Determinantes da evolução ponderal em gestantes atendidas em uma unidade da rede pública de saúde do Município do Rio de Janeiro, Brasil: estudo prospectivo, 2005-2007
Patricia Lima RodriguesI; Elisa Maria de Aquino LacerdaI; Michael Maia SchlüsselI; Maria Helena Constantino SpyridesII; Gilberto KacI
IInstituto de Nutrição Josué de Castro, Universidade Federal do Rio de Janeiro, Rio de Janeiro, Brasil
IIDepartamento de Estatística, Universidade Federal do Rio Grande do Norte, Rio Grande do Norte, Brasil
The objective of this study was to evaluate the determinants of weight gain during pregnancy. The study adopted a prospective cohort design with four follow-up waves and included a sample of 255 pregnant women that received prenatal care at a public health care facility in Rio de Janeiro, Brazil. A mixed-effects linear longitudinal regression model was used, having as the dependent variable the weight assessed in four follow-up waves, and as independent variables: demographic, socioeconomic, reproductive, behavioral, and nutritional data. Mean weight gain was 0.413kg per gestational week, consistent with recommendations by the Institute of Medicine. Per capita family income and smoking were associated with total weight gain during gestation. According to the longitudinal multiple linear regression model, age (β = 0.6315), menarche (β = -2.3861), triglycerides (β = 0.0437), blood glucose (β = 0.1544), and adequacy of energy consumption (β = -0.0642) were associated with gestational weight gain. Special attention should be given to these sub-groups, due to increased risk of excessive weight gain.
Nutritional Epidemiology; Weight Gain; Pregnancy
O objetivo do estudo foi avaliar os fatores determinantes da evolução ponderal durante a gestação. Trata-se de uma investigação com desenho do tipo coorte prospectiva com quatro ondas de seguimento, composta por 255 gestantes atendidas em pré-natal público da cidade do Rio de Janeiro, Brasil. Utilizou-se o procedimento de regressão linear longitudinal com efeitos mistos, tendo como variável dependente o peso aferido em quatro ondas de seguimento, e como independentes variáveis demográficas e sócio-econômicas, reprodutivas, comportamentais e nutricionais. A velocidade média de ganho de peso ponderal foi de 0,413kg por semana de gestação, compatível com o recomendado pelo Institute of Medicine (Estados Unidos). A renda familiar per capita e o hábito de fumar estiveram associados ao ganho de peso total na gestação. O modelo múltiplo de regressão linear longitudinal revelou que a idade (β = 0,6315), menarca (β = -2,3861), triglicérides (β = 0,0437), glicose (β = 0,1544) e adequação do consumo energético (β = -0,0642) estiveram associados ao ganho de peso gestacional. Sugere-se atenção especial para esses subgrupos, em decorrência do maior risco de ganho excessivo.
Epidemiologia Nutricional; Ganho de Peso; Gravidez
Weight gain during pregnancy includes three components: the product of conception (fetus, placenta, extracellular and amniotic fluid), maternal tissue expansion (uterus, breasts, and blood volume), and maternal fat reserve 1,2. Normal mean total gestational weight gain is estimated at 12.5kg 1,2,3,4.
Weight gain measured at various moments during pregnancy is the most common way of assessing the pregnant woman's nutritional status, besides indirectly assessing fetal growth 4,5, since it is more sensitive (as compared to other anthropometric indicators) to acute intra-gestational stress 3. It is thus an important indicator for observing normal evolution of pregnancy and is widely used in prenatal care 4.
Pre-gestational maternal nutritional status and gestational weight gain have been studied systematically, due not only to the growing prevalence of deviations from their normal values, but especially to their determinant role in gestational outcomes 2 and the lifelong consequences for the mother and child 6,7.
Low birth weight, intrauterine growth retardation, and prematurity are related to insufficient weight gain during pregnancy 8,9,10,11. Meanwhile, excessive maternal weight gain is associated with macrosomy, increased cesarean rate, diabetes mellitus, pregnancy-induced hypertension, and postpartum weight retention 2,12,13,14,15,16,17,18.
Complex interactions between maternal biological and metabolic factors influence the weight gain pattern during pregnancy, besides numerous social factors that can act as determinants. The latter include pre-gestational nutritional status, schooling, socio-demographic situation, skin color, work, physical activity, calorie intake, smoking, alcohol consumption, reproductive history, and prenatal care 2,4,19,20.
Although the amount of gestational weight gain and obstetric outcomes are well documented in the scientific literature, the determinants of gestational weight change have received relatively little attention. The objective of the current study was thus to investigate demographic, socioeconomic, reproductive, behavioral, and nutritional determinants of weight change during pregnancy.
This was a prospective cohort study with a dynamic sample consisting of pregnant women treated at a primary health care center (Mother Thereza of Calcutta Municipal Clinic), located in the Ilha do Governador neighborhood in the city of Rio de Janeiro, Brazil. Free recruitment of subjects occurred for 22 months, from June 2005 to April 2007.
The study included women 18 to 40 years of age, in the 8th to 13th weeks of pregnancy, free of non-communicable chronic diseases (like hypertension and diabetes) or infectious diseases (HIV), with singleton pregnancies. The prenatal care service contacted a total of 292 pregnant women who met the eligibility criteria. Of these, 255 agreed to participate in the study and began the follow-up period.
Individual interviews were held in four follow-up waves during gestation: 8-13 gestational weeks (baseline), 19-21, 26-28, and 36-40, when anthropometric measures were taken and previously tested questionnaires were applied. The main target covariables for the current study were measured during the first wave. However, various other constructs were also studied, like anxiety, depression, oral hygiene, caffeine consumption, and family violence. This information was collected at the other follow-up points, but their use is beyond the scope of the current study. Blood samples were taken at the 1st, 3rd, and 4th waves and were analyzed at the central municipal laboratory of Rio de Janeiro.
The dependent variable was weight measured at each follow-up wave to determine weight change. Total weight gain during pregnancy was calculated as the difference between weight as measured at the fourth and first follow-up waves.
The covariables used in the current analysis were collected at baseline (8th-13th gestational week) and separated in five blocks: demographic and socioeconomic variables: age (18-24, 25-40 years), self-reported skin color (white, brown, black), marital status (married, living with partner, single), schooling (< 8, > 8 years), per capita family income (< 0.5; 0.5-1.0; > 1.0 times the minimum wage); and work outside the home (yes, no); reproductive variables: age at menarche (< 12; > 12 years), parity (primiparous, multiparous); inter-pregnancy spacing; behavioral variables: smoking (non-smoker, former smoker, smoker), alcohol consumption (non-consumer, former consumer, consumer), intensity of physical activities (sedentary, light activity). Information on smoking also included questions on age when the individual began smoking, number of cigarettes per day, and time during which the woman smoked. However, none of these variables showed an effect on weight change. The alcohol consumption variable was based on a questionnaire on frequency of alcohol consumption that included information on the type of alcoholic beverage consumed, frequency, and amount, in addition to age when the individual began drinking; nutritional variables: pre-gestational nutritional status (underweight, normal weight, overweight, obese), adequacy of calorie intake (below adequate, adequate, more than adequate), daily protein, lipid, and carbohydrate energy intake; biochemical variables: hematocrit (%), hemoglobin (g/dL), blood glucose (mg/dL), total cholesterol total (mg/dL), low density cholesterol (LDL-cholesterol, mg/dL), high density cholesterol (HDL-cholesterol, mg/dL), and triglycerides (mg/dL).
The women were weighed on a digital scale with a minimum capacity of 2.5kg and maximum of 150kg, accurate to 0.1kg (Filizzola PL 150, Filizzola Ltda., São Paulo, Brazil). Stature was measured in duplicate with a Harpeden portable stadiometer (Harpenden Inc., UK) with a minimum capacity of 70.1cm and maximum of 208.5cm, with a maximum allowable variation of 0.5cm between the two measurements. All the anthropometric measurements were taken by trained interviewers and standardized according to recommended guidelines 21.
Pre-gestational body mass index [BMI = weight (kg)/stature (m2)] was obtained during the first follow-up wave, the maximum period for establishing a pre-gestational nutritional diagnosis based on the weight measurement. The BMI cutoff points were those proposed by the World Health Organization (BMI < 18.5kg/m2 - underweight; 18.5 < BMI < 25.0kg/m2 - normal weight; 25.0 < BMI < 30.0kg/m2 - overweight; and BMI > 30.0kg/m2 - obese) 4. Data on pre-gestational nutritional status were also analyzed using the cutoff points recommended by the Institute of Medicine 1 (BMI < 19.8kg/m2 - underweight; 19.8 < BMI < 26.0kg/m2 - normal weight; 26.0 < BMI < 29.0kg/m2 - overweight; and BMI > 29.0kg/m2 - obese) for purposes of comparison, in the discussion, with studies that adopted these cutoffs.
The pregnant women's level of physical activity was investigated by means of a scale measuring the intensity of physical activities 22. First, the mean weekly frequency with which each of the activities listed on the questionnaire was investigated. Subjects were then asked about the mean duration of these activities, and this value was multiplied by the weekly frequency of the respective activity, thus obtaining the mean weekly time for each activity. The mean weekly time for all the activities was then summed. The mean weekly time for each activity was multiplied by an intensity factor associated with the activity (MET - metabolic equivalent test) 23 and a new sum total was performed. The pregnant women's level of physical activity was then estimated by dividing the second total by the first. Finally, the pregnant women were categorized according to level of physical activity and classified according to the cutoff points proposed by Chasan-Taber et al. 24: sedentary (METgest < 1.5) and light (METgest > 1.5).
Food consumption was measured by means of a semi-quantitative food frequency questionnaire (Food Frequency Questionnaire - FFQ) 25, previously validated for adults, containing a food list with 81 items and eight possible answers for frequency of current consumption (> 3 times/day, 2-3 times/day, once/day; 5-6 times/week, 2-4 times/week, once/week, 1-3 times/month, and never/rarely). The overall frequencies thus obtained were transformed into daily frequencies and multiplied by the amounts of foods consumed, thereby obtaining the daily consumption of energy, carbohydrates, lipids, and proteins. The databanks adopted for this purpose were the Brazilian Food Composition Table (TACO) 26, the table of the Brazilian Institute of Geography and Statistics (IBGE) 27, and the USDA (United States Department of Agriculture) table 28. The analyses excluded 33 women with energy consumption less than 600 or greater than 6,000kcal, who were considered outliers. The food intake energy adequacy was calculated according to the recommended energy for age, weight 29, and estimated level of physical activity, considering adequate gestational weight gain 1,30. Energy consumption was considered adequate from 90 to 110%, low when it was less than 90%, and high when it was greater than 110%.
The blood tests of the pregnant women participating in the study were done on 5mL blood samples, drawn by a designated professional from the health unit. Subjects had been fasting for at least 12 hours before drawing the blood sample. The samples were stored in the laboratory under controlled conditions and standard temperature (6ºC), and were analyzed by a properly trained lab technician. Blood samples were centrifuged (3,000rpm) for plasma separation and extraction, after which they were immediately frozen at -20ºC for subsequent analysis. Hemoglobin and hematocrit tests were performed using an automatic counter. The enzymatic method was used to obtain total cholesterol and triglycerides, while the colorimetric method was used to obtain HDL-cholesterol. LDL-cholesterol, was measured by the formula proposed by Friedwald et al. 31: [LDL-c = (TC) - (HDL-c) - (TG)/5)].
Data on bodyweight and gestational age were also obtained from medical charts of the pregnant women who began follow-up but who missed any of the subsequent interviews. Weight measurements were also taken at the time of prenatal visits, by trained health professionals, using only the measurements that fit the period proposed for each of the study's follow-up waves.
Data were entered using Epi Info version 6.02 (Centers for Disease Control and Prevention, Atlanta, USA). The consistency of the resulting databank was confirmed using SPSS 13.0 (SPSS Inc., Chicago, USA) and S-Plus 2000 (Mathsoft Inc., Seattle, USA).
The statistical analysis initially involved the description of the pregnant women participating in the cohort, according to established procedures like means and 95% confidence intervals (95%CI) for the continuous variables, in addition to the mean weight measured at each follow-up and the total gestational weight gain according to the selected covariables. The Student t test and analysis of variance (ANOVA) were used to test the equality of the mean total gestational weight gain.
Mixed-effects linear longitudinal regression modeling was used as the statistical procedure, with weight measured at each follow-up as the dependent variable and the selected covariables as independent variables, based on a minimum model, controlling for gestational age in weeks. The categorical variables were analyzed in the factor format, allowing estimates for each of the strata in relation to the reference category. The mixed-effects procedure generates regression coefficients and their respective standard errors. The explanatory variables displaying a significant association (p-value < 0.20) with the outcome were candidates for the multiple model. The mixed-effects linear model was adopted based on its great statistical efficiency 32.
The pattern of losses was evaluated based on the final follow-up rate (number of pregnant women who began/concluded follow-up). The results were analyzed using the chi-squared test for proportions.
The study was approved by the Institutional Review Board of the Martagão Gesteira Institute of Childcare and Pediatrics at the Federal University in Rio de Janeiro and by the Rio de Janeiro Municipal Health Secretariat, and complies with Ruling nº. 196/1996 of the Brazilian National Health Council 33. All of the participants signed a free and informed term of consent, having received all the necessary clarifications.
The final rate of loss to follow-up was 32.1%. However, the pattern of losses was random in relation to the different variables listed in Table 1.
The data analysis included 255 pregnant women in the first follow-up wave (baseline). Of these, 197 appeared for the second interview, 186 completed the third, and 173 concluded the entire follow-up with the fourth interview, as displayed in Figure 1. For the sample of pregnant women as a whole, 11.7% (n = 23), 17.9% (n = 33), and 45.1% (n = 78) had their weight data retrieved from their medical charts at the second, third, and fourth follow-up waves, respectively. No significant differences were found between the mean weights as measured directly and retrieved from medical charts, after controlling for gestational age.
Table 2 shows the baseline means for several selected variables for the 255 pregnant women who began the follow-up. On average, the women were 25.7 years old, had eight years of schooling, a per capita monthly family income of BR$ 353.00 (approximately U$ 220.00), and age at menarche of 12 years. Mean pre-gestational BMI was 24.0kg/m2.
Mean pre-gestational weight at baseline was 61.2kg (95%CI: 59.6-62.7), and mean weight measured at the second, third, and fourth waves was 64.3 (95%CI: 62.6-66.0), 66.8 (95%CI: 65.2-68.5), and 72.8kg (95%CI: 70.8-74.8), respectively (Figure 1). Mean total weight gain was 11.7kg (95%CI: 11.0-12.4). In addition, 33.4% of the women began the pregnancy with excess weight (12.2% with obesity) and 5.5% with pre-gestational underweight, according to the WHO cutoff points, while the values according to the Institute of Medicine guidelines were 13.7%, 15.3%, and 18% for overweight, obesity, and underweight, respectively (results not shown).
Tables 3 and 4 show the mean weight measurements at each follow-up wave and the mean total weight gain according to the selected variables. Mean weight was higher in pregnant women with per capita family income greater than one minimum wage, as was total weight gain (12.5 versus 10.8kg). Former smokers showed higher total gestational weight gain (13.9kg), as well as higher mean bodyweight throughout pregnancy.
Pre-selection of variables for the mixed-effects linear model (Table 5) showed a positive association between weight gain and the following covariables: gestational age, age, marital status (married/living with partner), parity, smoking (non or former smoker), alcohol consumption (none/former), pre-gestational BMI, stature, blood glucose, and triglycerides. Meanwhile, age at menarche and adequacy of energy consumption were inversely associated with weight gain. The variables inter-pregnancy spacing, alcohol consumption (none/former), and HDL-cholesterol showed statistical significance < 0.20 and were also candidates for the multiple model.
The covariables that remained in the final linear longitudinal regression model (Table 6) as positively and significantly associated with weight gain were: gestational age (β = 0.4132; p < 0.0001), maternal age (β = 0.6315; p < 0.0001), triglycerides (β = 0.0437; p = 0.0231), and blood glucose (β = 0.1544; p = 0.0194), while age at menarche (β = -2.5977; p < 0.0001) and adequacy of energy consumption (β = -0.0642; p = 0.0007) were inversely associated.
The study's findings demonstrate that mean gestational weight gain was 0.413kg per week of pregnancy, consistent with the weight gain recommended by the Institute of Medicine for women with pre-gestational BMI within the normal range 1,34. Analyzing the mean weight gain per trimester of pregnancy, our results were similar to those of Nucci et al. 35 based on data collected by the Brazilian Study on Gestational Diabetes from 1991 to 1995 with more than three thousand pregnant women in six Brazilian State capitals. In the current study, mean weight gain was 0.41kg and 0.43kg per week in the second and third trimesters, respectively (data not shown in tables). In Nucci et al. 35, the figures were 0.43kg and 0.40kg per week for the second and third trimesters, respectively.
The prevalence rates for women who began pregnancy with excess weight and underweight were 33.4% and 5.5%, respectively, based on the WHO cutoff points 4. These figures disagree with those found in health services in the States of São Paulo (24% and 21%) 19, Pernambuco (26.3% and 25.4%) 36, and Paraíba (27% and 23%) 11. A lower prevalence rate for excess pre-gestational weight was described by Kac et al. 13,14, who found 17.5%, based on the results of a cohort of women monitored for nine months postpartum in Rio de Janeiro from 1999 to 2001. A multi-center study by Nucci et al. 16 showed 29% with excess weight and 6% with underweight, similar to our findings. Importantly, the use of different diagnostic criteria for evaluating pre-gestational nutritional status can explain the differences in various studies for low pre-gestational weight, since only Nucci et al. 16 and the current study used the WHO cutoff points 4, while Kac et al. 13,14 used the Institute of Medicine criteria 1,34 and other studies used the cutoff points proposed by Atalah et al. 37, which differ from the WHO guidelines as to the diagnosis of underweight.
According to the linear multiple regression model, maternal age, serum triglycerides and blood glucose, age at menarche, and adequacy of energy consumption remained associated with gestational weight gain.
For each increase of one year in the woman's age, there was an increase of 0.631kg in weight gain. In other words, comparing 20 and 30-year-old pregnant women, the difference in total weight gain could reach nearly 6kg. Age is a non-modifiable factor and has proven to be an important determinant of anthropometric measurements 38. For pregnant women, the literature shows lower weight gain in younger women 39, which is consistent with the current study's findings.
We observed an inverse association between weight gain and age at menarche. In other words, the earlier the menarche, the higher the gestational weight gain, on average -2.4kg per year. In the epidemiological context, age at menarche has been inversely associated with excess bodyweight in childbearing-age women, and early age at menarche has been reported as an important risk factor for future obesity 40,41. Some authors suggest that this association can be attributed to excess weight in childhood 42,43. Other studies 44,45 confirm that menarche before 12 years of age can represent predisposition to fat accumulation, as well as to the tendency to deposit adipose tissue during pregnancy in women without excess pre-gestational weight. Early menarche also leads to early initiation of the reproductive cycle, which can influence hormonal activity and body fat deposition due to physiological immaturity. Gunderson et al. 44 reported that women with age at menarche < 12 years showed 2.57 times the odds of presenting postpartum overweight. A study of childbearing-age women in Belo Horizonte by Kac et al. 45 showed a 3.2 odds ratio of obesity in women with age at menarche less than 12 years. Helm et al. 41 found that early menarche was associated with excess weight (OR = 5.0; 95%CI: 2.4-10.6).
Higher triglycerides in early pregnancy were directly associated with weight gain, although the coefficient was relatively small (0.043kg per 1mg/dL). Changes in lipid metabolism during pregnancy lead to an accumulation of maternal fat in early and mid-pregnancy. During early pregnancy, estrogen, progesterone, and insulin levels are increased, favoring lipid deposition and inhibiting lipolysis. Butte 46 demonstrated that lipoprotein lipase activity is increased in adipose tissue in the femoral region from the 8th to the 11th week of pregnancy. This hypothesis provides a probable explanation for the association between triglyceride levels in early pregnancy and greater subsequent weight gain.
Serum glucose concentrations were positively associated with weight gain, estimated at 0.154kg per 1mg/dL, meaning, for example, that a woman who begins pregnancy with a blood glucose of 110mg/dL would experience a 4.6kg greater weight gain as compared to women with blood glucose of 80mg/dL. Saldanha et al. 47, studying the relationship between gestational weight gain and glucose tolerance in women, observed that weight gain was significantly higher in women with gestational diabetes than in those with normal blood glucose. Studying a cohort of 700 women to evaluate the relationship between BMI, glucose tolerance, and gestational outcomes, Bo et al. 48 observed that hyperglycemia in pregnancy was a risk factor for excess gestational weight gain (OR = 1.06; 95%CI: 1.02-1.10). The results of the current study corroborate the findings from the studies quoted above.
An inverse association was observed between adequacy of energy consumption in the first trimester and weight gain during pregnancy. For each percentage point drop in adequacy, there was a weight gain of approximately 0.064kg. Importantly, bodyweight for the pregnant women was measure up to the 13th week to calculate adequacy of energy consumption 1,34. A possible explanation is that some women may display a significant weight drop in early pregnancy, since they are more susceptible to nausea and vomiting 1,3. This can overestimate the percentage adequacy for those who lost weight and underestimate it for those who gained weight. Another plausible explanation is the underreporting of food consumption (as measured by the FFQ) by pregnant women with greater bodyweight. In the study that validated the FFQ used in the present study, Sichieri & Everhart 25 observed that energy consumption by women decreased with the increase in energy expenditure, suggesting that women with excess weight underreported their calorie consumption.
Stulbach et al. 19 evaluated the impact of socio-demographic factors, gestational history, and pre-gestational nutritional status on excess weight gain in pregnancy, and found a high frequency, particularly in women with the following characteristics: more schooling (RR = 1.9; 95%CI: 1.22-2.97), unmarried/without a partner (RR = 1.7; 95%CI: 1.06-2.59), primiparous (RR = 2.1; 95%CI: 1.20-3.85), and pre-gestational overweight/obesity (RR = 2.0; 95%CI: 1.04-3.92). A recently published study with a similar design and using multilevel analysis identified the effect of schooling, marital status, parity, and baseline BMI on weight gain in pregnant women enrolled in a public prenatal clinic in the city of São Paulo, Brazil 49.
The results of the linear longitudinal regression model in the current study showed an effect on weight gain, particularly from biological and food consumption variables, which may only indirectly reflect the pregnant woman's socioeconomic status, thus partially differing from the findings of Stulbach et al. 19. Meanwhile, the results shown in Tables 3 and 4 showed other associations between total weight gain, income, and smoking.
It is suggested that low schooling and low socioeconomic status are associated with increased risk of insufficient gestational weight gain 2. In the current analysis, lower socioeconomic status of pregnant women, as represented by per capita family income, showed lower total gestational weight gain (10.8kg).
Studies focusing on the association between bodyweight and smoking have produced inconclusive evidence 50. Smoking and bodyweight show an inverse association, and smokers, especially women, frequently gain weight when they quit the habit. Smoking is known to induce an acute reaction in the metabolic rate that can lead to a reduction in relative food consumption as compared to non-smokers 51. For pregnant women, it has been documented that smokers gain less weight during pregnancy as compared to non-smokers and former smokers 1. Mongoven et al. 52 observed that women who quit smoking gained more weight than smokers, regardless of pre-gestational nutritional status. In addition, smokers had a higher risk of low weight gain as compared to those who quit smoking (28% versus 13%) 52. Oslon & Strawderman 53 found an association between smoking and weight gain in pregnancy, whereby women who smoked 1.5 packs a day gained significantly less weight. Hellerstedt et al. 54 found that smokers showed lower mean weight gain as compared to non-smokers (9.3 and 9.7kg, respectively), when the women were obese at the beginning of pregnancy; however, women with normal baseline weight gained less weight when they were non-smokers (13.4 versus 15.0kg).
In the current study, smoking was associated with total gestational weight gain. Pregnant women who were former smokers showed the highest total weight gain (13.9kg), followed by smokers (11.7kg) and non-smokers (10.9kg). Our results differ from those of part of the literature, since the current study showed that non-smokers gained less weight by the end of pregnancy. One possible explanation for the discordant findings is the way the smoking habit was measured, which should have included information on quitting, since some women may only have stopped smoking shortly before the first interview.
Losses to follow-up are an important issue for studies with a prospective cohort design, and can thus be considered a potential limitation in the current study. Although care was taken during the study to minimize this problem, losses by the end of the fourth follow-up interview amounted to 31.8%, consistent with similar studies 19. Meanwhile, no selective losses were observed according to socioeconomic characteristics and pre-gestational nutritional status of women who began follow-up as compared to those who concluded the study. A particularly important aspect of the current study was its design and analytical approach. A prospective design, for example, allows calculating important indicators like mean gestational weight gain, rarely used due to the difficulty in calculating it. In addition, the use of mixed-effects models is relevant due to the greater precision and the power to detect significant differences as compared to cross-sectional studies or even the results from analyses of variance for repeated measurements 32.
The results of the current study can be expected to be applicable to pregnant women with the same characteristics as this sample. Thus, special attention should be given during prenatal nutritional follow-up for older women, those with early menarche, high serum triglycerides and glucose, lower-than-recommended energy consumption for satisfactory weight gain, and specific population sub-groups like former smokers and pregnant women with lower socioeconomic status.
P. L. Rodrigues participated in the data collection, elaboration, statistical analysis, and interpretation and preparation of the final paper. E. M. A. Lacerda collaborated in the analysis and revision of the final draft. M. M. Schlüssel contributed to the data interpretation and elaboration and revision of the final draft. M. H. C. Spyrides participated in the statistical analysis and critical revision of the final draft. G. Kac participated in all stages of the study, from the planning to the final revision.
The original research project was funded by the Brazilian National Research Council (CNPq) through the Call for Projects CT SAÚDE/MCT/MS/CNPq, no. 030/2004. G. Kac is a CNPq researcher.
1. Institute of Medicine. Nutrition during pregnancy. Part I: weight gain. Part II: nutrient supplements. Washington DC: National Academies Press; 1990.
2. National Research Council/Institute of Medicine. Influence of pregnancy weight on maternal and child health: workshop report. Washington DC: National Academies Press; 2007.
3. Amorim AR, Lacerda EMA, Kac G. Uso e interpretação dos indicadores antropométricos na avaliação do estado nutricional de gestantes. In: Kac G, Sichieri R, Gigante DP, organizadores. Epidemiologia nutricional. Rio de Janeiro: Fundação Oswaldo Cruz/Editora Atheneu; 2007. p. 31-48.
4. World Health Organization. Physical status: the use and interpretation of anthropometry. WHO Expert Committee. Geneva: World Health Organization; 1995. (Technical Report Series, 854).
5. Thame M, Osmond C, Bennett F, Wilks R, Forrester T. Fetal growth is directly related to maternal anthropometry and placental volume. Eur J Clin Nutr 2004; 58:894-900.
6. Barker D. The best start in life. London: Century Books; 2003.
7. Forsén T, Eriksson JG, Tuomilehto J, Teramo K, Osmond C, Barker DJP. Mother's weight in pregnancy and coronary heart disease in a cohort of Finnish men: follow-up study. BMJ 1997; 315:837-40.
8. Thorsdottir I, Torfadottir JE, Birgisdottir BE, Geirsson GT. Weight gain in women of normal weight before pregnancy: complications in pregnancy or delivery and birth outcome. Obstet Gynecol 2002; 99:799-806.
9. Schieve LA, Cogswell ME, Scanlon KS, Perry G, Ferre C, Blackmore-Prince C, et al. Prepregnancy body mass index and pregnancy weight gain: associations with preterm delivery. Obstet Gynecol 2000; 96:194-200.
10. Seeds JW, Peng T. Impaired growth and risk of fetal death. Is the tenth percentile the appropriate standard? Am J Obstet Gynecol 1998; 178:658-69.
11. Melo ASO, Assunção PL, Gondim SSR, Carvalho DF, Amorim MMR, Benício MHDA, et al. Estado nutricional materno, ganho de peso gestacional e peso ao nascer. Rev Bras Epidemiol 2007; 10:249-57.
12. Kac G, Velásquez-Melández G. Ganho de peso gestacional e macrossomia em uma coorte de mães e filhos. J Pediatr (Rio J) 2005; 81:47-53.
13. Kac G, Benício MHDA, Velásquez-Meléndez G, Valente JG, Struchiner CJ. Gestational weight gain and prepregnancy weight influence postpartum weight retention in a cohort of Brazilian women. J Nutr 2004; 134:661-6.
14. Kac G, Benício MHDA, Velásquez-Meléndez G, Valente JG. Nine months postpartum weight retention predictors for Brazilian women. Public Health Nutr 2004; 7:661-8.
15. Lacerda EMA, Leal MC. Fatores associados com a retenção e o ganho de peso pós-parto: uma revisão sistemática. Rev Bras Epidemiol 2004; 7:187-200.
16. Nucci LB, Schmidt MI, Duncan BB, Fuchs SC, Fleck ET, Britto MMS. Nutritional status of pregnant women: prevalence and associated pregnancy outcomes. Rev Saúde Pública 2001; 35:502-7.
17. Abrams B, Altman SL, Pickett KE. Pregnancy weight gain: still controversial. Am J Clin Nutr 2000; 71(5 Suppl):1233S-41S.
18. Caulfield LE, Stoltzfus RJ, Witter FR. Implications of the Institute of Medicine weight gain recommendations for preventing adverse pregnancy outcomes in black and white women. Am J Public Health 1998; 88:1168-72.
19. Stulbath TE, Benício MHDA, Andrezza R, Kono S. Determinantes do ganho ponderal excessivo durante a gestação. Rev Bras Epidemiol 2007; 10:99-108.
20. Hickey CA. Sociocultural and behavioral influences on weight gain during pregnancy. Am J Clin Nutr 2000; 71(5 Suppl):1364S-70S.
21. Gordon CC, Chumlea WC, Roche AF. Stature, recumbent length, and weight. In: Lohman TG, Roche AF, Martorell R, editors. Anthropometric standardization reference manual. Champaign: Human Kinetics Books; 1988. p. 3-8.
22. Takito MY, Benício MHDA, Latorre MRDO. Postura materna durante a gestação e sua influência sobre o peso ao nascer. Rev Saúde Pública 2005; 39:325-32.
23. Ainsworth BE, Haskell WL, Whitt MC, Irwin ML, Swartz AM, Strath SJ, et al. Compendium of physical activities: an update of activity codes and MET intensities. Med Sci Sports Exerc 2000; 32(9 Suppl):S498-516.
24. Chasan-Taber L, Schmidt MD, Roberts DE, Hosmer D, Markenson G, Freedson PS, et al. Development and validation of a pregnancy physical activity questionnaire. Med Sci Sports Exerc 2004; 36:1750-60.
25. Sichieri R, Everhart JE. Validity of a Brazilian food frequency questionnaire against dietary recalls and estimated energy intake. Nutr Res 1998; 18:1649-59.
26. Núcleo de Estudos e Pesquisas em Alimentação, Universidade Estadual de Campinas. Tabela brasileira de composição de alimentos. v. 2. Campinas: Universidade Estadual de Campinas; 2006.
27. Instituto Brasileiro de Geografia e Estatística. Estudo Nacional de Despesa Familiar. Rio de Janeiro: Instituto Brasileiro de Geografia e Estatística; 1981.
28. Agricultural Research Service, U.S. Department of Agriculture. National nutrient database for standard reference, release 18. http://www.nal.usda.gov/fnic/foodcomp/search/ (accessed on 09/Apr/2007).
29. United Nations University/World Health Organization/Food and Agriculture Organization. Human energy requirements. Report of a Joint FAO/WHO/UNU Expert Consultation. Rome: United Nations University/World Health Organization/Food and Agriculture Organization; 2004. (Food and Nutrition Technical Report Series, 1).
30. Secretaria de Atenção à Saúde, Ministério da Saúde. Pré-natal e puerpério: atenção qualificada e humanizada. Brasília: Ministério da Saúde; 2005. (Série A: Normas e Manuais Técnicos).
31. Friedwald WT, Levy RI, Fredrickson DS. Estimation of the concentration of LDL-cholesterol in plasma without the use of a preparative centrifuge. Clin Chem 1972; 18:499-502.
32. Pinheiro JC, Bates DM. Mixed-effects models in S and S-PLUS. New York: Springer Verlag; 2000.
33. Conselho Nacional de Saúde. Resolução nº. 196/96. sobre pesquisa envolvendo serem humanos. Bioética 1996; 4:415-25.
34. Institute of Medicine. Nutrition during pregnancy and lactation. Washington DC: National Academies Press; 1992.
35. Nucci LB, Duncan BB, Mengue SS, Branchtein L, Schmidt MI, Fleck ET. Assessment of weight gain during pregnancy in general prenatal care services in Brazil. Cad Saúde Pública 2001; 17:1367-74.
36. Andreto LM, Souza AI, Figueroa JN, Cabral Filho JE. Fatores associados ao ganho ponderal excessivo em gestantes atendidas em um serviço público de pré-natal na cidade de Recife, Pernambuco, Brasil. Cad Saúde Pública 2006; 22:2401-9.
37. Atalah E, Castillo C, Castro R, Aldea A. Propuesta de un nuevo estándar de evaluación nutricional en embarazadas. Rev Med Chile 1997; 125:1429-36.
38. Han TS, Bijnen FCH, Lean MEJ, Seidell JC. Separate associations of waist and hip circumference with lifestyle factors. Int J Obes 1998; 27:422-30.
39. Ximenes FMA, Oliveira MCR. A influência da idade materna sobre as condições perinatais. Rev Bras Promoção Saúde 2004; 17:56-60.
40. van Lenthe FJ, Kemper CG, van Mechelen W. Rapid maturation in adolescence results in greater obesity in adulthood: The Amsterdam Growth and Health Study. Am J Clin Nutr 1996; 64:18-24.
41. Helm P, Munster K, Schmidt L. Recalled menarche in relation to infertility and adult weight and height. Acta Obstet Gynecol Scand 1995; 74:718-22.
42. Freedman DS, Khan LK, Serdula MK, Dietz WH, Srinivasan SR, Berensn GS. The relation of menarche age to obesity in childhood and adulthood: the Bogalusa heart study. BMC Pediatrics 2003. http://www.biomedcentral.com/1471-2431/3/3 (accessed on 09/Jan/2008).
43. Must A, Naumova EN, Phillips SM, Blum M, Dawson-Hughes B, Rand WM. Childhood overweight and maturational timing in the development of adult overweight and fatness: The Newton girls study and its follow-up. Pediatrics 2005; 116:620-7.
44. Gunderson EP, Abrams B, Selvin S. The relative importance of gestational gain and maternal characteristics associated with the risk of becoming overweight after pregnancy. Int J Obes 2000; 24:1660-8.
45. Kac G, Velásquez-Meléndez G, Valente JG. Menarca, gravidez precoce e obesidade em mulheres brasileiras selecionadas em um Centro de Saúde de Belo Horizonte, Minas Gerais, Brasil. Cad Saúde Publica 2003; 19 Suppl 1:S111-8.
46. Butte NF. Carbohydrate and lipid metabolism in pregnancy: normal compared with gestational diabetes mellitus. Am J Clin Nutr 2000; 71(5 Suppl):1256S-61S.
47. Saldana TM, Siega-Riz AM, Adair LS, Suchindran C. The relationship between pregnancy weight gain and glucose tolerance status among black and white women in central North Carolina. Am J Obstet Gynecol 2006; 195:1629-35.
48. Bo S, Menato G, Signorile A, Bardelli C, Lezo A, Gallo ML, et al. Obesity or diabetes: what is worse for the mother and for the baby? Diabetes Metab 2003; 29(2 Pt 1):175-8.
49. Konno SC, Benício MHDA, Barros AJD. Fatores associados à evolução ponderal de gestantes: uma análise multinível. Rev Saúde Pública 2007; 41:995-1002.
50. Lahti-Koski M, Pietinen P, Heliövaara M, Vartiainen E. Associations of body mass index and obesity with physical activity, food choices, alcohol intake, and smoking in the 1982-1997 FINRISK Studies. Am J Clin Nutr 2002; 75:809-17.
51. Bray GA. Contemporary diagnosis and management of obesity. Newtown: Handbooks in Health Care; 1998.
52. Mongoven M, Dolan-Mullen P, Groff JY, Nicol L, Burau K. Weight gain associated with prenatal smoking cessation in white, non-Hispanic women. Am J Obstet Gynecol 1996; 174:72-7.
53. Olson CM, Strawderman MS. Modifiable behavioral factors in a biopsychosocial model predict inadequate and excessive gestational weight gain. J Am Diet Assoc 2003; 103:48-54.
54. Hellerstedt WL, Himes JH, Story M, Alton IR, Edwards LE. The effects of cigarette smoking and gestational weight change on birth outcomes in obese and normal-weight women. Am J Public Health 1997; 87:543-4.
Departamento de Nutrição Social e Aplicada
Instituto de Nutrição Josué de Castro
Universidade Federal do Rio de Janeiro
Av. Brigadeiro Trompowsky s/n, Bloco J, 2º andar
Rio de Janeiro, RJ
Submitted on 31/Jan/2008
Final version resubmitted on 18/Mar/2008
Approved on 29/Apr/2008