Shah EbrahimIII; Gerry ShaperIV; Hassen GhannemV; Bakuti ShengeliaVI (WHO-PREMISE (Phase I) Study Group)
IWorld Health Organization, Avenue Appia 20, CH-1211 Geneva 27, Switzerland
IIMacMaster University, Ontario, Canada
IIIUniversity of Bristol, Bristol, England
IVRoyal Free and University Medical Schools, London, England
VUniversity Hospital Farhat, Hached, Tunisia
OBJECTIVE: To determine the extent of secondary prevention of coronary heart disease (CHD) and cerebrovascular disease (CVD) in low- and middle-income countries.
METHODS: A descriptive cross-sectional survey of a sample of 10 000 CHD (85.2%) and CVD (14.8%) patients (6252 men; 3748 women) was conducted over 6 months in geographically defined areas. The mean age was 59.2 years (standard deviation (SD), 10.8). Consecutive patients were recruited from a stratified random sample of primary, secondary and tertiary care facilities in defined areas in 10 countries (Brazil, Egypt, India, Indonesia, Islamic Republic of Iran, Pakistan, Russian Federation, Sri Lanka, Tunisia and Turkey). The main outcome measures were levels of lifestyle and physiological risk factors, and the use of drugs for secondary prevention of CHD and CVD.
FINDINGS: Approximately 82%, 89% and 77% of patients were aware of the cardiovascular benefits of quitting smoking, a heart-healthy
diet and regular physical activity, respectively. About half (52.5%) engaged in less than 30 minutes of physical activity per day, 35% did not follow a heart-healthy diet and 12.5 % were current tobacco users. Blood pressure had been measured in 93.8% (range 71100%), blood cholesterol in 85.5% (range 2997%) and blood sugar in 75.5% (range 6599%) in the preceding 12 months. The proportions who had received medications among CHD and CVD patients were: aspirin, 81.2%, 70.6%; beta-blockers, 48.1%, 22.8%; angiotensin-converting enzyme inhibitor, 39.8%, 37.8%; statins, 29.8%, 14.1%, respectively. About one-fifth of patients with CHD had undergone revascularization.
CONCLUSION: A significant proportion of patients did not receive appropriate medications. About 47% of patients had at least two or more modifiable risk factors (smoking, physical inactivity, hypertension, diabetes or hypercholesterolaemia). There are considerable missed opportunities for prevention of recurrences in those with established CVD in low- and middle-income countries.
Keywords: Myocardial ischemia/drug therapy; Cerebrovascular accident/drug therapy; Cardiovascular diseases/drug therapy; Aspirin/therapeutic use; Adrenergic beta-agonists/therapeutic use; Angiotensin-converting enzyme inhibitors/therapeutic use; Hydroxymethylglutaryl-CoA reductase inhibitors/therapeutic use; Life style; Risk factors; Developing countries (source: MeSH, NLM).
OBJECTIF: Déterminer l'ampleur de la prévention secondaire des cardiopathies coronariennes et des accidents vasculaires cérébraux (AVC) dans les pays à revenus faibles et moyens.
MÉTHODES: Une étude descriptive transversale d'un échantillon comprenant 10 000 cas d'AVC (85,2 %) et de cardiopathies coronariennes (14,8 %) et composé de 6252 hommes et 3748 femmes a été menée sur 6 mois dans des zones définies géographiquement. L'âge moyen des malades était de 59,2 ans (écart type : 10,8). Les malades ont été successivement recrutés à partir d'un échantillon stratifié d'installations de soins de santé primaires, secondaires et tertiaires, situées dans des zones définies de 10 pays (Brésil, Égypte, Inde, Indonésie, République Islamique d'Iran, Pakistan, Fédération de Russie, Sri Lanka, Tunisie et Turquie). Les principaux critères d'évaluation utilisés étaient le mode de vie, les facteurs de risque physiologiques et l'utilisation de médicaments pour la prévention secondaire des cardiopathies coronariennes et des AVC.
RÉSULTATS: Environ 82 %, 89 % et 77 % respectivement des malades étaient conscients des bénéfices sur le plan cardiovasculaire d'un arrêt du tabac, d'un régime alimentaire sain pour le cur et d'une activité physique régulière. Environ la moitié (52,5 %) avaient pratiqué moins de 30 min d'activité physique par jour, 35 % n'avaient pas suivi de régime sain pour le cur et 12,5 % étaient encore consommateurs de tabac. Au cours des 12 mois précédents, on avait mesuré la tension artérielle chez 93,8 % en moyenne (71 à 100 % des sujets), le taux de cholestérol sanguin chez 85,5 % en moyenne (29 à 97 %) des sujets et le taux de sucre dans le sang chez 75,5 % en moyenne (65 à 99 %) d'entre eux. Parmi les personnes ayant souffert d'un AVC ou d'une cardiopathie coronarienne, 81,2 et 70,6 % respectivement avaient reçu de l'aspirine, 48,1 et 22,8 % respectivement, des bêtabloquants, 39,8 et 37,8 % respectivement, de l'inhibiteur de l'enzyme de conversion et 29,8 et 14,1 % respectivement, des statines. Environ un cinquième des personnes victimes d'un AVC avaient subi une revascularisation.
CONCLUSION: Une proportion importante des malades n'avait pas reçu de médication appropriée. Environ 47 % d'entre eux présentaient au moins deux facteurs de risque ou plus modifiables (tabagisme, inactivité physique, hypertension, diabète ou hypercholestérolémie). Dans les pays à revenus faibles et moyens, les possibilités non exploitées de prévenir les récidives chez les personnes ayant subi un AVC sont donc considérables.
Mots clés: Ischémie myocardique/chimiothérapie; Accident vasculaire cerebral/chimiothérapie; Cardiovasculaires, Maladies/chimiothérapie; Acide acétylsalicylique/usage thérapeutique; Sympathomimétiques beta/usage thérapeutique; Inhibiteurs dipeptidyl carboxypeptidase I/usage thérapeutique; Inhibiteurs hydroxyméthylglutaryl CoA réductases/usage thérapeutique; Style vie; Facteur risqué; Pays en développement (source: MeSH, INSERM).
OBJETIVO: Determinar el grado de prevención secundaria de la cardiopatía coronaria (CC) y las enfermedades cerebrovasculares (ECV) en los países de ingresos bajos y medios.
MÉTODOS: A lo largo de 6 meses se llevó a cabo un estudio transversal descriptivo de una muestra de 10 000 casos de CC (85,2%) y de ECV (14,8%) (6252 hombres; 3748 mujeres) en varias zonas geográficas delimitadas. La media de edad era de 59,2 años (desviación estándar: 10,8). Se seleccionó a pacientes consecutivos en una muestra aleatoria estratificada de establecimientos de atención primaria, secundaria y terciaria de zonas concretas de 10 países (Brasil, Egipto, India, Indonesia, República Islámica del Irán, Pakistán, Federación de Rusia, Sri Lanka, Túnez y Turquía). Las principales medidas de resultado fueron los niveles de diversos factores de riesgo fisiológicos o relacionados con el modo de vida, y el uso de medicamentos de prevención secundaria de la CC y la ECV.
RESULTADOS: Aproximadamente el 82%, el 89% y el 77% de los pacientes conocían los beneficios cardiovasculares que conllevan dejar de fumar, una dieta cardiosaludable y la actividad física regular, respectivamente. Alrededor de la mitad (52,5%) hacían menos de 30 minutos de actividad física al día, el 35% no seguía una dieta cardiosaludable, y el 12,5% eran fumadores habituales en el momento del estudio. La tensión arterial había sido determinada en un 93,8% de los casos (intervalo: 71%100%), el colesterol sanguíneo en un 85,5% (intervalo: 29%97%) y la glucemia en un 75,5% (intervalo 65%99%) durante los 12 meses precedentes. El porcentaje de pacientes que habían recibido medicamentos entre quienes habían sufrido CC y ECV fueron los siguientes: aspirina, 81,2% y 70,6%; betabloqueantes, 48,1% y 22,8%; inhibidores de la enzima conversora de la angiotensina, 39,8% y 37,8%; y estatinas, 29,8% y 14,1%, respectivamente. Alrededor de una quinta parte de los pacientes con CC habían sido sometidos a revascularización.
CONCLUSIÓN: Una proporción considerable de los pacientes no recibía la medicación adecuada. Alrededor del 47% de los enfermos presentaban dos o más factores de riesgo modificables (tabaquismo, inactividad física, hipertensión, diabetes o hipercolesterolemia). Se están desaprovechando muchas oportunidades para prevenir las recidivas en las personas que han sufrido un accidente cerebrovascular en los países de ingresos bajos y medios.
Palabras clave: Isquemia miocárdica/quimioterapia; Accidente cerebrovascular/quimioterapia; Enfermedades cardiovasculares/quimioterapia; Aspirina/uso terapéutico; betaagonistas Adrenérgicos/uso terapéutico; Inhibidores de la enzima convertidora de angiotensina/uso terapéutico; Inhibidores de la hidroximetilglutaril-CoA reductasa/uso terapéutico; Estilo de vida; Factores de riesgo; Países en desarrollo (fuente: DeCS, BIREME).
Every year about 32 million individuals suffer acute coronary and cerebral vascular events and at least half of these occur in people with established coronary heart disease (CHD) and cerebrovascular disease (CVD) (1, 2). Patients who have suffered a stroke are at an increased risk of a further stroke, about 7% per annum (3). Similarly survivors of myocardial infarction (MI) are at an increased risk of recurrent infarctions and have an annual death rate at least five to six times higher than that of people who do not have CHD (4, 5). Systematically identifying patients who have had MI or stroke and offering them intensive preventive treatment could prevent many vascular events and deaths, improve health related quality of life and reduce the health care costs associated with invasive and expensive revascularization treatment. Thus secondary prevention of major cardiovascular disease (CVD) is recognized as a key component of a cost-effective public health strategy to reduce the rising burden of this disease (6).
Treatment of patients with CHD with aspirin, betablockers, angiotensin converting enzyme inhibitors (ACEI), or lipid-lowering drugs, separately, lowers the risk of future vascular events by about a quarter each. When used in appropriate combinations they can reduce recurrent vascular events by between two-thirds and three-quarters (7, 8). When the potential benefits of quitting smoking for smokers and of lowering blood pressure in hypertensive patients are added to the four-drug regime, it may be possible to lower the risk of future events in high-risk individuals by more than four-fifths (7, 8).
Although cost-effective treatment is available for the prevention of recurrent vascular attacks, many individuals who have suffered MI or stroke are not receiving adequate preventive treatment even in developed countries (915).
There is a scarcity of data related to the secondary prevention of CVD in lower- and middle-income countries, which currently bear 75% of the CVD burden (1). In this context, WHO has initiated a programme on Prevention of REcurrences of Myocardial Infarction and StrokE (WHO-PREMISE) which aims to provide technical cooperation to countries for assessing and scaling up secondary prevention of CVD. Projects have been launched in defined areas in selected countries to assess the current status of secondary prevention (phase 1). The ultimate goal of this programme is to implement evidence-based, affordable and sustainable interventions for secondary prevention, first in the demonstration areas (phase 2) and subsequently on a national scale (phase 3).
Phase 1 of the WHO-PREMISE study is an international multicentre collaborative effort aimed at:
assessing current practice patterns related to secondary preventionof CHD and CVD;
documenting the use of secondary prevention interventions; and
identifying barriers to and opportunities for scaling up secondary prevention.
Methods and data
The WHO-PREMISE study is a descriptive, cross-sectional study involving, at this stage, three low-income and seven middle-income countries (Brazil, Egypt, India, Indonesia, Islamic Republic of Iran, Pakistan, Russian Federation, Sri Lanka, Tunisia and Turkey). The countries were selected according to the following criteria: logistic feasibility of the study; availability of financial and human resources for its continuation; and commitment of the ministries of health to improving the secondary prevention of CVD.
In each country, one geographical area with a population greater than 500 000 people was selected. A stratified random sample of primary and secondary care facilities was drawn from the catchment area of a randomly identified tertiary care facility in each study area. The sample included private, public, urban and rural facilities.
Selection of patients
One thousand consecutive patients were recruited from the study area in each country over a period of 6 months. Approximately 85% of patients were recruited from the outpatient clinics of secondary and tertiary health care facilities and the remainder from primary health care facilities. The recruitment criteria were: previous MI, stable angina, unstable angina, percutaneous transluminal coronary angioplasty (PTCA), coronary artery bypass graft (CABG), stroke, transient ischaemic attack (TIA) or carotid endarterectomy. Patients were included if their first cardiovascular event had occurred more than 1 month but not later than 3 years ago. The diagnosis was verified by checking the patient's health records. The overall response rate was 80%.
During a period of 6 months (in 200203), the patients recruited from outpatient clinics were asked to participate in a 30-minute interview. After obtaining informed consent from the patients, interviews were conducted by a trained research assistant using a standardized questionnaire. The following data were collected: demographic and personal details, information on exposure to risk factors, knowledge of and attitude to risk factors, adherence to treatment and perceived barriers, access to care, and availability and affordability of drugs. The presence of diseases and risk factors was recorded based on self-report. The drugs taken were verified by inspecting tablets, past prescriptions, medical records and diagnosis cards.
Training and standardization
The following procedures were used to ensure standardization and high quality of the data: an operations manual; training workshops for national coordinators and research assistants; protocols that described the recruitment criteria, data collection and interview techniques; and detailed notes outlining problems with data collected at specific sites which were compiled and sent periodically to the sites concerned.
Forty-three of the 10 000 questionnaires were excluded from the analysis because they were incomplete. We conducted univariate analysis by descriptive statistics of the relevant variables. Means and standard deviations were obtained for quantitative variables; relative frequencies were derived for qualitative variables. Bivariate analysis was applied to categorical data, where appropriate, using a c2 test. Multivariate analysis using logistic regression was performed to adjust for potential confounding factors with a 5% significance level. Only variables significant at the 5% bivariate level were included in the multivariate model (see the list of variables in Table 1 (web version only, available at: http://www.who.int/bulletin) and Table 2).
The ethics committee of each study centre sought ethical approval. Informed consent was obtained from each patient prior to participation. All data at the project office were kept secure and anonymous. No subject identifiers appeared on any files transmitted to any committee or any clinical centre.
Baseline characteristics, modes of payment and access to facilities
The mean age of patients in the study was 59.2 years (standard deviation (SD), 10.8). About 45.6% of patients were aged more than 60 years, and 22.5% less than 50 years. These younger patients made up more than 30% of the study population in three of the 10 countries. Table 3 shows the age distribution of patients by country. The majority were men (62.1%). Although women comprised 37.9% of the study sample there was a wide variation between countries in the percentage of women recruited (14.5%54.5%). The extent to which these data reflect differences in disease prevalence and/or barriers to access to heath care is not clear.
About 52% of patients had had secondary education or above, 19% had had primary school education and 29.2% had had no formal education (Table 4, web version only, available at: http:www.int/bulletin).
Almost half of the patients (48.7%) paid some or all of the costs of their health care. However, the percentage of patients making full or partial financial contributions varied widely, ranging from 2.5% to 88.8% in different countries. In no country were health-care services free at the point of use. A primary health care facility was the first point of access for 30.6% (range 10.665.9%) of the patients for their most recent cardiovascular event, including for acute MI.
Knowledge of lifestyle-related risk factors and healthy behaviours
Approximately 82%, 89% and 77% of patients were aware of the cardiovascular benefits of quitting smoking, a heart-healthy diet and regular physical activity, respectively. Doctors were the main source of patients' knowledge about lifestyle risk factors. Most patients were aware that they should consume less fat (91.1%), less salt (86.2%) and more fruits (84.7%). Fewer patients (69.9%) were aware of the benefits of consuming fish. About 35% (range 8.257.0%) of patients reported difficulties in complying with dietary advice, due mainly to the expense and lack of availability of healthy food items.
In response to questions on their physical activity, 52.5% of study participants reported no engagement in regular moderate physical activity (at least 30 minutes a day). The main reasons reported for inadequate physical activity were: the belief that physical activity has negative effects on health (25.8%), lack of time (10.7%) and lack of facilities (10.9%). A higher percentage of patients with formal education (50%) than uneducated patients (40%) engaged in physical exercise during their leisure time (c2 = 93.75; degrees of freedom, 2; P < 0.001).
Medications for secondary prevention
Aspirin had been prescribed to 79.6% of CVD patients (range 64.894.4%), beta-blockers to 44.2% (range 8.969.2%), ACEI to 39.5% (range 10.468%) and statins to 19.6% (range 3.739.1%). Among patients with CHD, 18.8% did not receive aspirin, 51.9% did not receive beta-blockers, 60.2% did not receive ACEI and 79.2% did not receive statins (Table 5).
Measurement and prevalence of cardiovascular risk factors
On average, 94% (range 71100%) of all CVD patients reported that their blood pressure had been measured within the last 12 months and since the last acute event. The percentage who reported a blood cholesterol check-up ranged from 29% to 97% (mean 86%), and was less than 40% in two countries. The percentage of patients who reported having their blood sugar measured during the past 12 months was, on average, 76%, and ranged from 65% to 99% across countries.
On average, 12.5% (range 619%) of the patients were current smokers. Past smokers constituted 26.8% of the total study population, but there was great variability between countries (range 4%48%). On average, 67.7% of patients reported high blood pressure and 40.3% high levels of blood cholesterol. About one-third (31.5%) of patients reported that they had diabetes. Analysis of the extent of exposure to risk factors, found that an average of only 16.2% of patients had no major coronary risk factors. About 46.6% of patients were exposed to at least two risk factors, and 16.4% at least three.
Sociodemographic and clinical characteristics and use of medication
Table 1 (web version only, available at: http:www.int/bulletin) summarizes the bivariate association between the use of medications and the sociodemographic and clinical parameters of all CVD patients. Higher reported number of hospitalizations, high blood cholesterol and high blood pressure were associated with increased use of most or all medications. Use of statins was particularly associated with being male, younger age, higher educational attainment and revascularization. Mode of payment (free versus part or full payment) was not associated with statin use, but free treatment was associated with increased use of aspirin and reduced use of ACEIs.
Table 2 presents a multivariate analysis of predictors for the use of each medication among patients with CHD, after adjusting for potential confounding factors. The most significant predictors were as follows:
of aspirin use: current smoking (odds ratio (OR), 1.83; 95% CI, 1.352.50) and male gender (OR, 1.53; 95% CI, 1.311.79);
of beta blocker use: reported high blood pressure (OR, 1.36; 95% CI, 1.211.52) and current smoking (OR, 1.32; 95% CI, 1.101.58);
of ACE inhibitor use: reported high blood pressure (OR, 1.74; 95% CI, 1.551.95) and male gender (OR, 1.16; 95% CI, 1.031.30);
of statin use: reported high blood cholesterol (OR, 4.34; 95% CI, 3.774.99), PTCA or CABG surgery (OR, 2.37; 95% CI, 2.072.72) and male gender (OR, 1.29; 95% CI, 1.111.49).
This study was conducted to gain an overview of the situation and identify barriers to secondary prevention of CVD in low- and middle-income countries. However the results of the study should be interpreted with caution. It should be recognized that the study has some limitations in terms of its generalizability. The data do not represent national profiles and therefore should not be used for comparisons between different countries. Sampling of patients from health-care facilities introduces a selection bias. Patients who attend outpatient clinics are likely to differ from the general population with regard to their health-seeking behaviour and access to health services. Also, in our study, the patients recruited from primary care facilities constituted only 15% of the sample. The situation regarding secondary prevention of CVD in the general population and among patients who attend primary care facilities is likely to be far worse than in our sample. Despite these limitations the study provides a useful insight into current practice with regard to secondary prevention.
We are also aware that the design and performance of health systems in various countries might be partly responsible for the differences in secondary prevention of CVD that we found, and health system-specific variables for each country were not included in the multivariate analysis.
Another limitation of this study is that the CVD risk factor profiles were based on patient self-reports which may have questionable validity and may be affected by cultural differences between populations. We tried to minimize the potential biases by using standardized data collection procedures and training of interviewers.
A resource-intensive population-based coverage study is required to address some of these limitations and will be conducted at the same sites in the future.
There is robust scientific evidence for recommending the use of aspirin (16), lipid lowering agents (1719), beta-blockers (20) and ACEI (21) for the secondary prevention of CVD. Recent data from studies in Europe and the USA suggest that there are significant gaps in secondary prevention even in developed countries (2224). For example, a US study based on national registry data, EUROPASPIRE II (European Action on Secondary Prevention by Intervention to Reduce Events) and other European studies have reported suboptimal prescription rates in patients with established CHD (22, 25, 26). Our results corroborate those of EUROASPIRE I and II with respect to the use of aspirin in CHD patients (81.2% in our study compared to 83.9% in EUROASPIRE II (25) and 81% for EUROASPIRE I (23)). The low cost of aspirin and its almost universal availability may explain the similarity of the findings.
The use of beta-blockers, however, was lower in the PREMISE study than in EUROASPIRE II (51.9% versus 66.4%). The use of ACEI in the PREMISE study was quite similar to that reported by EUROASPIRE II (38.8% and 42.7%, respectively). For statins we observed a very low rate of use, 20.8% as opposed to 57.7% reported by EUROASPIRE II. It is of concern that about one-tenth of patients with coronary heart disease in the PREMISE study were not on any medications, not even on aspirin or beta-blockers which are inexpensive and widely available.
The treatment gaps observed in the PREMISE study could have several causes, such as lack of implementation of evidence-based clinical practice by health-care providers; unaffordability and unavailability of medications; and selective prescription of drugs to certain categories of patients, among others (27).
In the PREMISE study 24.5%, 14.5% and 6.2% of patients, respectively, had not had their blood sugar, blood cholesterol and blood pressure checked in the past year. Lack of facilities in health-care centres, the need for patients to pay for tests and differences in health care practice may have contributed to these deficiencies.
In our study, fewer patients reported being smokers (12.5%) than recorded in EUROASPIRE II (21%). Although the potential effects of selection and information bias cannot be ruled out, this might be related to a generally lower prevalence of smoking in the populations of some of the countries participating in the PREMISE study (28). Furthermore the smoking prevalences in the present study were not adjusted for gender and age, and are therefore difficult to compare within our study across countries, and across different studies.
Drug treatment is by no means the only effective method of secondary prevention. Dietary advice, smoking cessation, weight reduction, physical exercise and other non-pharmacological preventive interventions are crucial for improving the cardiovascular risk profile and prognosis of patients with CVD (2932). In our study nearly 84% of patients had risk factors. These findings are in agreement with those of Khot et al. (33) who reported the presence of one or more conventional risk factors in 80.6% of patients with CHD enrolled in 14 international clinical trials.
About a quarter of the patients with CVD held the erroneous belief that they should not engage in physical activity and a significant proportion lacked knowledge and awareness of major lifestyle risks although they were cared for by physicians. If health-care providers do not miss opportunities for patient health education and counselling, this can have a significant positive effect on smoking cessation, patients' dietary habits and physical activity. It is also important to note that a substantial proportion of patients had had no formal education (29.2%), highlighting the need for simple health education messages and methods of communication.
The findings of our study also point to a clear need for capacity building in health care systems in low- and middle-income countries both in terms of infrastructure and human resources. Bearing in mind that in the PREMISE study about one-third of patients accessed primary health care facilities for obtaining treatment, primary health care physicians need to be targeted in continuing medical education programmes related to secondary prevention and should be provided with suitable incentives to engage in clinical prevention. There is considerable potential for improving secondary prevention of CVD through better clinical prevention, particularly in primary health care (34). Repeated advice by health-care professionals to stop smoking is of great importance. Physicians should recognize the importance of documenting smoking status, body mass index and the level of physical activity during follow-up visits (35, 36).
In conclusion, despite the availability of cost-effective interventions, there are significant gaps in secondary prevention of CVD in low- and middle-income countries. There is a need to increase access to preventive drug therapy and to improve the quality of providerpatient relationships. This would ensure that patients benefit fully from available knowledge and medical technology in the secondary prevention of CVD. Health system capacity for managing CVD needs to be enhanced through the development of effective national drug policies, rational and evidence-based selection of medicines for inclusion in national drug lists, affordable prices for pharmaceuticals and sustainable financing and supply systems. Proactive policies are also required to promote clinical prevention, strengthen the infrastructure of health-care facilities particularly at the primary health care level, and to provide continuing medical education to health-care providers. To ensure sustainability of these measures, they need to be supported with complementary population-wide strategies that promote healthy lifestyles. Finally effective information systems are crucial for monitoring the performance of secondary prevention programmes.
Funding: This study was financially supported by the Department for International Development (DFID) of the United Kingdom.
Competing interests: none declared.
1. The World Health Report 2002. Reducing risks, promoting healthy life. Geneva: World Health Organization; 2002. [ Links ]
2. Chambless L, Keil U, Dobson A, Mahonen M, Kuulasmaa K, Rajakangas AM, et al. Population versus clinical view of case fatality from acute coronary heart disease: results from the WHO MONICA Project 19851990. Multinational MONItoring of Trends and Determinants in CArdiovascular Disease. Circulation 1997;96:3849-59. [ Links ]
3. Mehta RH, Eagle KA. Secondary prevention in acute myocardial infarction. BMJ 1998;316:838-42. [ Links ]
4. Royal College of Surgeons. National clinical guidelines for stroke. London: Royal College of Surgeons; 2000. [ Links ]
5. Law MR, Watt HC, Wald NJ. The underlying risk of death after myocardial infarction in the absence of treatment. Arch Int Med 2002;162:2405-10. [ Links ]
6. Secondary prevention of noncommunicable diseases in low- and middle- income countries through community-based and health service interventions. Geneva: World Health Organization; 2002. WHO document WHO/EDM/2000.1.World Health Organization Wellcome Trust meeting report, 13 August 2001. [ Links ]
7. Yusuf S. Two decades of progress in preventing vascular disease. Lancet 2002;360:2-3. [ Links ]
8. Wald NJ, Law MR. A strategy to reduce cardiovascular disease by more than 80%. BMJ 2003;326:1419. [ Links ]
9. McCormick D, Gurwitz JH, Lessard D, Yarzebski J, Gore JM, Goldberg RJ. Use of aspirin, b-blockers, and lipid-lowering medications before recurrent acute myocardial infarction. Arch Int Med 1999;159:561-67. [ Links ]
10. Campbell NC, Thain J, Deans HG, Ritchie LD, Rawles JM. Secondary prevention in coronary heart disease. BMJ 1998;316:1430-34. [ Links ]
11. Ellerbeck EF, Jencks SF, Radford MJ, Kresowik TF, Craig AS, Gold JA, et al. Quality of care for Medicare patients with acute myocardial infarction. JAMA 1995;273:1509-14. [ Links ]
12. The Heart Outcomes Prevention Evaluation Study Investigators. Effects of an angiotensin-converting-enzyme inhibitor, ramipril, on cardiovascular events in high-risk patients. NEJM 2000;342:145-53. [ Links ]
13. Schwartz GG, Olsson AG, Ezekowitz MD, Ganz P, Oliver MF, Waters D, et al. Effects of atorvastatin on early recurrent ischemic events in acute coronary syndromes. JAMA 2001;285:1711-8. [ Links ]
14. Sacks FM, Pfeffer MA, Moye LA, Rouleau JL, Rutherford JD, Cole TG, et al. The effect of pravastatin on coronary events after myocardial infarction in patients with average cholesterol levels. NEJM 1996;335:1001-9. [ Links ]
15. Pitt B, Byington RP, Furberg CD, Hunninghake DB, Mancini GB, Miller ME, et al. Effect of amlodipine on the progression of atherosclerosis and the occurrence of clinical events. Circulation 2000;102:1503-10. [ Links ]
16. Antithrombotic Trialists' Collaboration. Collaborative meta-analysis of randomised trials of antiplatelet therapy for prevention of death, myocardial infarction, and stroke in high risk patients. BMJ 2002;324:7186. [ Links ]
17. Aronow HD, Topol EJ, Roe MT, Houghtaling PL, Wolski KE, Lincoff AM, et al. Effect of lipid-lowering therapy on early mortality after acute coronary syndromes: an observational study. Lancet 2001;357:1063-8. [ Links ]
18. Bucher HC, Griffith LE, Guyatt GH. Systematic review on the risk and benefit of different cholesterol lowering interventions. Arterioscler Thromb Vasc Biol 1999;19:187-95. [ Links ]
19. Law MR, Wald NJ, Rudnicka AR. Quantifying effect of statins on low density lipoprotein cholesterol, ischaemic heart disease, and stroke: systematic review and meta-analysis. BMJ 2003;326:1423-9. [ Links ]
20. Freemantle N, Cleland J, Young P, Mason J, Harrison J. Beta blockade after myocardial infarction: systematic review and meta regression analysis. BMJ 1999;318:1730-7. [ Links ]
21. Pfeffer MA, Braunwald E, Moye LA, Basta L, Brown EJ Jr, Cuddy TE, et al. Effect of captopril on mortality and morbidity in patients with left ventricular dysfunction after myocardial infarction. Results of the survival and ventricular enlargement trial. The SAVE Investigators. NEJM 1992;327:669-77. [ Links ]
22. Fonarow GC, French WJ, Parsons LS, Sun H, Malmgren JA. Use of lipid lowering medications at discharge in patients with acute myocardial infarction: data from the National Registry of Myocardial Infarction 3. Circulation 2001; 103:38-44. [ Links ]
23. EUROASPIRE Study Group. A European Society of Cardiology survey on secondary prevention of coronary heart disease. Principal results. Eur Heart J 1997;18:1569-82. [ Links ]
24. EUROASPIRE II Group. Lifestyle and risk factor management and use of drug therapies in coronary patients from 15 countries: principal results from EUROASPIRE II Euro Heart Survey Programme. Eur Heart J 2001;22:554-72. [ Links ]
25. EUROASPIRE I and II Group. Clinical reality of coronary prevention guidelines: a comparison of EUROASPIRE I and II in nine countries. Lancet 2001; 357:995-1001. [ Links ]
26. Steg PG, Iung B, Feldman LJ, Cokkinos D, Deckers J, Fox KA, et al. Impact of availability and use of coronary interventions on the prescription of aspirin and lipid lowering treatment after acute coronary syndromes. Heart 2002;88:20-4. [ Links ]
27. Reid FDA, Cook DG, Whincup PH. Use of statins in the secondary prevention of coronary heart disease: is treatment equitable? Heart 2002;88:15-9. [ Links ]
28. Ahmadi J, Khalili H, Jooybar R, Namazi N, Mohammadagaei P. Prevalence of cigarette smoking in Iran. Psychol Rep 2001;89:339-41. [ Links ]
29. Kromhout D, Menotti A, Kesteloot H, Sans S. Prevention of coronary heart disease by diet and lifestyle: Evidence from prospective cross cultural, cohort and intervention studies. Circulation 2002;105:893-8. [ Links ]
30. Hjermann I, Velve Byre K, Holme I, Leren P. Effect of diet and smoking intervention on the incidence of coronary heart disease. Report from the Oslo Study Group of a randomised trial in healthy men. Lancet 1981;2:1303-10. [ Links ]
31. De Lorgeril M, Salen P, Martin JL, Monjaud I, Delaye J, Mamelle N. Mediterranean diet, traditional risk factors, and the rate of cardiovascular complications after myocardial infarction: final report of the Lyon Diet Heart Study. Circulation 1999;99:779-85. [ Links ]
32. Ornish D, Scherwitz LW, Billings JH, Brown SE, Gould KL, Merritt TA, et al. Intensive lifestyle changes for reversal of coronary heart disease. JAMA 1998; 280:2001-7. [ Links ]
33. Khot UN, Khot MB, Bajzer CT, Sapp SK, Ohman EM, Brener SJ, et al. Prevalence of conventional risk factors in patients with coronary heart disease. JAMA 2003;290:898-904. [ Links ]
34. Hobbs FD, Erhardt L. Acceptance of guideline recommendations and perceived implementation of coronary heart disease prevention among primary care physicians in five European countries: the Reassessing European Attitudes about Cardiovascular Treatment (REACT) survey. Fam Prac 2002;19:596-604. [ Links ]
35. Van Berkel TF, Boersma H, De Baquer D, Deckers JW, Wood D. Registration and management of smoking behaviour in patients with coronary heart disease. The EUROASPIRE survey. Eur Heart J 1999;20:1630-7. [ Links ]
36. Montaye M, De Bacquer D, De Backer G, Amouyel P. Overweight and obesity: a major challenge for coronary heart disease secondary prevention in clinical practice in Europe. Eur Heart J 2000;21:808-13. [ Links ]
(Submitted: 04 June 2004 Final revised version received: 02 March 2005 Accepted: 17 March 2005)
WHO-PREMISE (Phase I) study group
S. Mendis, S. Yusuf, S. Ebrahim, G. Shaper, S. Ounpuu, D. Abegunde, W. Dissanayake (Sri Lanka), H. Ghannem (Tunisia). B. Gorenek (Turkey), Y. Kisjanto (Indonesia), J.G. Fernandes (Brazil), S. Nishtar (Pakistan), P. Pais (India), N. Salim (Russian Federation), N. Sarraf-Zadegan (Islamic Republic of Iran).
J. Leowski, A. Shatchkute, O. Khatib, A. Filipe, S. Robles, Z.K.M. Bile, Z. Hallaj, S.J. Habayeb, G. Petersen, E.F.Z. El Samani, A. Toro Ocampo, K. Tun, M. Vienonen, R. Bengoa, C. Legales Camus, D. Yach.
S. Mendis, D. Abegunde, S. Yusuf, S. Ebrahim, G. Shaper, H. Ghannem, B. Shengalia.
Coordination and data management
S. Mendis, D. Abegunde, F. Celletti, A. Price, M. Nassef.
Country project teams
Brazil: J.G. Fernandes, E. Moriguchi, I. Cruz, J. Siviero.
Egypt: N.M. Salim, S.S. Abdel-kader, M.A. Ahmad, A.F. Osman, M.A. Adam, D.Y. Abdel-Hamid.
India: P. Pais, D. Misquith, D. Xavier.
Indonesia: J. Kisjanto, B. Sutrisna, S.M.L. Tobing, Y. Misbach, S.F. Supari, S.M. Suryapradja.
Islamic Republic of Iran: N. Sarraf-Zadegan, M.R. Omrani, M. Fatemi, H.R. Tolouei, R. Pyman, A.R. Mazroie, A. Akhavan
Pakistan: S. Nishtar, A. Badar, H.Z. Abbasi, H. Ali, M.A. Mattu, N. Ara, H.S Memon, J. Shakoor.
Russian Federation: E. Volkova, S. Levashov, T. Karasikova, A. Startseva, I. Gabrin, V. Gabrin, V. Levit, V. Lasoreva, O. Mirgorodskaya, T. Zhurkina, E. Belinskaya.
Sri Lanka: W.P. Dissanayake, S. Dharmaratne, B. Subasinghe, S. Wijesundara, C. Subasinghe , M. Marasinghe, A. Karunaratne M. Weerakoon, P. Bandara.
Tunisia: H. Ghannem, E. Boughzala, G. Jeridi, S. Ben Ammou. A. Ben Abdelaziz.
Turkey: B. Gorenek, T. Ozkan, S. Bakar, D. Gucuyener, B. Timuralp, A. Unsal, S. Metintas.
Brazil: Hospital São Lucas - Pontifical Catholic University of Rio Grande do Sul, Grupo Hospitalar Conceição, Porto Alegre.
Egypt: Assuit University Hospital; Assuit Health Insurance Hospital; Primary Health Care Centre of Assuit University Hospital; Primary Health Centre of Assuit Friends Society for Rehabilitation of Cardiac patients, Assuit.
India: St John's Medical College, Bangalore.
Indonesia: Division of Cardiology, Department of Medicine, University of Indonesia, Jakarta.
Islamic Republic of Iran: Isfahan Cardiovascular Research Center (WHO Collaborating Centre); Isfahan Provincial Health Centre and the Ministry of Health, Noncommunicable Disease Department, Isfahan.
Pakistan: Heartfile, Pakistan Institute of Medical Sciences, Islamabad, Rawalpindi General Hospital, Rawalpindi.
Russian Federation: Ural State Medical Academy for Additional Education, Chelyabinsk, Administration of Public Heath Service of Chelyabinsk, Chelyabinsk.
Sri Lanka: General Hospital, Anuradhapura, Faculty of Medicine, University of Peradeniya, Peradeniya; Provincial Council Ministry of Health, North Central Province.
Tunisia: Service of Cardiology, University Hospital Sahloul; Service of Cardiology, and Service of Epidemiology, University Hospital Farhat Hached; Service of Neurology, University Hospital Sahloul, Sousse.
Turkey: Osmangazi University, Ministry of Health, Eskisehir.