HTLV infection and cessation of breastfeeding: context and challenges in implementing universal prevention policies in Brazil

Infección por HTLV y cese de la lactancia materna: contexto y desafíos en la implementación de políticas de prevención de forma universal en Brasil

Carolina Rosadas Angélica Espinosa Miranda About the authors

The benefits of breastfeeding are extensive and well known. However, in certain medical conditions it is contraindicated, such as in women living with a human T-cell lymphotropic virus type 1 (HTLV-1) infection.11. Meek JY, Noble L. Policy statement: breastfeeding and the use of human milk. Pediatrics. 2022;150(1):e2022057988. doi: 10.1542/peds.2022-057988
https://doi.org/10.1542/peds.2022-057988...
HTLV-1 was discovered in the 1980s, although its impact was underestimated and neglected for many years.22. Martin F, Tagaya Y, Gallo R. Time to eradicate HTLV-1: an open letter to WHO. Lancet. 2018;391(10133):1893-4. doi: 10.1016/S0140-6736(18)30974-7
https://doi.org/10.1016/S0140-6736(18)30...
It is commonly reported in the scientific literature that only 5% to 10% of infected individuals experience symptoms of the virus infection; nevertheless, there is a consensus that its deleterious effects are broader and more frequent than previously recognized.22. Martin F, Tagaya Y, Gallo R. Time to eradicate HTLV-1: an open letter to WHO. Lancet. 2018;391(10133):1893-4. doi: 10.1016/S0140-6736(18)30974-7
https://doi.org/10.1016/S0140-6736(18)30...
HTLV-1 is the etiological agent of adult T-cell leukemia/lymphoma (ATLL), an unfavorable prognosis neoplasm, and HTLV-1-associated myelopathy (HAM), a progressive neurological disease. The virus can also cause inflammatory diseases, such as uveitis, infective dermatitis, encephalitis, as well as pulmonary, intestinal and urinary alterations, in addition to erectile dysfunction, psychological disorders and negative impact on co-infections.33. Ministério da Saúde (BR). Secretaria de Vigilância em Saúde. Departamento de Doenças de Condições Crônicas e Infecções Sexualmente Transmissíveis. Guia de manejo clínico da infecção pelo HTLV [Internet]. Brasília: Ministério da Saúde; 2021 [citado 2023 Julho 08]. 103 p. Disponível em: Disponível em: https://www.gov.br/aids/pt-br/centrais-de-conteudo/publicacoes/2022/guia_htlv_internet_24-11-21-2_3.pdf/view
https://www.gov.br/aids/pt-br/centrais-d...
A study commissioned by the World Health Organization (WHO) revealed that the risk of death among people living with HTLV-1 increases by 57%.44. Schierhout G, McGregor S, Gessain A, Einsiedel L, Martinello M, Kaldor J. Association between HTLV-1 infection and adverse health outcomes: a systematic review and meta-analysis of epidemiological studies. Lancet Infect Dis. 2020;20(1):133-43. doi: 10.1016/S1473-3099(19)30402-5
https://doi.org/10.1016/S1473-3099(19)30...
Notwithstanding, the virus, which affects between 800,000 and 2.5 million Brazilians, remains neglected in the country.

HTLV-1 is transmitted through unprotected sexual intercourse, contact with infected blood (blood transfusion, organ transplantation or contact with sharp objects) and mother-to-child transmission, mainly through breastfeeding. There is no vaccine or curative treatment for HTLV-1.33. Ministério da Saúde (BR). Secretaria de Vigilância em Saúde. Departamento de Doenças de Condições Crônicas e Infecções Sexualmente Transmissíveis. Guia de manejo clínico da infecção pelo HTLV [Internet]. Brasília: Ministério da Saúde; 2021 [citado 2023 Julho 08]. 103 p. Disponível em: Disponível em: https://www.gov.br/aids/pt-br/centrais-de-conteudo/publicacoes/2022/guia_htlv_internet_24-11-21-2_3.pdf/view
https://www.gov.br/aids/pt-br/centrais-d...
),(55. World Health Organization. Human T-lymphotropic virus type 1: technical report [Internet]. Genva: World Health Organization; 2021 [cited 2023 Julho 08]. 78 p. Available from: Available from: https://www.who.int/publications/i/item/9789240020221
https://www.who.int/publications/i/item/...
In Brazil, the risk of parenteral transmission is reduced due to universal screening of blood and organ donors.66. Brasil. Ministério da Saúde. Portaria Nº 2.600, de 21 de outubro de 2009. Aprova o Regulamento Técnico do Sistema Nacional de Transplantes [Internet]. Diário Oficial da União, Brasília (DF), 2009 Out 30 [citado 2020 Jun 14], Seção 1:77. Disponível em: Disponível em: https://pesquisa.in.gov.br/imprensa/jsp/visualiza/index.jsp?data=30/10/2009&jornal=1&pagina=77&totalArquivos=264
https://pesquisa.in.gov.br/imprensa/jsp/...
),(77. Brasil. Ministério da Saúde. Portaria Nº 371, de 7 de maio de 2014. Institui diretrizes para a organização da atenção integral e humanizada ao recém-nascido (RN) no Sistema Único de Saúde(SUS) [Internet]. Diário Oficial da União, Brasília (DF), 2014 Abr 8 [citado 2020 Jun 14], Seção 1:50. Disponível em: Disponível em: https://pesquisa.in.gov.br/imprensa/jsp/visualiza/index.jsp?jornal=1&pagina=50&data=08/05/2014
https://pesquisa.in.gov.br/imprensa/jsp/...
In order to prevent mother-to-child transmission, the Brazilian Ministry of Health recommends the cessation of breastfeeding for mothers living with the virus.88. Ministério da Saúde (BR). Secretaria de Vigilância em Saúde. Departamento de Doenças de Condições Crônicas e Infecções Sexualmente Transmissíveis. Protocolo Clínico e Diretrizes Terapêuticas para atenção integral às pessoas com infeções sexualmente transmissíveis (IST) [Internet]. Brasília: Ministério da Saúde; 2020 [citado 2020 Jun 14]. 248 p. Disponível em: Disponível em: https://portaldeboaspraticas.iff.fiocruz.br/wp-content/uploads/2020/08/pcdt_ist_final_revisado_020420.pdf
https://portaldeboaspraticas.iff.fiocruz...
),(99. Ministério da Saúde (BR). Secretaria de Vigilância em Saúde. Departamento de Doenças de Condições Crônicas e Infecções Sexualmente Transmissíveis. Protocolo clínico e diretrizes terapêuticas para prevenção da transmissão vertical de HIV, sífilis e hepatites virais [Internet]. Brasília: Ministério da Saúde; 2019 [citado 2023 Julho 08]. 267 p. Disponível em Disponível em https://portaldeboaspraticas.iff.fiocruz.br/biblioteca/protocolo-clinico-e-diretrizes-terapeuticas-para-prevencao-da-transmissao-vertical-do-hiv/
https://portaldeboaspraticas.iff.fiocruz...
Antiretroviral therapy is not effective in reducing HTLV-1 proviral load and therefore it is not recommended for people living with HTLV-1.1010. Rosadas C, Menezes MLB, Galvão-Castro B, Assone T, Miranda AE, Aragón MG et al. Blocking HTLV-1/2 silent transmission in Brazil: current public health policies and proposal for additional strategies. PLoS Negl Trop Dis. 2021;15(9):e0009717. doi: 10.1371/journal.pntd.0009717
https://doi.org/10.1371/journal.pntd.000...
Avoidance of breastfeeding, on the other hand, prevents about 85% of childhood infections, consequently it is considered the most effective intervention currently available.1111. Rosadas C, Taylor GP. Current Interventions to prevent HTLV-1 mother-to-child transmission and their effectiveness: a systematic review and meta-analysis. Microorganisms. 2022;10(11):2227. doi: 10.3390/microorganisms10112227
https://doi.org/10.3390/microorganisms10...

The public policy proposed by the Ministry of Health (lactation inhibition) is also a strategy recommended in several countries, such as Japan, Chile, Colombia, Uruguay, Santa Lucia and Canada, as well as agencies, such as the National Institute of Health in the United States1111. Rosadas C, Taylor GP. Current Interventions to prevent HTLV-1 mother-to-child transmission and their effectiveness: a systematic review and meta-analysis. Microorganisms. 2022;10(11):2227. doi: 10.3390/microorganisms10112227
https://doi.org/10.3390/microorganisms10...
and the Brazilian Federation of Gynecology and Obstetrics Associations (Federação Brasileira de Ginecologia e Obstetrícia - FEBRASGO). Contraindication to breastfeeding is included in the Clinical Protocol and Therapeutic Guidelines for prevention of Mother-to-child Transmission and Sexually Transmitted Infections (STIs).88. Ministério da Saúde (BR). Secretaria de Vigilância em Saúde. Departamento de Doenças de Condições Crônicas e Infecções Sexualmente Transmissíveis. Protocolo Clínico e Diretrizes Terapêuticas para atenção integral às pessoas com infeções sexualmente transmissíveis (IST) [Internet]. Brasília: Ministério da Saúde; 2020 [citado 2020 Jun 14]. 248 p. Disponível em: Disponível em: https://portaldeboaspraticas.iff.fiocruz.br/wp-content/uploads/2020/08/pcdt_ist_final_revisado_020420.pdf
https://portaldeboaspraticas.iff.fiocruz...
),(99. Ministério da Saúde (BR). Secretaria de Vigilância em Saúde. Departamento de Doenças de Condições Crônicas e Infecções Sexualmente Transmissíveis. Protocolo clínico e diretrizes terapêuticas para prevenção da transmissão vertical de HIV, sífilis e hepatites virais [Internet]. Brasília: Ministério da Saúde; 2019 [citado 2023 Julho 08]. 267 p. Disponível em Disponível em https://portaldeboaspraticas.iff.fiocruz.br/biblioteca/protocolo-clinico-e-diretrizes-terapeuticas-para-prevencao-da-transmissao-vertical-do-hiv/
https://portaldeboaspraticas.iff.fiocruz...
However, there is still a lack of knowledge among health professionals and policymakers on HTLV-1 and infection prevention measures.1010. Rosadas C, Menezes MLB, Galvão-Castro B, Assone T, Miranda AE, Aragón MG et al. Blocking HTLV-1/2 silent transmission in Brazil: current public health policies and proposal for additional strategies. PLoS Negl Trop Dis. 2021;15(9):e0009717. doi: 10.1371/journal.pntd.0009717
https://doi.org/10.1371/journal.pntd.000...
),(1212. Miranda AE, Rosadas C, Assone T, Pereira GFM, Vallinoto ACR, Ishak R. Strengths, Weaknesses, Opportunities and Threats (SWOT) analysis of the implementation of public health policies on HTLV-1 in Brazil. Front Med. 2022;9:859115. doi: 10.3389/fmed.2022.859115
https://doi.org/10.3389/fmed.2022.859115...

In the Brazilian context, the right to free infant formula provided by the Brazilian National Health System (Sistema Único de Saúde - SUS), stands out. Information Note No. 4/2021-CGIST/DCCI/SVS/MS addresses the recommendation for the use of cabergoline in lactation inhibition and infant formula in the prevention of mother-to-child transmission of HIV and HTLV.1313. Brasil. Ministério da Saúde. Secretaria de Vigilância em Saúde. Departamento de Doenças de Condições Crônicas e Infecções Sexualmente Transmissíveis. Nota Informativa Nº 4/2021 - CGIST/DCCI/SVS/MS. Dispõe sobre a recomendação do medicamento cabergolina 0,5mg e da fórmula láctea infantil na prevenção da transmissão verti cal do HIV e do HTLV[Internet]. Brasília: Ministério da Saúde ; 2021 [citado 2023 Julho 08]. Disponível em: Disponível em: http://antigo.aids.gov.br/pt-br/legislacao/nota-informativa-no-42021-cgistdccisvsms
http://antigo.aids.gov.br/pt-br/legislac...
Despite the fact that it has been included in the Pregnant Woman's Booklet since its third edition, in 2016, (Figure 1), many people are unaware of their right to infant formula.1414. Ministério da Saúde (BR). Caderneta da Gestante 2022 [Internet]. 6. ed. rev. Brasília: Ministério da Saúde; 2022 [citado 2023 Julho 08]. 47 p. Disponível em: Disponível em: https://bvsms.saude.gov.br/bvs/publicacoes/caderneta_gestante_versao_eletronica_2022.pdf
https://bvsms.saude.gov.br/bvs/publicaco...
Thus, many barriers persist in the access to the recommended public policies.

Figure 1
Pregnant Woman's Booklet, published by the Brazilian Ministry of Health, indicating the right to infant formula for mothers living with HTLV-1

Recently, the WHO has recognized HTLV-1 as a public health problem.55. World Health Organization. Human T-lymphotropic virus type 1: technical report [Internet]. Genva: World Health Organization; 2021 [cited 2023 Julho 08]. 78 p. Available from: Available from: https://www.who.int/publications/i/item/9789240020221
https://www.who.int/publications/i/item/...
Concurrently, the Pan American Health Organization (PAHO) has been focusing on HTLV-1 and acknowledging its significance in the Americas region; the prevention of mother-to-child transmission is considered a priority action in response to the virus, both by PAHO and WHO, and has been addressed in the WHO’s strategic plan for STIs.1515. World Health Organization. Global health sector strategies on, respectively, HIV, viral hepatitis and sexually transmitted infections for the period 2022-2030 [Internet]. Geneva: World Health Organization; 2022 [cited 2023 Julho 08]. 134 p. https://www.who.int/publications/i/item/9789240053779
https://www.who.int/publications/i/item/...
)-(1717. Pan American Health Organization. The response to HTLV in the framework of maternal and child health [Internet]. Washington: Pan American Health Organization ; 2022 [cited AAAA Mmm DD]. 21 p. Available from: https://iris.paho.org/handle/10665.2/56888
https://iris.paho.org/handle/10665.2/568...
The inclusion of HTLV-1 in the initiative to eliminate mother-to-child transmission of HIV, syphilis, hepatitis and Chagas disease is currently under discussion by international agencies.1717. Pan American Health Organization. The response to HTLV in the framework of maternal and child health [Internet]. Washington: Pan American Health Organization ; 2022 [cited AAAA Mmm DD]. 21 p. Available from: https://iris.paho.org/handle/10665.2/56888
https://iris.paho.org/handle/10665.2/568...
Brazil plays a prominent role in responding to HTLV-1, however, despite this international recognition,1616. Pan American Health Organization. International Health Policy Forum for the Elimination of HTLV: advancing HTLV health policies around the world. Meeting Report, 10 November 2021 [Internet]. Washington: Pan American Health Organization; 2022 [cited 2023 Julho 08]. Available from: https://iris.paho.org/handle/10665.2/56052
https://iris.paho.org/handle/10665.2/560...
it still has incipient policies that require expansion and strengthening.

Among the priority actions to strengthen the response to HTLV-1 in the context of maternal and child health in the country, the following stand out: (i) intensification of capacity building for healthcare professionals and public policymakers; (ii) expanding HTLV-1 testing coverage in antenatal care; (iii) ensuring access to infant formula; (iv) establishing and strengthening multidisciplinary care networks for the comprehensive support and clinical follow-up of pregnant women living with HTLV-1 and HTLV-1 exposed children; and (v) implementing a surveillance system for HTLV-1 infection in pregnant women and exposed children (Figure 2).

Figure 2
Key aspects for expanding and strengthening the response to HTLV-1 in the context of maternal and child health

The sensitization of managers is of fundamental importance for the inclusion of HTLV-1 in the public health agenda, regarding capacity building for professionals, especially in primary healthcare. This is a crucial action to ensure that mothers have access to adequate information about HTLV-1, modes of transmission, associated diseases, and methods for reducing transmission risks. The Ministry of Health has included HTLV-1 in a training course on STIs and regularly conducts awareness campaigns.1212. Miranda AE, Rosadas C, Assone T, Pereira GFM, Vallinoto ACR, Ishak R. Strengths, Weaknesses, Opportunities and Threats (SWOT) analysis of the implementation of public health policies on HTLV-1 in Brazil. Front Med. 2022;9:859115. doi: 10.3389/fmed.2022.859115
https://doi.org/10.3389/fmed.2022.859115...
Continuous work focusing on this subject is essential, as well as stronger collaboration with important stakeholders such as medical and nursing councils, and professional associations such as FEBRASGO and the Brazilian Society of Pediatrics. Collaboration with the Ministry of Education, for the inclusion of HTLV-1 in the curriculum of professional development courses, is another strategy to be take into consideration. In addition, the coordination between the Ministry of Health and the Ministry of Women is valuable due to their shared interest in this topic.

The identification of mothers living with HTLV-1 is essential for the success of any strategy aimed at reducing mother-to-child transmission of the virus. However, despite its cost-effectiveness, testing for HTLV-1 during antenatal care1818. Rosadas C, Senna K, Costa M, Assone T, Casseb J, Nukui Y, et al. Economic analysis of antenatal screening for human T-cell lymphotropic virus type 1 in Brazil: an open access cost-utility model. Lancet Glob Health. 2023;11(5):e781-90 . doi: 10.1016/S2214-109X(23)00065-7
https://doi.org/10.1016/S2214-109X(23)00...
is not universally offered in Brazil, and its evaluation by the National Committee for Health Technology Incorporation in the Brazilian National Health System (Comissão Nacional de Incorporação de Tecnologias - CONITEC) is currently underway, at the time of the conclusion of this article. It is noteworthy that antenatal screening had been included in Ordinance GM/MS No. 715, issued on April 4, 2022, when the now defunct maternal and child healthcare program (rede de atenção materno-infantil - RAMI) was established,1919. Brasil. Ministério da Saúde. Portaria GM/MS Nº 715, de 4 de abril de 2022. Altera a Portaria de Consolidação GM/MS nº 3, de 28 de setembro de 2017, para instituir a Rede de Atenção Materna e Infantil (Rami) [Internet]. Diário Oficial da União, Brasília (DF) , 2022 Abr 6 [citado 2023 Julho 08], Seção 1:591. Disponível em: Disponível em: https://www.in.gov.br/web/dou/-/portaria-gm/ms-n-715-de-4-de-abril-de-2022-391070559
https://www.in.gov.br/web/dou/-/portaria...
and was repealed by Ordinance GM/MS No. 13, on January 13, 2023.2020. Brasil. Ministério da Saúde. Portaria GM/MS Nº 13, de 13 de janeiro de 2023. Revoga Portarias que específica e dá outras providências [Internet]. Diário Oficial da União, Brasília (DF) , 2023 Jan 16 [citado 2023 Julho 08], Seção 1:37. Disponível em: Disponível em: https://www.in.gov.br/web/dou/-/portaria-gm/ms-n-13-de-13-de-janeiro-de-2023-457959944
https://www.in.gov.br/web/dou/-/portaria...
The diagnosis of HTLV-1 involves both screening and confirmatory tests, all of which are included in the SUS.33. Ministério da Saúde (BR). Secretaria de Vigilância em Saúde. Departamento de Doenças de Condições Crônicas e Infecções Sexualmente Transmissíveis. Guia de manejo clínico da infecção pelo HTLV [Internet]. Brasília: Ministério da Saúde; 2021 [citado 2023 Julho 08]. 103 p. Disponível em: Disponível em: https://www.gov.br/aids/pt-br/centrais-de-conteudo/publicacoes/2022/guia_htlv_internet_24-11-21-2_3.pdf/view
https://www.gov.br/aids/pt-br/centrais-d...
Some Federative Units, such as Bahia,2121. Governo do Estado (BA). Portaria Nº 460, de 19 de novembro de 2020. Institui a Linha de Cuidado às Pessoas Convivendo com HTLV e dá outras Providências [Internet]. Diário Oficial do Estado da Bahia, Salvador, 2020 Nov 21 [citado 2023 Julho 08], Seção Executiva:34. Disponível em: Disponível em: http://www.saude.ba.gov.br/wp-content/uploads/2020/11/Portaria-no-460-de-19-de-novembro-de-2020-Linha-do-Cuidado-HTLV.pdf
http://www.saude.ba.gov.br/wp-content/up...
Mato Grosso do Sul and the Federal District, as well as municipalities such as Belo Horizonte (state of Minas Gerais) and Rio Verde (state of Goiás), have already issued ordinances guaranteeing the implementation of universal testing of pregnant women. Recently, other state health departments have established technical cooperation in the implementation HTLV-1 line of care network. Important measures for expanding HTLV-1 testing coverage include technical training [with a particular focus on professionals from the Central Public Health Laboratories (Laboratórios Centrais de Saúde Pública - LACEN)], promoting interstate discussions, developing informative notes, manuals and technical guides, in addition to allocating financial resources. In this sense, the support of the federal government can act as a catalyst.

It is worth highlighting the need for an acceptable, feasible, affordable, sustainable and safe (AFASS) intervention. Although there is limited data, the literature demonstrates that prenatal testing and intervention have high acceptance rates: over 90% of mothers choose to follow medical recommendations, a finding confirmed by representatives of people living with HTLV-1, both in Brazil and in other countries.1111. Rosadas C, Taylor GP. Current Interventions to prevent HTLV-1 mother-to-child transmission and their effectiveness: a systematic review and meta-analysis. Microorganisms. 2022;10(11):2227. doi: 10.3390/microorganisms10112227
https://doi.org/10.3390/microorganisms10...
),(1616. Pan American Health Organization. International Health Policy Forum for the Elimination of HTLV: advancing HTLV health policies around the world. Meeting Report, 10 November 2021 [Internet]. Washington: Pan American Health Organization; 2022 [cited 2023 Julho 08]. Available from: https://iris.paho.org/handle/10665.2/56052
https://iris.paho.org/handle/10665.2/560...
),(2222. Pan American Health Organization. EMTCT PLUS framework for elimination of mother-to-child transmission of HIV, syphilis, hepatitis B, and Chagas [Internet]. Washington: Pan American Health Organization; 2017 [cited 2023 Julho 08] Available from: Available from: https://iris.paho.org/bitstream/handle/10665.2/34306/PAHOCHA17009-eng.pdf?sequence=1&isAllowed=y .
https://iris.paho.org/bitstream/handle/1...
In order for the intervention to be AFASS in Brazil, access to free infant formula is essential. People living in vulnerable situations, with low income and low education level, are the most commonly affected by HTLV-1. Therefore, it is crucial that women living with this virus receive support, have access to adequate and understandable information about HTLV-1, prevention and care measures, and have their rights guaranteed (including the supply of infant formula). Access to infant formula should be immediate. Maternity hospitals must provide a sufficient quantity of infant formula until the HTLV-1 exposed child is properly enrolled in follow-up services.1313. Brasil. Ministério da Saúde. Secretaria de Vigilância em Saúde. Departamento de Doenças de Condições Crônicas e Infecções Sexualmente Transmissíveis. Nota Informativa Nº 4/2021 - CGIST/DCCI/SVS/MS. Dispõe sobre a recomendação do medicamento cabergolina 0,5mg e da fórmula láctea infantil na prevenção da transmissão verti cal do HIV e do HTLV[Internet]. Brasília: Ministério da Saúde ; 2021 [citado 2023 Julho 08]. Disponível em: Disponível em: http://antigo.aids.gov.br/pt-br/legislacao/nota-informativa-no-42021-cgistdccisvsms
http://antigo.aids.gov.br/pt-br/legislac...
Clear guidance on the hygienic and safe preparation, storage and feeding of breast-milk substitutes needs to be provided. It is important to ensure that the family has access to potable water and items such as baby bottles and cleaning products. Health professionals should take into consideration that stigma can be a barrier to adherence and, therefore, should focus on providing support and acceptance.2323. Carroll C, Booth A, Campbell F, Relton C. Qualitative evidence synthesis of values and preferences to inform infant feeding in the context of non-HIV transmission risk. PLoS One. 2020;15(12):e0242669. doi: 10.1371/journal.pone.0242669
https://doi.org/10.1371/journal.pone.024...
In a context that promotes breastfeeding, those mothers who do not breastfeed may feel excluded and pressured. Several initiatives observed in Bahia, a state with a comprehensive care network for HTLV-1, aim to support mothers living with HTLV-1.2121. Governo do Estado (BA). Portaria Nº 460, de 19 de novembro de 2020. Institui a Linha de Cuidado às Pessoas Convivendo com HTLV e dá outras Providências [Internet]. Diário Oficial do Estado da Bahia, Salvador, 2020 Nov 21 [citado 2023 Julho 08], Seção Executiva:34. Disponível em: Disponível em: http://www.saude.ba.gov.br/wp-content/uploads/2020/11/Portaria-no-460-de-19-de-novembro-de-2020-Linha-do-Cuidado-HTLV.pdf
http://www.saude.ba.gov.br/wp-content/up...
),(2424. Galvão-Castro B, Grassi MFR, Galvão-Castro AV, Nunes A, Galvão-Barroso AK, Araújo THA, et al. Integrative and multidisciplinary care for people living with human T-cell lymphotropic virus in Bahia, Brazil: 20 years of experience. Front Med . 2022; 9:884127. doi: 10.3389/fmed.2022.884127
https://doi.org/10.3389/fmed.2022.884127...

The establishment of multi-professional care networks for HTLV-1 is another priority. A survey conducted by the Ministry of Health showed that centers for HTLV care are scarce and unevenly distributed in the country. Many of these centers are associated with research groups, without government financial support.1212. Miranda AE, Rosadas C, Assone T, Pereira GFM, Vallinoto ACR, Ishak R. Strengths, Weaknesses, Opportunities and Threats (SWOT) analysis of the implementation of public health policies on HTLV-1 in Brazil. Front Med. 2022;9:859115. doi: 10.3389/fmed.2022.859115
https://doi.org/10.3389/fmed.2022.859115...
It is necessary to reverse this situation in order to ensure universal and equitable access to healthcare services.

Implementation of a notification and surveillance system for the infection in pregnant women and exposed children is important for identifying priority areas, designing more effective interventions and monitoring the impact of existing policies.1010. Rosadas C, Menezes MLB, Galvão-Castro B, Assone T, Miranda AE, Aragón MG et al. Blocking HTLV-1/2 silent transmission in Brazil: current public health policies and proposal for additional strategies. PLoS Negl Trop Dis. 2021;15(9):e0009717. doi: 10.1371/journal.pntd.0009717
https://doi.org/10.1371/journal.pntd.000...
),(1212. Miranda AE, Rosadas C, Assone T, Pereira GFM, Vallinoto ACR, Ishak R. Strengths, Weaknesses, Opportunities and Threats (SWOT) analysis of the implementation of public health policies on HTLV-1 in Brazil. Front Med. 2022;9:859115. doi: 10.3389/fmed.2022.859115
https://doi.org/10.3389/fmed.2022.859115...
The laboratory interface and greater coordination with the Digital Health and Information Secretariat of the Ministry of Health will be welcome, as well as the implementation of the dialogue with the state and municipal health departments, so that the three spheres of government are involved in this process.

Cessation of breastfeeding, an effective measure to prevent mother-to-child transmission of HTLV-1, is recommended by the Brazilian Ministry of Health. It is crucial to ensure (i) HTLV-1 testing during antenatal care and (ii) an AFASS intervention. Access to free infant formula plays an important role in promoting adherence; however, many mothers living with the human T-cell lymphotropic virus type 1 - HTLV-1 are unaware of this right. Despite the advancements achieved, it is necessary to expand and strengthen public policies aimed at controlling this important, yet neglected disease.

references

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    » https://doi.org/10.1542/peds.2022-057988
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    Martin F, Tagaya Y, Gallo R. Time to eradicate HTLV-1: an open letter to WHO. Lancet. 2018;391(10133):1893-4. doi: 10.1016/S0140-6736(18)30974-7
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Publication Dates

  • Publication in this collection
    25 Sept 2023
  • Date of issue
    2023
Secretaria de Vigilância em Saúde e Ambiente - Ministério da Saúde do Brasil Brasília - Distrito Federal - Brazil
E-mail: ress.svs@gmail.com