Depression among diabetic women in urban centers in Mexico and the United States of America: a comparative study


Depresión en mujeres diabéticas de los centros urbanos de México y los Estados Unidos: un estudio comparativo



María del Carmen Lara MuñozI; Elizabeth A. JacobsII; Marco Antonio EscamillaIII; Emily MendenhallIV

IFacultad de Medicina, Benemérita Universidad Autónoma de Puebla México, Puebla, Mexico
IIHealth Innovation and Population Studies, University of Wisconsin-Madison School of Medicine, Madison, Wisconsin, United States of America
IIIInstituto Mexicano del Seguro Social, Puebla, Mexico
IVScience, Technology, and International Affairs Program, Walsh School of Foreign Service, Georgetown University, Washington D.C., United States of America. Send correspondence to Emily Mendenhall, em1061@georgetown.edu




OBJECTIVE: To compare the prevalence and patterns of depressive symptoms among women with type 2 diabetes in Puebla, Mexico, and Chicago, United States.
METHODS: Two cross-sectional studies were conducted independently, in Puebla (September 2010-March 2011) and in Chicago (January-July 2010). Depression symptomatology was evaluated in a random sample of 241 women self-reporting type 2 diabetes in Puebla and a convenience sample of 121 women of Mexican descent seeking care for type 2 diabetes in Chicago. Depressive symptomatology was measured by the Center for Epidemiologic Studies Depression Scale administered in either English or Spanish. Women were similarly socioeconomically disadvantaged with low education levels in both locations.
RESULTS: The Chicago sample of women reported higher levels of depression than the Puebla sample (38% versus 17%, P < 0.0001). Among those with comorbid depression and diabetes in both sites, minimal variations in symptoms were observed. Depressive symptoms, specifically the subjective element (feeling sad) and symptoms associated with diabetes (fatigue and sleep problems) were heightened in both groups. More frequent reporting of "feeling fearful" was statistically significant in Puebla.
CONCLUSIONS: Despite a higher prevalence of depression among Mexican immigrant women with diabetes in the United States compared to Mexico, there was little variation in their depressive symptoms, regardless of residence. However, women in Mexico did report a higher incidence of fear. Screening for depression in patients with diabetes should take into account symptoms of fatigue and sleep and the bi-directional relationship of depression and diabetes.

Keywords: Depressive disorder; diabetes mellitus, type 2; sleep disorders; emigration and immigration; Mexico; United States.


OBJETIVO: Comparar la prevalencia y las características de los síntomas depresivos en mujeres aquejadas de diabetes tipo 2 en Puebla (México) y Chicago (Estados Unidos).
MÉTODOS: Se llevaron a cabo independientemente dos estudios transversales, en Puebla (de septiembre del 2010 a marzo del 2011) y en Chicago (de enero a julio del 2010). Se evaluó la sintomatología depresiva en una muestra aleatoria de 241 mujeres con diagnóstico de diabetes de tipo 2 en Puebla, y en una muestra de conveniencia de 121 mujeres de ascendencia mexicana que acudieron en busca de atención de su diabetes de tipo 2 en Chicago. La sintomatología depresiva se midió mediante la Escala de Depresión del Centro de Estudios Epidemiológicos, administrada ya fuera en inglés o en español. En ambas ubicaciones, las mujeres pertenecían a niveles socioeconómicos desfavorecidos de forma similar y sus niveles de educación eran bajos.
RESULTADOS: Se notificaron niveles más altos de depresión en la muestra de mujeres de Chicago que en la muestra de Puebla (38 frente a 17%, P < 0,0001). En ambos sitios, se observaron variaciones mínimas en los síntomas de las mujeres que padecían depresión y diabetes de manera concomitante. Los síntomas depresivos, específicamente el elemento subjetivo (sentirse triste) y los síntomas asociados con la diabetes (cansancio y problemas de sueño), aparecían intensificados en ambos grupos. La mayor frecuencia de la notificación de "sentirse temerosa"encontrada en Puebla fue estadísticamente significativa.
CONCLUSIONES: A pesar de una mayor prevalencia de depresión en las mujeres mexicanas con diabetes inmigrantes en los Estados Unidos, en comparación con las que vivían en México, hubo poca variación en los síntomas depresivos, independientemente de la residencia. Sin embargo, las mujeres residentes en México notificaron una mayor incidencia de temor. El tamizaje de la depresión en pacientes con diabetes debe tener en cuenta los síntomas de cansancio y de trastornos del sueño, y la relación bidireccional entre la depresión y la diabetes.

Palabras clave: Trastorno depresivo; diabetes mellitus tipo 2; trastornos del sueño; migración internacional; México; Estados Unidos.



Diabetes mellitus, type 2, is a global problem that disproportionately affects low-income populations-80% of individuals with diabetes live in low- and middle-income countries (1). Mexico now has the highest obesity rate in the world and a diabetes prevalence of 15.9% (1). By contrast, the overall rate of type 2 diabetes in the United States is 9.3% (2); however, diabetes prevalence among Mexican-Americans, at 15.6%, mirrors that of Mexico (3). Moreover, depression has been identified as an important comorbidity for people with diabetes in both countries. Clinical studies suggest that comorbid depression among urban residents with diabetes in Mexico is 27%-48% (4, 5), while in the United States, it is 25% (6), with a somewhat higher rate of 32% for Mexican-Americans (7).

Multiple studies have documented a bi-directional relationship between depression and type 2 diabetes (8-11). While living with diabetes contributes to depression (12, 13), biological and behavioral pathways also link depression to diabetes via neurohormonal pathways, alterations in glucose transport, increased immunoinflammatory activation, and the use of antidepressants (8, 11). Depression among those with diabetes is associated with non-adherence to diabetes treatment (14-17), increased diabetes complications (18), and poor glycemic control (19). However, little is known about which depressive symptoms are common among people with diabetes and the symptoms may be linked to social versus diabetes issues.

The bi-directional comorbidity of depression and type 2 diabetes among the urban poor is a growing concern. In the United States, untreated depression among the poor has been associated with heightened diabetes-related morbidity and mortality (18, 19). This study's objective was to compare the prevalence and patterns of depressive symptoms reported by urban women with type 2 diabetes in Mexico (Puebla) and the United States (Chicago).



Two studies were conducted independently: in Puebla, Mexico, from January-July 2010, and in Chicago, Illinois, United States, from January-July 2010. Both locations excluded patients with cognitive impairment, active substance abuse, or a degree of psychosis that might interfere with data collection. Each study's methods are outlined below.

Sample from Puebla, Mexico

This was an observational, cross-sectional study of women previously diagnosed with type 2 diabetes, recruited from any one of 24 outpatient, public clinics known as a "Family Medicine Unit" within the Instituto Mexicano del Seguro Social (Mexican Social Security Institute, Mexico City, Mexico). Potential participants were selected randomly from one shift per day, which was also randomly selected. Study participants were females 18-60 years of age, with diabetes duration of at least 12 months, and who verbally agreed to be interviewed. Participants who were unable to answer the questionnaire due to lack of Spanish-language competence were excluded. To form a sample comparable to that of Chicago, only female respondents 40 years of age or more were included in the analysis. In all, 267 women were evaluated; 22 were excluded for being less than 40 years of age, and 4 incomplete questionnaires were eliminated. The final Puebla sample was 241 women 40-60 years of age with diabetes.

All data collection was reviewed and approved by the Mexican Institute of Social Security's Institutional Review Board in Puebla, Mexico. Although not completed anonymously, questionnaires were physically and electronically protected and identifying data was concealed.

Sample from Chicago, Illinois, United States

This was a cross-sectional study of 121 first- and second-generation Mexican immigrant women seeking diabetes care at a public hospital in Chicago. A convenience sample was composed of female patients who self-identified as Mexican or Mexican-American, were 40-65 years of age, and could give written consent in either English or Spanish. Participants were interviewed for 2-6 hours regarding stressful life events, mental health, immigration, and diabetes. A more extensive discussion of the methods and findings have been published elsewhere (20). To reduce the impact that older age might have on predicting depression and to form a sample comparable to that of Puebla, 29 participants were excluded for being more than 60 years of age.

All data collection was reviewed and approved by Institutional Review Boards of John H. Stroger, Jr. Hospital of Cook County (Chicago, Illinois, United States) and Northwestern University (Evanston, Illinois, United States). Data was physically and electronically protected; questionnaires were completed anonymously.

Data collection and study instrument

The specific sociodemographics collected and analyzed for this study were: age, education (< 12 years or 12 years of schooling), geographic location (Puebla or Chicago), and birthplace (Mexico or the United States). Acculturation was assessed by years lived in the United States. Clinical data evaluated were diabetes control and duration and obesity. In Chicago, Hemoglobin A1c was used to evaluate glycemic control via finger-stick blood samples; in Puebla, it was determined by the mean of the three most recent fasting glucose measurements noted in the patient's medical record. In both locations, participants were informed of their depression-screening results and referred to a specialist as needed. They were also given a brochure on depression.

Center for Epidemiologic Studies Depression Scale (CES-D). Depression was measured in both Chicago and Puebla by administering the CES-D, a widely used 20-item questionnaire designed to assess the major symptoms of depression, in English (21) or in its validated Spanish translation (22).

The CES-D targets symptoms such as depressed mood, changes in appetite and sleep, low energy, feelings of hopelessness, low self-esteem, and loneliness. Respondents are asked to consider the presence and duration of each item/symptom over the past week and to rate each along a four-point scale from 0 (rarely or never) to 3 (most or all of the time). Possible scores range from 0-60. Data shown by the present study was for a cut-off score 23, recommended for depression screening among clinical populations (23).


The primary objective of the analysis was to compare the prevalence of depression across study sites. First, demographic and clinical variables between Chicago and Puebla were compared using chi-square and Student's t-test (Table 1). Then, to identify the variables associated with depression in each site, we compared the demographic and clinical variables between patients with and without depression in Chicago and Puebla, separately, using chi-square and Student's t-test (Table 2). We also performed a logistic regression analysis to explore which variables were associated with depression, controlling for relevant demographic and clinical variables at each of the two sites (Table 3).





A secondary objective was to determine if depressive symptoms among women in Mexico were similar to those of Mexican immigrants in the United States (Table 4). For this analysis, we compared only women who were depressed in Chicago to depressed women in Puebla; responses to each item on the CES-D were dichotomized into two categories: "almost every day" and "not almost every day." The second category included "rarely or none of the time (less than 1 day)," "some or a little of the time (1-2 days)," and "occasionally or a moderate amount of time (3-4 days)." This dichotomy is consistent with the diagnostic criteria outlined by the Diagnostic and Statistical Manual of Mental Disorders, 4th edition, which states that symptoms should be present almost every day to meet criteria for depression. Table 4 presents a chi-square analysis of each item, and whether or not they were the same in the Chicago and Puebla samples.




Table 1 shows sociodemographic characteristics of the Chicago and Puebla samples, as well as the frequency of depression among the women in both groups. Among the women in Chicago, 38% met the criterion for depression, compared to only 17.5% of those in Puebla. While the sociodemographics of the two groups were similar, education levels differed: almost half of the women in Chicago had at least 12 years of schooling compared to only 20% of those in Puebla. Diabetes control also differed, with more uncontrolled diabetes in Chicago (78%) than in Puebla (53.9%).

Table 2 presents sociodemographics and depression results by study site, including some variables disaggregated by Chicago as birthplace. The only variables significantly associated with depression were age and schooling, but not in the same sites. In Chicago, women with depression were significantly older than those without depression (54 ± 5.7 versus 50.66 ± 6.26, P = 0.01). In Puebla, women with fewer years of schooling were depressed more frequently than those with 12 or more years (20% versus 6.5%, P = 0.03).

Table 3 presents the logistic regression results. The dependent variable was depression; the independent variables, selected because they were the only two that showed significant differences between the two sites, were lack of diabetes control and years of schooling. This table demonstrates that the only variables that predicted depression were the group.

Table 4 addresses the study's secondary objective: identifying similarities and differences in the pattern of depressive symptoms reported by women in Chicago and Puebla. Table 4 shows that in both groups the following symptoms occurred most frequently: "I felt depressed," "I felt that everything I did was an effort," "My sleep was restless," and "I felt sad," demonstrating similar patterns in heightened depressive symptoms. Table 4 also shows that only "I felt fearful" (item 10) was significantly different between the women in Puebla and those in Chicago. By including item 10, plus "I thought my life had been a failure" (item 9; P = 0.053) and "I talked less than usual" (item 13; P = 0.06) in a logistic regression analysis, only "I felt fearful" maintained a significant difference between the two groups (Odds ratio [OR] = 3.259; 95% Confidence Interval [95%CI] = 1.065-9.973). These three symptoms appeared "almost every day" in the women from Puebla, more so than in Chicago. Regarding birthplace in the Chicago sample, there were no significant differences among women born in the United States versus those born in Mexico.



To the best of our knowledge, this transnational study is the first to examine differential patterns and symptoms of depression among women with type 2 diabetes in urban Mexico and the United States. We employed similar procedures and instruments at both sites, despite the research being conducted by two teams of researchers. The data clearly indicate that depressive symptoms were much higher among the women with diabetes in Chicago (38%) than in Puebla (17%). However, among the depressed women, there was congruence in depressive symptomatology across study sites. We will discuss this major finding and its implications in turn.

First, nearly twice as many women in Chicago reported depression. This suggests that the mental health of women of Mexican descent residing in the United States with diabetes is worse than that of their counterparts in Mexico. Previous studies have shown that the longer immigrants live in the United States, the worse their health becomes (24); this tendency is apparent for both diabetes (2, 25, 26) and depression (27). However, for those with diabetes, our findings did not indicate a relationship between depression and time of residence in the United States. The lack of a relationship between depression and time of residency questions whether "acculturation" plays a role in these disparate findings, or if instead, other social and economic issues in urban centers in the United States are contributing. During the study interviews, the women in Chicago described other important social and economic factors that might influence depression-interpersonal abuse, poverty, and a breakdown of social support resulting from immigration (20).

Second, the only symptom that significantly differentiated the groups was "feeling fearful," reported most commonly by women residing in Mexico. This was an interesting finding because, while cultural background has been found to influence self-reported health status (28), cultural background was not a variant in this study; the only variance was immigration status. There is some evidence of fear playing a role in mental health, culminating in "fear-based behaviors" (29) and, specifically, a fear of being unable to pay for diabetes care (30). However, why the women in Mexico felt more fear than those in the United States is unclear. It has been shown that neighborhood violence has a direct and indirect impact on depression (31), and recently, that crime does mediate the relationship between disorder perceptions, self-rated health, and depression, though the mediating pathways are weak (32). Yet, since Chicago has one of the highest homicide rates in the United States, it is unlikely that women living there would report lower levels of fear, but it could be that first generation immigrants who tend to reside in immigrant enclaves (24) feel less fearful.

Finally, frequent reporting of certain depressive symptoms among those with diabetes brings up some important questions. For example, is diabetes the cause of great duress, or are other (social) problems playing a role? Frequent reporting of depression-related symptoms might be pointing to factors such as those that emerged from an in-depth analysis of the life history narratives gathered during the interviews in Chicago (e.g., interpersonal abuse, feeling socially isolated, and immigration-related stress) (20).

In Mexico, social contributors to feeling fearful may contribute to depression. More mixed-methods research is needed to fully understand the social complexities around the bi-directional relationship of depression and diabetes.

Also, could targeted mental health screening improve diabetes care? Similarities in the frequency with which both the Chicago and Puebla women reported sleep problems and fatigue-DSM-IV criteria for depression and symptoms associated with diabetes (33, 34)-underscore the importance of mental health care for people with diabetes. A recent article indicated a bi-directional relationship between sleep problems and diabetes, where sleep problems may promote insulin resistance and diabetes itself may cause alterations in sleep (33). Moreover, like the CES-D, many depression inventories incorporate symptoms that overlap with diabetes (35). For instance, in the CES-D, item 7 ("I felt that everything I did was an effort") refers to fatigue, which is also a clinical symptom for both type 1 and 2 diabetes. "Feeling that everything is an effort" is also an item of the K6 screening scale (36), a non-specific psychological distress scale widely-used to screen for mental illness among patients with diabetes (37, 38). In addition, "feeling tired or having little energy" is included in the Patient Health Questionnaire (PHQ-9), a clinical inventory commonly used by diabetes researchers to identify depression (39, 40). Therefore, depression screening can provide clinicians with important diabetes-specific symptoms that could improve medical care.

Study limitations

A limitation of this research was that the samples were taken from separate studies conducted by two research teams at two distinct sites, i.e., there may be some lack of congruence between sociodemographic variables and methods for measuring diabetes control. Also, we did not examine the relative impact of the social and health care systems in each country, so what role Mexico's progressive public health system may have played in lower depression cannot be determined. In addition, cross-cultural comparisons of some sociodemographics may pose disparity; for example, with "years of education," the context may reflect different levels of competence in each location. Moreover, since a random sample was used in Puebla and a convenience sample in Chicago, it is not surprising that higher levels of depression were found in the latter. Also, since most of the Chicago sample had lived there for almost three decades, the results may be biased toward long-standing immigrants. While important to note these limitations, these study findings are relevant nonetheless, demonstrating a depression-symptom profile of patients with diabetes in both places.


This study provides evidence of increased mental distress among Mexican immigrant women with diabetes in Chicago over their counterparts in Puebla, Mexico. These findings also reveal that there is little variation in the depressive symptoms of women with comorbid diabetes and depression, regardless of residence. Across both groups, the women similarly reported the subjective element (feeling sad) and diabetes-related symptoms (fatigue and sleep problems).

Since fatigue and sleep problems may occur as a result of diabetes or as a result of a depressive disorder, causal inference is difficult. These study findings, however, provide some insight into factors surrounding the bi-directional relationship of depression and diabetes. Although more research is needed, screening for depression in patients with diabetes should take into account symptoms of fatigue and sleep and the bi-directional relationship of depression and diabetes.

Conflict of interests. None.



1. International Diabetes Federation. IDF Diabetes Atlas, 6th ed. Brussels, Belgium: IDF; 2013.         

2. United States Center for Disease Control and Prevention. National Diabetes Statistics Report: Estimates of diabetes and its burden in the United States. Washington, DC: U.S. Department of Health and Human Services; 2014.         

3. Castro-Ake G, Tovar-Espinosa JA, Mendoza-Cruz U. Trastorno depresivo y control glucémico en el paciente con diabetes mellitus 2. Rev Med Inst Mex Seguro Soc. 2009;47(4):377-82.         

4. Colunga-Rodriguez C, Tovar-Espinosa J, Mendoza-Cruz U. Diabetes Tipo 2 y Depresión en Guadalajara, México, 2005. Rev Salud Publica (Bogota). 2008;10(1):137-49.         

5. Tovilla-Zárate C, Juárez-Rojop I, Jimenez YP, Jiménez M, Vázquez S, Bermúdez-Ocaña D, et al. Prevalence of anxiety and depression among outpatients with type 2 diabetes in the Mexican population. PLoS One. 2012;7(5):e36887.         

6. Anderson RJ, Freedland KE, Clouse RE, Lustman PJ. The prevalence of comorbid depression in adults with diabetes: a meta-analysis. Diabetes Care. 2001;24(6):1069-78.         

7. de Groot M, Pinkerman B, Wagner J, Hockman E. Depression treatment and satisfaction in a multicultural sample of type 1 and type 2 diabetic patients. Diabetes Care. 2006;29:549-53.         

8. Knol M, Twisk J, Beekman A, Heine R, Snoek F, Pouwer F. Depression as a risk factor for the onset of type 2 diabetes mellitus: a meta-analysis. Diabetologia. 2006;49(5):837-45.         

9. Golden S, Lazo M, Carnethon M, Bertoni A, Schreiner P, Roux A, et al. Examining a bidirectional association between depressive symptoms and diabetes. JAMA. 2008;299(23):2751-9.         

10. Talbot F, Nouwen . A review of the relationship between depression and diabetes in adults. Diabetes Care. 2000;23:1556-62.         

11. Mezuk B, Eaton W, Albrecht S, Golden S. Depression and type 2 diabetes over the lifespan: a meta-analysis. Diabetes Care. 2008;31(12):2383-90.         

12. Nouwen A, Nefs G, Caramlau I, Connock M, Winkley K, Lloyd CE, et al. Prevalence of depression in individuals with impaired glucose metabolism or undiagnosed diabetes: a systematic review and meta-analysis of the European Depression in Diabetes (EDID) Research Consortium. Diabetes Care. 2011; 34(3):752-62.         

13. Nouwen A, Winkley K, Twisk J, Lloyd CE, Peyrot M, Ismail K, et al. Type 2 diabetes mellitus as a risk factor for the onset of depression: a systematic review and meta-analysis. Diabetologia. 2010;53(12):2480-6.         

14. Duangdao KM, Roesch SC. Coping with diabetes in adulthood: a meta-analysis. J Behav Med. 2008;31(4):291-300.         

15. Gonzalez JS, Peyrot M, McCarl LA, Collins EM, Serpa L, Mimiaga MJ, et al. Depression and diabetes treatment nonadherence: a meta-analysis. Diabetes Care. 2008;31(12):2398-403.         

16. van der Feltz-Cornelis CM, Nuyen J, Stoop C, Chan J, Jacobson AM, Katon W, et al. Effect of interventions for major depressive disorder and significant depressive symptoms in patients with diabetes mellitus: a systematic review and meta-analysis. Gen Hosp Psychiatry. 2010;32(4):380-95.         

17. Iovieno N, Tedeschini E, Ameral VE, Rigatelli M, Papakostas GI. Antidepressants for major depressive disorder in patients with a co-morbid axis-III disorder: a meta-analysis of patient characteristics and placebo response rates in randomized controlled trials. Int Clin Psychopharmacol. 2011;26(2):69-74.         

18. de Groot M, Anderson R, Freedland KE, Clouse RE, Lustman PJ. Association of depression and diabetes complications: a meta-analysis. Psychosom Med. 2001;63(4): 619-30.         

19. Lustman PJ, Anderson RJ, Freedland KE, de Groot M, Carney RM, Clouse RE. Depression and poor glycemic control: a meta-analytic review of the literature. Diabetes Care. 2000;23(7):934-42.         

20. Mendenhall E, Jacobs EA. Interpersonal abuse and depression among Mexican immigrant women with type 2 diabetes. Cult Med Psychiatry. 2012;36(1):136-53.         

21. Radloff LS. The CES-D scale: A self report depression scale for research in the general population. Appl Psychol Meas. 1977;1: 385-401.         

22. Soler J, Pérez-Sola V, Puigdemont D, Pérez-Blanco J, Figueres M, Alvarez E. Estudio de validación del Center for Epidemiologic Studies-Depresion (CES-D) en una población española de pacientes con trastornos afectivos. Actas Luso Esp Neurol Psiquiatr Cienc Afines. 1997;25(4):243-9.         

23. Khamseh ME, Baradaran HR, Javanbakht A, Mirghorbani M, Yadollahi Z, Malek M. Comparison of the CES-D and PHQ-9 depression scales in people with type 2 diabetes in Tehran, Iran. BMC Psychiatry 2011;16:11:61.         

24. Lara M, Gamboa C, Kahramanian MI, Morales LS, Bautista DE. Acculturation and Latino health in the United States: a review of the literature and its sociopolitical context. Ann Rev Public Health. 2005;26:367-97.         

25. Borrell L, Borrell LN, Crawford ND, Dallo FJ, Baquero MC. Self-reported diabetes in Hispanic subgroup, non-Hispanic black, and non-Hispanic white populations: National Health Interview Survey, 1997-2005. Public Health Reports. 2009;124(5):702-10.         

26. Pabon-Nau LP, Cohen A, Meigs JB, Grant RW. Hypertension and diabetes prevalence among U.S. Hispanics by country of origin: the national health interview survey 2000-2005. J Gen Intern Med. 2010;25(8):847-52.         

27. González HM, Ceballos M, Tarraf W, West BT, Bowen ME, Vega WA. The health of older Mexican Americans in the long run. Am J Public Health. 2009;10(99):1879-85.         

28. Franzini L1, Fernandez-Esquer ME. Socioeconomic, cultural, and personal influences on health outcomes in low income Mexican-origin individuals in Texas. Soc Sci Med. 2004; 59(8):1629-46.         

29. Sullivan MM, Rehm R. Mental health of undocumented Mexican immigrants: a review of the literature. ANS Adv Nurs Sci. 2005;28(3):240-51.         

30. Page-Reeves J, Niforatos J, Mishra S, Regino L, Gingrich A, Bulten R. Health disparity and structural violence: how fear undermines health among immigrants at risk for diabetes. J Health Dispar Res Pract. 2013;6(2):30-47.         

31. Curry A, Latkin C, Davey-Rothwell M. Pathways to depression: the impact of neighborhood violent crime on inner-city residents in Baltimore, Maryland, USA. Soc Sci Med. 2008;67(1):23-30.         

32. Wallace D. Examining fear and stress as mediators between disorder perceptions and personal health, depression, and anxiety. Soc Sci Res. 2012;41(6):1515-28.         

33. Barone MT, Menna-Barreto L. Diabetes and sleep: a complex cause-and-effect relationship. Diabetes Res Clin Pract. 2011;91(2):129-37.         

34. Fritschi C, Quinn L, Hacker ED, Penckofer SM, Wang E, Foreman M, et al. Fatigue in women with type 2 diabetes. Diabetes Educ. 2012;38(5):662-72.         

35. Roy T, Lloyd CE, Pouwer F, Holt RI, Sartorius N. Screening tools used for measuring depression among people with Type 1 and Type 2 diabetes: a systematic review. Diabet Med. 2012;29(2):164-75.         

36. Kessler RC, Barker PR, Colpe LJ, Epstein JF, Gfroerer JC, Hiripi E, et al. Screening for serious mental illness in the general population. Arch Gen Psychiatry. 2003;60(2):184-9.         

37. Williams SL, Haskard-Zolnierek KB, Banta JE, Haviland MG, DiMatteo MR, Anderson DL, et al. Serious psychological distress and diabetes care among California adults. Int J Psychiatry Med. 2010;40(3):233-45.         

38. Egede LE, Dismuke CE. Serious psychological distress and diabetes: a review of the literature. Curr Psychiatry Rep. 2012;14(1):15-22.         

39. Anderson D, Horton C, O'Toole ML, Brownson CA, Fazzone P, Fisher EB. Integrating depression care with diabetes care in real-world settings: lessons from the Robert Wood Johnson Foundation Diabetes Initiative. Diabetes Spectr 2007;20:10-6.         

40. Katon WJ, Lin EH, Von Korff M, Ciechanowski P, Ludman EJ, Young B, et al. Collaborative care for patients with depression and chronic illnesses. N Engl J Med. 2010; 363(27):2611-20.         



Manuscript received on 3 June 2014
Revised version accepted for publication on 20 October 2014

Organización Panamericana de la Salud Washington - Washington - United States
E-mail: contacto_rpsp@paho.org