Prevalência de ansiedade em profissionais da saúde em tempos de COVID-19: revisão sistemática com metanálise

Prevalence of anxiety among health professionals in times of COVID-19: a systematic review with meta-analysis

David Franciole Oliveira Silva Ricardo Ney Cobucci Vanessa de Paula Soares-Rachetti Severina Carla Vieira Cunha Lima Fábia Barbosa de Andrade Sobre os autores

Resumo

O objetivo deste estudo é identificar a prevalência de ansiedade em profissionais de saúde durante a pandemia da COVID-19. Trata-se de revisão sistemática de estudos publicados em qualquer idioma em 2020. Foi realizada busca nas bases de dados Embase, LILACS e PubMed utilizando os descritores anxiety, COVID-19, health workers, e sinônimos. A estimativa da prevalência geral de ansiedade com intervalo de confiança de 95% foi calculada utilizando o modelo de efeitos aleatórios. Dos 861 registros identificados, 36 artigos foram incluídos na revisão sistemática e 35 na metanálise. A prevalência geral de ansiedade foi de 35% (IC95%: 29-40). Foi identificado maior risco de ansiedade nas mulheres em relação aos homens (Odds Ratio: 1.64 [IC95%: 1,47-1,84]), e nos enfermeiros, na comparação com médicos (Odds Ratio: 1.19 [IC95%: 1,07-1,33]). Atuar na linha de frente no combate a COVID-19, estar infectado com coronavírus e apresentar doenças crônicas também foram fatores associados com maior risco de ansiedade. Observa-se alta prevalência de ansiedade entre profissionais de saúde, com maior risco entre mulheres e enfermeiros. Há necessidade de medidas que visem sua prevenção, bem como o fornecimento de tratamento precoce e adequado aos com ansiedade moderada e grave.

Key words:
Anxiety; Pandemic; COVID-19; Health professionals; Systematic review

Abstract

This study sets out to identify the prevalence of anxiety among health professionals during the COVID-19 pandemic. It involves a systematic review and meta-analysis of studies published in any language in 2020. A search was conducted in the Embase, LILACS and PubMed databases using the keywords anxiety, COVID-19, health workers, and synonyms. The estimated overall prevalence of anxiety with a 95% confidence interval was calculated using the random effects model. Of the 861 records identified, 36 articles were included in the systematic review and 35 in the meta-analysis. The overall prevalence of anxiety was 35% (95%CI: 29-40). A higher risk of anxiety was identified among women compared to men (Odds Ratio: 1.64 [95%CI: 1.47-1.84]), and in nurses, in comparison with physicians (Odds Ratio: 1.19 [95%CI: 1.07-1.33]). Being on the front line of COVID-19, being infected with coronavirus and having chronic diseases were also factors associated with a higher risk of anxiety. A high prevalence of anxiety among health professionals was observed, with higher risk among women and nurses. There is a pressing need for measures aimed at prevention of anxiety and providing early and appropriate treatment for those suffering from moderate and severe anxiety.

Key words:
Anxiety; Pandemic; COVID-19; Health professionals; Systematic review

Introdução

A pandemia da COVID-19 (doença causada pelo novo coronavírus) é atualmente o mais grave problema de saúde pública a ser enfrentado no mundo11 Lai CC, Shih TP, Ko WC, Tang HJ, Hsueh PR. Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and corona virus disease-2019 (COVID-19): the epidemic and the challenges. Int J Antimicrob Agents 2020; 55(3):105924.. Segundo dados da Organização Mundial da Saúde22 World Health Organization (WHO). Coronavirus disease 2019 (COVID-19). Situation Report - 195 [Internet]. 2020 [acessado 2020 Ago 3]. Disponível em: https: https://www.who.int/docs/default-source/coronaviruse/situation-reports/20200802-covid-19-sitrep-195.pdf?sfvrsn=5e5da0c5_2
https: https://www.who.int/docs/default-...
, até meados de agosto de 2020 foram registrados 17 milhões de casos confirmados, com 680 mil mortes.

Períodos de epidemia são particularmente críticos para a saúde mental da população33 Ahmed MZ, Ahmed O, Aibao Z, Hanbin S, Siyu L, Ahmad A. Epidemic of COVID-19 in China and associated Psychological Problems. Asian J Psychiatr 2020; 51:102092.

4 Rajkumar RP. COVID-19 and mental health: A review of the existing literature. Asian J Psychiatr 2020; 52:102066.
-55 Gao J, Zheng P, Jia Y, Chen H, Mao Y, Chen S, Wang Y, Fu H, Dai J. Mental health problems and social media exposure during COVID-19 outbreak. Plos One 2020; 15(4):e0231924.. O medo que é uma reação instintiva e fundamental para o ser humano, muitas vezes se torna crônico ou desproporcional nesses períodos, contribuindo para o aumento das desordens psicológicas, incluindo a ansiedade66 Ornell, Schuch JB, Sordi AO, Kessler FHP. "Pandemic fear" and COVID-19: mental health burden and strategies. Braz J Psychiatry 2020; 42(3):232-235.. Apesar dos dados conhecidos na população em geral33 Ahmed MZ, Ahmed O, Aibao Z, Hanbin S, Siyu L, Ahmad A. Epidemic of COVID-19 in China and associated Psychological Problems. Asian J Psychiatr 2020; 51:102092.

4 Rajkumar RP. COVID-19 and mental health: A review of the existing literature. Asian J Psychiatr 2020; 52:102066.

5 Gao J, Zheng P, Jia Y, Chen H, Mao Y, Chen S, Wang Y, Fu H, Dai J. Mental health problems and social media exposure during COVID-19 outbreak. Plos One 2020; 15(4):e0231924.
-66 Ornell, Schuch JB, Sordi AO, Kessler FHP. "Pandemic fear" and COVID-19: mental health burden and strategies. Braz J Psychiatry 2020; 42(3):232-235., estudos sobre prevalência e fatores causais em grupos específicos, como os profissionais da saúde, são ainda escassos durante a pandemia causada pelo novo coronavirus77 Lee SM, Kang WS, Cho AR, Kim T, Park JK. Psychological impact of the 2015 MERS outbreak on hospital workers and quarantined hemodialysis patients. Compr Psychiatry 2018; 87:123-127.

8 Gee S, Skovdal M. Navigating 'riskscapes': The experiences of international health care workers responding to the Ebola outbreak in West Africa. Health Place 2017; 45:173-180.
-99 World Health Organization (WHO). Mental health and psychosocial considerations during the COVID-19 outbreak [Internet]. 2020 [acessado 2020 Abr 12]. Disponível em: https://apps.who.int/iris/bitstream/handle/10665/331490/WHO-2019-nCoV-MentalHealth-2020.1-eng.pdf
https://apps.who.int/iris/bitstream/hand...
.

Nas epidemias da síndrome respiratória aguda grave (SARS) em 20031010 Chan AO, Huak CY. Psychological impact of the 2003 severe acute respiratory syndrome outbreak on health care workers in a medium size regional general hospital in Singapore. Occup Med 2004; 54(3):190-196., H1N1 em 20091111 Everts J. Announcing swine flu and the interpretation of pandemic anxiety. Antipode 2013; 45(4):809-825.,1212 Taha S, Matheson K, Cronin T, Anisman H. Intolerance of uncertainty, appraisals, coping, and anxiety: The case of the 2009 H 1 N 1 pandemic. Br J Health Psychol 2014; 19(3):592-605. e do Ebola em 20141313 Lehmann M, Bruenahl CA, Löwe B, Addo MM, Schmiedel S, Lohse AW, Schramm C. Ebola and psychological stress of health care professionals. Emerg Infect Dis 2015; 21(5):913. estudos registraram elevada prevalência de ansiedade nos profissionais de saúde. Na epidemia da SARS, os estudos identificaram prevalência de ansiedade de 13%1414 Bai Y, Lin CC, Lin CY, Chen JY, Chue CM, Chou P. Survey of stress reactions among health care workers involved with the SARS outbreak. Psychiatr Serv 2004; 55(9):1055-1057. a 51%1515 Wong WC, Wong SY, Lee A, Goggins WB. How to provide an effective primary health care in fighting against severe acute respiratory syndrome: the experiences of two cities. Am J Infect Control 2007; 35(1):50-55.. Durante a epidemia da Ebola, Ji et al.1616 Ji D, Ji YJ, Duan XZ, Li WG, Sun ZQ, Song XA, Meng YH, Tang HM, Chu F, Niu XX, Chen GF. Prevalence of psychological symptoms among Ebola survivors and healthcare workers during the 2014-2015 Ebola outbreak in Sierra Leone: a cross-sectional study. Oncotarget 2017; 8(8):12784. verificaram que 39% de profissionais de saúde apresentaram ansiedade.

Fatores como elevada carga horária de trabalho, estresse, pressão decorrente do elevado número de atendimento de casos graves, poucas horas de sono, infraestrutura inadequada, indisponibilidade de equipamentos de proteção individual em quantidade suficiente, o risco de ser infectado e de transmitir para familiares e outras pessoas podem contribuir para o aumento da ansiedade nesses períodos1717 Park JS, Lee EH, Park NR, Choi YH. Mental health of nurses working at a government-designated hospital during a MERS-CoV outbreak: a cross-sectional study. Arch Psychiatr Nurs 2018; 32(1):2-6.

18 Vyas KJ, Delaney EM, Webb-Murphy JA, Johnston SL. Psychological impact of deploying in support of the US response to Ebola: a systematic review and meta-analysis of past outbreaks. Mil Med 2016; 181(11-12):e1515-e1531.

19 Ornell F, Halpern SC, Kessler FHP, Narvaez JCM. The impact of the COVID-19 pandemic on the mental health of healthcare professionals. Cad Saude Publica 2020; 36(4):e00063520.
-2020 Greenberg N. Mental health of health-care workers in the COVID-19 era. Nat Rev Nephrol 2020; 16:425-426..

Pappa et al.2121 Pappa S, Ntella V, Giannakas T, Giannakoulis VG, Papoutsi E, Katsaounou P. Prevalence of depression, anxiety, and insomnia among healthcare workers during the COVID-19 pandemic: A systematic review and meta-analysis. Brain Behav Immun 2020; 88:901-907. realizaram revisão sistemática sobre depressão, ansiedade e insônia, analisando a prevalência de ansiedade entre profissionais de saúde em 12 estudos. Entretanto, não analisaram a prevalência de ansiedade entre os profissionais da linha de frente, a associação entre o diagnóstico de COVID-19 e de doenças crônicas com a ansiedade, bem como não compararam a prevalência de ansiedade entre as diversas categorias profissionais.

É importante a realização de estudos que avaliem a prevalência de ansiedade nestes profissionais, de modo a desenvolver estratégias que visem favorecer a qualidade de vida e a saúde mental durante a pandemia da COVID-19 e, dessa forma, contribuir para a garantia da força de trabalho necessária para o combate a doença, bem como a saúde mental destes profissionais no período pós pandemia2020 Greenberg N. Mental health of health-care workers in the COVID-19 era. Nat Rev Nephrol 2020; 16:425-426.,2222 Jones JH, Salathe M. Early assessment of anxiety and behavioral response to novel swine-origin influenza A (H1N1). PLoS one 2009; 4(12):e8032.

23 Schwartz J, King CC, Yen MY. Protecting healthcare workers during the coronavirus disease 2019 (COVID-19) outbreak: lessons from Taiwan's severe acute respiratory syndrome response. Clin Infect Dis 2020; 71(15):858-860.
-2424 Huang J, Liu F, Teng Z, Chen J, Zhao J, Wang X, Wu R. Care for the psychological status of frontline medical staff fighting against COVID-19. Clin Infect Dis 2020; ciaa385..

Nesse contexto, o objetivo desta revisão sistemática com metanálise é identificar a prevalência de ansiedade em profissionais de saúde durante à pandemia da COVID-19.

Métodos

Revisão sistemática com metanálise elaborada e redigida conforme às recomendações do PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-Analyzes)2525 Moher D, Liberati A, Tetzlaff J, Altman DG, Prisma Group. Preferred reporting items for systematic reviews and meta-analyses: the PRISMA statement. PLoS Med 2009; 6(7):e1000097..

Pergunta de pesquisa

Qual a prevalência de ansiedade nos profissionais da saúde durante a pandemia da COVID-19?

Critérios de elegibilidade

Foram considerados elegíveis estudos observacionais publicados em 2020 em qualquer idioma que apresentaram a prevalência de ansiedade em profissionais de saúde de qualquer faixa etária durante a pandemia da COVID-19.

P - População: profissionais da saúde de qualquer faixa etária; I - Interesse: ansiedade; Co - Contexto: pandemia da COVID-19.

Foram excluídos editoriais, artigos de revisão e estudos que não apresentaram a prevalência da ansiedade.

Fontes de informação e estratégia de busca

Foi realizada busca virtual nas bases de dados Embase, PubMed e LILACS em 11 de julho de 2020 por dois pesquisadores de forma independente. Além disso, foram analisadas as referências dos artigos selecionados para verificar se algum preenchia os critérios de inclusão, bem como busca manual. A estratégia de busca utilizada em cada base de dados é apresentada no Quadro 1.

Quadro 1
Estratégia de busca e filtros utilizados por base de dados.

Triagem e seleção dos estudos

O processo de seleção dos estudos para inclusão na revisão sistemática foi realizado inicialmente pela leitura do título e resumo por DS e revisado por FA e RC. Em seguida, DS e RC analisaram o texto-completo dos estudos selecionados para verificar o preenchimento dos critérios de elegibilidade e, para os artigos em que houve conflito, a seleção foi revisada por FA.

Extração dos dados

Os dados coletados dos estudos foram: autoria, delineamento do estudo, número, sexo e faixa etária dos participantes, formação acadêmica, área de atuação profissional, instrumentos e critérios utilizados para a avaliação e diagnóstico da ansiedade e principais resultados obtidos.

Avaliação da qualidade dos estudos

A escala Newcastle-Ottawa adaptada para estudos transversais foi utilizada para a avaliação da qualidade dos estudos incluídos na revisão2626 The modified Newcastle Ottawa scale for cross sectional studies [Internet]. [acessado 2020 Ago 1]. Disponível em: http://journals.plos.org/plosone/article/file?id=info%3Adoi/10.1371/journal.pone.0136065.s004&type=supplementary
http://journals.plos.org/plosone/article...
. Este instrumento é composto por sete itens, nos domínios seleção (4 itens), comparação (1 item) e desfecho (2 itens). Porém, como nesta revisão não foi realizada análise sobre exposição e comparabilidade, foram considerados para análise cinco domínios: 1) representatividade da amostra; 2) tamanho da amostra; 3) taxa de resposta (não respondentes); 4) Avaliação do desfecho; e, 5) Análises estatísticas. Para cada item pode ser atribuída uma estrela, sendo que para desfecho pode se pontuar com até duas estrelas. Deste modo, a pontuação total pode ser de 0 a 6 pontos. Os estudos que receberam quatro estrelas ou mais foram classificados com boa qualidade metodológica.

Análise dos dados

O desfecho primário da metanálise foi a prevalência geral (p) de ansiedade nos profissionais de saúde, com o respectivo intervalo de confiança (IC) e a taxa percentual (p x 100%), sendo incluídos os estudos com amostra igual ou maior que trinta (n≥30). O teste Q de Cochran e a estatística I² foram utilizados para avaliar a heterogeneidade2727 Cochran WG. The combination of estimates from different experiments. Biometrics 1954; 10(1):101-129.,2828 Higgins JP, Thompson SG, Deeks JJ, Altman DG. Measuring inconsistency in meta-analyses. BMJ 2003; 327(7414):557-560.. Foi estabelecido o emprego do modelo de efeitos aleatórios para a identificação da prevalência combinada quando verificada elevada heterogeneidade (I²>50% e teste Q de Cochran P<0.10). No caso de heterogeneidade baixa (I²<50% e P>0.10), foi utilizado o modelo de efeitos fixos.

Foi realizada análise de subgrupo por categoria profissional, continente de atuação dos profissionais, pelos instrumentos empregados para o diagnóstico da ansiedade e qualidade metodológica dos estudos primários para explorar possíveis fontes de heterogeneidade. A estimativa do Odds Ratio (OR) com o respectivo intervalo de confiança (IC) para os desfechos dicotômicos sexo e profissão foi realizada utilizando modelos aleatórios (I²>50% e teste Q de Cochran P<0,10) ou modelos fixos (I²<50% e P>0,10). Análise de sensibilidade foi realizada retirando cada estudo e calculando a prevalência com os estudos remanescentes, com o objetivo de identificar quais afetaram consideravelmente a prevalência. A análise estatística foi realizada no software Revman (Review Manager) versão 5.4 e no OpenMetaAnalyst.

Para os casos em que não foi possível conduzir metanálise para a avaliação da associação entre variáveis e a prevalência de ansiedade, foi empregada a síntese sem metanálise2929 Campbell M, McKenzie JE, Sowden A, Katikireddi SV, Brennan SE, Ellis S, Hartmann-Boyce J, Ryan R, Shepperd S, Thomas J, Welch V. Synthesis without meta-analysis (SWiM) in systematic reviews: reporting guideline. BMJ 2020; 368:l6890.. Para isso, foram considerados estudos com associação no mesmo sentido (por exemplo, associação positiva entre comorbidades e a prevalência de ansiedade) e comparados com estudos com resultados no sentido oposto (por exemplo, associação negativa entre comorbidades e a prevalência de ansiedade), ou que não identificaram associação significativa.

Resultados

A busca nas bases de dados recuperou 860 registros e um foi identificado por meio da busca manual, totalizando 861 artigos. Os duplicados (n=192) foram removidos, resultando em 669 estudos para avaliação. Depois da análise do título e resumo, 82 estudos tiveram o texto-completo avaliado. Trinta e seis estudos foram incluídos na revisão sistemática3030 Apisarnthanarak A, Apisarnthanarak P, Siripraparat C, Saengaram P, Leeprechanon N, Weber DJ. Impact of Anxiety and Fear for COVID-19 Toward Infection Control Practices Among Thai Healthcare Workers. Infect Control Hosp Epidemiol 2020; 41(9):1093-1094.

31 Badahdah A, Khamis F, Al Mahyijari N, Al Balushi M, Al Hatmi H, Al Salmi I, Albulushi Z, Al Noomani J. The mental health of health care workers in Oman during the COVID-19 pandemic. Int J Soc Psychiatry 2020; 20764020939596.

32 Chatterjee SS, Bhattacharyya R, Bhattacharyya S, Gupta S, Das S, Banerjee BB. Attitude, practice, behavior, and mental health impact of COVID-19 on doctors. Indian J Psychiatry 2020; 62(3):257.

33 Chen Y, Zhou H, Zhou Y, Zhou F. Prevalence of self-reported depression and anxiety among pediatric medical staff members during the COVID-19 outbreak in Guiyang, China. Psychiatry Res 2020; 288:113005.

34 Chew QH, Chia FL, Ng WK, Lee WC, Tan PL, Wong CS, Puah SH, Shelat VG, Seah EJ, Huey CW, Phua EJ. Psychological and coping responses to COVID-19 amongst residents in training across ACGME-I accredited specialties in Singapore. Psychiatry Res 2020; 290:113146.

35 Civantos AM, Byrnes Y, Chang C, Prasad A, Chorath K, Poonia SK, Jenks CM, Bur AM, Thakkar P, Graboyes EM, Seth R. Mental health among otolaryngology resident and attending physicians during the COVID-19 pandemic: National study. Head Neck 2020; 42(7):1597-1609.

36 Consolo U, Bellini P, Bencivenni D, Iani C, Checchi V. Epidemiological Aspects and Psychological Reactions to COVID-19 of Dental Practitioners in the Northern Italy Districts of Modena and Reggio Emilia. Int J Environ Res Public Health 2020; 17(10):3459.

37 Corbett GA, Milne SJ, Mohan S, Reagu S, Farrell T, Lindow SW, Hehir MP, O'Connell MP. Anxiety and Depression Scores in Maternity Healthcare Workers during the Covid-19 Pandemic. Int J Gynaecol Obstet 2020; 151(2):297-298.

38 Dal'Bosco EB, Floriano LSM, Skupien SV, Arcaro G, Martins AR, Anselmo ACC. Mental health of nursing in coping with COVID-19 at a regional university hospital. Rev Bras Enferm 2020; 73(Supl. 2):e20200434.

39 Du J, Dong L, Wang T, Yuan C, Fu R, Zhang L, Liu B, Zhang M, Yin Y, Qin J, Bouey J. Psychological symptoms among frontline healthcare workers during COVID-19 outbreak in Wuhan. Gen Hosp Psychiatry 2020; 67:144-145.

40 Elbay RY, Kurtulmus A, Arpacioglu S, Karadere E. Depression, anxiety, stress levels of physicians and associated factors in Covid-19 pandemics. Psychiatry Res 2020; 290:113130.

41 Gupta AK, Mehra A, Niraula A, Kafle K, Deo SP, Singh B, Sahoo S, Grover S. Prevalence of anxiety and depression among the healthcare workers in Nepal during the COVID-19 pandemic. Asian J Psychiatr 2020; 54:102260.

42 Hu D, Kong Y, Li W, Han Q, Zhang X, Zhu LX, Wan SW, Zuofeng LI, Qu SH, Jingqiu YA, Hong-Gu HE. Frontline nurses' burnout, anxiety, depression, and fear statuses and their associated factors during the COVID-19 outbreak in Wuhan, China: A large-scale cross-sectional study. EClinicalMedicine 2020; 24:100424.

43 Huang JZ, Han MF, Luo TD, Ren AK, Zhou XP. Mental health survey of medical staff in a tertiary infectious disease hospital for COVID-19. Zhonghua Lao Dong Wei Sheng Zhi Ye Bing Za Zhi 2020; 38(3):192-195.

44 Lai J, Ma S, Wang Y, Cai Z, Hu J, Wei N, Wu J, Du H, Chen T, Li R, Tan H. Factors associated with mental health outcomes among health care workers exposed to coronavirus disease 2019. JAMA Netw Open 2020; 3(3):e203976.

45 Lin K, Yang BX, Luo D, Liu Q, Ma S, Huang R, Lu W, Majeed A, Lee Y, Lui LM, Mansur RB. The mental health effects of COVID-19 on health care providers in China. Am J Psychiatry 2020; 177(7):635-636.

46 Liu CY, Yang YZ, Zhang XM, Xu X, Dou QL, Zhang WW, Cheng AS. The prevalence and influencing factors in anxiety in medical workers fighting COVID-19 in China: a cross-sectional survey. Epidemiol Infect 2020; 148:e98.

47 Lu W, Wang H, Lin Y, Li L. Psychological status of medical workforce during the COVID-19 pandemic: A cross-sectional study. Psychiatry Res 2020; 288:112936.

48 Moghadasi AN. Evaluation of the Level of Anxiety among Iranian Multiple Sclerosis Fellowships During the Outbreak of COVID-19. Arch Iran Med 2020; 23(4):283.

49 Naser AY, Dahmash EZ, Al-Rousan R, Alwafi H, Alrawashdeh HM, Ghoul I, Abidine A, Bokhary MA, Al-Hadithi HT, Ali D, Abuthawabeh R, Abdelwahab GM, Alhartani YJ, Al Muhaisen H, Dagash A, Alyami HS. Mental health status of the general population, healthcare professionals, and university students during 2019 coronavirus disease outbreak in Jordan: A cross-sectional study. Brain Behav 2020; 10(8):e01730.

50 Que J, Le Shi JD, Liu J, Zhang L, Wu S, Gong Y, Huang W, Yuan K, Yan W, Sun Y, Ran M. Psychological impact of the COVID-19 pandemic on healthcare workers: a cross-sectional study in China. Gen Psychiatry 2020; 33(3):e100259.

51 Rossi R, Socci V, Pacitti F, Di Lorenzo G, Di Marco A, Siracusano A, Rossi A. Mental Health Outcomes Among Frontline and Second-Line Health Care Workers During the Coronavirus Disease 2019 (COVID-19) Pandemic in Italy. JAMA Net Open 2020; 3(5):e2010185.

52 Shechter A, Diaz F, Moise N, Anstey DE, Ye S, Agarwal S, Birk JL, Brodie D, Cannone DE, Chang B, Claassen J. Psychological distress, coping behaviors, and preferences for support among New York healthcare workers during the COVID-19 pandemic. Gen Hosp Psychiatry 2020; 66:1-8.

53 Tan BY, Chew NW, Lee GK, Jing M, Goh Y, Yeo LL, Zhang K, Chin HK, Ahmad A, Khan FA, Shanmugam GN, Chan BPL, Sunny S, Chandra B, Ong JJY, Paliwal PR, Wong LYH, Sagayanathan R, Chen JT, Ng AYY, Teoh HL, Ho CS, Ho RC, Sharma VK. Psychological impact of the COVID-19 pandemic on health care workers in Singapore. Ann Intern Med 2020; 173(4):317-320.

54 Temsah MH, Al-Sohime F, Alamro N, Al-Eyadhy A, Al-Hasan K, Jamal A, Al-Maglouth I, Aljamaan F, Al Amri M, Barry M, Al-Subaie S. The psychological impact of COVID-19 pandemic on health care workers in a MERS-CoV endemic country. J Infect Public Health 2020; 13(6):877-882.

55 Vanni G, Materazzo M, Santori F, Pellicciaro M, Costesta M, Orsaria P, Cattadori F, Pistolese CA, Perretta T, Chiocchi M, Meucci R. The Effect of Coronavirus (COVID-19) on Breast Cancer Teamwork: A Multicentric Survey. In Vivo 2020; 34(3 Supl.):1685-1694.

56 Wang S, Xie L, Xu Y, Yu S, Yao B, Xiang D. Sleep disturbances among medical workers during the outbreak of COVID-2019. Occup Med (Lond) 2020; 70(5):364-369.

57 Xiao X, Zhu X, Fu S, Hu Y, Li X, Xiao J. Psychological impact of healthcare workers in China during COVID-19 pneumonia epidemic: A multi-center cross-sectional survey investigation. J Affect Disord 2020; 274:405-410.

58 Yang S, Kwak SG, Ko EJ, Chang MC. The mental health burden of the covid-19 pandemic on physical therapists. Int J Environ Res Public Health 2020; 17(10):3723.

59 Zandifar A, Badrfam R, Khonsari NM, Assareh M, Karim H, Azimzadeh M, Sepehr MN, Tajbakhsh R, Rahimi F, Ghanipour N, Agoushi A, Gelsefid SH, Etemadi F, Qorbani M. COVID-19 and medical staff's mental health in educational hospitals in Alborz Province, Iran. Psychiatry Clin Neurosci 2020; 74(9):499-501.

60 Zhang C, Yang L, Liu S, Ma S, Wang Y, Cai Z, Du H, Li R, Kang L, Su M, Zhang J, Liu Z, Zhang B. Survey of insomnia and related social psychological factors among medical staff involved in the 2019 novel coronavirus disease outbreak. Front Psychiatry 2020; 11:306.

61 Zhang SX, Liu J, Jahanshahi AA, Nawaser K, Yousefi A, Li J, Sun S. At the height of the storm: Healthcare staff's health conditions and job satisfaction and their associated predictors during the epidemic peak of COVID-19. Brain Behav Immun 2020; 87:144-146.

62 Zhang WR, Wang K, Yin L, Zhao WF, Xue Q, Peng M, Min BQ, Tian Q, Leng HX, Du JL, Chang H. Mental health and psychosocial problems of medical health workers during the COVID-19 epidemic in China. Psychother Psychosom 2020; 89(4):242-250.

63 Zhao N, Huang Y. Chinese mental health burden during COVID-19 outbreak: a web-based cross-sectional survey. Asian J Psychiatr 2020; 51:102052.

64 Zhu Z, Xu S, Wang H, Liu Z, Wu J, Li G, Miao J, Zhang C, Yang Y, Sun W, Zhu S. COVID-19 in Wuhan: Sociodemographic characteristics and hospital support measures associated with the immediate psychological impact on healthcare workers. EClinicalMedicine 2020; 24:100443.
-6565 Zhu J, Sun L, Zhang L, Wang H, Fan A, Yang B, Li W, Xiao S. Prevalence and Influencing Factors of Anxiety and Depression Symptoms in the First-Line Medical Staff Fighting Against COVID-19 in Gansu. Front Psychiatry 2020; 11:386.. Na metanálise, foram incluídos 35 estudos com 32.367 participantes de 15 países em três continentes3030 Apisarnthanarak A, Apisarnthanarak P, Siripraparat C, Saengaram P, Leeprechanon N, Weber DJ. Impact of Anxiety and Fear for COVID-19 Toward Infection Control Practices Among Thai Healthcare Workers. Infect Control Hosp Epidemiol 2020; 41(9):1093-1094.

31 Badahdah A, Khamis F, Al Mahyijari N, Al Balushi M, Al Hatmi H, Al Salmi I, Albulushi Z, Al Noomani J. The mental health of health care workers in Oman during the COVID-19 pandemic. Int J Soc Psychiatry 2020; 20764020939596.

32 Chatterjee SS, Bhattacharyya R, Bhattacharyya S, Gupta S, Das S, Banerjee BB. Attitude, practice, behavior, and mental health impact of COVID-19 on doctors. Indian J Psychiatry 2020; 62(3):257.

33 Chen Y, Zhou H, Zhou Y, Zhou F. Prevalence of self-reported depression and anxiety among pediatric medical staff members during the COVID-19 outbreak in Guiyang, China. Psychiatry Res 2020; 288:113005.

34 Chew QH, Chia FL, Ng WK, Lee WC, Tan PL, Wong CS, Puah SH, Shelat VG, Seah EJ, Huey CW, Phua EJ. Psychological and coping responses to COVID-19 amongst residents in training across ACGME-I accredited specialties in Singapore. Psychiatry Res 2020; 290:113146.

35 Civantos AM, Byrnes Y, Chang C, Prasad A, Chorath K, Poonia SK, Jenks CM, Bur AM, Thakkar P, Graboyes EM, Seth R. Mental health among otolaryngology resident and attending physicians during the COVID-19 pandemic: National study. Head Neck 2020; 42(7):1597-1609.

36 Consolo U, Bellini P, Bencivenni D, Iani C, Checchi V. Epidemiological Aspects and Psychological Reactions to COVID-19 of Dental Practitioners in the Northern Italy Districts of Modena and Reggio Emilia. Int J Environ Res Public Health 2020; 17(10):3459.

37 Corbett GA, Milne SJ, Mohan S, Reagu S, Farrell T, Lindow SW, Hehir MP, O'Connell MP. Anxiety and Depression Scores in Maternity Healthcare Workers during the Covid-19 Pandemic. Int J Gynaecol Obstet 2020; 151(2):297-298.

38 Dal'Bosco EB, Floriano LSM, Skupien SV, Arcaro G, Martins AR, Anselmo ACC. Mental health of nursing in coping with COVID-19 at a regional university hospital. Rev Bras Enferm 2020; 73(Supl. 2):e20200434.

39 Du J, Dong L, Wang T, Yuan C, Fu R, Zhang L, Liu B, Zhang M, Yin Y, Qin J, Bouey J. Psychological symptoms among frontline healthcare workers during COVID-19 outbreak in Wuhan. Gen Hosp Psychiatry 2020; 67:144-145.

40 Elbay RY, Kurtulmus A, Arpacioglu S, Karadere E. Depression, anxiety, stress levels of physicians and associated factors in Covid-19 pandemics. Psychiatry Res 2020; 290:113130.

41 Gupta AK, Mehra A, Niraula A, Kafle K, Deo SP, Singh B, Sahoo S, Grover S. Prevalence of anxiety and depression among the healthcare workers in Nepal during the COVID-19 pandemic. Asian J Psychiatr 2020; 54:102260.

42 Hu D, Kong Y, Li W, Han Q, Zhang X, Zhu LX, Wan SW, Zuofeng LI, Qu SH, Jingqiu YA, Hong-Gu HE. Frontline nurses' burnout, anxiety, depression, and fear statuses and their associated factors during the COVID-19 outbreak in Wuhan, China: A large-scale cross-sectional study. EClinicalMedicine 2020; 24:100424.

43 Huang JZ, Han MF, Luo TD, Ren AK, Zhou XP. Mental health survey of medical staff in a tertiary infectious disease hospital for COVID-19. Zhonghua Lao Dong Wei Sheng Zhi Ye Bing Za Zhi 2020; 38(3):192-195.

44 Lai J, Ma S, Wang Y, Cai Z, Hu J, Wei N, Wu J, Du H, Chen T, Li R, Tan H. Factors associated with mental health outcomes among health care workers exposed to coronavirus disease 2019. JAMA Netw Open 2020; 3(3):e203976.

45 Lin K, Yang BX, Luo D, Liu Q, Ma S, Huang R, Lu W, Majeed A, Lee Y, Lui LM, Mansur RB. The mental health effects of COVID-19 on health care providers in China. Am J Psychiatry 2020; 177(7):635-636.

46 Liu CY, Yang YZ, Zhang XM, Xu X, Dou QL, Zhang WW, Cheng AS. The prevalence and influencing factors in anxiety in medical workers fighting COVID-19 in China: a cross-sectional survey. Epidemiol Infect 2020; 148:e98.
-4747 Lu W, Wang H, Lin Y, Li L. Psychological status of medical workforce during the COVID-19 pandemic: A cross-sectional study. Psychiatry Res 2020; 288:112936.,4949 Naser AY, Dahmash EZ, Al-Rousan R, Alwafi H, Alrawashdeh HM, Ghoul I, Abidine A, Bokhary MA, Al-Hadithi HT, Ali D, Abuthawabeh R, Abdelwahab GM, Alhartani YJ, Al Muhaisen H, Dagash A, Alyami HS. Mental health status of the general population, healthcare professionals, and university students during 2019 coronavirus disease outbreak in Jordan: A cross-sectional study. Brain Behav 2020; 10(8):e01730.

50 Que J, Le Shi JD, Liu J, Zhang L, Wu S, Gong Y, Huang W, Yuan K, Yan W, Sun Y, Ran M. Psychological impact of the COVID-19 pandemic on healthcare workers: a cross-sectional study in China. Gen Psychiatry 2020; 33(3):e100259.

51 Rossi R, Socci V, Pacitti F, Di Lorenzo G, Di Marco A, Siracusano A, Rossi A. Mental Health Outcomes Among Frontline and Second-Line Health Care Workers During the Coronavirus Disease 2019 (COVID-19) Pandemic in Italy. JAMA Net Open 2020; 3(5):e2010185.

52 Shechter A, Diaz F, Moise N, Anstey DE, Ye S, Agarwal S, Birk JL, Brodie D, Cannone DE, Chang B, Claassen J. Psychological distress, coping behaviors, and preferences for support among New York healthcare workers during the COVID-19 pandemic. Gen Hosp Psychiatry 2020; 66:1-8.

53 Tan BY, Chew NW, Lee GK, Jing M, Goh Y, Yeo LL, Zhang K, Chin HK, Ahmad A, Khan FA, Shanmugam GN, Chan BPL, Sunny S, Chandra B, Ong JJY, Paliwal PR, Wong LYH, Sagayanathan R, Chen JT, Ng AYY, Teoh HL, Ho CS, Ho RC, Sharma VK. Psychological impact of the COVID-19 pandemic on health care workers in Singapore. Ann Intern Med 2020; 173(4):317-320.

54 Temsah MH, Al-Sohime F, Alamro N, Al-Eyadhy A, Al-Hasan K, Jamal A, Al-Maglouth I, Aljamaan F, Al Amri M, Barry M, Al-Subaie S. The psychological impact of COVID-19 pandemic on health care workers in a MERS-CoV endemic country. J Infect Public Health 2020; 13(6):877-882.

55 Vanni G, Materazzo M, Santori F, Pellicciaro M, Costesta M, Orsaria P, Cattadori F, Pistolese CA, Perretta T, Chiocchi M, Meucci R. The Effect of Coronavirus (COVID-19) on Breast Cancer Teamwork: A Multicentric Survey. In Vivo 2020; 34(3 Supl.):1685-1694.

56 Wang S, Xie L, Xu Y, Yu S, Yao B, Xiang D. Sleep disturbances among medical workers during the outbreak of COVID-2019. Occup Med (Lond) 2020; 70(5):364-369.

57 Xiao X, Zhu X, Fu S, Hu Y, Li X, Xiao J. Psychological impact of healthcare workers in China during COVID-19 pneumonia epidemic: A multi-center cross-sectional survey investigation. J Affect Disord 2020; 274:405-410.

58 Yang S, Kwak SG, Ko EJ, Chang MC. The mental health burden of the covid-19 pandemic on physical therapists. Int J Environ Res Public Health 2020; 17(10):3723.

59 Zandifar A, Badrfam R, Khonsari NM, Assareh M, Karim H, Azimzadeh M, Sepehr MN, Tajbakhsh R, Rahimi F, Ghanipour N, Agoushi A, Gelsefid SH, Etemadi F, Qorbani M. COVID-19 and medical staff's mental health in educational hospitals in Alborz Province, Iran. Psychiatry Clin Neurosci 2020; 74(9):499-501.

60 Zhang C, Yang L, Liu S, Ma S, Wang Y, Cai Z, Du H, Li R, Kang L, Su M, Zhang J, Liu Z, Zhang B. Survey of insomnia and related social psychological factors among medical staff involved in the 2019 novel coronavirus disease outbreak. Front Psychiatry 2020; 11:306.

61 Zhang SX, Liu J, Jahanshahi AA, Nawaser K, Yousefi A, Li J, Sun S. At the height of the storm: Healthcare staff's health conditions and job satisfaction and their associated predictors during the epidemic peak of COVID-19. Brain Behav Immun 2020; 87:144-146.

62 Zhang WR, Wang K, Yin L, Zhao WF, Xue Q, Peng M, Min BQ, Tian Q, Leng HX, Du JL, Chang H. Mental health and psychosocial problems of medical health workers during the COVID-19 epidemic in China. Psychother Psychosom 2020; 89(4):242-250.

63 Zhao N, Huang Y. Chinese mental health burden during COVID-19 outbreak: a web-based cross-sectional survey. Asian J Psychiatr 2020; 51:102052.

64 Zhu Z, Xu S, Wang H, Liu Z, Wu J, Li G, Miao J, Zhang C, Yang Y, Sun W, Zhu S. COVID-19 in Wuhan: Sociodemographic characteristics and hospital support measures associated with the immediate psychological impact on healthcare workers. EClinicalMedicine 2020; 24:100443.
-6565 Zhu J, Sun L, Zhang L, Wang H, Fan A, Yang B, Li W, Xiao S. Prevalence and Influencing Factors of Anxiety and Depression Symptoms in the First-Line Medical Staff Fighting Against COVID-19 in Gansu. Front Psychiatry 2020; 11:386.. A Figura 1 apresenta o fluxograma de seleção dos estudos.

Figura 1
Fluxograma PRISMA de seleção dos estudos.

Qualidade metodológica dos estudos

Vinte e seis estudos incluídos na revisão apresentaram boa qualidade metodológica3030 Apisarnthanarak A, Apisarnthanarak P, Siripraparat C, Saengaram P, Leeprechanon N, Weber DJ. Impact of Anxiety and Fear for COVID-19 Toward Infection Control Practices Among Thai Healthcare Workers. Infect Control Hosp Epidemiol 2020; 41(9):1093-1094.,3434 Chew QH, Chia FL, Ng WK, Lee WC, Tan PL, Wong CS, Puah SH, Shelat VG, Seah EJ, Huey CW, Phua EJ. Psychological and coping responses to COVID-19 amongst residents in training across ACGME-I accredited specialties in Singapore. Psychiatry Res 2020; 290:113146.

35 Civantos AM, Byrnes Y, Chang C, Prasad A, Chorath K, Poonia SK, Jenks CM, Bur AM, Thakkar P, Graboyes EM, Seth R. Mental health among otolaryngology resident and attending physicians during the COVID-19 pandemic: National study. Head Neck 2020; 42(7):1597-1609.
-3636 Consolo U, Bellini P, Bencivenni D, Iani C, Checchi V. Epidemiological Aspects and Psychological Reactions to COVID-19 of Dental Practitioners in the Northern Italy Districts of Modena and Reggio Emilia. Int J Environ Res Public Health 2020; 17(10):3459.,3838 Dal'Bosco EB, Floriano LSM, Skupien SV, Arcaro G, Martins AR, Anselmo ACC. Mental health of nursing in coping with COVID-19 at a regional university hospital. Rev Bras Enferm 2020; 73(Supl. 2):e20200434.,4141 Gupta AK, Mehra A, Niraula A, Kafle K, Deo SP, Singh B, Sahoo S, Grover S. Prevalence of anxiety and depression among the healthcare workers in Nepal during the COVID-19 pandemic. Asian J Psychiatr 2020; 54:102260.

42 Hu D, Kong Y, Li W, Han Q, Zhang X, Zhu LX, Wan SW, Zuofeng LI, Qu SH, Jingqiu YA, Hong-Gu HE. Frontline nurses' burnout, anxiety, depression, and fear statuses and their associated factors during the COVID-19 outbreak in Wuhan, China: A large-scale cross-sectional study. EClinicalMedicine 2020; 24:100424.

43 Huang JZ, Han MF, Luo TD, Ren AK, Zhou XP. Mental health survey of medical staff in a tertiary infectious disease hospital for COVID-19. Zhonghua Lao Dong Wei Sheng Zhi Ye Bing Za Zhi 2020; 38(3):192-195.

44 Lai J, Ma S, Wang Y, Cai Z, Hu J, Wei N, Wu J, Du H, Chen T, Li R, Tan H. Factors associated with mental health outcomes among health care workers exposed to coronavirus disease 2019. JAMA Netw Open 2020; 3(3):e203976.

45 Lin K, Yang BX, Luo D, Liu Q, Ma S, Huang R, Lu W, Majeed A, Lee Y, Lui LM, Mansur RB. The mental health effects of COVID-19 on health care providers in China. Am J Psychiatry 2020; 177(7):635-636.

46 Liu CY, Yang YZ, Zhang XM, Xu X, Dou QL, Zhang WW, Cheng AS. The prevalence and influencing factors in anxiety in medical workers fighting COVID-19 in China: a cross-sectional survey. Epidemiol Infect 2020; 148:e98.
-4747 Lu W, Wang H, Lin Y, Li L. Psychological status of medical workforce during the COVID-19 pandemic: A cross-sectional study. Psychiatry Res 2020; 288:112936.,4949 Naser AY, Dahmash EZ, Al-Rousan R, Alwafi H, Alrawashdeh HM, Ghoul I, Abidine A, Bokhary MA, Al-Hadithi HT, Ali D, Abuthawabeh R, Abdelwahab GM, Alhartani YJ, Al Muhaisen H, Dagash A, Alyami HS. Mental health status of the general population, healthcare professionals, and university students during 2019 coronavirus disease outbreak in Jordan: A cross-sectional study. Brain Behav 2020; 10(8):e01730.

50 Que J, Le Shi JD, Liu J, Zhang L, Wu S, Gong Y, Huang W, Yuan K, Yan W, Sun Y, Ran M. Psychological impact of the COVID-19 pandemic on healthcare workers: a cross-sectional study in China. Gen Psychiatry 2020; 33(3):e100259.
-5151 Rossi R, Socci V, Pacitti F, Di Lorenzo G, Di Marco A, Siracusano A, Rossi A. Mental Health Outcomes Among Frontline and Second-Line Health Care Workers During the Coronavirus Disease 2019 (COVID-19) Pandemic in Italy. JAMA Net Open 2020; 3(5):e2010185.,5353 Tan BY, Chew NW, Lee GK, Jing M, Goh Y, Yeo LL, Zhang K, Chin HK, Ahmad A, Khan FA, Shanmugam GN, Chan BPL, Sunny S, Chandra B, Ong JJY, Paliwal PR, Wong LYH, Sagayanathan R, Chen JT, Ng AYY, Teoh HL, Ho CS, Ho RC, Sharma VK. Psychological impact of the COVID-19 pandemic on health care workers in Singapore. Ann Intern Med 2020; 173(4):317-320.

54 Temsah MH, Al-Sohime F, Alamro N, Al-Eyadhy A, Al-Hasan K, Jamal A, Al-Maglouth I, Aljamaan F, Al Amri M, Barry M, Al-Subaie S. The psychological impact of COVID-19 pandemic on health care workers in a MERS-CoV endemic country. J Infect Public Health 2020; 13(6):877-882.

55 Vanni G, Materazzo M, Santori F, Pellicciaro M, Costesta M, Orsaria P, Cattadori F, Pistolese CA, Perretta T, Chiocchi M, Meucci R. The Effect of Coronavirus (COVID-19) on Breast Cancer Teamwork: A Multicentric Survey. In Vivo 2020; 34(3 Supl.):1685-1694.

56 Wang S, Xie L, Xu Y, Yu S, Yao B, Xiang D. Sleep disturbances among medical workers during the outbreak of COVID-2019. Occup Med (Lond) 2020; 70(5):364-369.

57 Xiao X, Zhu X, Fu S, Hu Y, Li X, Xiao J. Psychological impact of healthcare workers in China during COVID-19 pneumonia epidemic: A multi-center cross-sectional survey investigation. J Affect Disord 2020; 274:405-410.
-5858 Yang S, Kwak SG, Ko EJ, Chang MC. The mental health burden of the covid-19 pandemic on physical therapists. Int J Environ Res Public Health 2020; 17(10):3723.,6060 Zhang C, Yang L, Liu S, Ma S, Wang Y, Cai Z, Du H, Li R, Kang L, Su M, Zhang J, Liu Z, Zhang B. Survey of insomnia and related social psychological factors among medical staff involved in the 2019 novel coronavirus disease outbreak. Front Psychiatry 2020; 11:306.,6262 Zhang WR, Wang K, Yin L, Zhao WF, Xue Q, Peng M, Min BQ, Tian Q, Leng HX, Du JL, Chang H. Mental health and psychosocial problems of medical health workers during the COVID-19 epidemic in China. Psychother Psychosom 2020; 89(4):242-250.

63 Zhao N, Huang Y. Chinese mental health burden during COVID-19 outbreak: a web-based cross-sectional survey. Asian J Psychiatr 2020; 51:102052.

64 Zhu Z, Xu S, Wang H, Liu Z, Wu J, Li G, Miao J, Zhang C, Yang Y, Sun W, Zhu S. COVID-19 in Wuhan: Sociodemographic characteristics and hospital support measures associated with the immediate psychological impact on healthcare workers. EClinicalMedicine 2020; 24:100443.
-6565 Zhu J, Sun L, Zhang L, Wang H, Fan A, Yang B, Li W, Xiao S. Prevalence and Influencing Factors of Anxiety and Depression Symptoms in the First-Line Medical Staff Fighting Against COVID-19 in Gansu. Front Psychiatry 2020; 11:386. e 10 foram classificados como tendo baixa qualidade3131 Badahdah A, Khamis F, Al Mahyijari N, Al Balushi M, Al Hatmi H, Al Salmi I, Albulushi Z, Al Noomani J. The mental health of health care workers in Oman during the COVID-19 pandemic. Int J Soc Psychiatry 2020; 20764020939596.

32 Chatterjee SS, Bhattacharyya R, Bhattacharyya S, Gupta S, Das S, Banerjee BB. Attitude, practice, behavior, and mental health impact of COVID-19 on doctors. Indian J Psychiatry 2020; 62(3):257.
-3333 Chen Y, Zhou H, Zhou Y, Zhou F. Prevalence of self-reported depression and anxiety among pediatric medical staff members during the COVID-19 outbreak in Guiyang, China. Psychiatry Res 2020; 288:113005.,3737 Corbett GA, Milne SJ, Mohan S, Reagu S, Farrell T, Lindow SW, Hehir MP, O'Connell MP. Anxiety and Depression Scores in Maternity Healthcare Workers during the Covid-19 Pandemic. Int J Gynaecol Obstet 2020; 151(2):297-298.,3939 Du J, Dong L, Wang T, Yuan C, Fu R, Zhang L, Liu B, Zhang M, Yin Y, Qin J, Bouey J. Psychological symptoms among frontline healthcare workers during COVID-19 outbreak in Wuhan. Gen Hosp Psychiatry 2020; 67:144-145.,4040 Elbay RY, Kurtulmus A, Arpacioglu S, Karadere E. Depression, anxiety, stress levels of physicians and associated factors in Covid-19 pandemics. Psychiatry Res 2020; 290:113130.,4848 Moghadasi AN. Evaluation of the Level of Anxiety among Iranian Multiple Sclerosis Fellowships During the Outbreak of COVID-19. Arch Iran Med 2020; 23(4):283.,5252 Shechter A, Diaz F, Moise N, Anstey DE, Ye S, Agarwal S, Birk JL, Brodie D, Cannone DE, Chang B, Claassen J. Psychological distress, coping behaviors, and preferences for support among New York healthcare workers during the COVID-19 pandemic. Gen Hosp Psychiatry 2020; 66:1-8.,5959 Zandifar A, Badrfam R, Khonsari NM, Assareh M, Karim H, Azimzadeh M, Sepehr MN, Tajbakhsh R, Rahimi F, Ghanipour N, Agoushi A, Gelsefid SH, Etemadi F, Qorbani M. COVID-19 and medical staff's mental health in educational hospitals in Alborz Province, Iran. Psychiatry Clin Neurosci 2020; 74(9):499-501.,6161 Zhang SX, Liu J, Jahanshahi AA, Nawaser K, Yousefi A, Li J, Sun S. At the height of the storm: Healthcare staff's health conditions and job satisfaction and their associated predictors during the epidemic peak of COVID-19. Brain Behav Immun 2020; 87:144-146.. A Tabela 1 apresenta a qualidade metodológica e as características dos estudos incluídos na revisão.

Tabela 1
Características dos estudos incluídos na revisão (n = 36).

Características dos estudos

Todos os estudos incluídos na revisão sistemática foram de delineamento transversal3030 Apisarnthanarak A, Apisarnthanarak P, Siripraparat C, Saengaram P, Leeprechanon N, Weber DJ. Impact of Anxiety and Fear for COVID-19 Toward Infection Control Practices Among Thai Healthcare Workers. Infect Control Hosp Epidemiol 2020; 41(9):1093-1094.

31 Badahdah A, Khamis F, Al Mahyijari N, Al Balushi M, Al Hatmi H, Al Salmi I, Albulushi Z, Al Noomani J. The mental health of health care workers in Oman during the COVID-19 pandemic. Int J Soc Psychiatry 2020; 20764020939596.

32 Chatterjee SS, Bhattacharyya R, Bhattacharyya S, Gupta S, Das S, Banerjee BB. Attitude, practice, behavior, and mental health impact of COVID-19 on doctors. Indian J Psychiatry 2020; 62(3):257.

33 Chen Y, Zhou H, Zhou Y, Zhou F. Prevalence of self-reported depression and anxiety among pediatric medical staff members during the COVID-19 outbreak in Guiyang, China. Psychiatry Res 2020; 288:113005.

34 Chew QH, Chia FL, Ng WK, Lee WC, Tan PL, Wong CS, Puah SH, Shelat VG, Seah EJ, Huey CW, Phua EJ. Psychological and coping responses to COVID-19 amongst residents in training across ACGME-I accredited specialties in Singapore. Psychiatry Res 2020; 290:113146.

35 Civantos AM, Byrnes Y, Chang C, Prasad A, Chorath K, Poonia SK, Jenks CM, Bur AM, Thakkar P, Graboyes EM, Seth R. Mental health among otolaryngology resident and attending physicians during the COVID-19 pandemic: National study. Head Neck 2020; 42(7):1597-1609.

36 Consolo U, Bellini P, Bencivenni D, Iani C, Checchi V. Epidemiological Aspects and Psychological Reactions to COVID-19 of Dental Practitioners in the Northern Italy Districts of Modena and Reggio Emilia. Int J Environ Res Public Health 2020; 17(10):3459.

37 Corbett GA, Milne SJ, Mohan S, Reagu S, Farrell T, Lindow SW, Hehir MP, O'Connell MP. Anxiety and Depression Scores in Maternity Healthcare Workers during the Covid-19 Pandemic. Int J Gynaecol Obstet 2020; 151(2):297-298.

38 Dal'Bosco EB, Floriano LSM, Skupien SV, Arcaro G, Martins AR, Anselmo ACC. Mental health of nursing in coping with COVID-19 at a regional university hospital. Rev Bras Enferm 2020; 73(Supl. 2):e20200434.

39 Du J, Dong L, Wang T, Yuan C, Fu R, Zhang L, Liu B, Zhang M, Yin Y, Qin J, Bouey J. Psychological symptoms among frontline healthcare workers during COVID-19 outbreak in Wuhan. Gen Hosp Psychiatry 2020; 67:144-145.

40 Elbay RY, Kurtulmus A, Arpacioglu S, Karadere E. Depression, anxiety, stress levels of physicians and associated factors in Covid-19 pandemics. Psychiatry Res 2020; 290:113130.

41 Gupta AK, Mehra A, Niraula A, Kafle K, Deo SP, Singh B, Sahoo S, Grover S. Prevalence of anxiety and depression among the healthcare workers in Nepal during the COVID-19 pandemic. Asian J Psychiatr 2020; 54:102260.

42 Hu D, Kong Y, Li W, Han Q, Zhang X, Zhu LX, Wan SW, Zuofeng LI, Qu SH, Jingqiu YA, Hong-Gu HE. Frontline nurses' burnout, anxiety, depression, and fear statuses and their associated factors during the COVID-19 outbreak in Wuhan, China: A large-scale cross-sectional study. EClinicalMedicine 2020; 24:100424.

43 Huang JZ, Han MF, Luo TD, Ren AK, Zhou XP. Mental health survey of medical staff in a tertiary infectious disease hospital for COVID-19. Zhonghua Lao Dong Wei Sheng Zhi Ye Bing Za Zhi 2020; 38(3):192-195.

44 Lai J, Ma S, Wang Y, Cai Z, Hu J, Wei N, Wu J, Du H, Chen T, Li R, Tan H. Factors associated with mental health outcomes among health care workers exposed to coronavirus disease 2019. JAMA Netw Open 2020; 3(3):e203976.

45 Lin K, Yang BX, Luo D, Liu Q, Ma S, Huang R, Lu W, Majeed A, Lee Y, Lui LM, Mansur RB. The mental health effects of COVID-19 on health care providers in China. Am J Psychiatry 2020; 177(7):635-636.

46 Liu CY, Yang YZ, Zhang XM, Xu X, Dou QL, Zhang WW, Cheng AS. The prevalence and influencing factors in anxiety in medical workers fighting COVID-19 in China: a cross-sectional survey. Epidemiol Infect 2020; 148:e98.

47 Lu W, Wang H, Lin Y, Li L. Psychological status of medical workforce during the COVID-19 pandemic: A cross-sectional study. Psychiatry Res 2020; 288:112936.

48 Moghadasi AN. Evaluation of the Level of Anxiety among Iranian Multiple Sclerosis Fellowships During the Outbreak of COVID-19. Arch Iran Med 2020; 23(4):283.

49 Naser AY, Dahmash EZ, Al-Rousan R, Alwafi H, Alrawashdeh HM, Ghoul I, Abidine A, Bokhary MA, Al-Hadithi HT, Ali D, Abuthawabeh R, Abdelwahab GM, Alhartani YJ, Al Muhaisen H, Dagash A, Alyami HS. Mental health status of the general population, healthcare professionals, and university students during 2019 coronavirus disease outbreak in Jordan: A cross-sectional study. Brain Behav 2020; 10(8):e01730.

50 Que J, Le Shi JD, Liu J, Zhang L, Wu S, Gong Y, Huang W, Yuan K, Yan W, Sun Y, Ran M. Psychological impact of the COVID-19 pandemic on healthcare workers: a cross-sectional study in China. Gen Psychiatry 2020; 33(3):e100259.

51 Rossi R, Socci V, Pacitti F, Di Lorenzo G, Di Marco A, Siracusano A, Rossi A. Mental Health Outcomes Among Frontline and Second-Line Health Care Workers During the Coronavirus Disease 2019 (COVID-19) Pandemic in Italy. JAMA Net Open 2020; 3(5):e2010185.

52 Shechter A, Diaz F, Moise N, Anstey DE, Ye S, Agarwal S, Birk JL, Brodie D, Cannone DE, Chang B, Claassen J. Psychological distress, coping behaviors, and preferences for support among New York healthcare workers during the COVID-19 pandemic. Gen Hosp Psychiatry 2020; 66:1-8.

53 Tan BY, Chew NW, Lee GK, Jing M, Goh Y, Yeo LL, Zhang K, Chin HK, Ahmad A, Khan FA, Shanmugam GN, Chan BPL, Sunny S, Chandra B, Ong JJY, Paliwal PR, Wong LYH, Sagayanathan R, Chen JT, Ng AYY, Teoh HL, Ho CS, Ho RC, Sharma VK. Psychological impact of the COVID-19 pandemic on health care workers in Singapore. Ann Intern Med 2020; 173(4):317-320.

54 Temsah MH, Al-Sohime F, Alamro N, Al-Eyadhy A, Al-Hasan K, Jamal A, Al-Maglouth I, Aljamaan F, Al Amri M, Barry M, Al-Subaie S. The psychological impact of COVID-19 pandemic on health care workers in a MERS-CoV endemic country. J Infect Public Health 2020; 13(6):877-882.

55 Vanni G, Materazzo M, Santori F, Pellicciaro M, Costesta M, Orsaria P, Cattadori F, Pistolese CA, Perretta T, Chiocchi M, Meucci R. The Effect of Coronavirus (COVID-19) on Breast Cancer Teamwork: A Multicentric Survey. In Vivo 2020; 34(3 Supl.):1685-1694.

56 Wang S, Xie L, Xu Y, Yu S, Yao B, Xiang D. Sleep disturbances among medical workers during the outbreak of COVID-2019. Occup Med (Lond) 2020; 70(5):364-369.

57 Xiao X, Zhu X, Fu S, Hu Y, Li X, Xiao J. Psychological impact of healthcare workers in China during COVID-19 pneumonia epidemic: A multi-center cross-sectional survey investigation. J Affect Disord 2020; 274:405-410.

58 Yang S, Kwak SG, Ko EJ, Chang MC. The mental health burden of the covid-19 pandemic on physical therapists. Int J Environ Res Public Health 2020; 17(10):3723.

59 Zandifar A, Badrfam R, Khonsari NM, Assareh M, Karim H, Azimzadeh M, Sepehr MN, Tajbakhsh R, Rahimi F, Ghanipour N, Agoushi A, Gelsefid SH, Etemadi F, Qorbani M. COVID-19 and medical staff's mental health in educational hospitals in Alborz Province, Iran. Psychiatry Clin Neurosci 2020; 74(9):499-501.

60 Zhang C, Yang L, Liu S, Ma S, Wang Y, Cai Z, Du H, Li R, Kang L, Su M, Zhang J, Liu Z, Zhang B. Survey of insomnia and related social psychological factors among medical staff involved in the 2019 novel coronavirus disease outbreak. Front Psychiatry 2020; 11:306.

61 Zhang SX, Liu J, Jahanshahi AA, Nawaser K, Yousefi A, Li J, Sun S. At the height of the storm: Healthcare staff's health conditions and job satisfaction and their associated predictors during the epidemic peak of COVID-19. Brain Behav Immun 2020; 87:144-146.

62 Zhang WR, Wang K, Yin L, Zhao WF, Xue Q, Peng M, Min BQ, Tian Q, Leng HX, Du JL, Chang H. Mental health and psychosocial problems of medical health workers during the COVID-19 epidemic in China. Psychother Psychosom 2020; 89(4):242-250.

63 Zhao N, Huang Y. Chinese mental health burden during COVID-19 outbreak: a web-based cross-sectional survey. Asian J Psychiatr 2020; 51:102052.

64 Zhu Z, Xu S, Wang H, Liu Z, Wu J, Li G, Miao J, Zhang C, Yang Y, Sun W, Zhu S. COVID-19 in Wuhan: Sociodemographic characteristics and hospital support measures associated with the immediate psychological impact on healthcare workers. EClinicalMedicine 2020; 24:100443.
-6565 Zhu J, Sun L, Zhang L, Wang H, Fan A, Yang B, Li W, Xiao S. Prevalence and Influencing Factors of Anxiety and Depression Symptoms in the First-Line Medical Staff Fighting Against COVID-19 in Gansu. Front Psychiatry 2020; 11:386.. Dezesseis estudos foram conduzidos na China3333 Chen Y, Zhou H, Zhou Y, Zhou F. Prevalence of self-reported depression and anxiety among pediatric medical staff members during the COVID-19 outbreak in Guiyang, China. Psychiatry Res 2020; 288:113005.,3939 Du J, Dong L, Wang T, Yuan C, Fu R, Zhang L, Liu B, Zhang M, Yin Y, Qin J, Bouey J. Psychological symptoms among frontline healthcare workers during COVID-19 outbreak in Wuhan. Gen Hosp Psychiatry 2020; 67:144-145.,4242 Hu D, Kong Y, Li W, Han Q, Zhang X, Zhu LX, Wan SW, Zuofeng LI, Qu SH, Jingqiu YA, Hong-Gu HE. Frontline nurses' burnout, anxiety, depression, and fear statuses and their associated factors during the COVID-19 outbreak in Wuhan, China: A large-scale cross-sectional study. EClinicalMedicine 2020; 24:100424.

43 Huang JZ, Han MF, Luo TD, Ren AK, Zhou XP. Mental health survey of medical staff in a tertiary infectious disease hospital for COVID-19. Zhonghua Lao Dong Wei Sheng Zhi Ye Bing Za Zhi 2020; 38(3):192-195.

44 Lai J, Ma S, Wang Y, Cai Z, Hu J, Wei N, Wu J, Du H, Chen T, Li R, Tan H. Factors associated with mental health outcomes among health care workers exposed to coronavirus disease 2019. JAMA Netw Open 2020; 3(3):e203976.

45 Lin K, Yang BX, Luo D, Liu Q, Ma S, Huang R, Lu W, Majeed A, Lee Y, Lui LM, Mansur RB. The mental health effects of COVID-19 on health care providers in China. Am J Psychiatry 2020; 177(7):635-636.

46 Liu CY, Yang YZ, Zhang XM, Xu X, Dou QL, Zhang WW, Cheng AS. The prevalence and influencing factors in anxiety in medical workers fighting COVID-19 in China: a cross-sectional survey. Epidemiol Infect 2020; 148:e98.
-4747 Lu W, Wang H, Lin Y, Li L. Psychological status of medical workforce during the COVID-19 pandemic: A cross-sectional study. Psychiatry Res 2020; 288:112936.,5050 Que J, Le Shi JD, Liu J, Zhang L, Wu S, Gong Y, Huang W, Yuan K, Yan W, Sun Y, Ran M. Psychological impact of the COVID-19 pandemic on healthcare workers: a cross-sectional study in China. Gen Psychiatry 2020; 33(3):e100259.,5656 Wang S, Xie L, Xu Y, Yu S, Yao B, Xiang D. Sleep disturbances among medical workers during the outbreak of COVID-2019. Occup Med (Lond) 2020; 70(5):364-369.,5757 Xiao X, Zhu X, Fu S, Hu Y, Li X, Xiao J. Psychological impact of healthcare workers in China during COVID-19 pneumonia epidemic: A multi-center cross-sectional survey investigation. J Affect Disord 2020; 274:405-410.,6060 Zhang C, Yang L, Liu S, Ma S, Wang Y, Cai Z, Du H, Li R, Kang L, Su M, Zhang J, Liu Z, Zhang B. Survey of insomnia and related social psychological factors among medical staff involved in the 2019 novel coronavirus disease outbreak. Front Psychiatry 2020; 11:306.,6262 Zhang WR, Wang K, Yin L, Zhao WF, Xue Q, Peng M, Min BQ, Tian Q, Leng HX, Du JL, Chang H. Mental health and psychosocial problems of medical health workers during the COVID-19 epidemic in China. Psychother Psychosom 2020; 89(4):242-250.

63 Zhao N, Huang Y. Chinese mental health burden during COVID-19 outbreak: a web-based cross-sectional survey. Asian J Psychiatr 2020; 51:102052.

64 Zhu Z, Xu S, Wang H, Liu Z, Wu J, Li G, Miao J, Zhang C, Yang Y, Sun W, Zhu S. COVID-19 in Wuhan: Sociodemographic characteristics and hospital support measures associated with the immediate psychological impact on healthcare workers. EClinicalMedicine 2020; 24:100443.
-6565 Zhu J, Sun L, Zhang L, Wang H, Fan A, Yang B, Li W, Xiao S. Prevalence and Influencing Factors of Anxiety and Depression Symptoms in the First-Line Medical Staff Fighting Against COVID-19 in Gansu. Front Psychiatry 2020; 11:386., três na Itália3636 Consolo U, Bellini P, Bencivenni D, Iani C, Checchi V. Epidemiological Aspects and Psychological Reactions to COVID-19 of Dental Practitioners in the Northern Italy Districts of Modena and Reggio Emilia. Int J Environ Res Public Health 2020; 17(10):3459.,5151 Rossi R, Socci V, Pacitti F, Di Lorenzo G, Di Marco A, Siracusano A, Rossi A. Mental Health Outcomes Among Frontline and Second-Line Health Care Workers During the Coronavirus Disease 2019 (COVID-19) Pandemic in Italy. JAMA Net Open 2020; 3(5):e2010185.,5555 Vanni G, Materazzo M, Santori F, Pellicciaro M, Costesta M, Orsaria P, Cattadori F, Pistolese CA, Perretta T, Chiocchi M, Meucci R. The Effect of Coronavirus (COVID-19) on Breast Cancer Teamwork: A Multicentric Survey. In Vivo 2020; 34(3 Supl.):1685-1694., três no Irã4848 Moghadasi AN. Evaluation of the Level of Anxiety among Iranian Multiple Sclerosis Fellowships During the Outbreak of COVID-19. Arch Iran Med 2020; 23(4):283.,5959 Zandifar A, Badrfam R, Khonsari NM, Assareh M, Karim H, Azimzadeh M, Sepehr MN, Tajbakhsh R, Rahimi F, Ghanipour N, Agoushi A, Gelsefid SH, Etemadi F, Qorbani M. COVID-19 and medical staff's mental health in educational hospitals in Alborz Province, Iran. Psychiatry Clin Neurosci 2020; 74(9):499-501.,6161 Zhang SX, Liu J, Jahanshahi AA, Nawaser K, Yousefi A, Li J, Sun S. At the height of the storm: Healthcare staff's health conditions and job satisfaction and their associated predictors during the epidemic peak of COVID-19. Brain Behav Immun 2020; 87:144-146., dois nos Estados Unidos3535 Civantos AM, Byrnes Y, Chang C, Prasad A, Chorath K, Poonia SK, Jenks CM, Bur AM, Thakkar P, Graboyes EM, Seth R. Mental health among otolaryngology resident and attending physicians during the COVID-19 pandemic: National study. Head Neck 2020; 42(7):1597-1609.,5252 Shechter A, Diaz F, Moise N, Anstey DE, Ye S, Agarwal S, Birk JL, Brodie D, Cannone DE, Chang B, Claassen J. Psychological distress, coping behaviors, and preferences for support among New York healthcare workers during the COVID-19 pandemic. Gen Hosp Psychiatry 2020; 66:1-8., um no Brasil3838 Dal'Bosco EB, Floriano LSM, Skupien SV, Arcaro G, Martins AR, Anselmo ACC. Mental health of nursing in coping with COVID-19 at a regional university hospital. Rev Bras Enferm 2020; 73(Supl. 2):e20200434., um na Jordânia4949 Naser AY, Dahmash EZ, Al-Rousan R, Alwafi H, Alrawashdeh HM, Ghoul I, Abidine A, Bokhary MA, Al-Hadithi HT, Ali D, Abuthawabeh R, Abdelwahab GM, Alhartani YJ, Al Muhaisen H, Dagash A, Alyami HS. Mental health status of the general population, healthcare professionals, and university students during 2019 coronavirus disease outbreak in Jordan: A cross-sectional study. Brain Behav 2020; 10(8):e01730., um em Singapura5353 Tan BY, Chew NW, Lee GK, Jing M, Goh Y, Yeo LL, Zhang K, Chin HK, Ahmad A, Khan FA, Shanmugam GN, Chan BPL, Sunny S, Chandra B, Ong JJY, Paliwal PR, Wong LYH, Sagayanathan R, Chen JT, Ng AYY, Teoh HL, Ho CS, Ho RC, Sharma VK. Psychological impact of the COVID-19 pandemic on health care workers in Singapore. Ann Intern Med 2020; 173(4):317-320., um na Índia3232 Chatterjee SS, Bhattacharyya R, Bhattacharyya S, Gupta S, Das S, Banerjee BB. Attitude, practice, behavior, and mental health impact of COVID-19 on doctors. Indian J Psychiatry 2020; 62(3):257., um na Coréia do Sul5858 Yang S, Kwak SG, Ko EJ, Chang MC. The mental health burden of the covid-19 pandemic on physical therapists. Int J Environ Res Public Health 2020; 17(10):3723., um na Irlanda3737 Corbett GA, Milne SJ, Mohan S, Reagu S, Farrell T, Lindow SW, Hehir MP, O'Connell MP. Anxiety and Depression Scores in Maternity Healthcare Workers during the Covid-19 Pandemic. Int J Gynaecol Obstet 2020; 151(2):297-298., um na Turquia4040 Elbay RY, Kurtulmus A, Arpacioglu S, Karadere E. Depression, anxiety, stress levels of physicians and associated factors in Covid-19 pandemics. Psychiatry Res 2020; 290:113130., um na Tailândia3030 Apisarnthanarak A, Apisarnthanarak P, Siripraparat C, Saengaram P, Leeprechanon N, Weber DJ. Impact of Anxiety and Fear for COVID-19 Toward Infection Control Practices Among Thai Healthcare Workers. Infect Control Hosp Epidemiol 2020; 41(9):1093-1094., um no Nepal4141 Gupta AK, Mehra A, Niraula A, Kafle K, Deo SP, Singh B, Sahoo S, Grover S. Prevalence of anxiety and depression among the healthcare workers in Nepal during the COVID-19 pandemic. Asian J Psychiatr 2020; 54:102260., um em Omã3131 Badahdah A, Khamis F, Al Mahyijari N, Al Balushi M, Al Hatmi H, Al Salmi I, Albulushi Z, Al Noomani J. The mental health of health care workers in Oman during the COVID-19 pandemic. Int J Soc Psychiatry 2020; 20764020939596., um na Arábia Saudita5454 Temsah MH, Al-Sohime F, Alamro N, Al-Eyadhy A, Al-Hasan K, Jamal A, Al-Maglouth I, Aljamaan F, Al Amri M, Barry M, Al-Subaie S. The psychological impact of COVID-19 pandemic on health care workers in a MERS-CoV endemic country. J Infect Public Health 2020; 13(6):877-882. e um incluiu profissionais de Singapura e Índia3434 Chew QH, Chia FL, Ng WK, Lee WC, Tan PL, Wong CS, Puah SH, Shelat VG, Seah EJ, Huey CW, Phua EJ. Psychological and coping responses to COVID-19 amongst residents in training across ACGME-I accredited specialties in Singapore. Psychiatry Res 2020; 290:113146..

O número de participantes entre os estudos variou de 144848 Moghadasi AN. Evaluation of the Level of Anxiety among Iranian Multiple Sclerosis Fellowships During the Outbreak of COVID-19. Arch Iran Med 2020; 23(4):283. a 5.062 profissionais de saúde6464 Zhu Z, Xu S, Wang H, Liu Z, Wu J, Li G, Miao J, Zhang C, Yang Y, Sun W, Zhu S. COVID-19 in Wuhan: Sociodemographic characteristics and hospital support measures associated with the immediate psychological impact on healthcare workers. EClinicalMedicine 2020; 24:100443.. Vinte e seis estudos incluíram mais mulheres que homens3030 Apisarnthanarak A, Apisarnthanarak P, Siripraparat C, Saengaram P, Leeprechanon N, Weber DJ. Impact of Anxiety and Fear for COVID-19 Toward Infection Control Practices Among Thai Healthcare Workers. Infect Control Hosp Epidemiol 2020; 41(9):1093-1094.,3131 Badahdah A, Khamis F, Al Mahyijari N, Al Balushi M, Al Hatmi H, Al Salmi I, Albulushi Z, Al Noomani J. The mental health of health care workers in Oman during the COVID-19 pandemic. Int J Soc Psychiatry 2020; 20764020939596.,3333 Chen Y, Zhou H, Zhou Y, Zhou F. Prevalence of self-reported depression and anxiety among pediatric medical staff members during the COVID-19 outbreak in Guiyang, China. Psychiatry Res 2020; 288:113005.,3434 Chew QH, Chia FL, Ng WK, Lee WC, Tan PL, Wong CS, Puah SH, Shelat VG, Seah EJ, Huey CW, Phua EJ. Psychological and coping responses to COVID-19 amongst residents in training across ACGME-I accredited specialties in Singapore. Psychiatry Res 2020; 290:113146.,3838 Dal'Bosco EB, Floriano LSM, Skupien SV, Arcaro G, Martins AR, Anselmo ACC. Mental health of nursing in coping with COVID-19 at a regional university hospital. Rev Bras Enferm 2020; 73(Supl. 2):e20200434.

39 Du J, Dong L, Wang T, Yuan C, Fu R, Zhang L, Liu B, Zhang M, Yin Y, Qin J, Bouey J. Psychological symptoms among frontline healthcare workers during COVID-19 outbreak in Wuhan. Gen Hosp Psychiatry 2020; 67:144-145.
-4040 Elbay RY, Kurtulmus A, Arpacioglu S, Karadere E. Depression, anxiety, stress levels of physicians and associated factors in Covid-19 pandemics. Psychiatry Res 2020; 290:113130.,4242 Hu D, Kong Y, Li W, Han Q, Zhang X, Zhu LX, Wan SW, Zuofeng LI, Qu SH, Jingqiu YA, Hong-Gu HE. Frontline nurses' burnout, anxiety, depression, and fear statuses and their associated factors during the COVID-19 outbreak in Wuhan, China: A large-scale cross-sectional study. EClinicalMedicine 2020; 24:100424.

43 Huang JZ, Han MF, Luo TD, Ren AK, Zhou XP. Mental health survey of medical staff in a tertiary infectious disease hospital for COVID-19. Zhonghua Lao Dong Wei Sheng Zhi Ye Bing Za Zhi 2020; 38(3):192-195.
-4444 Lai J, Ma S, Wang Y, Cai Z, Hu J, Wei N, Wu J, Du H, Chen T, Li R, Tan H. Factors associated with mental health outcomes among health care workers exposed to coronavirus disease 2019. JAMA Netw Open 2020; 3(3):e203976.,4646 Liu CY, Yang YZ, Zhang XM, Xu X, Dou QL, Zhang WW, Cheng AS. The prevalence and influencing factors in anxiety in medical workers fighting COVID-19 in China: a cross-sectional survey. Epidemiol Infect 2020; 148:e98.,4747 Lu W, Wang H, Lin Y, Li L. Psychological status of medical workforce during the COVID-19 pandemic: A cross-sectional study. Psychiatry Res 2020; 288:112936.,4949 Naser AY, Dahmash EZ, Al-Rousan R, Alwafi H, Alrawashdeh HM, Ghoul I, Abidine A, Bokhary MA, Al-Hadithi HT, Ali D, Abuthawabeh R, Abdelwahab GM, Alhartani YJ, Al Muhaisen H, Dagash A, Alyami HS. Mental health status of the general population, healthcare professionals, and university students during 2019 coronavirus disease outbreak in Jordan: A cross-sectional study. Brain Behav 2020; 10(8):e01730.

50 Que J, Le Shi JD, Liu J, Zhang L, Wu S, Gong Y, Huang W, Yuan K, Yan W, Sun Y, Ran M. Psychological impact of the COVID-19 pandemic on healthcare workers: a cross-sectional study in China. Gen Psychiatry 2020; 33(3):e100259.

51 Rossi R, Socci V, Pacitti F, Di Lorenzo G, Di Marco A, Siracusano A, Rossi A. Mental Health Outcomes Among Frontline and Second-Line Health Care Workers During the Coronavirus Disease 2019 (COVID-19) Pandemic in Italy. JAMA Net Open 2020; 3(5):e2010185.

52 Shechter A, Diaz F, Moise N, Anstey DE, Ye S, Agarwal S, Birk JL, Brodie D, Cannone DE, Chang B, Claassen J. Psychological distress, coping behaviors, and preferences for support among New York healthcare workers during the COVID-19 pandemic. Gen Hosp Psychiatry 2020; 66:1-8.

53 Tan BY, Chew NW, Lee GK, Jing M, Goh Y, Yeo LL, Zhang K, Chin HK, Ahmad A, Khan FA, Shanmugam GN, Chan BPL, Sunny S, Chandra B, Ong JJY, Paliwal PR, Wong LYH, Sagayanathan R, Chen JT, Ng AYY, Teoh HL, Ho CS, Ho RC, Sharma VK. Psychological impact of the COVID-19 pandemic on health care workers in Singapore. Ann Intern Med 2020; 173(4):317-320.

54 Temsah MH, Al-Sohime F, Alamro N, Al-Eyadhy A, Al-Hasan K, Jamal A, Al-Maglouth I, Aljamaan F, Al Amri M, Barry M, Al-Subaie S. The psychological impact of COVID-19 pandemic on health care workers in a MERS-CoV endemic country. J Infect Public Health 2020; 13(6):877-882.

55 Vanni G, Materazzo M, Santori F, Pellicciaro M, Costesta M, Orsaria P, Cattadori F, Pistolese CA, Perretta T, Chiocchi M, Meucci R. The Effect of Coronavirus (COVID-19) on Breast Cancer Teamwork: A Multicentric Survey. In Vivo 2020; 34(3 Supl.):1685-1694.
-5656 Wang S, Xie L, Xu Y, Yu S, Yao B, Xiang D. Sleep disturbances among medical workers during the outbreak of COVID-2019. Occup Med (Lond) 2020; 70(5):364-369.,5858 Yang S, Kwak SG, Ko EJ, Chang MC. The mental health burden of the covid-19 pandemic on physical therapists. Int J Environ Res Public Health 2020; 17(10):3723.,6060 Zhang C, Yang L, Liu S, Ma S, Wang Y, Cai Z, Du H, Li R, Kang L, Su M, Zhang J, Liu Z, Zhang B. Survey of insomnia and related social psychological factors among medical staff involved in the 2019 novel coronavirus disease outbreak. Front Psychiatry 2020; 11:306.

61 Zhang SX, Liu J, Jahanshahi AA, Nawaser K, Yousefi A, Li J, Sun S. At the height of the storm: Healthcare staff's health conditions and job satisfaction and their associated predictors during the epidemic peak of COVID-19. Brain Behav Immun 2020; 87:144-146.
-6262 Zhang WR, Wang K, Yin L, Zhao WF, Xue Q, Peng M, Min BQ, Tian Q, Leng HX, Du JL, Chang H. Mental health and psychosocial problems of medical health workers during the COVID-19 epidemic in China. Psychother Psychosom 2020; 89(4):242-250.,6464 Zhu Z, Xu S, Wang H, Liu Z, Wu J, Li G, Miao J, Zhang C, Yang Y, Sun W, Zhu S. COVID-19 in Wuhan: Sociodemographic characteristics and hospital support measures associated with the immediate psychological impact on healthcare workers. EClinicalMedicine 2020; 24:100443.,6565 Zhu J, Sun L, Zhang L, Wang H, Fan A, Yang B, Li W, Xiao S. Prevalence and Influencing Factors of Anxiety and Depression Symptoms in the First-Line Medical Staff Fighting Against COVID-19 in Gansu. Front Psychiatry 2020; 11:386., sendo que em 13 estudos as mulheres representaram mais de 75% dos participantes22 World Health Organization (WHO). Coronavirus disease 2019 (COVID-19). Situation Report - 195 [Internet]. 2020 [acessado 2020 Ago 3]. Disponível em: https: https://www.who.int/docs/default-source/coronaviruse/situation-reports/20200802-covid-19-sitrep-195.pdf?sfvrsn=5e5da0c5_2
https: https://www.who.int/docs/default-...
,3333 Chen Y, Zhou H, Zhou Y, Zhou F. Prevalence of self-reported depression and anxiety among pediatric medical staff members during the COVID-19 outbreak in Guiyang, China. Psychiatry Res 2020; 288:113005.,3838 Dal'Bosco EB, Floriano LSM, Skupien SV, Arcaro G, Martins AR, Anselmo ACC. Mental health of nursing in coping with COVID-19 at a regional university hospital. Rev Bras Enferm 2020; 73(Supl. 2):e20200434.,4242 Hu D, Kong Y, Li W, Han Q, Zhang X, Zhu LX, Wan SW, Zuofeng LI, Qu SH, Jingqiu YA, Hong-Gu HE. Frontline nurses' burnout, anxiety, depression, and fear statuses and their associated factors during the COVID-19 outbreak in Wuhan, China: A large-scale cross-sectional study. EClinicalMedicine 2020; 24:100424.

43 Huang JZ, Han MF, Luo TD, Ren AK, Zhou XP. Mental health survey of medical staff in a tertiary infectious disease hospital for COVID-19. Zhonghua Lao Dong Wei Sheng Zhi Ye Bing Za Zhi 2020; 38(3):192-195.
-4444 Lai J, Ma S, Wang Y, Cai Z, Hu J, Wei N, Wu J, Du H, Chen T, Li R, Tan H. Factors associated with mental health outcomes among health care workers exposed to coronavirus disease 2019. JAMA Netw Open 2020; 3(3):e203976.,4646 Liu CY, Yang YZ, Zhang XM, Xu X, Dou QL, Zhang WW, Cheng AS. The prevalence and influencing factors in anxiety in medical workers fighting COVID-19 in China: a cross-sectional survey. Epidemiol Infect 2020; 148:e98.,4747 Lu W, Wang H, Lin Y, Li L. Psychological status of medical workforce during the COVID-19 pandemic: A cross-sectional study. Psychiatry Res 2020; 288:112936.,5151 Rossi R, Socci V, Pacitti F, Di Lorenzo G, Di Marco A, Siracusano A, Rossi A. Mental Health Outcomes Among Frontline and Second-Line Health Care Workers During the Coronavirus Disease 2019 (COVID-19) Pandemic in Italy. JAMA Net Open 2020; 3(5):e2010185.,5454 Temsah MH, Al-Sohime F, Alamro N, Al-Eyadhy A, Al-Hasan K, Jamal A, Al-Maglouth I, Aljamaan F, Al Amri M, Barry M, Al-Subaie S. The psychological impact of COVID-19 pandemic on health care workers in a MERS-CoV endemic country. J Infect Public Health 2020; 13(6):877-882.,5656 Wang S, Xie L, Xu Y, Yu S, Yao B, Xiang D. Sleep disturbances among medical workers during the outbreak of COVID-2019. Occup Med (Lond) 2020; 70(5):364-369.,6060 Zhang C, Yang L, Liu S, Ma S, Wang Y, Cai Z, Du H, Li R, Kang L, Su M, Zhang J, Liu Z, Zhang B. Survey of insomnia and related social psychological factors among medical staff involved in the 2019 novel coronavirus disease outbreak. Front Psychiatry 2020; 11:306.,6464 Zhu Z, Xu S, Wang H, Liu Z, Wu J, Li G, Miao J, Zhang C, Yang Y, Sun W, Zhu S. COVID-19 in Wuhan: Sociodemographic characteristics and hospital support measures associated with the immediate psychological impact on healthcare workers. EClinicalMedicine 2020; 24:100443.. Os estudos incluíram profissionais de saúde com idade entre 184444 Lai J, Ma S, Wang Y, Cai Z, Hu J, Wei N, Wu J, Du H, Chen T, Li R, Tan H. Factors associated with mental health outcomes among health care workers exposed to coronavirus disease 2019. JAMA Netw Open 2020; 3(3):e203976.,4646 Liu CY, Yang YZ, Zhang XM, Xu X, Dou QL, Zhang WW, Cheng AS. The prevalence and influencing factors in anxiety in medical workers fighting COVID-19 in China: a cross-sectional survey. Epidemiol Infect 2020; 148:e98.,4949 Naser AY, Dahmash EZ, Al-Rousan R, Alwafi H, Alrawashdeh HM, Ghoul I, Abidine A, Bokhary MA, Al-Hadithi HT, Ali D, Abuthawabeh R, Abdelwahab GM, Alhartani YJ, Al Muhaisen H, Dagash A, Alyami HS. Mental health status of the general population, healthcare professionals, and university students during 2019 coronavirus disease outbreak in Jordan: A cross-sectional study. Brain Behav 2020; 10(8):e01730.,6060 Zhang C, Yang L, Liu S, Ma S, Wang Y, Cai Z, Du H, Li R, Kang L, Su M, Zhang J, Liu Z, Zhang B. Survey of insomnia and related social psychological factors among medical staff involved in the 2019 novel coronavirus disease outbreak. Front Psychiatry 2020; 11:306. e mais que 75 anos5252 Shechter A, Diaz F, Moise N, Anstey DE, Ye S, Agarwal S, Birk JL, Brodie D, Cannone DE, Chang B, Claassen J. Psychological distress, coping behaviors, and preferences for support among New York healthcare workers during the COVID-19 pandemic. Gen Hosp Psychiatry 2020; 66:1-8..

Trinta e um estudos incluíram médicos3030 Apisarnthanarak A, Apisarnthanarak P, Siripraparat C, Saengaram P, Leeprechanon N, Weber DJ. Impact of Anxiety and Fear for COVID-19 Toward Infection Control Practices Among Thai Healthcare Workers. Infect Control Hosp Epidemiol 2020; 41(9):1093-1094.

31 Badahdah A, Khamis F, Al Mahyijari N, Al Balushi M, Al Hatmi H, Al Salmi I, Albulushi Z, Al Noomani J. The mental health of health care workers in Oman during the COVID-19 pandemic. Int J Soc Psychiatry 2020; 20764020939596.

32 Chatterjee SS, Bhattacharyya R, Bhattacharyya S, Gupta S, Das S, Banerjee BB. Attitude, practice, behavior, and mental health impact of COVID-19 on doctors. Indian J Psychiatry 2020; 62(3):257.

33 Chen Y, Zhou H, Zhou Y, Zhou F. Prevalence of self-reported depression and anxiety among pediatric medical staff members during the COVID-19 outbreak in Guiyang, China. Psychiatry Res 2020; 288:113005.

34 Chew QH, Chia FL, Ng WK, Lee WC, Tan PL, Wong CS, Puah SH, Shelat VG, Seah EJ, Huey CW, Phua EJ. Psychological and coping responses to COVID-19 amongst residents in training across ACGME-I accredited specialties in Singapore. Psychiatry Res 2020; 290:113146.
-3535 Civantos AM, Byrnes Y, Chang C, Prasad A, Chorath K, Poonia SK, Jenks CM, Bur AM, Thakkar P, Graboyes EM, Seth R. Mental health among otolaryngology resident and attending physicians during the COVID-19 pandemic: National study. Head Neck 2020; 42(7):1597-1609.,3737 Corbett GA, Milne SJ, Mohan S, Reagu S, Farrell T, Lindow SW, Hehir MP, O'Connell MP. Anxiety and Depression Scores in Maternity Healthcare Workers during the Covid-19 Pandemic. Int J Gynaecol Obstet 2020; 151(2):297-298.,3939 Du J, Dong L, Wang T, Yuan C, Fu R, Zhang L, Liu B, Zhang M, Yin Y, Qin J, Bouey J. Psychological symptoms among frontline healthcare workers during COVID-19 outbreak in Wuhan. Gen Hosp Psychiatry 2020; 67:144-145.

40 Elbay RY, Kurtulmus A, Arpacioglu S, Karadere E. Depression, anxiety, stress levels of physicians and associated factors in Covid-19 pandemics. Psychiatry Res 2020; 290:113130.
-4141 Gupta AK, Mehra A, Niraula A, Kafle K, Deo SP, Singh B, Sahoo S, Grover S. Prevalence of anxiety and depression among the healthcare workers in Nepal during the COVID-19 pandemic. Asian J Psychiatr 2020; 54:102260.,4343 Huang JZ, Han MF, Luo TD, Ren AK, Zhou XP. Mental health survey of medical staff in a tertiary infectious disease hospital for COVID-19. Zhonghua Lao Dong Wei Sheng Zhi Ye Bing Za Zhi 2020; 38(3):192-195.

44 Lai J, Ma S, Wang Y, Cai Z, Hu J, Wei N, Wu J, Du H, Chen T, Li R, Tan H. Factors associated with mental health outcomes among health care workers exposed to coronavirus disease 2019. JAMA Netw Open 2020; 3(3):e203976.

45 Lin K, Yang BX, Luo D, Liu Q, Ma S, Huang R, Lu W, Majeed A, Lee Y, Lui LM, Mansur RB. The mental health effects of COVID-19 on health care providers in China. Am J Psychiatry 2020; 177(7):635-636.

46 Liu CY, Yang YZ, Zhang XM, Xu X, Dou QL, Zhang WW, Cheng AS. The prevalence and influencing factors in anxiety in medical workers fighting COVID-19 in China: a cross-sectional survey. Epidemiol Infect 2020; 148:e98.

47 Lu W, Wang H, Lin Y, Li L. Psychological status of medical workforce during the COVID-19 pandemic: A cross-sectional study. Psychiatry Res 2020; 288:112936.

48 Moghadasi AN. Evaluation of the Level of Anxiety among Iranian Multiple Sclerosis Fellowships During the Outbreak of COVID-19. Arch Iran Med 2020; 23(4):283.

49 Naser AY, Dahmash EZ, Al-Rousan R, Alwafi H, Alrawashdeh HM, Ghoul I, Abidine A, Bokhary MA, Al-Hadithi HT, Ali D, Abuthawabeh R, Abdelwahab GM, Alhartani YJ, Al Muhaisen H, Dagash A, Alyami HS. Mental health status of the general population, healthcare professionals, and university students during 2019 coronavirus disease outbreak in Jordan: A cross-sectional study. Brain Behav 2020; 10(8):e01730.

50 Que J, Le Shi JD, Liu J, Zhang L, Wu S, Gong Y, Huang W, Yuan K, Yan W, Sun Y, Ran M. Psychological impact of the COVID-19 pandemic on healthcare workers: a cross-sectional study in China. Gen Psychiatry 2020; 33(3):e100259.

51 Rossi R, Socci V, Pacitti F, Di Lorenzo G, Di Marco A, Siracusano A, Rossi A. Mental Health Outcomes Among Frontline and Second-Line Health Care Workers During the Coronavirus Disease 2019 (COVID-19) Pandemic in Italy. JAMA Net Open 2020; 3(5):e2010185.

52 Shechter A, Diaz F, Moise N, Anstey DE, Ye S, Agarwal S, Birk JL, Brodie D, Cannone DE, Chang B, Claassen J. Psychological distress, coping behaviors, and preferences for support among New York healthcare workers during the COVID-19 pandemic. Gen Hosp Psychiatry 2020; 66:1-8.

53 Tan BY, Chew NW, Lee GK, Jing M, Goh Y, Yeo LL, Zhang K, Chin HK, Ahmad A, Khan FA, Shanmugam GN, Chan BPL, Sunny S, Chandra B, Ong JJY, Paliwal PR, Wong LYH, Sagayanathan R, Chen JT, Ng AYY, Teoh HL, Ho CS, Ho RC, Sharma VK. Psychological impact of the COVID-19 pandemic on health care workers in Singapore. Ann Intern Med 2020; 173(4):317-320.

54 Temsah MH, Al-Sohime F, Alamro N, Al-Eyadhy A, Al-Hasan K, Jamal A, Al-Maglouth I, Aljamaan F, Al Amri M, Barry M, Al-Subaie S. The psychological impact of COVID-19 pandemic on health care workers in a MERS-CoV endemic country. J Infect Public Health 2020; 13(6):877-882.

55 Vanni G, Materazzo M, Santori F, Pellicciaro M, Costesta M, Orsaria P, Cattadori F, Pistolese CA, Perretta T, Chiocchi M, Meucci R. The Effect of Coronavirus (COVID-19) on Breast Cancer Teamwork: A Multicentric Survey. In Vivo 2020; 34(3 Supl.):1685-1694.

56 Wang S, Xie L, Xu Y, Yu S, Yao B, Xiang D. Sleep disturbances among medical workers during the outbreak of COVID-2019. Occup Med (Lond) 2020; 70(5):364-369.
-5757 Xiao X, Zhu X, Fu S, Hu Y, Li X, Xiao J. Psychological impact of healthcare workers in China during COVID-19 pneumonia epidemic: A multi-center cross-sectional survey investigation. J Affect Disord 2020; 274:405-410.,5959 Zandifar A, Badrfam R, Khonsari NM, Assareh M, Karim H, Azimzadeh M, Sepehr MN, Tajbakhsh R, Rahimi F, Ghanipour N, Agoushi A, Gelsefid SH, Etemadi F, Qorbani M. COVID-19 and medical staff's mental health in educational hospitals in Alborz Province, Iran. Psychiatry Clin Neurosci 2020; 74(9):499-501.

60 Zhang C, Yang L, Liu S, Ma S, Wang Y, Cai Z, Du H, Li R, Kang L, Su M, Zhang J, Liu Z, Zhang B. Survey of insomnia and related social psychological factors among medical staff involved in the 2019 novel coronavirus disease outbreak. Front Psychiatry 2020; 11:306.

61 Zhang SX, Liu J, Jahanshahi AA, Nawaser K, Yousefi A, Li J, Sun S. At the height of the storm: Healthcare staff's health conditions and job satisfaction and their associated predictors during the epidemic peak of COVID-19. Brain Behav Immun 2020; 87:144-146.
-6262 Zhang WR, Wang K, Yin L, Zhao WF, Xue Q, Peng M, Min BQ, Tian Q, Leng HX, Du JL, Chang H. Mental health and psychosocial problems of medical health workers during the COVID-19 epidemic in China. Psychother Psychosom 2020; 89(4):242-250.,6464 Zhu Z, Xu S, Wang H, Liu Z, Wu J, Li G, Miao J, Zhang C, Yang Y, Sun W, Zhu S. COVID-19 in Wuhan: Sociodemographic characteristics and hospital support measures associated with the immediate psychological impact on healthcare workers. EClinicalMedicine 2020; 24:100443.,6565 Zhu J, Sun L, Zhang L, Wang H, Fan A, Yang B, Li W, Xiao S. Prevalence and Influencing Factors of Anxiety and Depression Symptoms in the First-Line Medical Staff Fighting Against COVID-19 in Gansu. Front Psychiatry 2020; 11:386., 29 incluíram enfermeiros3030 Apisarnthanarak A, Apisarnthanarak P, Siripraparat C, Saengaram P, Leeprechanon N, Weber DJ. Impact of Anxiety and Fear for COVID-19 Toward Infection Control Practices Among Thai Healthcare Workers. Infect Control Hosp Epidemiol 2020; 41(9):1093-1094.

31 Badahdah A, Khamis F, Al Mahyijari N, Al Balushi M, Al Hatmi H, Al Salmi I, Albulushi Z, Al Noomani J. The mental health of health care workers in Oman during the COVID-19 pandemic. Int J Soc Psychiatry 2020; 20764020939596.
-3232 Chatterjee SS, Bhattacharyya R, Bhattacharyya S, Gupta S, Das S, Banerjee BB. Attitude, practice, behavior, and mental health impact of COVID-19 on doctors. Indian J Psychiatry 2020; 62(3):257.,3434 Chew QH, Chia FL, Ng WK, Lee WC, Tan PL, Wong CS, Puah SH, Shelat VG, Seah EJ, Huey CW, Phua EJ. Psychological and coping responses to COVID-19 amongst residents in training across ACGME-I accredited specialties in Singapore. Psychiatry Res 2020; 290:113146.,3737 Corbett GA, Milne SJ, Mohan S, Reagu S, Farrell T, Lindow SW, Hehir MP, O'Connell MP. Anxiety and Depression Scores in Maternity Healthcare Workers during the Covid-19 Pandemic. Int J Gynaecol Obstet 2020; 151(2):297-298.

38 Dal'Bosco EB, Floriano LSM, Skupien SV, Arcaro G, Martins AR, Anselmo ACC. Mental health of nursing in coping with COVID-19 at a regional university hospital. Rev Bras Enferm 2020; 73(Supl. 2):e20200434.
-3939 Du J, Dong L, Wang T, Yuan C, Fu R, Zhang L, Liu B, Zhang M, Yin Y, Qin J, Bouey J. Psychological symptoms among frontline healthcare workers during COVID-19 outbreak in Wuhan. Gen Hosp Psychiatry 2020; 67:144-145.,4141 Gupta AK, Mehra A, Niraula A, Kafle K, Deo SP, Singh B, Sahoo S, Grover S. Prevalence of anxiety and depression among the healthcare workers in Nepal during the COVID-19 pandemic. Asian J Psychiatr 2020; 54:102260.

42 Hu D, Kong Y, Li W, Han Q, Zhang X, Zhu LX, Wan SW, Zuofeng LI, Qu SH, Jingqiu YA, Hong-Gu HE. Frontline nurses' burnout, anxiety, depression, and fear statuses and their associated factors during the COVID-19 outbreak in Wuhan, China: A large-scale cross-sectional study. EClinicalMedicine 2020; 24:100424.

43 Huang JZ, Han MF, Luo TD, Ren AK, Zhou XP. Mental health survey of medical staff in a tertiary infectious disease hospital for COVID-19. Zhonghua Lao Dong Wei Sheng Zhi Ye Bing Za Zhi 2020; 38(3):192-195.

44 Lai J, Ma S, Wang Y, Cai Z, Hu J, Wei N, Wu J, Du H, Chen T, Li R, Tan H. Factors associated with mental health outcomes among health care workers exposed to coronavirus disease 2019. JAMA Netw Open 2020; 3(3):e203976.

45 Lin K, Yang BX, Luo D, Liu Q, Ma S, Huang R, Lu W, Majeed A, Lee Y, Lui LM, Mansur RB. The mental health effects of COVID-19 on health care providers in China. Am J Psychiatry 2020; 177(7):635-636.

46 Liu CY, Yang YZ, Zhang XM, Xu X, Dou QL, Zhang WW, Cheng AS. The prevalence and influencing factors in anxiety in medical workers fighting COVID-19 in China: a cross-sectional survey. Epidemiol Infect 2020; 148:e98.
-4747 Lu W, Wang H, Lin Y, Li L. Psychological status of medical workforce during the COVID-19 pandemic: A cross-sectional study. Psychiatry Res 2020; 288:112936.,4949 Naser AY, Dahmash EZ, Al-Rousan R, Alwafi H, Alrawashdeh HM, Ghoul I, Abidine A, Bokhary MA, Al-Hadithi HT, Ali D, Abuthawabeh R, Abdelwahab GM, Alhartani YJ, Al Muhaisen H, Dagash A, Alyami HS. Mental health status of the general population, healthcare professionals, and university students during 2019 coronavirus disease outbreak in Jordan: A cross-sectional study. Brain Behav 2020; 10(8):e01730.

50 Que J, Le Shi JD, Liu J, Zhang L, Wu S, Gong Y, Huang W, Yuan K, Yan W, Sun Y, Ran M. Psychological impact of the COVID-19 pandemic on healthcare workers: a cross-sectional study in China. Gen Psychiatry 2020; 33(3):e100259.

51 Rossi R, Socci V, Pacitti F, Di Lorenzo G, Di Marco A, Siracusano A, Rossi A. Mental Health Outcomes Among Frontline and Second-Line Health Care Workers During the Coronavirus Disease 2019 (COVID-19) Pandemic in Italy. JAMA Net Open 2020; 3(5):e2010185.

52 Shechter A, Diaz F, Moise N, Anstey DE, Ye S, Agarwal S, Birk JL, Brodie D, Cannone DE, Chang B, Claassen J. Psychological distress, coping behaviors, and preferences for support among New York healthcare workers during the COVID-19 pandemic. Gen Hosp Psychiatry 2020; 66:1-8.

53 Tan BY, Chew NW, Lee GK, Jing M, Goh Y, Yeo LL, Zhang K, Chin HK, Ahmad A, Khan FA, Shanmugam GN, Chan BPL, Sunny S, Chandra B, Ong JJY, Paliwal PR, Wong LYH, Sagayanathan R, Chen JT, Ng AYY, Teoh HL, Ho CS, Ho RC, Sharma VK. Psychological impact of the COVID-19 pandemic on health care workers in Singapore. Ann Intern Med 2020; 173(4):317-320.

54 Temsah MH, Al-Sohime F, Alamro N, Al-Eyadhy A, Al-Hasan K, Jamal A, Al-Maglouth I, Aljamaan F, Al Amri M, Barry M, Al-Subaie S. The psychological impact of COVID-19 pandemic on health care workers in a MERS-CoV endemic country. J Infect Public Health 2020; 13(6):877-882.

55 Vanni G, Materazzo M, Santori F, Pellicciaro M, Costesta M, Orsaria P, Cattadori F, Pistolese CA, Perretta T, Chiocchi M, Meucci R. The Effect of Coronavirus (COVID-19) on Breast Cancer Teamwork: A Multicentric Survey. In Vivo 2020; 34(3 Supl.):1685-1694.

56 Wang S, Xie L, Xu Y, Yu S, Yao B, Xiang D. Sleep disturbances among medical workers during the outbreak of COVID-2019. Occup Med (Lond) 2020; 70(5):364-369.
-5757 Xiao X, Zhu X, Fu S, Hu Y, Li X, Xiao J. Psychological impact of healthcare workers in China during COVID-19 pneumonia epidemic: A multi-center cross-sectional survey investigation. J Affect Disord 2020; 274:405-410.,5959 Zandifar A, Badrfam R, Khonsari NM, Assareh M, Karim H, Azimzadeh M, Sepehr MN, Tajbakhsh R, Rahimi F, Ghanipour N, Agoushi A, Gelsefid SH, Etemadi F, Qorbani M. COVID-19 and medical staff's mental health in educational hospitals in Alborz Province, Iran. Psychiatry Clin Neurosci 2020; 74(9):499-501.

60 Zhang C, Yang L, Liu S, Ma S, Wang Y, Cai Z, Du H, Li R, Kang L, Su M, Zhang J, Liu Z, Zhang B. Survey of insomnia and related social psychological factors among medical staff involved in the 2019 novel coronavirus disease outbreak. Front Psychiatry 2020; 11:306.

61 Zhang SX, Liu J, Jahanshahi AA, Nawaser K, Yousefi A, Li J, Sun S. At the height of the storm: Healthcare staff's health conditions and job satisfaction and their associated predictors during the epidemic peak of COVID-19. Brain Behav Immun 2020; 87:144-146.
-6262 Zhang WR, Wang K, Yin L, Zhao WF, Xue Q, Peng M, Min BQ, Tian Q, Leng HX, Du JL, Chang H. Mental health and psychosocial problems of medical health workers during the COVID-19 epidemic in China. Psychother Psychosom 2020; 89(4):242-250.,6464 Zhu Z, Xu S, Wang H, Liu Z, Wu J, Li G, Miao J, Zhang C, Yang Y, Sun W, Zhu S. COVID-19 in Wuhan: Sociodemographic characteristics and hospital support measures associated with the immediate psychological impact on healthcare workers. EClinicalMedicine 2020; 24:100443.,6565 Zhu J, Sun L, Zhang L, Wang H, Fan A, Yang B, Li W, Xiao S. Prevalence and Influencing Factors of Anxiety and Depression Symptoms in the First-Line Medical Staff Fighting Against COVID-19 in Gansu. Front Psychiatry 2020; 11:386., um incluiu farmacêuticos4949 Naser AY, Dahmash EZ, Al-Rousan R, Alwafi H, Alrawashdeh HM, Ghoul I, Abidine A, Bokhary MA, Al-Hadithi HT, Ali D, Abuthawabeh R, Abdelwahab GM, Alhartani YJ, Al Muhaisen H, Dagash A, Alyami HS. Mental health status of the general population, healthcare professionals, and university students during 2019 coronavirus disease outbreak in Jordan: A cross-sectional study. Brain Behav 2020; 10(8):e01730., um incluiu fisioterapeutas5858 Yang S, Kwak SG, Ko EJ, Chang MC. The mental health burden of the covid-19 pandemic on physical therapists. Int J Environ Res Public Health 2020; 17(10):3723. e um incluiu dentistas3636 Consolo U, Bellini P, Bencivenni D, Iani C, Checchi V. Epidemiological Aspects and Psychological Reactions to COVID-19 of Dental Practitioners in the Northern Italy Districts of Modena and Reggio Emilia. Int J Environ Res Public Health 2020; 17(10):3459.. Seis estudos apresentaram dados sobre o tempo de profissão4242 Hu D, Kong Y, Li W, Han Q, Zhang X, Zhu LX, Wan SW, Zuofeng LI, Qu SH, Jingqiu YA, Hong-Gu HE. Frontline nurses' burnout, anxiety, depression, and fear statuses and their associated factors during the COVID-19 outbreak in Wuhan, China: A large-scale cross-sectional study. EClinicalMedicine 2020; 24:100424.,4343 Huang JZ, Han MF, Luo TD, Ren AK, Zhou XP. Mental health survey of medical staff in a tertiary infectious disease hospital for COVID-19. Zhonghua Lao Dong Wei Sheng Zhi Ye Bing Za Zhi 2020; 38(3):192-195.,4444 Lai J, Ma S, Wang Y, Cai Z, Hu J, Wei N, Wu J, Du H, Chen T, Li R, Tan H. Factors associated with mental health outcomes among health care workers exposed to coronavirus disease 2019. JAMA Netw Open 2020; 3(3):e203976.,5757 Xiao X, Zhu X, Fu S, Hu Y, Li X, Xiao J. Psychological impact of healthcare workers in China during COVID-19 pneumonia epidemic: A multi-center cross-sectional survey investigation. J Affect Disord 2020; 274:405-410.,6060 Zhang C, Yang L, Liu S, Ma S, Wang Y, Cai Z, Du H, Li R, Kang L, Su M, Zhang J, Liu Z, Zhang B. Survey of insomnia and related social psychological factors among medical staff involved in the 2019 novel coronavirus disease outbreak. Front Psychiatry 2020; 11:306.,6464 Zhu Z, Xu S, Wang H, Liu Z, Wu J, Li G, Miao J, Zhang C, Yang Y, Sun W, Zhu S. COVID-19 in Wuhan: Sociodemographic characteristics and hospital support measures associated with the immediate psychological impact on healthcare workers. EClinicalMedicine 2020; 24:100443.. Em todos os estudos o nível profissional mais frequente foi iniciante, seguido por intermediário e sênior4242 Hu D, Kong Y, Li W, Han Q, Zhang X, Zhu LX, Wan SW, Zuofeng LI, Qu SH, Jingqiu YA, Hong-Gu HE. Frontline nurses' burnout, anxiety, depression, and fear statuses and their associated factors during the COVID-19 outbreak in Wuhan, China: A large-scale cross-sectional study. EClinicalMedicine 2020; 24:100424.,4343 Huang JZ, Han MF, Luo TD, Ren AK, Zhou XP. Mental health survey of medical staff in a tertiary infectious disease hospital for COVID-19. Zhonghua Lao Dong Wei Sheng Zhi Ye Bing Za Zhi 2020; 38(3):192-195.,4444 Lai J, Ma S, Wang Y, Cai Z, Hu J, Wei N, Wu J, Du H, Chen T, Li R, Tan H. Factors associated with mental health outcomes among health care workers exposed to coronavirus disease 2019. JAMA Netw Open 2020; 3(3):e203976.,5757 Xiao X, Zhu X, Fu S, Hu Y, Li X, Xiao J. Psychological impact of healthcare workers in China during COVID-19 pneumonia epidemic: A multi-center cross-sectional survey investigation. J Affect Disord 2020; 274:405-410.,6060 Zhang C, Yang L, Liu S, Ma S, Wang Y, Cai Z, Du H, Li R, Kang L, Su M, Zhang J, Liu Z, Zhang B. Survey of insomnia and related social psychological factors among medical staff involved in the 2019 novel coronavirus disease outbreak. Front Psychiatry 2020; 11:306.,6464 Zhu Z, Xu S, Wang H, Liu Z, Wu J, Li G, Miao J, Zhang C, Yang Y, Sun W, Zhu S. COVID-19 in Wuhan: Sociodemographic characteristics and hospital support measures associated with the immediate psychological impact on healthcare workers. EClinicalMedicine 2020; 24:100443..

O número de profissionais que atuavam na linha de frente de combate a COVID-19 ou com maior risco de terem contato com pacientes com COVID-19 foi apresentado em 25 estudos3030 Apisarnthanarak A, Apisarnthanarak P, Siripraparat C, Saengaram P, Leeprechanon N, Weber DJ. Impact of Anxiety and Fear for COVID-19 Toward Infection Control Practices Among Thai Healthcare Workers. Infect Control Hosp Epidemiol 2020; 41(9):1093-1094.

31 Badahdah A, Khamis F, Al Mahyijari N, Al Balushi M, Al Hatmi H, Al Salmi I, Albulushi Z, Al Noomani J. The mental health of health care workers in Oman during the COVID-19 pandemic. Int J Soc Psychiatry 2020; 20764020939596.

32 Chatterjee SS, Bhattacharyya R, Bhattacharyya S, Gupta S, Das S, Banerjee BB. Attitude, practice, behavior, and mental health impact of COVID-19 on doctors. Indian J Psychiatry 2020; 62(3):257.
-3333 Chen Y, Zhou H, Zhou Y, Zhou F. Prevalence of self-reported depression and anxiety among pediatric medical staff members during the COVID-19 outbreak in Guiyang, China. Psychiatry Res 2020; 288:113005.,3939 Du J, Dong L, Wang T, Yuan C, Fu R, Zhang L, Liu B, Zhang M, Yin Y, Qin J, Bouey J. Psychological symptoms among frontline healthcare workers during COVID-19 outbreak in Wuhan. Gen Hosp Psychiatry 2020; 67:144-145.

40 Elbay RY, Kurtulmus A, Arpacioglu S, Karadere E. Depression, anxiety, stress levels of physicians and associated factors in Covid-19 pandemics. Psychiatry Res 2020; 290:113130.

41 Gupta AK, Mehra A, Niraula A, Kafle K, Deo SP, Singh B, Sahoo S, Grover S. Prevalence of anxiety and depression among the healthcare workers in Nepal during the COVID-19 pandemic. Asian J Psychiatr 2020; 54:102260.

42 Hu D, Kong Y, Li W, Han Q, Zhang X, Zhu LX, Wan SW, Zuofeng LI, Qu SH, Jingqiu YA, Hong-Gu HE. Frontline nurses' burnout, anxiety, depression, and fear statuses and their associated factors during the COVID-19 outbreak in Wuhan, China: A large-scale cross-sectional study. EClinicalMedicine 2020; 24:100424.
-4343 Huang JZ, Han MF, Luo TD, Ren AK, Zhou XP. Mental health survey of medical staff in a tertiary infectious disease hospital for COVID-19. Zhonghua Lao Dong Wei Sheng Zhi Ye Bing Za Zhi 2020; 38(3):192-195.,4444 Lai J, Ma S, Wang Y, Cai Z, Hu J, Wei N, Wu J, Du H, Chen T, Li R, Tan H. Factors associated with mental health outcomes among health care workers exposed to coronavirus disease 2019. JAMA Netw Open 2020; 3(3):e203976.

45 Lin K, Yang BX, Luo D, Liu Q, Ma S, Huang R, Lu W, Majeed A, Lee Y, Lui LM, Mansur RB. The mental health effects of COVID-19 on health care providers in China. Am J Psychiatry 2020; 177(7):635-636.

46 Liu CY, Yang YZ, Zhang XM, Xu X, Dou QL, Zhang WW, Cheng AS. The prevalence and influencing factors in anxiety in medical workers fighting COVID-19 in China: a cross-sectional survey. Epidemiol Infect 2020; 148:e98.
-4747 Lu W, Wang H, Lin Y, Li L. Psychological status of medical workforce during the COVID-19 pandemic: A cross-sectional study. Psychiatry Res 2020; 288:112936.,4949 Naser AY, Dahmash EZ, Al-Rousan R, Alwafi H, Alrawashdeh HM, Ghoul I, Abidine A, Bokhary MA, Al-Hadithi HT, Ali D, Abuthawabeh R, Abdelwahab GM, Alhartani YJ, Al Muhaisen H, Dagash A, Alyami HS. Mental health status of the general population, healthcare professionals, and university students during 2019 coronavirus disease outbreak in Jordan: A cross-sectional study. Brain Behav 2020; 10(8):e01730.,5151 Rossi R, Socci V, Pacitti F, Di Lorenzo G, Di Marco A, Siracusano A, Rossi A. Mental Health Outcomes Among Frontline and Second-Line Health Care Workers During the Coronavirus Disease 2019 (COVID-19) Pandemic in Italy. JAMA Net Open 2020; 3(5):e2010185.

52 Shechter A, Diaz F, Moise N, Anstey DE, Ye S, Agarwal S, Birk JL, Brodie D, Cannone DE, Chang B, Claassen J. Psychological distress, coping behaviors, and preferences for support among New York healthcare workers during the COVID-19 pandemic. Gen Hosp Psychiatry 2020; 66:1-8.
-5353 Tan BY, Chew NW, Lee GK, Jing M, Goh Y, Yeo LL, Zhang K, Chin HK, Ahmad A, Khan FA, Shanmugam GN, Chan BPL, Sunny S, Chandra B, Ong JJY, Paliwal PR, Wong LYH, Sagayanathan R, Chen JT, Ng AYY, Teoh HL, Ho CS, Ho RC, Sharma VK. Psychological impact of the COVID-19 pandemic on health care workers in Singapore. Ann Intern Med 2020; 173(4):317-320.,5555 Vanni G, Materazzo M, Santori F, Pellicciaro M, Costesta M, Orsaria P, Cattadori F, Pistolese CA, Perretta T, Chiocchi M, Meucci R. The Effect of Coronavirus (COVID-19) on Breast Cancer Teamwork: A Multicentric Survey. In Vivo 2020; 34(3 Supl.):1685-1694.

56 Wang S, Xie L, Xu Y, Yu S, Yao B, Xiang D. Sleep disturbances among medical workers during the outbreak of COVID-2019. Occup Med (Lond) 2020; 70(5):364-369.

57 Xiao X, Zhu X, Fu S, Hu Y, Li X, Xiao J. Psychological impact of healthcare workers in China during COVID-19 pneumonia epidemic: A multi-center cross-sectional survey investigation. J Affect Disord 2020; 274:405-410.

58 Yang S, Kwak SG, Ko EJ, Chang MC. The mental health burden of the covid-19 pandemic on physical therapists. Int J Environ Res Public Health 2020; 17(10):3723.

59 Zandifar A, Badrfam R, Khonsari NM, Assareh M, Karim H, Azimzadeh M, Sepehr MN, Tajbakhsh R, Rahimi F, Ghanipour N, Agoushi A, Gelsefid SH, Etemadi F, Qorbani M. COVID-19 and medical staff's mental health in educational hospitals in Alborz Province, Iran. Psychiatry Clin Neurosci 2020; 74(9):499-501.
-6060 Zhang C, Yang L, Liu S, Ma S, Wang Y, Cai Z, Du H, Li R, Kang L, Su M, Zhang J, Liu Z, Zhang B. Survey of insomnia and related social psychological factors among medical staff involved in the 2019 novel coronavirus disease outbreak. Front Psychiatry 2020; 11:306.,6262 Zhang WR, Wang K, Yin L, Zhao WF, Xue Q, Peng M, Min BQ, Tian Q, Leng HX, Du JL, Chang H. Mental health and psychosocial problems of medical health workers during the COVID-19 epidemic in China. Psychother Psychosom 2020; 89(4):242-250.,6464 Zhu Z, Xu S, Wang H, Liu Z, Wu J, Li G, Miao J, Zhang C, Yang Y, Sun W, Zhu S. COVID-19 in Wuhan: Sociodemographic characteristics and hospital support measures associated with the immediate psychological impact on healthcare workers. EClinicalMedicine 2020; 24:100443.,6565 Zhu J, Sun L, Zhang L, Wang H, Fan A, Yang B, Li W, Xiao S. Prevalence and Influencing Factors of Anxiety and Depression Symptoms in the First-Line Medical Staff Fighting Against COVID-19 in Gansu. Front Psychiatry 2020; 11:386.. Em 12 estudos mais de 40% dos profissionais incluídos atuavam na linha de frente ou tiveram contato com pacientes com COVID-193030 Apisarnthanarak A, Apisarnthanarak P, Siripraparat C, Saengaram P, Leeprechanon N, Weber DJ. Impact of Anxiety and Fear for COVID-19 Toward Infection Control Practices Among Thai Healthcare Workers. Infect Control Hosp Epidemiol 2020; 41(9):1093-1094.,3232 Chatterjee SS, Bhattacharyya R, Bhattacharyya S, Gupta S, Das S, Banerjee BB. Attitude, practice, behavior, and mental health impact of COVID-19 on doctors. Indian J Psychiatry 2020; 62(3):257.,3939 Du J, Dong L, Wang T, Yuan C, Fu R, Zhang L, Liu B, Zhang M, Yin Y, Qin J, Bouey J. Psychological symptoms among frontline healthcare workers during COVID-19 outbreak in Wuhan. Gen Hosp Psychiatry 2020; 67:144-145.,4040 Elbay RY, Kurtulmus A, Arpacioglu S, Karadere E. Depression, anxiety, stress levels of physicians and associated factors in Covid-19 pandemics. Psychiatry Res 2020; 290:113130.,4242 Hu D, Kong Y, Li W, Han Q, Zhang X, Zhu LX, Wan SW, Zuofeng LI, Qu SH, Jingqiu YA, Hong-Gu HE. Frontline nurses' burnout, anxiety, depression, and fear statuses and their associated factors during the COVID-19 outbreak in Wuhan, China: A large-scale cross-sectional study. EClinicalMedicine 2020; 24:100424.,4444 Lai J, Ma S, Wang Y, Cai Z, Hu J, Wei N, Wu J, Du H, Chen T, Li R, Tan H. Factors associated with mental health outcomes among health care workers exposed to coronavirus disease 2019. JAMA Netw Open 2020; 3(3):e203976.,4949 Naser AY, Dahmash EZ, Al-Rousan R, Alwafi H, Alrawashdeh HM, Ghoul I, Abidine A, Bokhary MA, Al-Hadithi HT, Ali D, Abuthawabeh R, Abdelwahab GM, Alhartani YJ, Al Muhaisen H, Dagash A, Alyami HS. Mental health status of the general population, healthcare professionals, and university students during 2019 coronavirus disease outbreak in Jordan: A cross-sectional study. Brain Behav 2020; 10(8):e01730.,5151 Rossi R, Socci V, Pacitti F, Di Lorenzo G, Di Marco A, Siracusano A, Rossi A. Mental Health Outcomes Among Frontline and Second-Line Health Care Workers During the Coronavirus Disease 2019 (COVID-19) Pandemic in Italy. JAMA Net Open 2020; 3(5):e2010185.,5656 Wang S, Xie L, Xu Y, Yu S, Yao B, Xiang D. Sleep disturbances among medical workers during the outbreak of COVID-2019. Occup Med (Lond) 2020; 70(5):364-369.,5757 Xiao X, Zhu X, Fu S, Hu Y, Li X, Xiao J. Psychological impact of healthcare workers in China during COVID-19 pneumonia epidemic: A multi-center cross-sectional survey investigation. J Affect Disord 2020; 274:405-410.,5959 Zandifar A, Badrfam R, Khonsari NM, Assareh M, Karim H, Azimzadeh M, Sepehr MN, Tajbakhsh R, Rahimi F, Ghanipour N, Agoushi A, Gelsefid SH, Etemadi F, Qorbani M. COVID-19 and medical staff's mental health in educational hospitals in Alborz Province, Iran. Psychiatry Clin Neurosci 2020; 74(9):499-501.,6060 Zhang C, Yang L, Liu S, Ma S, Wang Y, Cai Z, Du H, Li R, Kang L, Su M, Zhang J, Liu Z, Zhang B. Survey of insomnia and related social psychological factors among medical staff involved in the 2019 novel coronavirus disease outbreak. Front Psychiatry 2020; 11:306., sendo que três estudos3232 Chatterjee SS, Bhattacharyya R, Bhattacharyya S, Gupta S, Das S, Banerjee BB. Attitude, practice, behavior, and mental health impact of COVID-19 on doctors. Indian J Psychiatry 2020; 62(3):257.,3939 Du J, Dong L, Wang T, Yuan C, Fu R, Zhang L, Liu B, Zhang M, Yin Y, Qin J, Bouey J. Psychological symptoms among frontline healthcare workers during COVID-19 outbreak in Wuhan. Gen Hosp Psychiatry 2020; 67:144-145.,6464 Zhu Z, Xu S, Wang H, Liu Z, Wu J, Li G, Miao J, Zhang C, Yang Y, Sun W, Zhu S. COVID-19 in Wuhan: Sociodemographic characteristics and hospital support measures associated with the immediate psychological impact on healthcare workers. EClinicalMedicine 2020; 24:100443. referem que 100% dos profissionais atuavam na linha de frente. Lu et al.4747 Lu W, Wang H, Lin Y, Li L. Psychological status of medical workforce during the COVID-19 pandemic: A cross-sectional study. Psychiatry Res 2020; 288:112936. verificaram que 20,4% dos profissionais apresentavam risco de contato com pacientes com COVID-19, no estudo de Chen et al.3333 Chen Y, Zhou H, Zhou Y, Zhou F. Prevalence of self-reported depression and anxiety among pediatric medical staff members during the COVID-19 outbreak in Guiyang, China. Psychiatry Res 2020; 288:113005. o percentual foi de 18,1%, enquanto que no estudo de Zhang et al.6262 Zhang WR, Wang K, Yin L, Zhao WF, Xue Q, Peng M, Min BQ, Tian Q, Leng HX, Du JL, Chang H. Mental health and psychosocial problems of medical health workers during the COVID-19 epidemic in China. Psychother Psychosom 2020; 89(4):242-250. 14,9% apresentavam elevado risco de contato com pacientes infectados pelo coronavírus. Wang et al.5656 Wang S, Xie L, Xu Y, Yu S, Yao B, Xiang D. Sleep disturbances among medical workers during the outbreak of COVID-2019. Occup Med (Lond) 2020; 70(5):364-369. registraram que 62,6% já tinham atuado no tratamento de pacientes infectados pelo SARS-COV-2.

Sete estudos referiram o número de casos suspeitos ou confirmados de COVID-19 nos profissionais de saúde3232 Chatterjee SS, Bhattacharyya R, Bhattacharyya S, Gupta S, Das S, Banerjee BB. Attitude, practice, behavior, and mental health impact of COVID-19 on doctors. Indian J Psychiatry 2020; 62(3):257.,3636 Consolo U, Bellini P, Bencivenni D, Iani C, Checchi V. Epidemiological Aspects and Psychological Reactions to COVID-19 of Dental Practitioners in the Northern Italy Districts of Modena and Reggio Emilia. Int J Environ Res Public Health 2020; 17(10):3459.,4040 Elbay RY, Kurtulmus A, Arpacioglu S, Karadere E. Depression, anxiety, stress levels of physicians and associated factors in Covid-19 pandemics. Psychiatry Res 2020; 290:113130.,4646 Liu CY, Yang YZ, Zhang XM, Xu X, Dou QL, Zhang WW, Cheng AS. The prevalence and influencing factors in anxiety in medical workers fighting COVID-19 in China: a cross-sectional survey. Epidemiol Infect 2020; 148:e98.,5656 Wang S, Xie L, Xu Y, Yu S, Yao B, Xiang D. Sleep disturbances among medical workers during the outbreak of COVID-2019. Occup Med (Lond) 2020; 70(5):364-369.,6161 Zhang SX, Liu J, Jahanshahi AA, Nawaser K, Yousefi A, Li J, Sun S. At the height of the storm: Healthcare staff's health conditions and job satisfaction and their associated predictors during the epidemic peak of COVID-19. Brain Behav Immun 2020; 87:144-146.,6464 Zhu Z, Xu S, Wang H, Liu Z, Wu J, Li G, Miao J, Zhang C, Yang Y, Sun W, Zhu S. COVID-19 in Wuhan: Sociodemographic characteristics and hospital support measures associated with the immediate psychological impact on healthcare workers. EClinicalMedicine 2020; 24:100443.. Neste sentido, Liu et al.4646 Liu CY, Yang YZ, Zhang XM, Xu X, Dou QL, Zhang WW, Cheng AS. The prevalence and influencing factors in anxiety in medical workers fighting COVID-19 in China: a cross-sectional survey. Epidemiol Infect 2020; 148:e98. verificaram que 41 participantes (8%) eram casos suspeitos de COVID-19 e Chatterjee et al.3232 Chatterjee SS, Bhattacharyya R, Bhattacharyya S, Gupta S, Das S, Banerjee BB. Attitude, practice, behavior, and mental health impact of COVID-19 on doctors. Indian J Psychiatry 2020; 62(3):257. referiram que 9,2% dos profissionais estavam em quarentena. No estudo de Zhang et.6161 Zhang SX, Liu J, Jahanshahi AA, Nawaser K, Yousefi A, Li J, Sun S. At the height of the storm: Healthcare staff's health conditions and job satisfaction and their associated predictors during the epidemic peak of COVID-19. Brain Behav Immun 2020; 87:144-146. 2,3% dos profissionais de saúde foram diagnosticados com COVID-19 e Zhu et al.6464 Zhu Z, Xu S, Wang H, Liu Z, Wu J, Li G, Miao J, Zhang C, Yang Y, Sun W, Zhu S. COVID-19 in Wuhan: Sociodemographic characteristics and hospital support measures associated with the immediate psychological impact on healthcare workers. EClinicalMedicine 2020; 24:100443. registraram que 3,1% eram casos suspeitos ou tiveram o diagnóstico de COVID-19.

O número de profissionais com doenças crônicas foi registrado em oito estudos3232 Chatterjee SS, Bhattacharyya R, Bhattacharyya S, Gupta S, Das S, Banerjee BB. Attitude, practice, behavior, and mental health impact of COVID-19 on doctors. Indian J Psychiatry 2020; 62(3):257.,3434 Chew QH, Chia FL, Ng WK, Lee WC, Tan PL, Wong CS, Puah SH, Shelat VG, Seah EJ, Huey CW, Phua EJ. Psychological and coping responses to COVID-19 amongst residents in training across ACGME-I accredited specialties in Singapore. Psychiatry Res 2020; 290:113146.,3737 Corbett GA, Milne SJ, Mohan S, Reagu S, Farrell T, Lindow SW, Hehir MP, O'Connell MP. Anxiety and Depression Scores in Maternity Healthcare Workers during the Covid-19 Pandemic. Int J Gynaecol Obstet 2020; 151(2):297-298.,4040 Elbay RY, Kurtulmus A, Arpacioglu S, Karadere E. Depression, anxiety, stress levels of physicians and associated factors in Covid-19 pandemics. Psychiatry Res 2020; 290:113130.,4141 Gupta AK, Mehra A, Niraula A, Kafle K, Deo SP, Singh B, Sahoo S, Grover S. Prevalence of anxiety and depression among the healthcare workers in Nepal during the COVID-19 pandemic. Asian J Psychiatr 2020; 54:102260.,5353 Tan BY, Chew NW, Lee GK, Jing M, Goh Y, Yeo LL, Zhang K, Chin HK, Ahmad A, Khan FA, Shanmugam GN, Chan BPL, Sunny S, Chandra B, Ong JJY, Paliwal PR, Wong LYH, Sagayanathan R, Chen JT, Ng AYY, Teoh HL, Ho CS, Ho RC, Sharma VK. Psychological impact of the COVID-19 pandemic on health care workers in Singapore. Ann Intern Med 2020; 173(4):317-320.,6262 Zhang WR, Wang K, Yin L, Zhao WF, Xue Q, Peng M, Min BQ, Tian Q, Leng HX, Du JL, Chang H. Mental health and psychosocial problems of medical health workers during the COVID-19 epidemic in China. Psychother Psychosom 2020; 89(4):242-250.,6464 Zhu Z, Xu S, Wang H, Liu Z, Wu J, Li G, Miao J, Zhang C, Yang Y, Sun W, Zhu S. COVID-19 in Wuhan: Sociodemographic characteristics and hospital support measures associated with the immediate psychological impact on healthcare workers. EClinicalMedicine 2020; 24:100443.. Três estudos verificaram que menos de 20% dos profissionais apresentavam doenças crônicas3434 Chew QH, Chia FL, Ng WK, Lee WC, Tan PL, Wong CS, Puah SH, Shelat VG, Seah EJ, Huey CW, Phua EJ. Psychological and coping responses to COVID-19 amongst residents in training across ACGME-I accredited specialties in Singapore. Psychiatry Res 2020; 290:113146.,3737 Corbett GA, Milne SJ, Mohan S, Reagu S, Farrell T, Lindow SW, Hehir MP, O'Connell MP. Anxiety and Depression Scores in Maternity Healthcare Workers during the Covid-19 Pandemic. Int J Gynaecol Obstet 2020; 151(2):297-298.,6464 Zhu Z, Xu S, Wang H, Liu Z, Wu J, Li G, Miao J, Zhang C, Yang Y, Sun W, Zhu S. COVID-19 in Wuhan: Sociodemographic characteristics and hospital support measures associated with the immediate psychological impact on healthcare workers. EClinicalMedicine 2020; 24:100443.. No estudo de Chatterjee et al.3232 Chatterjee SS, Bhattacharyya R, Bhattacharyya S, Gupta S, Das S, Banerjee BB. Attitude, practice, behavior, and mental health impact of COVID-19 on doctors. Indian J Psychiatry 2020; 62(3):257. referiram que somente 5,9% não apresentavam doenças crônicas, sendo que 56,5% apresentavam hipertensão arterial sistêmica, diabetes mellitus e doença pulmonar obstrutiva crônica.

Critérios de avaliação da ansiedade

Os estudos incluídos na revisão utilizaram diferentes critérios para a avaliação da ansiedade. A 7-item Generalized Anxiety Disorder (GAD-7) scale6666 Spitzer RL, Kroenke K, Williams JB, Löwe B. A brief measure for assessing generalized anxiety disorder: the GAD-7. Arch Intern Med 2006; 166(10):1092-1097. foi utilizada para avaliar a ansiedade em 16 estudos3030 Apisarnthanarak A, Apisarnthanarak P, Siripraparat C, Saengaram P, Leeprechanon N, Weber DJ. Impact of Anxiety and Fear for COVID-19 Toward Infection Control Practices Among Thai Healthcare Workers. Infect Control Hosp Epidemiol 2020; 41(9):1093-1094.,3131 Badahdah A, Khamis F, Al Mahyijari N, Al Balushi M, Al Hatmi H, Al Salmi I, Albulushi Z, Al Noomani J. The mental health of health care workers in Oman during the COVID-19 pandemic. Int J Soc Psychiatry 2020; 20764020939596.,3535 Civantos AM, Byrnes Y, Chang C, Prasad A, Chorath K, Poonia SK, Jenks CM, Bur AM, Thakkar P, Graboyes EM, Seth R. Mental health among otolaryngology resident and attending physicians during the COVID-19 pandemic: National study. Head Neck 2020; 42(7):1597-1609.,3636 Consolo U, Bellini P, Bencivenni D, Iani C, Checchi V. Epidemiological Aspects and Psychological Reactions to COVID-19 of Dental Practitioners in the Northern Italy Districts of Modena and Reggio Emilia. Int J Environ Res Public Health 2020; 17(10):3459.,3737 Corbett GA, Milne SJ, Mohan S, Reagu S, Farrell T, Lindow SW, Hehir MP, O'Connell MP. Anxiety and Depression Scores in Maternity Healthcare Workers during the Covid-19 Pandemic. Int J Gynaecol Obstet 2020; 151(2):297-298.,4141 Gupta AK, Mehra A, Niraula A, Kafle K, Deo SP, Singh B, Sahoo S, Grover S. Prevalence of anxiety and depression among the healthcare workers in Nepal during the COVID-19 pandemic. Asian J Psychiatr 2020; 54:102260.,4444 Lai J, Ma S, Wang Y, Cai Z, Hu J, Wei N, Wu J, Du H, Chen T, Li R, Tan H. Factors associated with mental health outcomes among health care workers exposed to coronavirus disease 2019. JAMA Netw Open 2020; 3(3):e203976.,4545 Lin K, Yang BX, Luo D, Liu Q, Ma S, Huang R, Lu W, Majeed A, Lee Y, Lui LM, Mansur RB. The mental health effects of COVID-19 on health care providers in China. Am J Psychiatry 2020; 177(7):635-636.,4949 Naser AY, Dahmash EZ, Al-Rousan R, Alwafi H, Alrawashdeh HM, Ghoul I, Abidine A, Bokhary MA, Al-Hadithi HT, Ali D, Abuthawabeh R, Abdelwahab GM, Alhartani YJ, Al Muhaisen H, Dagash A, Alyami HS. Mental health status of the general population, healthcare professionals, and university students during 2019 coronavirus disease outbreak in Jordan: A cross-sectional study. Brain Behav 2020; 10(8):e01730.,5050 Que J, Le Shi JD, Liu J, Zhang L, Wu S, Gong Y, Huang W, Yuan K, Yan W, Sun Y, Ran M. Psychological impact of the COVID-19 pandemic on healthcare workers: a cross-sectional study in China. Gen Psychiatry 2020; 33(3):e100259.,5151 Rossi R, Socci V, Pacitti F, Di Lorenzo G, Di Marco A, Siracusano A, Rossi A. Mental Health Outcomes Among Frontline and Second-Line Health Care Workers During the Coronavirus Disease 2019 (COVID-19) Pandemic in Italy. JAMA Net Open 2020; 3(5):e2010185.,5454 Temsah MH, Al-Sohime F, Alamro N, Al-Eyadhy A, Al-Hasan K, Jamal A, Al-Maglouth I, Aljamaan F, Al Amri M, Barry M, Al-Subaie S. The psychological impact of COVID-19 pandemic on health care workers in a MERS-CoV endemic country. J Infect Public Health 2020; 13(6):877-882.,5858 Yang S, Kwak SG, Ko EJ, Chang MC. The mental health burden of the covid-19 pandemic on physical therapists. Int J Environ Res Public Health 2020; 17(10):3723.,6060 Zhang C, Yang L, Liu S, Ma S, Wang Y, Cai Z, Du H, Li R, Kang L, Su M, Zhang J, Liu Z, Zhang B. Survey of insomnia and related social psychological factors among medical staff involved in the 2019 novel coronavirus disease outbreak. Front Psychiatry 2020; 11:306.,6363 Zhao N, Huang Y. Chinese mental health burden during COVID-19 outbreak: a web-based cross-sectional survey. Asian J Psychiatr 2020; 51:102052.,6464 Zhu Z, Xu S, Wang H, Liu Z, Wu J, Li G, Miao J, Zhang C, Yang Y, Sun W, Zhu S. COVID-19 in Wuhan: Sociodemographic characteristics and hospital support measures associated with the immediate psychological impact on healthcare workers. EClinicalMedicine 2020; 24:100443.. Seis estudos3232 Chatterjee SS, Bhattacharyya R, Bhattacharyya S, Gupta S, Das S, Banerjee BB. Attitude, practice, behavior, and mental health impact of COVID-19 on doctors. Indian J Psychiatry 2020; 62(3):257.,3434 Chew QH, Chia FL, Ng WK, Lee WC, Tan PL, Wong CS, Puah SH, Shelat VG, Seah EJ, Huey CW, Phua EJ. Psychological and coping responses to COVID-19 amongst residents in training across ACGME-I accredited specialties in Singapore. Psychiatry Res 2020; 290:113146.,4040 Elbay RY, Kurtulmus A, Arpacioglu S, Karadere E. Depression, anxiety, stress levels of physicians and associated factors in Covid-19 pandemics. Psychiatry Res 2020; 290:113130.,5353 Tan BY, Chew NW, Lee GK, Jing M, Goh Y, Yeo LL, Zhang K, Chin HK, Ahmad A, Khan FA, Shanmugam GN, Chan BPL, Sunny S, Chandra B, Ong JJY, Paliwal PR, Wong LYH, Sagayanathan R, Chen JT, Ng AYY, Teoh HL, Ho CS, Ho RC, Sharma VK. Psychological impact of the COVID-19 pandemic on health care workers in Singapore. Ann Intern Med 2020; 173(4):317-320.,5555 Vanni G, Materazzo M, Santori F, Pellicciaro M, Costesta M, Orsaria P, Cattadori F, Pistolese CA, Perretta T, Chiocchi M, Meucci R. The Effect of Coronavirus (COVID-19) on Breast Cancer Teamwork: A Multicentric Survey. In Vivo 2020; 34(3 Supl.):1685-1694.,5959 Zandifar A, Badrfam R, Khonsari NM, Assareh M, Karim H, Azimzadeh M, Sepehr MN, Tajbakhsh R, Rahimi F, Ghanipour N, Agoushi A, Gelsefid SH, Etemadi F, Qorbani M. COVID-19 and medical staff's mental health in educational hospitals in Alborz Province, Iran. Psychiatry Clin Neurosci 2020; 74(9):499-501. utilizaram a Depression, anxiety and stress scales (DASS-21)6767 Lovibond SH, Lovibond PF. Manual for the Depression Anxiety Stress Scales. Sydney: Psychology Foundation; 1995.. A Zung Self-rating Anxiety Scale (SAS)6868 Zung WWK. A rating instrument for anxiety disorders. Psychosomatics 1971; 12:371-379. foi utilizada para o diagnóstico da ansiedade em seis estudos3333 Chen Y, Zhou H, Zhou Y, Zhou F. Prevalence of self-reported depression and anxiety among pediatric medical staff members during the COVID-19 outbreak in Guiyang, China. Psychiatry Res 2020; 288:113005.,4242 Hu D, Kong Y, Li W, Han Q, Zhang X, Zhu LX, Wan SW, Zuofeng LI, Qu SH, Jingqiu YA, Hong-Gu HE. Frontline nurses' burnout, anxiety, depression, and fear statuses and their associated factors during the COVID-19 outbreak in Wuhan, China: A large-scale cross-sectional study. EClinicalMedicine 2020; 24:100424.,4343 Huang JZ, Han MF, Luo TD, Ren AK, Zhou XP. Mental health survey of medical staff in a tertiary infectious disease hospital for COVID-19. Zhonghua Lao Dong Wei Sheng Zhi Ye Bing Za Zhi 2020; 38(3):192-195.,4646 Liu CY, Yang YZ, Zhang XM, Xu X, Dou QL, Zhang WW, Cheng AS. The prevalence and influencing factors in anxiety in medical workers fighting COVID-19 in China: a cross-sectional survey. Epidemiol Infect 2020; 148:e98.,5656 Wang S, Xie L, Xu Y, Yu S, Yao B, Xiang D. Sleep disturbances among medical workers during the outbreak of COVID-2019. Occup Med (Lond) 2020; 70(5):364-369.,6464 Zhu Z, Xu S, Wang H, Liu Z, Wu J, Li G, Miao J, Zhang C, Yang Y, Sun W, Zhu S. COVID-19 in Wuhan: Sociodemographic characteristics and hospital support measures associated with the immediate psychological impact on healthcare workers. EClinicalMedicine 2020; 24:100443.. Zhang et al.6262 Zhang WR, Wang K, Yin L, Zhao WF, Xue Q, Peng M, Min BQ, Tian Q, Leng HX, Du JL, Chang H. Mental health and psychosocial problems of medical health workers during the COVID-19 epidemic in China. Psychother Psychosom 2020; 89(4):242-250. e Shechter et al.5252 Shechter A, Diaz F, Moise N, Anstey DE, Ye S, Agarwal S, Birk JL, Brodie D, Cannone DE, Chang B, Claassen J. Psychological distress, coping behaviors, and preferences for support among New York healthcare workers during the COVID-19 pandemic. Gen Hosp Psychiatry 2020; 66:1-8. avaliaram a ansiedade por meio da Generalized Anxiety Disorder 2-item (GAD-2)6969 Kroenke K, Spitzer RL, Williams JB, Monahan PO, Löwe B. Anxiety disorders in primary care: prevalence, impairment, comorbidity, and detection. Ann Intern Med 2007; 146:317-325.. Zhang et al.6161 Zhang SX, Liu J, Jahanshahi AA, Nawaser K, Yousefi A, Li J, Sun S. At the height of the storm: Healthcare staff's health conditions and job satisfaction and their associated predictors during the epidemic peak of COVID-19. Brain Behav Immun 2020; 87:144-146. referiram o emprego do Patient Health Questionnaire-4 (PHQ-4)7070 Kroenke K, Spitzer RL, Williams JB, Löwe B. An ultra-brief screening scale for anxiety and depression: the PHQ-4. Psychosomatics 2009; 50:613-621., que tem como subescala para avaliação da ansiedade o GAD-2.

O Beck Anxiety Inventory (BAI)7171 Beck AT, Epstein N, Brown G, Steer RA. An inventory for measuring clinical anxiety: psychometric properties. J Consult Clin Psychol 1988; 56(6):893. foi utilizado em dois estudos3939 Du J, Dong L, Wang T, Yuan C, Fu R, Zhang L, Liu B, Zhang M, Yin Y, Qin J, Bouey J. Psychological symptoms among frontline healthcare workers during COVID-19 outbreak in Wuhan. Gen Hosp Psychiatry 2020; 67:144-145.,4848 Moghadasi AN. Evaluation of the Level of Anxiety among Iranian Multiple Sclerosis Fellowships During the Outbreak of COVID-19. Arch Iran Med 2020; 23(4):283.; a Hospital Anxiety and Depression Scale (HAD)72 também foi empregada em dois estudos3838 Dal'Bosco EB, Floriano LSM, Skupien SV, Arcaro G, Martins AR, Anselmo ACC. Mental health of nursing in coping with COVID-19 at a regional university hospital. Rev Bras Enferm 2020; 73(Supl. 2):e20200434.,5757 Xiao X, Zhu X, Fu S, Hu Y, Li X, Xiao J. Psychological impact of healthcare workers in China during COVID-19 pneumonia epidemic: A multi-center cross-sectional survey investigation. J Affect Disord 2020; 274:405-410.; e no estudo realizado por Lu et al.4747 Lu W, Wang H, Lin Y, Li L. Psychological status of medical workforce during the COVID-19 pandemic: A cross-sectional study. Psychiatry Res 2020; 288:112936. foi utilizada a Hamilton Anxiety Scale (HAMA)7373 Hamilton M. The assessment of anxiety states by rating. Br J Med Psychol 1959; 32:50-55. para o diagnóstico da ansiedade. Os critérios dos instrumentos são apresentados no Quadro 2.

Quadro 2
Critérios de avaliação da ansiedade nos estudos incluídos na revisão.

Prevalência de ansiedade nos profissionais de saúde durante a pandemia da COVID-19

A prevalência geral de ansiedade (leve, moderada e grave) foi de 35% (IC95%: 29-40), variando de 7.0%5656 Wang S, Xie L, Xu Y, Yu S, Yao B, Xiang D. Sleep disturbances among medical workers during the outbreak of COVID-2019. Occup Med (Lond) 2020; 70(5):364-369. a 70.8%4949 Naser AY, Dahmash EZ, Al-Rousan R, Alwafi H, Alrawashdeh HM, Ghoul I, Abidine A, Bokhary MA, Al-Hadithi HT, Ali D, Abuthawabeh R, Abdelwahab GM, Alhartani YJ, Al Muhaisen H, Dagash A, Alyami HS. Mental health status of the general population, healthcare professionals, and university students during 2019 coronavirus disease outbreak in Jordan: A cross-sectional study. Brain Behav 2020; 10(8):e01730., com forte heterogeneidade entre os estudos (I²=99%, P<0,01) (Figura 2). Na análise de sensibilidade removendo um estudo por vez foi verificado que os intervalos de confiança se sobrepõem em todos os casos analisados, de modo que nenhum estudo impactou significativamente na prevalência de ansiedade. No entanto, pela inspeção visual, se observa considerável alteração nos intervalos de confiança com a remoção dos estudos de Badahdah et al.3131 Badahdah A, Khamis F, Al Mahyijari N, Al Balushi M, Al Hatmi H, Al Salmi I, Albulushi Z, Al Noomani J. The mental health of health care workers in Oman during the COVID-19 pandemic. Int J Soc Psychiatry 2020; 20764020939596., Naser et al.4949 Naser AY, Dahmash EZ, Al-Rousan R, Alwafi H, Alrawashdeh HM, Ghoul I, Abidine A, Bokhary MA, Al-Hadithi HT, Ali D, Abuthawabeh R, Abdelwahab GM, Alhartani YJ, Al Muhaisen H, Dagash A, Alyami HS. Mental health status of the general population, healthcare professionals, and university students during 2019 coronavirus disease outbreak in Jordan: A cross-sectional study. Brain Behav 2020; 10(8):e01730., Wang et al.5656 Wang S, Xie L, Xu Y, Yu S, Yao B, Xiang D. Sleep disturbances among medical workers during the outbreak of COVID-2019. Occup Med (Lond) 2020; 70(5):364-369. e Zhang et al.6262 Zhang WR, Wang K, Yin L, Zhao WF, Xue Q, Peng M, Min BQ, Tian Q, Leng HX, Du JL, Chang H. Mental health and psychosocial problems of medical health workers during the COVID-19 epidemic in China. Psychother Psychosom 2020; 89(4):242-250., sugerindo que estes estudos podem ser os que mais contribuíram para a elevada heterogeneidade observada (Figura 4). Foi identificada diferença significativa na prevalência com base nos instrumentos utilizados para o diagnóstico da ansiedade (P<0,01). Na comparação da prevalência entre os continentes Ásia, Europa e América, não foi identificada diferença (P=0,42). Não foi registrada diferença na prevalência de ansiedade na comparação entre os estudos com boa e baixa qualidade metodológica (P=0,69). A Tabela 2 apresenta a prevalência de ansiedade por análise de subgrupo.

Figura 2
Prevalência de ansiedade em profissionais de saúde durante a pandemia da COVID-19.

Figura 3
Prevalência da ansiedade por sexo e formação dos profissionais da saúde durante a pandemia da Covid-19.

Figura 4
Gráfico da análise de sensibilidade removendo um estudo por vez.

Tabela 2
Prevalência de ansiedade em profissionais de saúde durante a pandemia da COVID-19 de acordo com instrumento utilizado, continentes de atuação e categoria profissional.

Na análise por sexo, realizada em 12 estudos, foi registrado maior risco de ansiedade nas mulheres que nos homens (Odds ratio [OR]: 1,64 [IC95%: 1,47-1,84], P<0.01) (Figura 3A). Com relação a profissão, foi verificado maior risco de ansiedade entre enfermeiros em relação aos médicos (OR: 1,19 [IC95%: 1,07-1,33] P<0.01) (Figura 3B). Na análise de subgrupo para prevalência de ansiedade nos diferentes níveis profissionais (iniciante, intermediário e sênior) não foi identificada diferença (P=0,60) (Tabela 2).

Sete estudos4040 Elbay RY, Kurtulmus A, Arpacioglu S, Karadere E. Depression, anxiety, stress levels of physicians and associated factors in Covid-19 pandemics. Psychiatry Res 2020; 290:113130.,4444 Lai J, Ma S, Wang Y, Cai Z, Hu J, Wei N, Wu J, Du H, Chen T, Li R, Tan H. Factors associated with mental health outcomes among health care workers exposed to coronavirus disease 2019. JAMA Netw Open 2020; 3(3):e203976.,4646 Liu CY, Yang YZ, Zhang XM, Xu X, Dou QL, Zhang WW, Cheng AS. The prevalence and influencing factors in anxiety in medical workers fighting COVID-19 in China: a cross-sectional survey. Epidemiol Infect 2020; 148:e98.,4747 Lu W, Wang H, Lin Y, Li L. Psychological status of medical workforce during the COVID-19 pandemic: A cross-sectional study. Psychiatry Res 2020; 288:112936.,5050 Que J, Le Shi JD, Liu J, Zhang L, Wu S, Gong Y, Huang W, Yuan K, Yan W, Sun Y, Ran M. Psychological impact of the COVID-19 pandemic on healthcare workers: a cross-sectional study in China. Gen Psychiatry 2020; 33(3):e100259.,5757 Xiao X, Zhu X, Fu S, Hu Y, Li X, Xiao J. Psychological impact of healthcare workers in China during COVID-19 pneumonia epidemic: A multi-center cross-sectional survey investigation. J Affect Disord 2020; 274:405-410.,6262 Zhang WR, Wang K, Yin L, Zhao WF, Xue Q, Peng M, Min BQ, Tian Q, Leng HX, Du JL, Chang H. Mental health and psychosocial problems of medical health workers during the COVID-19 epidemic in China. Psychother Psychosom 2020; 89(4):242-250. verificaram que os profissionais que atuavam na linha de frente no combate a COVID-19 ou com maior risco de ter contato com pacientes diagnosticados com COVID-19 apresentaram maior prevalência de ansiedade na comparação com os que não atuavam na linha de frente ou com menor risco de contato. No entanto, outros seis estudos não verificaram diferença entre os grupos3131 Badahdah A, Khamis F, Al Mahyijari N, Al Balushi M, Al Hatmi H, Al Salmi I, Albulushi Z, Al Noomani J. The mental health of health care workers in Oman during the COVID-19 pandemic. Int J Soc Psychiatry 2020; 20764020939596.,3333 Chen Y, Zhou H, Zhou Y, Zhou F. Prevalence of self-reported depression and anxiety among pediatric medical staff members during the COVID-19 outbreak in Guiyang, China. Psychiatry Res 2020; 288:113005.,5151 Rossi R, Socci V, Pacitti F, Di Lorenzo G, Di Marco A, Siracusano A, Rossi A. Mental Health Outcomes Among Frontline and Second-Line Health Care Workers During the Coronavirus Disease 2019 (COVID-19) Pandemic in Italy. JAMA Net Open 2020; 3(5):e2010185.,5555 Vanni G, Materazzo M, Santori F, Pellicciaro M, Costesta M, Orsaria P, Cattadori F, Pistolese CA, Perretta T, Chiocchi M, Meucci R. The Effect of Coronavirus (COVID-19) on Breast Cancer Teamwork: A Multicentric Survey. In Vivo 2020; 34(3 Supl.):1685-1694.,5959 Zandifar A, Badrfam R, Khonsari NM, Assareh M, Karim H, Azimzadeh M, Sepehr MN, Tajbakhsh R, Rahimi F, Ghanipour N, Agoushi A, Gelsefid SH, Etemadi F, Qorbani M. COVID-19 and medical staff's mental health in educational hospitals in Alborz Province, Iran. Psychiatry Clin Neurosci 2020; 74(9):499-501.,6464 Zhu Z, Xu S, Wang H, Liu Z, Wu J, Li G, Miao J, Zhang C, Yang Y, Sun W, Zhu S. COVID-19 in Wuhan: Sociodemographic characteristics and hospital support measures associated with the immediate psychological impact on healthcare workers. EClinicalMedicine 2020; 24:100443..

Liu et al.4646 Liu CY, Yang YZ, Zhang XM, Xu X, Dou QL, Zhang WW, Cheng AS. The prevalence and influencing factors in anxiety in medical workers fighting COVID-19 in China: a cross-sectional survey. Epidemiol Infect 2020; 148:e98. verificaram que os profissionais de saúde com suspeita de COVID-19 apresentavam maior risco de ansiedade que os profissionais que não eram casos suspeitos (escore SAS, casos suspeitos: média de 42,52, com desvio padrão [DP] de 9,69 versus não casos suspeitos: média 39,05, com DP de 8,62). Zhu et al.6464 Zhu Z, Xu S, Wang H, Liu Z, Wu J, Li G, Miao J, Zhang C, Yang Y, Sun W, Zhu S. COVID-19 in Wuhan: Sociodemographic characteristics and hospital support measures associated with the immediate psychological impact on healthcare workers. EClinicalMedicine 2020; 24:100443. identificaram maior prevalência de casos de COVID-19 entre os profissionais com ansiedade (4,6%) que entre profissionais que não apresentavam ansiedade (2,7%). Zhang et al.6161 Zhang SX, Liu J, Jahanshahi AA, Nawaser K, Yousefi A, Li J, Sun S. At the height of the storm: Healthcare staff's health conditions and job satisfaction and their associated predictors during the epidemic peak of COVID-19. Brain Behav Immun 2020; 87:144-146. não identificaram associação entre o diagnóstico de COVID-19 com ansiedade (Coeficiente de regressão β [IC95%]: 0,157; -0,956-1,271), mas, verificaram associação entre incerteza sobre estar infectado e ansiedade (β [IC95%]: 0,688; 0,303-1,073).

A associação entre ansiedade e doenças crônicas preexistentes foi avaliada em três estudos3232 Chatterjee SS, Bhattacharyya R, Bhattacharyya S, Gupta S, Das S, Banerjee BB. Attitude, practice, behavior, and mental health impact of COVID-19 on doctors. Indian J Psychiatry 2020; 62(3):257.,6262 Zhang WR, Wang K, Yin L, Zhao WF, Xue Q, Peng M, Min BQ, Tian Q, Leng HX, Du JL, Chang H. Mental health and psychosocial problems of medical health workers during the COVID-19 epidemic in China. Psychother Psychosom 2020; 89(4):242-250.,6464 Zhu Z, Xu S, Wang H, Liu Z, Wu J, Li G, Miao J, Zhang C, Yang Y, Sun W, Zhu S. COVID-19 in Wuhan: Sociodemographic characteristics and hospital support measures associated with the immediate psychological impact on healthcare workers. EClinicalMedicine 2020; 24:100443.. Zhu et al.6464 Zhu Z, Xu S, Wang H, Liu Z, Wu J, Li G, Miao J, Zhang C, Yang Y, Sun W, Zhu S. COVID-19 in Wuhan: Sociodemographic characteristics and hospital support measures associated with the immediate psychological impact on healthcare workers. EClinicalMedicine 2020; 24:100443. verificaram que 23,1% dos profissionais com diagnóstico de ansiedade apresentavam doenças crônicas, enquanto entre os profissionais sem ansiedade 14,8% referiram ter alguma doença crônica. No estudo de Zhang et al.6262 Zhang WR, Wang K, Yin L, Zhao WF, Xue Q, Peng M, Min BQ, Tian Q, Leng HX, Du JL, Chang H. Mental health and psychosocial problems of medical health workers during the COVID-19 epidemic in China. Psychother Psychosom 2020; 89(4):242-250. também relataram maior risco de ansiedade nos profissionais com doenças preexistentes (OR: 2,85; IC95%: 1,73-4,68). No entanto, Chatterjee et al.3232 Chatterjee SS, Bhattacharyya R, Bhattacharyya S, Gupta S, Das S, Banerjee BB. Attitude, practice, behavior, and mental health impact of COVID-19 on doctors. Indian J Psychiatry 2020; 62(3):257. identificaram prevalência de 55,6% nos profissionais que não tinham nenhuma comorbidade, enquanto que nos que tinham diabetes mellitus, hipertensão e doença pulmonar obstrutiva crônica a prevalência foi de 36,1%. Como neste estudo de Chatterjee et al.3232 Chatterjee SS, Bhattacharyya R, Bhattacharyya S, Gupta S, Das S, Banerjee BB. Attitude, practice, behavior, and mental health impact of COVID-19 on doctors. Indian J Psychiatry 2020; 62(3):257. somente nove (5,9%) profissionais não apresentaram comorbidades, se observa necessidade de maior cautela em sua análise.

Discussão

Nesta revisão sistemática, os resultados indicam elevada prevalência de ansiedade nos profissionais da saúde durante a pandemia da COVID-19, evidenciando a necessidade de medidas que visem prevenir este transtorno e que resultem em melhorias na qualidade de vida e na saúde psicológica destes trabalhadores. Além disso, não foi verificada diferença na prevalência entre os continentes, evidenciando que a doença causada pelo novo coronavírus tornou a ansiedade prevalente entre profissionais de saúde nas mais diversas regiões do mundo.

Os estudos incluídos na revisão utilizaram diferentes instrumentos para o diagnóstico da ansiedade. Houve diferença significativa na prevalência de ansiedade conforme o instrumento utilizado. Estas diferenças podem ser explicadas considerando que os diversos instrumentos utilizados nos estudos foram desenvolvidos para público e contexto específicos, bem como apresentam diferentes sensibilidade e especificidade7474 Remes O, Brayne C, Van Der Linde R, Lafortune L. A systematic review of reviews on the prevalence of anxiety disorders in adult populations. Brain Behav 2016; 6(7):e00497..

A prevalência de ansiedade identificada nesta metanálise para os profissionais de saúde durante a pandemia da COVID-19 é semelhante a identificada na população em geral neste mesmo período. Em metanálise que incluiu 17 estudos, Salari et al.7575 Salari N, Hosseinian-Far A, Jalali R, Vaisi-Raygani A, Rasoulpoor S, Mohammadi M, Rasoulpoor S, Khaledi-Paveh B. Prevalence of stress, anxiety, depression among the general population during the COVID-19 pandemic: a systematic review and meta-analysis. Global Health 2020; 16(1):57. identificaram prevalência de ansiedade na população geral durante a pandemia da COVID-19 de 31,9% (IC95%: 27,5-36,7).

Vários fatores foram relacionados com o maior risco para ansiedade, os quais devem ser considerados no processo de tomada de decisão quanto às estratégias e grupos prioritários para as ações de prevenção e tratamento da ansiedade nos profissionais de saúde. As mulheres apresentaram maior risco de ansiedade que os homens. Esta diferença na prevalência de ansiedade entre os sexos tem sido referida por vários autores e registrada em estudos com a população em geral7676 Asher M, Asnaani A, Aderka IM. Gender differences in social anxiety disorder: A review. Clin Psychol Rev 2017; 56:1-12.,7777 Jalnapurkar I, Allen M, Pigott T. Sex differences in anxiety disorders: A review. HSOA J Psychiatry Depress Anxiety 2018; 4:012.. Dados do Global Burden of Disease Study7878 World Health Organization (WHO). Depression and other common mental disorders: global health estimates. Genebra: WHO; 2017. de 2015 registraram prevalência global de ansiedade nas mulheres de 4,6% e nos homens de 2,6%. Neste estudo7878 World Health Organization (WHO). Depression and other common mental disorders: global health estimates. Genebra: WHO; 2017., maior prevalência de ansiedade no sexo feminino em relação ao sexo masculino foi identificada em todas as faixas etárias analisadas, bem como em todos os continentes.

Além do possível papel dos hormônios sexuais estradiol e progesterona no desenvolvimento da ansiedade7979 Li SH, Graham BM. Why are women so vulnerable to anxiety, trauma-related and stress-related disorders? The potential role of sex hormones. Lancet Psychiatry 2017; 4(1):73-82., uma das teorias da área psicossocial sobre o maior risco de ansiedade relacionada ao gênero, a self-construal theory, refere que mulheres e homens se interpretam de maneira diferente8080 Cross SE, Madson L. Models of the self: self-construals and gender. Psychol Bull 1997; 122(1):5.. Neste sentido, enquanto os homens analisam a si próprios de maneira independente aos outros, as mulheres tendem a se analisar relacionando com os demais, de modo interdependente.

Além disso, o fato de as mulheres representarem em maior proporção a força de trabalho em saúde - aproximadamente 80%, inclusive atuando na linha de frente8181 Del Campo MT, Romo PE, de la Hoz RE, Villamor JM, Mahíllo-Fernández I. Anxiety and depression predict musculoskeletal disorders in health care workers. Arch Environ Occup Health 2017; 72(1):39-44.,8282 Salehi H, Pennathur PR, Da Silva JP, Herwaldt LA. Examining health care personal protective equipment use through a human factors engineering and product design lens. Am J Infect Control 2019; 47(5):595-598., pode explicar o fato de estarem mais sujeitas a apresentarem ansiedade que os homens.

Com relação a profissão, houve risco significativamente maior de ansiedade nos enfermeiros, na comparação com médicos. Considerando que há a possibilidade de haver mais mulheres que homens entre os profissionais de enfermagem, este resultado pode ser fruto de confundimento por sexo, pois foi registrado maior risco de ansiedade nas mulheres que nos homens3131 Badahdah A, Khamis F, Al Mahyijari N, Al Balushi M, Al Hatmi H, Al Salmi I, Albulushi Z, Al Noomani J. The mental health of health care workers in Oman during the COVID-19 pandemic. Int J Soc Psychiatry 2020; 20764020939596.,3535 Civantos AM, Byrnes Y, Chang C, Prasad A, Chorath K, Poonia SK, Jenks CM, Bur AM, Thakkar P, Graboyes EM, Seth R. Mental health among otolaryngology resident and attending physicians during the COVID-19 pandemic: National study. Head Neck 2020; 42(7):1597-1609.,3939 Du J, Dong L, Wang T, Yuan C, Fu R, Zhang L, Liu B, Zhang M, Yin Y, Qin J, Bouey J. Psychological symptoms among frontline healthcare workers during COVID-19 outbreak in Wuhan. Gen Hosp Psychiatry 2020; 67:144-145.,4343 Huang JZ, Han MF, Luo TD, Ren AK, Zhou XP. Mental health survey of medical staff in a tertiary infectious disease hospital for COVID-19. Zhonghua Lao Dong Wei Sheng Zhi Ye Bing Za Zhi 2020; 38(3):192-195.,4444 Lai J, Ma S, Wang Y, Cai Z, Hu J, Wei N, Wu J, Du H, Chen T, Li R, Tan H. Factors associated with mental health outcomes among health care workers exposed to coronavirus disease 2019. JAMA Netw Open 2020; 3(3):e203976.,5757 Xiao X, Zhu X, Fu S, Hu Y, Li X, Xiao J. Psychological impact of healthcare workers in China during COVID-19 pneumonia epidemic: A multi-center cross-sectional survey investigation. J Affect Disord 2020; 274:405-410.,5959 Zandifar A, Badrfam R, Khonsari NM, Assareh M, Karim H, Azimzadeh M, Sepehr MN, Tajbakhsh R, Rahimi F, Ghanipour N, Agoushi A, Gelsefid SH, Etemadi F, Qorbani M. COVID-19 and medical staff's mental health in educational hospitals in Alborz Province, Iran. Psychiatry Clin Neurosci 2020; 74(9):499-501.,6565 Zhu J, Sun L, Zhang L, Wang H, Fan A, Yang B, Li W, Xiao S. Prevalence and Influencing Factors of Anxiety and Depression Symptoms in the First-Line Medical Staff Fighting Against COVID-19 in Gansu. Front Psychiatry 2020; 11:386.. O maior tempo de cuidado direto com pacientes da equipe de enfermagem em comparação aos médicos pode ser uma das explicações para o maior risco de ansiedade em enfermeiros registrada em alguns estudos8383 Sang AX, Tisdale RL, Nielsen D, Loica-Mersa S, Miller T, Chong I, Shieh L. How Much Time are Physicians and Nurses Spending Together at the Patient Bedside? J Hosp Med 2019; 14(8):468-473.. Neste sentido, Butler et al.8484 Butler R, Monsalve M, Thomas GW, Herman T, Segre AM, Polgreen PM, Suneja M. Estimating time physicians and other health care workers spend with patients in an intensive care unit using a sensor network. Am J Med 2018; 131(8):972.e9-972.e15. verificaram que em 13,1% do tempo os pacientes recebem cuidados dos médicos, enquanto para os enfermeiros o percentual é de 86,1%. Ademais, como os enfermeiros passam mais tempo com os pacientes, bem como geralmente são os profissionais que realizam a coleta de secreções das vias aéreas ou de sangue para os exames que detectam SARS-CoV-2 ou anticorpos, podem estar mais expostos a infecções que os médicos, contribuindo para a maior ansiedade nestes profissionais8585 Wang J, Zhou M, Liu F. Reasons for healthcare workers becoming infected with novel coronavirus disease 2019 (COVID-19) in China. J Hosp infect 2020; 105(1):100-101.,8686 Zhang M, Zhou M, Tang F, Wang Y, Nie H, Zhang L, You G. Knowledge, attitude, and practice regarding COVID-19 among healthcare workers in Henan, China. J Hosp infect 2020; 105(2):183-187..

A prevalência de ansiedade entre os profissionais com diferentes graus de experiência não se mostrou mais elevada entre os iniciantes. Considerando que a pandemia da COVID-19 é um momento que requer maior cuidado e perícia na oferta de serviços em saúde, se entende que os profissionais de nível intermediário e sênior, que apresentam maior experiência e expertise que os iniciantes, podem estar mais sobrecarregados com a elevada demanda de atendimento8686 Zhang M, Zhou M, Tang F, Wang Y, Nie H, Zhang L, You G. Knowledge, attitude, and practice regarding COVID-19 among healthcare workers in Henan, China. J Hosp infect 2020; 105(2):183-187.,8787 Emanuel EJ, Persad G, Upshur R, Thome B, Parker M, Glickman A, Zhang C, Boyle C, Smith M, Phillips JP. Fair allocation of scarce medical resources in the time of Covid-19. N Engl J Med 2020; 382:2049-2055.. No caso dos profissionais iniciantes, por terem menos experiência, podem apresentar maior insegurança8787 Emanuel EJ, Persad G, Upshur R, Thome B, Parker M, Glickman A, Zhang C, Boyle C, Smith M, Phillips JP. Fair allocation of scarce medical resources in the time of Covid-19. N Engl J Med 2020; 382:2049-2055.. Ademais, neste período de enfrentamento a COVID-19, muitos profissionais de saúde recém-formados foram recrutados para o atendimento clínico durante a pandemia. O início no primeiro emprego neste período pode também representar um dos fatores contribuintes para a ansiedade nos profissionais iniciantes.

Os resultados, na maioria dos estudos incluídos nesta revisão, apontaram maior prevalência de ansiedade nos profissionais atuantes na linha de frente quando comparados com aqueles menos expostos aos cuidados de pacientes infectados. Vários estudos4040 Elbay RY, Kurtulmus A, Arpacioglu S, Karadere E. Depression, anxiety, stress levels of physicians and associated factors in Covid-19 pandemics. Psychiatry Res 2020; 290:113130.,4444 Lai J, Ma S, Wang Y, Cai Z, Hu J, Wei N, Wu J, Du H, Chen T, Li R, Tan H. Factors associated with mental health outcomes among health care workers exposed to coronavirus disease 2019. JAMA Netw Open 2020; 3(3):e203976.,4646 Liu CY, Yang YZ, Zhang XM, Xu X, Dou QL, Zhang WW, Cheng AS. The prevalence and influencing factors in anxiety in medical workers fighting COVID-19 in China: a cross-sectional survey. Epidemiol Infect 2020; 148:e98.,4747 Lu W, Wang H, Lin Y, Li L. Psychological status of medical workforce during the COVID-19 pandemic: A cross-sectional study. Psychiatry Res 2020; 288:112936.,5050 Que J, Le Shi JD, Liu J, Zhang L, Wu S, Gong Y, Huang W, Yuan K, Yan W, Sun Y, Ran M. Psychological impact of the COVID-19 pandemic on healthcare workers: a cross-sectional study in China. Gen Psychiatry 2020; 33(3):e100259.,5757 Xiao X, Zhu X, Fu S, Hu Y, Li X, Xiao J. Psychological impact of healthcare workers in China during COVID-19 pneumonia epidemic: A multi-center cross-sectional survey investigation. J Affect Disord 2020; 274:405-410.,6262 Zhang WR, Wang K, Yin L, Zhao WF, Xue Q, Peng M, Min BQ, Tian Q, Leng HX, Du JL, Chang H. Mental health and psychosocial problems of medical health workers during the COVID-19 epidemic in China. Psychother Psychosom 2020; 89(4):242-250. registraram maior prevalência de ansiedade entre os profissionais que atuavam na linha de frente no combate a COVID-19. Dentre os fatores que podem explicar maior prevalência nestes profissionais se tem a preocupação em fornecer efetivo e humanizado atendimento a elevado número de pacientes críticos; o maior número de encontros profissional-paciente, o maior tempo em cada encontro com os pacientes, a maior proximidade física com os pacientes; o não recebimento de equipamentos de proteção individual em quantidade e qualidade adequadas para o período de trabalho e o medo de ser infectado pelo SARS-COV-2 e de transmitir o vírus para os familiares8888 Adams JG, Walls RM. Supporting the health care workforce during the COVID-19 global epidemic. JAMA 2020; 323(15):1439-1440.,8989 Dy LF, Rabajante JF. A COVID-19 Infection Risk Model for Frontline Health Care Workers. Netw Model Anal Health Inform Bioinform 2020; 9(1):57..

Estudos realizados durante outras epidemias também revelaram elevada prevalência de estresse e ansiedade em profissionais de saúde com maior risco de contato ou em contato direto com pacientes infectados9090 Liu X, Kakade M, Fuller CJ, Fan B, Fang Y, Kong J, Guan Z, Wu P. Depression after exposure to stressful events: lessons learned from the severe acute respiratory syndrome epidemic. Compr Psychiatry 2012; 53(1):15-23.,9191 Brooks SK, Dunn R, Amlôt R, Rubin GJ, Greenberg N. A systematic, thematic review of social and occupational factors associated with psychological outcomes in healthcare employees during an infectious disease outbreak. J Occup Environ Med 2018; 60(3):248-257.. Revisão sistemática realizada por Brooks et al.9191 Brooks SK, Dunn R, Amlôt R, Rubin GJ, Greenberg N. A systematic, thematic review of social and occupational factors associated with psychological outcomes in healthcare employees during an infectious disease outbreak. J Occup Environ Med 2018; 60(3):248-257. demonstrou maior prevalência de ansiedade e esgotamento físico em profissionais que atuaram na linha de frente durante epidemias, inclusive na SARS em 2003.

Os profissionais que referiram ser casos suspeitos ou que foram diagnosticados com a COVID-19 apresentaram mais ansiedade que os não infectados, conforme também registrado na população em geral, tanto em outras epidemias1111 Everts J. Announcing swine flu and the interpretation of pandemic anxiety. Antipode 2013; 45(4):809-825.,1212 Taha S, Matheson K, Cronin T, Anisman H. Intolerance of uncertainty, appraisals, coping, and anxiety: The case of the 2009 H 1 N 1 pandemic. Br J Health Psychol 2014; 19(3):592-605., quanto na pandemia da COVID-19. Kong et al.9292 Kong X, Zheng K, Tang M, Kong F, Zhou J, Diao L, Wu S, Jiao P, Su T, Dong Y. Prevalence and factors associated with depression and anxiety of hospitalized patients with COVID-19. MedRxiv 2020; preprint. identificaram que 34,7% dos pacientes com COVID-19 apresentaram ansiedade. O medo de transmitir para os familiares e o maior risco à saúde em decorrência da doença são possíveis fatores que podem explicar a maior ansiedade nestes profissionais8888 Adams JG, Walls RM. Supporting the health care workforce during the COVID-19 global epidemic. JAMA 2020; 323(15):1439-1440..

Dois estudos verificaram que os profissionais de saúde com doenças crônicas apresentaram maior prevalência de ansiedade6262 Zhang WR, Wang K, Yin L, Zhao WF, Xue Q, Peng M, Min BQ, Tian Q, Leng HX, Du JL, Chang H. Mental health and psychosocial problems of medical health workers during the COVID-19 epidemic in China. Psychother Psychosom 2020; 89(4):242-250.,6464 Zhu Z, Xu S, Wang H, Liu Z, Wu J, Li G, Miao J, Zhang C, Yang Y, Sun W, Zhu S. COVID-19 in Wuhan: Sociodemographic characteristics and hospital support measures associated with the immediate psychological impact on healthcare workers. EClinicalMedicine 2020; 24:100443.. O maior risco de complicações e morte relacionadas à COVID-19 em pessoas com doenças crônicas são fatores que explicam a maior ansiedade nesse caso8888 Adams JG, Walls RM. Supporting the health care workforce during the COVID-19 global epidemic. JAMA 2020; 323(15):1439-1440..

Esse estudo apresenta como ponto positivo a avaliação da prevalência e fatores associados à ansiedade em profissionais de saúde durante à pandemia da COVID-19, podendo contribuir para o processo de tomada de decisão quanto aos grupos prioritários para direcionamento das ações de prevenção e tratamento. Entre as limitações destaca-se o não registro do protocolo da revisão; no entanto, a estratégia de busca completa para cada base de dados com os filtros aplicados foi disponibilizada de modo a proporcionar a reprodutibilidade dos achados. Além disso, foi registrada elevada heterogeneidade entre os estudos incluídos na revisão, pois nos estudos os autores utilizaram diferentes escalas e pontos de corte para a avaliação e o diagnóstico da ansiedade. Ademais, muitos tinham informações incompletas sobre o diagnóstico da COVID-19 por subgrupos, comprometendo as análises e rebaixando o nível da evidência encontrada. Ademais, os estudos foram conduzidos com diferentes amostras populacionais e em diferentes regiões do planeta em que condições de trabalho, acesso a equipamentos de proteção individual e capacidade técnica dos profissionais podem variar, resultando em maior ou menor prevalência de ansiedade.

Contribuições do estudo e implicações para a prática clínica

Esta revisão sistemática evidencia que a prevalência de ansiedade em profissionais de saúde durante a pandemia da COVID-19 é alta e maior entre as mulheres, profissionais de enfermagem e nos que atuam na linha de frente. Deste modo, estes resultados podem contribuir para o processo de tomada de decisão quanto aos grupos prioritários para as ações de prevenção e tratamento da ansiedade. Entretanto, limitações desta revisão como predomínio de estudos envolvendo médicos e profissionais da enfermagem, impedem que os resultados sejam extrapolados para outras profissões da saúde que também atuam na linha de frente no combate a COVID-19, como os fisioterapeutas. Por outro lado, ao apresentar dados comparando prevalência de ansiedade entre médicos e enfermeiros, este estudo aponta um fator potencial de afastamento do trabalho por motivo de saúde destes profissionais, com implicações importantes para a prática clínica, como por exemplo redução de médicos e profissionais de enfermagem durante a pandemia, com risco de assistência inadequada nos serviços de saúde públicos e privados.

Conclusão

A prevalência de ansiedade nos profissionais de saúde durante à pandemia da COVID-19 é elevada, independentemente do continente de atuação profissional e da qualidade metodológica dos estudos. A ansiedade foi mais prevalente nos profissionais do sexo feminino, enfermeiros, que atuam na linha de frente, infectados pelo SARS-CoV-2 e que apresentavam doenças crônicas. Há escassez de estudos nos países com maior número de casos como Brasil e Estados Unidos e entre profissionais com importante atuação na pandemia como fisioterapeutas. Medidas que visem a prevenção e o tratamento da ansiedade nos profissionais de saúde que atuam no combate a COVID-19, bem como o fornecimento de seguimento e suporte adequados para os com ansiedade moderada e grave, são necessárias para melhorar a qualidade de vida e para garantir a força de trabalho fundamental para o enfrentamento da pandemia, bem como a saúde mental destes profissionais no período pós-pandemia.

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Datas de Publicação

  • Publicação nesta coleção
    12 Fev 2021
  • Data do Fascículo
    Fev 2021

Histórico

  • Recebido
    11 Ago 2020
  • Aceito
    06 Nov 2020
  • Publicado
    08 Nov 2020
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