BCG vaccine effective for 50 years



The bacille Calmette–Guérin (BCG) vaccine provides protection against tuberculosis for 50 to 60 years, a new study has shown. Although the vaccine has been in use for 80 years, its long-term efficacy was not known. Naomi Aronson and colleagues whose study was published in JAMA (2204;291:2086-91) reviewed medical records and death certificates of participants in a placebo-controlled, single dose BCG vaccine trial which took place between 1935 and 1938. The investigation followed patients up until 1998 and spanned two generations.

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