About the journal

Basic information


Annali dell?Istituto Superiore di Sanità. Editor in Chief: Enrico Alleva, Director Section of Behavioural Neurosciences, Department of Cellular Biology and Neurosciences, Istituto Superiore di Sanità, Rome, Italy.

Objectives: Annali is published since 1965 (previously, from 1938, Rendiconti dell?Istituto di Sanità Pubblica, then from 1941 Rendiconti dell?Istituto Superiore di Sanità). It is a quarterly scientific journal which publishes in the different fields of public health: original articles, reviews, monographic issues, brief and technical notes.

Its abbreviated title is Ann Ist Super Sanità, which should be used in bibliographies, footnotes and bibliographical references and strips.



Index sources

  • FSTA
  • Zoological Records




The publication receives financial support from:

  • The journal is edited and financially supported only by Istituto Superiore di Sanità (ISS), Viale Regina Elena, 299. 00161 Rome Italy.  E-mail: annali@iss.it www.iss.it


Editorial Board

Editor in chief


Enrico Alleva
Director Dipartimento di Biologia Cellulare e Neuroscienze, (block 19, floor 3, room 2), Istituto Superiore di Sanità, Rome, Italy
Tel.: +39-06-4990-2352/3179
Fax: +39-06-4957821
e-mail: alleva@iss.it



Editorial committee

  • Luca Busani, Dipartimento di Sanità Pubblica Veterinaria e Sicurezza Alimentare (SPVSA), ISS, Rome, Italy luca.busani@iss.it
  • Pietro Comba, Dipartimento di Ambiente e Connessa Prevenzione Primaria (AMPP), ISS, Rome, Italy pietro.comba@iss.it
  • Paola De Castro, Settore Attività Editoriali (SAE-SIDBAE) ISS, Rome, Italy paola.decastro@iss.it
  • Paola Fattibene, Dipartimento di Tecnologie e Salute (TES), ISS, Rome, Italy paola.fattibene@iss.it
  • Maria Ferrantini, Dipartimento di Biologia Cellulare e Neuroscienze (BCE), ISS, Rome Italy maria.ferrantini@iss.it
  • Alessandro Giuliani, Dipartimento di Ambiente e Connessa Prevenzione Primaria (AMPP), ISS, Rome, Italy alessandro.giuliani@iss.it
  • Teodora Macchia, Dipartimento del Farmaco (FARM), ISS, Rome, Italy teodora.macchia@iss.it
  • Giovanni Rezza, Dipartimento di Malattie Infettive, Parassitarie ed Immunomediate, ISS, Rome, Italy giovanni.rezza@iss.it
  • Emanuele Scafato, Centro Nazionale di Epidemiologia, Sorveglianza e Promozione della Salute (CNESPS), ISS, Rome, Italy emanuele.scafato@iss.it
  • Stefano Vella, Dipartimento del Farmaco (FARM), ISS, Rome, Italy stefano.vella@iss.it


Advisory board

  • Dino Amadori, Direttore Scientifico, Istituto Scientifico Romagnolo per lo Studio e la Cura dei Tumori (IRST), Meldola (FC), Italy - direzione.scientifica@irst.emr.it
  • Chris Beyer, Johns Hopkins Bloomberg, School of Public Health, Baltimore, USA - cbeyrer@jhsph.edu
  • Jacqueline Crawley, Laboratory of Behav. Neuroscience, IRP, NIMH, NIH, Bethesda, USA - crawleyj@mail.nih.gov
  • Juana Martín de las Mulas, González-Albo, Facultad de Veterinaria, Universidad de Córdoba, Córdoba, Spain - an1magoj@uco.es
  • Patrick Smeesters, Université Catholique de Louvain, Louvain-La-Neuve, Belgium
  • Tony Fletcher, London School of Hygiene and Tropical Medicine, London, United Kingdom - tony.fletcher@Ishtm.ac.uk
  • Sui Huang, Institute for Systems Biology, Seattle, USA - sui.huang@ucalgary.ca
  • Stefania Maggi, CNR Aging Branch, Institute of Neuroscience, Padova, Italy - stefania.maggi@in.cnr.it
  • Francesco M. Marincola, Immunogenetics Section (IDIS), Department of Transfusion Medicine, Bethesda, USA - fmarincola@mail.cc.nih.gov
  • Ana Marušic, University of Split, School of Medicine, Split, Croatia - ana.marusic@mefst.hr
  • David Vlahov, School of Nursing, Univ of California, San Francisco, San Francisco, USA - david.Vlahov@nursing.UCSF.edu
  • Bernard Zalc, l'Inst. du Cerveau et de la Moelle epiniere, GH Pitie-Salpetriere, Batiment ICM, Paris, France - bernard.zalc@upmc.fr
  • Jean-Francois Delfraissy - jf.delfraissy@anrs.fr


Editorial production

  • Assistant Editor
    Federica Napolitani Cheyne
  • Editing and graphics
    Maria Cristina Barbaro
    Alessandra Fuglieni
    Ilaria Palazzesi
    Laura Radiciotti


Instructions to authors

Scope and policy


Annali dell'Istituto Superiore di Sanità is a peer reviewed quarterly science journal which publishes research articles in biomedicine, translational research and in many other disciplines of the health sciences. The journal includes the following material: original articles, reviews, monographic issues, commentaries, editorials, brief and technical notes, book reviews. Annali follows the Uniform Requirements for Manuscripts Submitted to Biomedical Journals, issued by the International Committee of Medical Journal Editors (ICMJE) www.icmje.org.



Manuscripts submission


Manuscripts should be submitted online to annali@iss.it. The submission should include:

• cover letter where the authors declare that the manuscript has not been published or submitted for publication elsewhere;
• manuscript;
• tables and figures;
• author's contribution statement (individual contribution to the manuscript);
• conflict of interest statement (a conflict of interest exists when authors or their institutions have financial or personal relationship with other people or organizations that could inappropriately bias conduct and findings of the study);
• permission to reproduce figures, if appropriate.
Receipt of author's paper will be acknowledged by an e-mail containing an identification number which should be used in future correspondence.

Review procedure

Each paper submitted to Annali is subjected to the following procedures:

• it is reviewed by the Editor-in-Chief for general suitability;
• if it is judged suitable, qualified referees are selected and a peer review process takes place (occasional contributions, such as commentaries, papers submitted on invitation, etc. are accepted without peer review);
• based on the recommendations of the referees and replies of the authors, the Editor-in-Chief decides whether the article should be accepted, modified or rejected;
• once the paper has been accepted, authors will receive proofs from the editorial office, which should be corrected and returned (usually within three working days).



Manuscript presentation


Please ensure that your manuscript follows these guidelines. For presentation of monographic issues refer to the instructions available online at www.iss.it/anna.

Manuscripts should be written in good English, as concisely as possible to allow a clear understanding of the text.

The title should be followed by the complete name of the authors, their affiliations – in the original language – town and country. The name and address, telephone and e-mail of the corresponding author should also be indicated. On the same page a running head of no more than 40 characters (including spaces) should be included.

Original articles should normally be organized into different sections (i.e.: Introduction, Materials and methods, Results, Discussion, Conclusions).

Each article should be accompanied by:

• a structured abstract of about 150 words;
• key words up to a maximum number of five (MeSH headings, whenever possible. Refer to: www.nlm.nih.gov/mesh/meshhome.html).

Tables and figures should be kept to a minimum and be presented only if necessary.

Authors should deal responsibly and effectively with security issues that might be raised by their papers (see: Statement on Scientific Publication and Security Science 2003;299:1149).

Authors are also encouraged to include data disaggregated by sex (and, whenever possible, by race) and provide a comprehensive analysis of gender and racial differences. The authors should include the number and percentage of men, women and, if appropriate, transgender persons who participated in the research study. Anatomical and physiological differences between men and women (height, weight, body fat-to-muscle ratios, cell counts, hormonal cycles, etc.), as well as social and cultural variables (socio-economic, education, access to care, etc.), should be taken into consideration in the presentation of data and/or analysis of the results. Authors should consider gender issues also in the authorship.

The name of the bioresource (and identifier, if available) who provided samples/data useful for the conduct of the study should be reported in extense, either in the Material and methods section or in the Acknowledgements.

Length of the text

To provide a text that meets the requirements of our publication:

• the editorial should be no longer than 1000 words;
• the commentary, 2000 words;
• the brief note, 3000 words, including about 15 references, one table and one figure;
• the article, 6000 words, including about 40 references, three tables and two figures;
• the review should be no longer than 10 000 words, including about 100 references, four tables and three figures.

Formatting guidelines


• Use Times New Roman font, 10 point, single spaced;
• do not use the automated features of your application (endnotes, headers, footers, especially for references);
• type a single space at the end of each sentence;
• avoid using bold characters to emphasise words or sentences within the text;
• indicate clearly titles of chapters and subchapters avoiding numbering.

Tables and figures

They should be understandable also without reference to the text and should be numbered in Arabic numerals in a consecutive and independent way according to their citation within the paper.

Tables should be presented on a separate sheet and preceeded by a title. Each column within the table should have a heading. Abbreviations should be reported in full in the legend.

Figures should be loaded as separate files. The following file formats are acceptable: JPEG, TIFF or EPS.

Vectorial images (flow charts, schemes, and other non bitmap material) should be in Macromedia Freehand, Adobe Illustrator, Microsoft Power Point.

Figures are redrawn into the Annali style by our in-house illustrators.

Photographs must have a minimum resolution of 300 dpi, width 107 mm and presented in black and white (an extra-cost is due by the author for each colour photograph).

Captions should be presented on a separate sheet and contain a sufficient explanation of their object.


All references in the text must be numbered in square brackets, i.e. [1, 2, 3-6], and mentioned at the end of the article in the order in which they are quoted. They should conform to the "Uniform Requirements for Manuscript Submitted to Biomedical Journals" (known as Vancouver style, www.icmje.org), with some variations according to the following examples.

Titles of periodicals should be abbreviated in accordance with the Medline abbreviation of the US National Library of Medicine (www.nlm.nih.gov/bsd/aim.html). Online journal articles can be cited using, in addition to the complete citation, the DOI number.

Articles in journal

Bozzuto G, Ruggieri P, Molinari A. Molecular aspects of tumor cell migration and invasion. Ann Ist Super Sanità 2010;46(1):66-80.

Books and chapters in a book

Godlee F, Jefferson T. Peer review in health sciences. London: BMJ Books; 1999.

Van Weely S, Leufkens HGM. Background paper: orphan diseases. In: Kaplan W, Laing R (Eds). Priority medicines for Europe and the world – a public health approach to innovation. Geneva: World Health Organization; 2004.


Fadda A, Giacomozzi C, Macellari V. Comparative measurements to validate a new telemetric pressure insoles system. In: 2. International Symposium on measurement, analysis and modelling of human functions. 1. Mediterranean Conference on measurement. Workshop on evaluation check of traceability. Proceedings. Genova: June 14-16, 2004. p. 425-7.

Technical reports

Della Seta M, Di Benedetto C, Leone L, Pizzarelli S, Siegmund U. ETHICSWEB technical guides. Manual for the creation of standards and guidelines for sharing information about knowledge organization systems on ethics and science. Roma: Istituto Superiore di Sanità; 2011. (Rapporti ISTISAN, 11/32).


Italia. Decreto legislativo 29 ottobre, n. 419. Riordinamento del sistema degli enti pubblici nazionali, a norma degli articoli 11 e 14 della legge 15 marzo 1997, n. 59. Gazzetta Ufficiale – Serie Generale n. 268, 15 ottobre 1999.

US Social Security Administration. Evidentiary requirements for making findings about medical equivalence. Final rules. Fed Reg 2006 Mar 1;71(40):10419-33.

The authors should check that each reference cited in the text appears in the reference list and viceversa. References should not include works submitted for publication but not yet accepted or unpublished results, etc. These can be mentioned in the text in parentheses.


All Latin or foreign words should be in italics. The authors should use internationally accepted abbreviations. All abbreviations should be spelled out in full the first time they occur in the text, followed by the shortened term in parentheses; afterwards use the abbreviation only.

Avoid abbreviations in the title of the manuscript.

For writing symbols, quantities and units of measurements refer to the International Systems of Units (SI) and the ISO standards.



Licenses and agreements


Extended quotations and illustrative material taken from other publications must be accompanied by the original permission granted by the Authors and by the publisher.

Responsibility for the contents and opinions expressed on this journal rests solely with the Author(s).

These instructions are available online at www.iss.it/anna. Please, contact the Editorial Office for any other information.

Editorial Office Publishing Unit
Istituto Superiore di Sanità
Viale Regina Elena, 299 00161 Rome, Italy
Tel.: +39 06 49902945 Fax: +39 06 49902253
E-mail: annali@iss.it Website: www.iss.it/anna

Istituto Superiore di Sanità Roma - Rome - Italy
E-mail: annali@iss.it